Chemopreventive effect of epigallocatechin-3-gallate (EGCG) and folic acid on the N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastrointestinal cancer in rat model

Journal of Digestive Diseases

Volumn 12, Issue 3, 2011, Pages 181-187

  Xu, Qi ^a   Yang, Chuan Hua ^a   Liu, Qiang ^a   Jin, Xi Feng ^a   Xu, Xi Tao ^a   Tong, Jin Lu ^a   Xiao, Shu Dong ^a   Ran, Zhi Hua ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Chemoprevention; Epigallocatechin 3 gallate; Folic acid; Gastrointestinal neoplasm; Ki 67 antigen

Indexed keywords

EPIGALLOCATECHIN GALLATE; FOLIC ACID; KI 67 ANTIGEN; METHYLNITRONITROSOGUANIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INCIDENCE; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; GASTROINTESTINAL TUMOR; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH CARCINOGENESIS;

ADENOCARCINOMA; ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; CATECHIN; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FOLIC ACID; GASTROINTESTINAL NEOPLASMS; HEMATINICS; MALE; METHYLNITRONITROSOGUANIDINE; RATS; RATS, WISTAR; SARCOMA; TREATMENT OUTCOME;

EID: 79957776534     PISSN: 17512972     EISSN: 17512980     Source Type: Journal    
DOI: 10.1111/j.1751-2980.2011.00494.x     Document Type: Article

References (33)

1. Suganuma M, Okabe S, Sueoka N etal. Green tea and cancer chemoprevention. Mutat Res 1999; 428: 339-44.
2. Wang ZY, Hong JY, Huang MT, Reuhl KR, Conney AH, Yang CS. Inhibition of N-nitrosodiethylamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-ind uced tumorigenesis in A/J mice by green tea and black tea. Cancer Res 1992; 52:1943-7.
3. Li N, Chen X, Liao J etal. Inhibition of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis 2002; 23: 1307-13.
4. Wang ZY, Wang LD, Lee MJ etal. Inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by green and black tea. Carcinogenesis 1995; 16: 2143-8.
5. Gupta S, Hastak K, Ahmad N, Lewin JS, Mukhtar H. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc Natl Acad Sci U S A 2001; 98: 10350-5.
6. Molloy AM, Scott JM. Folates and prevention of disease. Public Health Nutr 2001; 4: 601-9.
7. Xiao SD, Meng XJ, Shi Y, Hu YB, Zhu SS, Wang CW. Interventional study of high dose folic acid in gastric carcinogenesis in beagles. Gut 2002; 50: 61-4.
8. Kim YI. Role of folate in colon cancer development and progression. J Nutr 2003; 133: 3731S-9S.
9. Tsao AS, Kim ES, Hong WK. Chemoprevention of cancer. CA Cancer J Clin 2004; 54: 150-80.
10. Das D, Arber N, Jankowski JA. Chemoprevention of colorectal cancer. Digestion 2007; 76: 51-67.
11. Dunn LJ, Jankowski J. Chemoprevention of gastrointestinal cancer. Br J Surg 2008; 95: 674-6.
12. Half E, Arber N. Colon cancer: preventive agents and the present status of chemoprevention. Expert Opin Pharmacother 2009; 10: 211-9.
13. Olejnik A, Tomczyk J, Kowalska K, Grajek W. The role of natural dietary compounds in colorectal cancer chemoprevention. Postepy Hig Med Dosw 2010; 64: 175-87. (in Polish).
14. Lin JK, Liang YC. Cancer chemoprevention by tea polyphenols. Proc Natl Sci Counc Repub China B 2000; 24: 1-13.
15. Moyers SB, Kumar NB. Green tea polyphenols and cancer chemoprevention: multiple mechanisms and endpoints for Phase II trials. Nutr Rev 2004; 62: 204-11.
16. Fujiki H, Suganuma M, Okabe S etal. Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1. Mutat Res 2001; 480-1: 299-304.
17. Kemberling JK, Hampton JA, Keck RW etal. Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate. J Urol 2003; 170: 773-6.
18. Mimoto J, Kiura K, Matsuo K etal. (-)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice. Carcinogenesis 2000; 21: 915-9.
19. Ran ZH, Zou J, Feng Y, Xiao SD. Experimental study on anti-neoplastic activity of epigallocatechin-3-gallate in digestive tract carcinomas. J Dig Dis 2003; 8: 326-31. (in chinese).
20. Ran ZH, Xu Q, Tong JL, Xiao SD. Apoptotic effect of epigallocatechin-3-gallate on the human gastric cancer cell line MKN45 via activation of the mitochondrial pathway. World J Gastroenterol 2007; 13: 4255-9.
21. Su LJ, Arab L. Tea consumption and the reduced risk of colon cancer - results from a national prospective cohort study. Public Health Nutr 2002; 5: 419-25.
22. Gao YT, McLaughlin JK, Blot WJ, Ji BT, Dai Q, Fraumeni JF Jr. Reduced risk of esophageal cancer associated with green tea consumption. J Natl Cancer Inst 1994; 86: 855-8.
23. Inoue M, Sasazuki S, Wakai K etal. Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies. Gut 2009; 58: 1323-32.
24. Fang JY, Xiao SD. Folic acid, polymorphism of methyl-group metabolism genes, and DNA methylation in relation to GI carcinogenesis. J Gastroenterol 2003; 38: 821-9.
25. Lambert JD, Yang CS. Mechanisms of cancer prevention by tea constituents. J Nutr 2003; 133: 3262S-7S.
26. Adachi S, Nagao T, To S etal. (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells. Carcinogenesis 2008; 29: 1986-93.
27. Navarro-Perán E, Cabezas-Herrera J, Sánchez-Del-Campo L, García-Cánovas F, Rodríguez-López JN. The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression. Inflamm Res 2008; 57: 472-8.
28. 2. Ann N Y Acad Sci 2009; 1171: 538-44.
29. Adachi S, Shimizu M, Shirakami Y etal. (-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells. Carcinogenesis 2009; 30: 1544-52.
30. Sukhthankar M, Choi CK, English A, Kim JS, Baek SJ. A potential proliferative gene, NUDT6, is down-regulated by green tea catechins at the posttranscriptional level. J Nutr Biochem 2010; 21: 98-106.
31. Guiterrez-Orozco F, Stephens BR, Neilson AP, Green R, Ferruzzi MG, Bomser JA. Green and black tea inhibit cytokine-induced Il-8 production and secretion in AGS gastric cancer cells via inhibition of NF-kappaB activity. Planta Med 2010; 76: 1659-65.
32. Sukhthankar M, Alberti S, Baek SJ. (-)-Epigallocatechin-3-gallate (EGCG) post-transcriptionally and post-translationally suppresses the cell proliferative protein TROP2 in human colorectal cancer cells. Anticancer Res 2010; 30: 2497-503.
33. Tran PL, Kim SA, Choi HS, Yoon JH, Ahn SG. Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo. BMC Cancer 2010; 10: 276.