The inhibitory effect of Opuntia humifusa Raf. ethyl acetate extract on platelet aggregation

Journal of Medicinal Plants Research

Volumn 5, Issue 8, 2011, Pages 1418-1424

  Oh, Won Jun ^a   Endale, Mehari ^a   Park, Ji Young ^a   Kwak, Yi Seong ^b   Kim, Suk ^c   Kim, Gon Sup ^c   Rhee, Man Hee ^a  

^a Kyungpook National University   (South Korea)

^b Korea Ginseng Corporation   (South Korea)

^c Gyeongsang National University   (South Korea)

Author keywords

Calcium; Opuntia humifusa extract; Platelet agonists; Rat platelets

Indexed keywords

ACETIC ACID ETHYL ESTER; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA1 INTEGRIN; ANTITHROMBOCYTIC AGENT; BETA2 INTEGRIN; CALCIUM; COLLAGEN; GLYCOPROTEIN VI; OPUNTIA HUMIFUSA EXTRACT; PLANT EXTRACT; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; PURINERGIC P2Y RECEPTOR; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CELL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGRANULATION; DRUG MECHANISM; ENZYME RELEASE; MALE; NONHUMAN; OPUNTIA; OPUNTIA HUMIFUSA; RAT; SECRETORY GRANULE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION;

OPUNTIA HUMIFUSA; RATTUS;

EID: 79957701083     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Acuna UM, Atha DE, Ma J, Nee MH, Kennelly EJ (2002). Antioxidant capacities of ten edible North American plants. Phytother. Res., 16: 63-65.
2. Butera D, Tesoriere L, Di GF, Bongiorno A, Allegra M, Pintaudi AM, Kohen R, Livrea MA (2002). Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. J. Agric. Food Chem., 50: 6895-6901.
3. Calderwood DA, Yan B, De PJM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH (2002). The phosphotyrosine binding-like domain of talin activates integrins. J. Biol. Chem., 277: 21749-21758.
4. Cho JY, Park SC, Kim TW, Kim KS, Song JC, Kim SK, Lee HM, Sung HJ, Park HJ, Song YB, Yoo ES, Lee CH, Rhee MH (2006). Radical scavenging and anti-inflammatory activity of extracts from Opuntia humifusa Raf. J. Pharm. Pharmacol., 58: 113-119.
5. Hyang DG, Lee KH, Kim HJ, Lee EH, Lee J, Song YS, Lee YH, Jin C, Lee YS, Cho J (2003). Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res., 965: 130-136.
6. Feugang JM, Konarski P, Zou D, Stintzing FC, Zou C (2006). Nutritional and medicinal use of Cactus pear (Opuntia spp.) cladodes and fruits. Front Biosci., 11: 2574-2589.
7. Galati EM, Tripodo MM, Trovato A, Miceli N, Monforte MT, (2002). Biological effect of Opuntia ficus indica (L.) Mill. (Cactaceae) waste matter. Note I: diuretic activity. J. Ethnopharmacol., 79: 17-21.
8. Goldstein G, Nobel PS (1994). Water Relations and Low-Temperature Acclimation for Cactus Species Varying in Freezing Tolerance. Plant Physiol., 104: 675-681.
9. Grenache DG, Coleman T, Semenkovich CF, Santoro SA, Zutter MM (2003) Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk. Arterioscler. Thromb. Vasc. Biol., 23: 2104-2109.
10. Hung CC, Tsai WJ, Kuo LM, Kuo YH (2005). Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents. Bioorg. Med. Chem., 13: 1791-1797.
11. Huo Y, Ley KF (2004). Role of platelets in the development of atherosclerosis. Trends Cardiovasc. Med., 14: 18-22.
12. Kamruzzaman SM, Endale M, Oh WJ, Park SC, Kim KS, Hong JH, Kwak YS, Yun BS, Rhee MH (2010). Inhibitory effects of Bulnesia sarmienti aqueous extract on agonist-induced platelet activation and thrombus formation involves mitogen-activated protein kinases. J. Ethnopharmacol., 130: 614-620.
13. Kang WS, Chung KH, Chung JH, Lee JY, Park JB, Zhang YH, Yoo HS, Yun YP (2001). Antiplatelet activity of green tea catechins is mediated by inhibition of cytoplasmic calcium increase. J. Cardiovasc. Pharmacol., 38: 875-884.
14. Kim JH, Park SM, Ha HJ, Moon CJ, Shin TK, Kim JM, Lee NH, Kim HC, Jang KJ, Wie MB (2006). Opuntia ficus-indica attenuates neuronal injury in in vitro and in vivo models of cerebral ischemia. J. Ethnopharmacol., 104: 257-262.
15. Kim SD, Park SK, Cho JY, Park HJ, Lim JHIYH, Park SC, Lee KY, Kim SK, Rhee MH, (2006). Surfactin C inhibits platelet aggregation. J. Pharm. Pharmacol., 58: 867-870.
16. Leclerc JR (2002) Platelet glycoprotein IIb/IIIa antagonists: lessons learned from clinical trials and future directions. Crit. Care Med., 30: S332-340.
17. Lee HS, Kim SD, Lee WM, Endale M, Kamruzzaman SM, Oh WJ, Cho JY, Kim SK, Cho HJ, Park HJ, Rhee MH (2010). A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations. Eur. J. Pharmacol., 627: 85-91.
18. Lee JC, Kim HR, Kim J, Jang YS (2002). Antioxidant property of an ethanol extract of the stem of Opuntia ficus-indica var. saboten. J. Agric. Food Chem., 50: 6490-6496.
19. Lee YY, Jang DS, Jin JL, Yun CHS (2005). Anti-platelet aggregating and anti-oxidative activities of 11-O-(4'-O-methylgalloyl)-bergenin, a new compound isolated from Crassula cv. 'Himaturi'. Planta Med., 71: 776-777.
20. Olas B, Wachowicz B, Majsterek I, Blasiak J (2005). Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytes. Anticancer Drugs, 16: 659-665.
21. Park EH, Chun MJ (2001). Wound healing activity of Opuntia ficusindica. Fitoterapia, 72: 165-167.
22. Park EH, Kahng JH, Paek EA (1998). Studies on the pharmacological action of cactus: identification of its anti-inflammatory effect. Arch. Pharm. Res., 21: 30-34.
23. Savage B, Cattaneo M, Ruggeri ZM (2001). Mechanisms of platelet aggregation. Curr. Opin. Hematol., 8: 270-276.
24. Schaeffer J, Blaustein MP (1989). Platelet free calcium concentrations measured with fura-2 are influenced by the transmembrane sodium gradient. Cell Calcium, 10: 101-113.
25. Shattil SJ, Kashiwagi H, Pampori N (1998). Integrin signaling: the platelet paradigm. Blood, 91: 2645-2657.
26. Son DJ, Cho MR, Jin YR, Kim SY, Park YH, Lee SH, Akiba S, Sato T, Yun YP (2004). Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. Prostaglandins Leukot Essent Fatty Acids, 71: 25-31.
27. Sreekanth D, Arunasree MK, Roy KR, Chandramohan RT, Reddy GV, Reddanna P (2007). Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562. Phytomedicine, 14: 739-746.
28. Stouffer GA, Smyth SS (2003). Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells. Arterioscler. Thromb. Vasc. Biol., 23: 1971-1978.
29. Woulfe DS (2005). Platelet G protein-coupled receptors in hemostasis and thrombosis. J. Thromb. Haemost., 3, 2193-2200.
30. Xiong JP, Stehle T, Goodman SL, Arnaout MA (2003). New insights into the structural basis of integrin activation. Blood, 102: 1155-1159.