New light labile linker for solid phase synthesis of 2′-O-acetalester oligonucleotides and applications to siRNA prodrug development

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 12, 2011, Pages 3721-3725

  Johnsson, Richard ^a   Lackey, Jeremy G ^a   Bogojeski, Jovanka J ^a   Damha, Masad J ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2' O ACETAL LEVULINIC ESTER; 2' O AMINO ACID ACETALESTER; ESTER; OLIGONUCLEOTIDE; OLIGORIBONUCLEOTIDE; PRODRUG; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; ROOM TEMPERATURE; SOLID PHASE SYNTHESIS;

ACETALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DIMERIZATION; ESTERS; LIGHT; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES; PRODRUGS; RNA, SMALL INTERFERING; TEMPERATURE;

EID: 79957804951     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.073     Document Type: Article

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