Improved utility of photolabile solid phase synthesis supports for the synthesis of oligonucleotides containing 3′-hydroxyl termini

Journal of Organic Chemistry

Volumn 61, Issue 2, 1996, Pages 525-529

  Venkatesan, Hariharan ^a   Greenberg, Marc M ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE;

ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHOTOCHEMISTRY; REACTION ANALYSIS; TECHNIQUE;

EID: 0030057011     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo951550w     Document Type: Article

References (14)

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6. (b) Barvian, M. R.; Greenberg, M. M. J. Am. Chem. Soc. 1995, 117, 8291.
7. A heteropolymer is defined as an oligonueleotide containing thyinidine and other nucleosides.
8. Schulhof, J. C.; Molko, D.; Teoule, R. Tetrahedron Lett. 1987, 28, 51.
9. Similar observations and suggested solutions were reported while this manuscript was under review. See: Pirrung, M C.; Bradley, J.-C. J. Org. Chem. 1995, 60, 6270.
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12. (b) Cadet, J.; Voituriez, L.; Hahn, B.-S.; Wang, S. Y. J. Chromatogr. 1980, 195, 139.
13. (a) Greenberg, M. M.; Barvian, M. R.; Cook, G. P.; Matray, T. J.; Venkatesan, H. J. Am. Chem. Soc. (submitted).
14. (b) Matray, T. J.; Greenberg, M. M. (unpublished results).