Design, synthesis and structure-activity relationship studies of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives as cardiotonic agents

Arzneimittel-Forschung/Drug Research

Volumn 58, Issue 11, 2008, Pages 569-573

  Wang, Teng ^a   Dong, Ying ^a   Wang, Li Chen ^a   Xiang, Bing Ren ^a   Chen, Zhen ^a   Qu, Ling Bo ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

3(2H) pyridazinones, cardiotonic activity, structure activity relationship, synthesis; Cardiotonic agents; CAS 141505 33 1; Levosimendan

Indexed keywords

2,3 DICHLORO N [4 (4 METHYL 6 OXO 1,4,5,6 TETRAHYDROPYRIDAZIN 3 YL)PHENYL]BENZAMIDE; 3 METHYL 4 NITRO N [4 (6 OXO 1,4,5,6 TETRAHYDROPYRIDAZIN 3 YL)PHENYL]BENZAMIDE; 4 AMINO 3 METHYL N [4 (4 METHYL 6 OXO 1,4,5,6 TETRAHYDROPYRIDAZIN 3 YL)PHENYL]BENZAMIDE; 4 AMINO 3 METHYL N [4 (6 OXO 1,4,5,6 TETRAHYDROPYRIDAZIN 3 YL)PHENYL]BENZAMIDE; 6 PHENYL 4,5 DIHYDRO 3(2H) PYRIDAZINONE DERIVATIVE; CARDIOTONIC AGENT; LEVOSIMENDAN; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 57649136974     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296558     Document Type: Article

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