Inhibition of 11β-hydroxysteroid dehydrogenase enzymatic activities by glycyrrhetinic acid in vivo supports direct glucocorticoid-mediated suppression of steroidogenesis in leydig cells

Journal of Andrology

Volumn 29, Issue 3, 2008, Pages 345-351

  Hu, Guo Xin ^a   Lin, Han ^b,c   Sottas, Chantal M ^c   Morris, David J ^d   Hardy, Matthew P ^f   Ge, Ren Shan ^a,c,e  

^a School of Pharmacy   (United States)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c ROCKEFELLER UNIVERSITY   (United States)

^d BROWN UNIVERSITY   (United States)

^e POPULATION COUNCIL   (United States)

^f NONE

Author keywords

CORT; Testosterone

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTERONE; GLUCOCORTICOID; GLYCYRRHETINIC ACID; LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IN VIVO STUDY; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; STEROIDOGENESIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; ANIMAL; BIOSYNTHESIS; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CORTICOSTERONE; GLUCOCORTICOIDS; GLYCYRRHETINIC ACID; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE;

EID: 43449126555     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.107.004242     Document Type: Article

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