Acetal Levulinyl Ester (ALE) groups for 2′-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays

Journal of the American Chemical Society

Volumn 131, Issue 24, 2009, Pages 8496-8502

  Lackey, Jeremy G ^a   Mitra, Debbie ^b   Somoza, Mark M ^b   Cerrina, Franco ^b   Damha, Masad J ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIP SURFACES; COUPLING EFFICIENCY; DEBLOCKING; DEPROTECTION; DIRECTED SYNTHESIS; HYDRAZINOLYSIS; OLIGORIBONUCLEOTIDES; PHOSPHATE GROUP; PHOSPHORAMIDITE; RIBONUCLEOSIDE; RIBONUCLEOSIDES; RNA SYNTHESIS; SOLID POLYMERS; SOLID SUPPORTS; SYNTHETIC STRATEGIES; SYNTHONS; TWO STAGE;

ACETONITRILE; DERIVATIVES; ESTERIFICATION; ESTERS; NUCLEIC ACIDS; RNA; SYNTHESIS (CHEMICAL);

MICROARRAYS;

ACETAL DERIVATIVE; ACETONITRILE; ADENINE; ESTER DERIVATIVE; FORMAMIDINE; GLASS; GUANINE DERIVATIVE; IMIDAZOLE DERIVATIVE; MONOMER; OLIGORIBONUCLEOTIDE; PHOSPHATE; PHOSPHORAMIDOUS ACID DERIVATIVE; RIBONUCLEOSIDE; RNA; COMPLEMENTARY RNA; ESTER; LEVULINIC ACID; ORGANOPHOSPHORUS COMPOUND; PHOSPHORAMIDOUS ACID;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BINDING; CHEMICAL REACTION; CONTROLLED STUDY; DEPROTECTION REACTION; DNA MICROARRAY; MOLECULAR INTERACTION; NANOFABRICATION; NUCLEIC ACID SYNTHESIS; PRODUCTIVITY; RNA PROBE; RNA SYNTHESIS; SEPARATION TECHNIQUE; SURFACE PROPERTY; CHEMISTRY; METHODOLOGY; SYNTHESIS;

ACETALS; ESTERS; LEVULINIC ACIDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGORIBONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; RIBONUCLEOSIDES; RNA, ANTISENSE;

EID: 67650557289     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9002074     Document Type: Article

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