Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection

Cellular Immunology

Volumn 269, Issue 2, 2011, Pages 104-114

  Larrubia, Juan R ^a   Benito Martínez, Selma ^a   Miquel, Joaquín ^a   Calvino, Miryam ^a,b   Sanz de Villalobos, Eduardo ^a   González Praetorius, Alejandro ^a   Albertos, Sonia ^c   García Garzón, Silvia ^a   Lokhande, Megha ^a   Parra Cid, Trinidad ^a,b  

^a HOSPITAL UNIVERSITARIO DE GUADALAJARA   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Apoptosis; Bim; CD127; Chronic hepatitis; Cytotoxic T lymphocytes; HCV; PD 1; PD L1; Viral persistence; Z VAD fmk

Indexed keywords

BIM PROTEIN; CD8 ANTIGEN; INTERLEUKIN 7 RECEPTOR; PEGINTERFERON ALPHA2B; PROGRAMMED DEATH 1 LIGAND 1; RIBAVIRIN;

ADULT; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLAVIVIRUS INFECTION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MORBIDITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STIMULATION; VIREMIA;

ADULT; AMINO ACID CHLOROMETHYL KETONES; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL COUNT; CELL PROLIFERATION; FEMALE; HEPATITIS C, CHRONIC; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LIVER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 79957661532     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.03.011     Document Type: Article

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