Analgesic activity of some 6-phenyl-4-substituted benzylidene tetrahydro pyridazin-3(2H)-ones

Global Journal of Pharmacology

Volumn 5, Issue 1, 2011, Pages 18-22

  Asif, Mohammad ^a   Singh, Deewan ^a   Singh, Anita ^b  

^a GRD (PG) Institute of Management and Technology   (India)

^b Devsthali Vidyapeeth College of Pharmacy   (India)

Author keywords

Analgesic activity; Aspirin; Pyridazinone; Spectral data

Indexed keywords

6 PHENYL 4 (4 CHLOROBENZYLIDENE)TETRAHYDROPYRIDAZIN 3(2H) ONE; 6 PHENYL 4 (4 METHOXYBENZYLIDENE)TETRAHYDROPYRIDAZIN 3(2H) ONE; 6 PHENYL 4 (BENZYLIDENE)TETRAHYDROPYRIDAZIN 3(H) ONE; ACETYLSALICYLIC ACID; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HOT PLATE TEST; INFRARED SPECTROMETRY; MALE; MOUSE; NONHUMAN; PAIN; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 79957667898     PISSN: 19920075     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Islam, M., A.A. Siddiqui and R. Ramadoss, 2008. Synthesis, antitubercular, antifungal and antibacterial activities of 6-substituted phenyl-2-(3í-substituted phenyl pyridazin-6í-yl)-2,3,4,5-tetrahydro- pyridazin-3-one. Acta Pol Pharm & Drug Res., 65: 441-447.
2. Pooja, S.B., P.K. Sharma and K.N. Rajesh, 2009. Synthesis and Anticonvulsant Activity of Pyridazinone Derivatives. Int. J. Chem Tech. Res., 1: 522-525.
3. Dinesh, K., C. Rosalia, C. De la Carmen, P.J. Dharam and B. Ranju, 2008. Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators. Acta Pharm., 58: 393-405.
4. Rathish, I.G., K. Javed, S. Bano, S. Ahmad, M.S. Alam and K.K. Pillai, 2009. Synthesis and blood glucose lowering effect of novel pyridazinone substituted benzenesulfonylurea derivatives. Eur. J. Med. Chem., 44: 2673-8.
5. Deniz, S.D., O. Tijen, O. Semiha, O. Selda and M.F. Sahin, 2008. Synthesis and Antimicrobial Activity of Some 3 (2H)-Pyridazinone and 1 (2H)-Phthalazinone Derivatives. Turk J. Chem., 32: 469-479.
6. Bansal, R., D. Kumar, R. Carron and C. De la Calle, 2009. Synthesis and vasodilatory activity of some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone. Eur. J. Med. Chem., 44: 4441-7.
7. Derson, V., R. Ward and L. Watson, 2009. Design and synthesis of pyridazinone-based 5-HT(2C) agonists. Bioorg. Med. Chem. Lett., 19(19): 5791-5.
8. Nour-Eddine, B., B. Abderazak, F. ElKalai, M. Ramdani and S. Daoui, 2008. Synthesis of 5-benzyl-2,6-dimethylpyridazin-3 (2H)-one. Molbank.
9. Wang, T., Y. Dong, L.C. Wang, B.R. Xiang, Z. Chen and L.B. Qu, 2008. Design, synthesis and structure-activity relationship studies of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives as cardiotonic agents. Arzneimittelforschung, 58: 569-73.
10. Abouzid, K., M.A. Hakeem, O. Khalil and Y. Maklad, 2008. Pyridazinone derivatives: design, synthesis and in vitro vasorelaxant activity, Bioorg. Med. Chem., 16: 382-389.
11. Rakib, E.M., S. Abouricha, A. Hannioui, N. Benchat, L.A. M'barek and A. Zyad, 2006. Synthesis and in vitro Cytotoxicity Studies of Novel Triazolo[4,3-b]pyridazinones. J. Iranian Chem Society, 3: 272-276.
12. Van, J.R. and R.M. Botting, 1995. New insights into the mode of action of antiinflammatory drugs. Inflamm Res., 44: 1-10.
13. Raskin, J.B., 1999. Gastrointestinal effects of nonsteroidal antiinflammatory therapy. Am. J. Med., 106: 3S-12S.
14. McCarthy, D., 1998. Nonsteroidal antiinflammatory drug-related gastrointestinal toxicity: definition and epidemiology. Am. J. Med., 105: 3S-9S.
15. Gokce, M., M.S. Colak, E. Kupeli and M.F. Sahin, 2009. Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives. Arzneimittelforschung, 59: 357-63.
16. Gokce, M., S. Utku and E. Kupeli, 2009. Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubsti- tuted benzal) hydraz- one derivatives. Eur. J. Med. Chem., 44: 3760-4.
17. Erden, B., S. Murat_C Ukuroglu, C. Burcu Calis CKanergun, N.B. Sultan, A. Eda and A.R.K. Mustafa, 2007. Synthesis of the Amide Derivatives of 3-[1-(3-Pyridazinyl)-5-phenyl-1H-pyrazole-3-yl] propanoic Acids as Potential Analgesic Compounds. Turk J. Chem., 31: 677-687.
18. Sukuroglu, M., E. Kupeli, E. Banoglu, S. Unlu, E. Yesilada and M.F. Sahin, 2006. Synthesis and analgesic activity of some 4,6-disubstituted-3(2H)-pyridazinone derivatives. Arzneimittelforschung, 56: 337-45.
19. Murat, S., C.E. Burcu, U. Serdar, M.F. Sahin, K. Esra, Y. Erdem and B. Erden, 2005. Synthesis, Analgesic and Anti-Inflammatory Activities of [6-(3,5-Dimethyl-4-Chloropyrazole-1-yl)-3(2H)-Pyridazinon-2-yl]Acetamides. Arch Pharm. Res., 28: 509-517.
20. Gokce, M., G. Bakir, M.F. Sahin, E. Kupeli and E. Yesilada, 2005. Synthesis of new Mannich bases of arylpyridazinones as analgesic and anti-inflammatory agents. Arzneimittelforschung, 55: 318-25.
21. Giovannoni, M.P., C. Vergelli, C. Ghelardini, N. Galeotti, A. Bartolini and V.D. Piaz, 2003. [(3-Chloro phenyl) piperazinylpropyl] pyridazinones and analogues as potent antinociceptive agents. J. Med. Chem., 46: 1055-1059.
22. Gokce, M., D. Dogruer and M.F. Sahin, 2001. Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives. Il Farmaco, 56: 233-237.
23. Furnish, B.S., A.J. Hanaford and P.W.G. Smith, 1989. Vogel's textbook of practical organic chemistry 5th edition, tatchell longeman group Ltd. London, 695: 1015.
24. Aly, A.A. and A.A.F. Wasfy, 2004. • -oxo carboxylic acids in heterocyclic synthesis. Part IV- synthesis of some pyridazines containing and tosyl amino acids using DCC as the condensing agents. Indian J. Chem. B., 43: 629-635.
25. Kulkarni, S.K., 1999. Handbook of experimental pharmacology 3rd edition vallabh publication New Delhi, pp: 131-133.
26. Takaya, M., M. Sato, K. Terashima and H. Tanizawa, 1979. A new nonsteroidal analgesic anti-inflammatory agent. Synthesis and activity of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone and related compounds. J. Med. Chem., 22: 53-58.
27. Piaz, D. V., M.P. Giovannoni, G. Ciciani, D. Barlocco, G. Giardina, G. Petrone and G.D. Clarke, 1996. 4,5-Functionalized 6-Phenyl-3(2H)-pyridazinones: Synthesis and Evaluation of Antinociceptive Activity. Eur. J. Med. Chem., 31: 65-70.