-
1
-
-
13544249943
-
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
-
DOI 10.1038/sj.tpj.6500285
-
Ingelman-Sundberg M: Genetic polymorphisms of cytochrome P450 2D6 {CYP2D6): clinical consequences, evolutionary aspects and functional diversity Pharmacogenomics J. 5, 6-13 (2005). (Pubitemid 40220611)
-
(2005)
Pharmacogenomics Journal
, vol.5
, Issue.1
, pp. 6-13
-
-
Ingelman-Sundberg, M.1
-
2
-
-
0037421584
-
Inheritance and drug response
-
DOI 10.1056/NEJMra020021
-
Weinshilboum R: Inheritance and drug response. N. Engl. J. Med. 348, 529-537 (2003). (Pubitemid 36159889)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.6
, pp. 529-537
-
-
Weinshilboum, R.1
-
3
-
-
0742286803
-
Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
-
DOI 10.1007/s00210-003-0832-2
-
Zanger UM, Raimundo S, Eichelbaum M: Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry Naunyn Schmiedebergs Arch. Pharmacol. 369, 23-37 (2004). (Pubitemid 38161221)
-
(2004)
Naunyn-Schmiedeberg's Archives of Pharmacology
, vol.369
, Issue.1
, pp. 23-37
-
-
Zanger, U.M.1
Raimundo, S.2
Eichelbaum, M.3
-
4
-
-
0034790063
-
Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6
-
DOI 10.1097/00008571-200110000-00004
-
Zanger UM, Fischer J, Raimundo S, et al. Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6. Pharmacogenetics 11, 573-585 (2001). (Pubitemid 32953583)
-
(2001)
Pharmacogenetics
, vol.11
, Issue.7
, pp. 573-585
-
-
Zanger, U.M.1
Fischer, J.2
Raimundo, S.3
Stuven, T.4
Evert, B.O.5
Schwab, M.6
Eichelbaum, M.7
-
5
-
-
33749005081
-
Impaired expression of CYP2D6 in intermediate metabolizers carrying the*41 allele caused by the intronic SNP 2988G>A: Evidence for modulation of splicing events
-
DOI 10.1097/01.fpc.0000230112.96086.e0, PII 0121301120061000000008
-
Toscano C, Klein K, Blievernicht J, et al. Impaired expression of CYP2D6 in intermediate metabolizers carrying the *4l allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events. Pharmacogenet. Genomics 16,755-766 (2006). (Pubitemid 44454870)
-
(2006)
Pharmacogenetics and Genomics
, vol.16
, Issue.10
, pp. 755-766
-
-
Toscano, C.1
Klein, K.2
Blievernicht, J.3
Schaeffeler, E.4
Saussele, T.5
Raimundo, S.6
Eichelbaum, M.7
Schwab, M.8
Zanger, U.M.9
-
6
-
-
0024796958
-
The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
-
Kimura S, Umeno M, Skoda RC, Meyer UA, Gonzalez FJ: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am. J. Hum. Genet. 45, 889-904 (1989). (Pubitemid 20045231)
-
(1989)
American Journal of Human Genetics
, vol.45
, Issue.6
, pp. 889-904
-
-
Kimura, S.1
Umeno, M.2
Skoda, R.C.3
Meyer, U.A.4
Gonzalez, F.J.5
-
7
-
-
0033461165
-
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
-
Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS: Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 9, 669-682 (1999). (Pubitemid 30011931)
-
(1999)
Pharmacogenetics
, vol.9
, Issue.6
, pp. 669-682
-
-
Gaedigk, A.1
Gotschall, R.R.2
Forbes, N.S.3
Simon, S.D.4
Kearns, G.L.5
Leeder, J.S.6
-
8
-
-
0036124107
-
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
-
DOI 10.1517/14622416.3.2.229
-
Bradford LD: CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 3, 229-243 (2002). (Pubitemid 34223859)
-
(2002)
Pharmacogenomics
, vol.3
, Issue.2
, pp. 229-243
-
-
Bradford, L.D.1
-
9
-
-
0036339071
-
Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
-
DOI 10.1067/mcp.2002.125783
-
Gaedigk A, Bradford LD, Marcucci KA, Leeder JS: Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin. Pharmacol. Ther. 72, 76-89 (2002). (Pubitemid 34833189)
-
(2002)
Clinical Pharmacology and Therapeutics
, vol.72
, Issue.1
, pp. 76-89
-
-
Gaedigk, A.1
Bradford, L.D.2
Marcucci, K.A.3
Leeder, J.S.4
-
10
-
-
33846195001
-
Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay
-
DOI 10.1016/j.mrgentox.2006.11.005, PII S1383571806003974
-
Bailliet G, Santos MR, Alfaro EL, et al. Allele and genotype frequencies of metabolic genes in native Americans from Argentina and Paraguay. Mutat. Res. 627, 171-177 (2007). (Pubitemid 46097495)
-
(2007)
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
, vol.627
, Issue.2
, pp. 171-177
-
-
Bailliet, G.1
Santos, M.R.2
Alfaro, E.L.3
Dipierri, J.E.4
Demarchi, D.A.5
Carnese, F.R.6
Bianchi, N.O.7
-
11
-
-
33645787537
-
CYP2D6 genotype and phenotype in Amerindians of Tepehuano origin and Mestizos of Durango Mexico
-
Sosa-Macias M, Elizondo G, Flores-Perez C et al: CYP2D6 genotype and phenotype in Amerindians of Tepehuano origin and Mestizos of Durango, Mexico. J. Clin. Pharmacol. 46, 527-536 (2006).
-
(2006)
J. Clin. Pharmacol.
, vol.46
, pp. 527-536
-
-
Sosa-Macias, M.1
Elizondo, G.2
Flores-Perez, C.3
-
12
-
-
41549109042
-
Cytochrome P450 enzyme polymorphism frequency in indigenous and native American populations: A systematic review
-
DOI 10.1159/000113876
-
Jaja C, Burke W, Thummel K, Edwards K, Veenstra DL: Cytochrome P450 enzyme polymorphism frequency in indigenous and native American populations: a systematic review. Community Genet. 11, 141-149 (2008). (Pubitemid 351465617)
-
(2008)
Community Genetics
, vol.11
, Issue.3
, pp. 141-149
-
-
Jaja, C.1
Burke, W.2
Thummel, K.3
Edwards, K.4
Veenstra, D.L.5
-
13
-
-
49349109652
-
Systematic polymorphism analysis of the CYP2D6gene in four different geographical Han populations in Mainland China
-
Qin S, Shen L, Zhang A, et al. Systematic polymorphism analysis of the CYP2D6gene in four different geographical Han populations in Mainland China. Genomics 92, 152-158 (2008).
-
(2008)
Genomics
, vol.92
, pp. 152-158
-
-
Qin, S.1
Shen, L.2
Zhang, A.3
-
14
-
-
33748210748
-
Sequence-based CYP2D6 genotyping in the Korean population
-
DOI 10.1097/01.ftd.0000211823.80854.db, PII 0000769120060600000018
-
Lee SY, Sohn KM, Ryu JY, Yoon YR, Shin JG, Kim JW: Sequence-based CYP2D6 genotyping in the Korean population. Ther. Drug Momt. 28, 382-387 (2006). (Pubitemid 44314926)
-
(2006)
Therapeutic Drug Monitoring
, vol.28
, Issue.3
, pp. 382-387
-
-
Lee, S.-Y.1
Sohn, K.M.2
Ryu, J.Y.3
Yoon, Y.R.4
Shin, J.G.5
Kim, J.-W.6
-
15
-
-
0031038038
-
Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
-
Sachse C, Brockmoller J, Bauer S, Roots I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. 60,284-295 (1997). (Pubitemid 27058401)
-
(1997)
American Journal of Human Genetics
, vol.60
, Issue.2
, pp. 284-295
-
-
Sachse, C.1
Brockmoller, J.2
Bauer, S.3
Roots, I.4
-
16
-
-
0034891594
-
Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in Southern California
-
DOI 10.1097/00008571-200108000-00004
-
Wan YJ, Poland RE, Han G et al: Analysis of the CYP2D6gene polymorphism and enzyme activity in African-Americans in southern California. Pharmacogenetics 11, 489-499 (2001). (Pubitemid 32778227)
-
(2001)
Pharmacogenetics
, vol.11
, Issue.6
, pp. 489-499
-
-
Yvonne Wan, Y.-J.1
Poland, R.E.2
Han, G.3
Konishi, T.4
Zheng, Y.-P.5
Berman, N.6
Lin, K.-M.7
-
17
-
-
0032810509
-
Comparative evolutionary pharmacogenetics of CYP2D6 in Ngawbe and Embera Amerindians of Panama and Colombia: Role of selection versus drift in world populations
-
Jorge LF, Eichelbaum M, Griese EU, Inaba T, Arias TD: Comparative evolutionary pharmacogenetics of CYP2D6 in Ngawbe and Embera Amerindians of Panama and Colombia: role of selection versus drift in world populations. Pharmacogenetics 9, 217-228 (1999). (Pubitemid 29359004)
-
(1999)
Pharmacogenetics
, vol.9
, Issue.2
, pp. 217-228
-
-
Jorge, L.F.1
Eichelbaum, M.2
Griese, E.-U.3
Ernst, U.4
Inaba, T.5
Arias, T.D.6
-
18
-
-
0031875940
-
Genetic polymorphisms of CYP2D6, CYP1A1 AND CYP2E1 in the South-Amerindian population of Chile
-
DOI 10.1097/00008571-199808000-00008
-
MunozS, Vollrath V,VallejosMP, et al. Genetic polymorphisms of CYP2D6, CYPlAl and CYP2E1 in the South-Amerindian population of Chile. Pharmacogenetics 8, 343-351 (1998). (Pubitemid 28372328)
-
(1998)
Pharmacogenetics
, vol.8
, Issue.4
, pp. 343-351
-
-
Munoz, S.1
Vollrath, V.2
Vallejos, M.P.3
Miquel, J.F.4
Covarrubias, C.5
Raddatz, A.6
Chianale, J.7
-
19
-
-
33847031732
-
CYP2D6worldwide genetic variation shows high frequency of altered activity variants and no continental structure
-
Sistonen J, SajantilaA, Lao O, CoranderJ, Barbujani G, Fuselli S: CYP2D6worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet. Genomics 17, 93-101 (2007).
-
(2007)
Pharmacogenet. Genomics
, vol.17
, pp. 93-101
-
-
Sistonen, J.1
Sajantila, A.2
Lao, O.3
Corander, J.4
Barbujani, G.5
Fuselli, S.6
-
20
-
-
27944474000
-
CYP2D6 genotype and phenotype determination in a Mexican Mestizo population
-
DOI 10.1007/s00228-005-0038-2
-
Lopez M, Guerrero J, Jung-Cook H, Alonso ME: CKP.2D 6" genotype and phenotype determination in a Mexican Mestizo population. Eur. J. Clin. Pharmacol. 61, 749-754(2005). (Pubitemid 41674261)
-
(2005)
European Journal of Clinical Pharmacology
, vol.61
, Issue.10
, pp. 749-754
-
-
Lopez, M.1
Guerrero, J.2
Jung-Cook, H.3
Alonso, M.E.4
-
21
-
-
28444496691
-
Identification of CYP2D6 impaired functional alleles in Mexican Americans
-
DOI 10.1007/s00228-005-0044-4
-
Luo HR, Gaedigk A, Aloumanis V, Wan YJ: Identification of CYP2D6 impaired functional alleles in Mexican Americans. Eur. J. Clin. Pharmacol. 61, 797-802 (2005). (Pubitemid 41722129)
-
(2005)
European Journal of Clinical Pharmacology
, vol.61
, Issue.11
, pp. 797-802
-
-
Luo, H.-R.1
Gaedigk, A.2
Aloumanis, V.3
Wan, Y.-J.Y.4
-
22
-
-
0035651785
-
CYP2D6 polymorphism in a Mexican American population
-
DOI 10.1067/mcp.2001.120675
-
Mendoza R, Wan YJ, Poland RE, et al. CKPD polymorphism in a Mexican American population. Clin. Pharmacol. Ther. 70,552-560 (2001). (Pubitemid 34008413)
-
(2001)
Clinical Pharmacology and Therapeutics
, vol.70
, Issue.6
, pp. 552-560
-
-
Mendoza, R.1
Wan, Y.-J.Y.2
Poland, R.E.3
Smith, M.4
Zheng, Y.5
Berman, N.6
Lin, K.-M.7
-
23
-
-
0034469337
-
Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population
-
DOI 10.1358/mf.2000.22.9.802286
-
Isaza CA, Henao J, Lopez AM, Cacabelos R: Isolation, sequence and genotyping of the drug metabolizer CYP2D6gene in the Colombian population. Methods Find. Exp. Clin. Pharmacol. 22, 695-705 (2000). (Pubitemid 32216825)
-
(2000)
Methods and Findings in Experimental and Clinical Pharmacology
, vol.22
, Issue.9
, pp. 695-705
-
-
Isaza, C.A.1
Henao, J.2
Lopez, A.M.3
Cacabelos, R.4
-
24
-
-
0030795692
-
Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: Impact of gene-flow from Europe
-
DOI 10.1097/00008571-199708000-00010
-
Agundez JA, Ramirez R, Hernandez M, LlerenaA, BenkezJ: Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe. Pharmacogenetics 7, 337-340 (1997). (Pubitemid 27356935)
-
(1997)
Pharmacogenetics
, vol.7
, Issue.4
, pp. 337-340
-
-
Agundez, J.A.G.1
Ramirez, R.2
Hernandez, M.3
Llerena, A.4
Benitez, J.5
-
25
-
-
0034143970
-
Admixture studies in Latin America: From the 20th to the 21st century
-
Sans M: Admixture studies in Latin America: from the 20th to the 21st century. Hum. Biol. 72, 155-177(2000). (Pubitemid 30132304)
-
(2000)
Human Biology
, vol.72
, Issue.1
, pp. 155-177
-
-
Sans, M.1
-
28
-
-
66649119427
-
Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico
-
Silva-Zolezzi I, Hidalgo-Miranda A, Estrada-Gil J, et al. Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico. Proc. Natl Acad. Sci. USA 106, 8611-8616 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 8611-8616
-
-
Silva-Zolezzi, I.1
Hidalgo-Miranda, A.2
Estrada-Gil, J.3
-
29
-
-
0033790979
-
Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6
-
Raimundo S, Fischer J, Eichelbaum M, Griese EU, Schwab M, Zanger UM: Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6. Pharmacogenetics 10, 577-581 (2000).
-
(2000)
Pharmacogenetics
, vol.10
, pp. 577-581
-
-
Raimundo, S.1
Fischer, J.2
Eichelbaum, M.3
Griese, E.U.4
Schwab, M.5
Zanger, U.M.6
-
30
-
-
3543014421
-
A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects
-
DOI 10.1016/j.clpt.2004.04.009, PII S0009923604001377
-
Raimundo S, Toscano C, Klein K et al: A novel intronic mutation, 2988G>A, with high predictivhy for impaired function of cytochrome p450 2D6 in white subjects. Clin. Pharmacol. Ther. 76, 128-138 (2004). (Pubitemid 39013403)
-
(2004)
Clinical Pharmacology and Therapeutics
, vol.76
, Issue.2
, pp. 128-138
-
-
Raimundo, S.1
Toscano, C.2
Klein, K.3
Fischer, J.4
Griese, E.-U.5
Eichelbaum, M.6
Schwab, M.7
Zanger, U.M.8
-
31
-
-
20744455857
-
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
-
DOI 10.1038/sj.tpj.6500305
-
Gaedigk A, BhathenaA, Ndjountche L, et al. Identification and characterization of novel sequence variations in the cytochrome P4502D6 {CYP2D6) gene in African Americans. Pharmacogenomics J. 5, 173-182 (2005). (Pubitemid 40852219)
-
(2005)
Pharmacogenomics Journal
, vol.5
, Issue.3
, pp. 173-182
-
-
Gaedigk, A.1
Bhathena, A.2
Ndjountche, L.3
Pearce, R.E.4
Abdel-Rahman, S.M.5
Alander, S.W.6
Bradford, L.D.7
Leeder, J.S.8
-
32
-
-
0842312531
-
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
-
DOI 10.1097/00008571-200401000-00001
-
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 14, 1-18 (2004). (Pubitemid 38183957)
-
(2004)
Pharmacogenetics
, vol.14
, Issue.1
, pp. 1-18
-
-
Nelson, D.R.1
Zeldin, D.C.2
Hoffman, S.M.G.3
Maltais, L.J.4
Wain, H.M.5
Nebert, D.W.6
-
33
-
-
31044436017
-
Determination of cytochrome P450 2D6 (CYP2D6) gene copy number by real-time quantitative PCR
-
DOI 10.1155/JBB.2005.248
-
Bodin L, Beaune PH, Loriot MA: Determination of cytochrome P450 2D6 {CYP2D6) gene copy number by real-time quantitative PCR. J. Biomed. Biotechnol. 2005, 248-253 (2005). (Pubitemid 43120932)
-
(2005)
Journal of Biomedicine and Biotechnology
, vol.2005
, Issue.3
, pp. 248-253
-
-
Bodin, L.1
Beaune, P.H.2
Loriot, M.-A.3
-
34
-
-
0242691208
-
A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data
-
DOI 10.1086/379378
-
Stephens M, Donnelly P: A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am. J. Hum. Genet. 73, 1162-1169 (2003). (Pubitemid 37414228)
-
(2003)
American Journal of Human Genetics
, vol.73
, Issue.5
, pp. 1162-1169
-
-
Stephens, M.1
Donnelly, P.2
-
35
-
-
0035071957
-
A new statistical method for haplotype reconstruction from population data
-
DOI 10.1086/319501
-
Stephens M, Smith NJ, Donnelly P: A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68, 978-989 (2001). (Pubitemid 32289743)
-
(2001)
American Journal of Human Genetics
, vol.68
, Issue.4
, pp. 978-989
-
-
Stephens, M.1
Smith, N.J.2
Donnelly, P.3
-
36
-
-
85007110786
-
Arlequin (version 3.0): An integrated software package for population genetics data analysis
-
Excoffier L, Laval G, Schneider S: Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evol. Bioinform. Online 1, 47-50 (2005).
-
(2005)
Evol. Bioinform. Online
, vol.1
, pp. 47-50
-
-
Excoffier, L.1
Laval, G.2
Schneider, S.3
-
37
-
-
0043122919
-
SIFT: Predicting amino acid changes that affect protein function
-
DOI 10.1093/nar/gkg509
-
Ng PC, Henikoff S: Sift: predicting amino acid changes that affect protein function. Nucleic Acids Res. 31, 3812-3814 (2003). (Pubitemid 37442253)
-
(2003)
Nucleic Acids Research
, vol.31
, Issue.13
, pp. 3812-3814
-
-
Ng, P.C.1
Henikoff, S.2
-
38
-
-
0036713510
-
Human non-synonymous SNPs: Server and survey
-
Ramensky V, Bork P, Sunyaev S: Human non-synonymous SNPs: server and survey. Nucleic Acids Res. 30, 3894-3900 (2002). (Pubitemid 35012462)
-
(2002)
Nucleic Acids Research
, vol.30
, Issue.17
, pp. 3894-3900
-
-
Ramensky, V.1
Bork, P.2
Sunyaev, S.3
-
39
-
-
13444269543
-
Haploview: Analysis and visualization of LD and haplotype maps
-
DOI 10.1093/bioinformatics/bth457
-
Barrett JC, Fry B, Mailer J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005). (Pubitemid 40202029)
-
(2005)
Bioinformatics
, vol.21
, Issue.2
, pp. 263-265
-
-
Barrett, J.C.1
Fry, B.2
Maller, J.3
Daly, M.J.4
-
40
-
-
0032900678
-
Median-joining networks for inferring intraspecific phylogenies
-
Bandelt HJ, Forster P, Rohl A: Median-joining networks for inferring intraspecific phylogenies. Mol. Biol. Evol. 16, 37-48 (1999). (Pubitemid 29024937)
-
(1999)
Molecular Biology and Evolution
, vol.16
, Issue.1
, pp. 37-48
-
-
Bandelt, H.-J.1
Forster, P.2
Rohl, A.3
-
41
-
-
7744246753
-
Molecular diversity at the CYP2D6 locus in the Mediterranean region
-
DOI 10.1038/sj.ejhg.5201243
-
Fuselli S, Dupanloup I, Frigato E, et al. Molecular diversity at the CYP2D6\oc\is in the Mediterranean region. Eur. J. Hum. Genet. 12,916-924 (2004). (Pubitemid 39462125)
-
(2004)
European Journal of Human Genetics
, vol.12
, Issue.11
, pp. 916-924
-
-
Fuselli, S.1
Dupanloup, I.2
Frigato, E.3
Cruciani, F.4
Scozzari, R.5
Moral, P.6
Sistonen, J.7
Barbujani, G.8
-
42
-
-
74149092567
-
Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2Cl9znd CYP2D6m Han Chinese
-
Zhou Q, Yu XM, Lin HB, et al. Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2Cl9znd CYP2D6m Han Chinese. PharmacogenomicsJ. 9, 380-394 (2009).
-
(2009)
Pharmacogenomics J.
, vol.9
, pp. 380-394
-
-
Zhou, Q.1
Yu, X.M.2
Lin, H.B.3
-
43
-
-
0025036544
-
Multiple mutations of the human cytochrome p450HD6 gene {CYP2D6) in poor metabolizers of debrisoquine Study of the functional significance of individual mutations by expression of chimeric genes
-
Kagimoto M, Heim M, Kagimoto K, Zeugin T, Meyer UA: Multiple mutations of the human cytochrome p450HD6 gene {CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J. Biol. Chem. 265, 17209-17214 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 17209-17214
-
-
Kagimoto, M.1
Heim, M.2
Kagimoto, K.3
Zeugin, T.4
Meyer, U.A.5
-
44
-
-
0035094764
-
Variation is the spice of life
-
DOI 10.1038/85776
-
Kruglyak L, Nickerson DA: Variation is the spice of life. Nat. Genet. 27, 234-236 (2001). (Pubitemid 32201838)
-
(2001)
Nature Genetics
, vol.27
, Issue.3
, pp. 234-236
-
-
Kruglyak, L.1
Nickerson, D.A.2
-
45
-
-
38349132802
-
The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype
-
GaedigkA, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, LeederJS: The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clin. Pharmacol. Ther. 83, 234-242 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 234-242
-
-
Gaedigk, A.1
Simon, S.D.2
Pearce, R.E.3
Bradford, L.D.4
Kennedy, M.J.5
Leeder, J.S.6
-
46
-
-
41149086705
-
The CYP2D6gene locus in south African coloureds: Unique allele distributions, novel alleles and gene arrangements
-
GaedigkA, Coetsee C: The CYP2D6gene locus in south African coloureds: unique allele distributions, novel alleles and gene arrangements. Eur. J. Clin. Pharmacol. 64, 465-475 (2008).
-
(2008)
Eur. J. Clin. Pharmacol.
, vol.64
, pp. 465-475
-
-
Gaedigk, A.1
Coetsee, C.2
-
47
-
-
84859005796
-
CYP2D6genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans
-
DOI:10.1038/tpj.2010.85 Epub ahead of print
-
LlerenaA, Dorado P, Ramirez R, et al. CYP2D6genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans. Pharmacogenomics J. DOI:10.1038/tpj.2010.85 (2010) (Epub ahead of print).
-
(2010)
Pharmacogenomics J.
-
-
Llerena, A.1
Dorado, P.2
Ramirez, R.3
-
48
-
-
33745923150
-
Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6gene in Japanese individuals
-
Ebisawa A, Hiratsuka M, Sakuyama K, Konno Y, Sasaki T, Mizugaki M: Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6gene in Japanese individuals. Drug Metab. Pharmacokinet. 20, 294-299 (2005).
-
(2005)
Drug Metab. Pharmacokinet.
, vol.20
, pp. 294-299
-
-
Ebisawa, A.1
Hiratsuka, M.2
Sakuyama, K.3
Konno, Y.4
Sasaki, T.5
Mizugaki, M.6
-
49
-
-
57349180672
-
Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, l4a-b, 18, 27, 36,39, 47-51, 53-55, and 57)
-
Sakuyama K, Sasaki T, Ujne S, et al. Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, l4a-b, 18, 27, 36,39, 47-51, 53-55, and 57). Drug Metab. Dispos. 36, 2460-2467 (2008).
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 2460-2467
-
-
Sakuyama, K.1
Sasaki, T.2
Ujne, S.3
-
50
-
-
77953915610
-
Differential quantification of CYP2D6gene copy number by four different quantitative real-time PCR assays
-
RamamoorthyA, Flockhart DA, Hosono N, Kubo M, Nakamura Y, Skaar TC: Differential quantification of CYP2D6gene copy number by four different quantitative real-time PCR assays. Pharmacogenet. Genomics 20, 451-454 (2010).
-
(2010)
Pharmacogenet. Genomics
, vol.20
, pp. 451-454
-
-
Ramamoorthy, A.1
Flockhart, D.A.2
Hosono, N.3
Kubo, M.4
Nakamura, Y.5
Skaar, T.C.6
-
51
-
-
73549100850
-
CYP2D7-2D6 hybrid tandems: Identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction
-
Gaedigk A, Fuhr U, Johnson C, Berard LA, Bradford D, LeederJS: CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction. Pharmacogenomics 11, 43-53 (2010).
-
(2010)
Pharmacogenomics
, vol.11
, pp. 43-53
-
-
Gaedigk, A.1
Fuhr, U.2
Johnson, C.3
Berard, L.A.4
Bradford, D.5
Leeder, J.S.6
-
53
-
-
33748624897
-
Characterization of variant alelles of cytochrome CYP2D6 in a Spanish population
-
DOI 10.1002/cbf.1258
-
Menoyo A, del Rio E, Baiget M: Characterization of variant alleles of cytochrome CYP2D6 in a Spanish population. CellBiochem. Funct. 24, 381-385 (2006). (Pubitemid 44379576)
-
(2006)
Cell Biochemistry and Function
, vol.24
, Issue.5
, pp. 381-385
-
-
Menoyo, A.1
Del Rio, E.2
Baiget, M.3
-
54
-
-
20844455582
-
Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays
-
Matsuzaki H, Dong S, Loi H, et al. Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat. Methods 1, 109-111 (2004).
-
(2004)
Nat. Methods
, vol.1
, pp. 109-111
-
-
Matsuzaki, H.1
Dong, S.2
Loi, H.3
-
55
-
-
77956188003
-
Discovery of the nonfunctional CYP2D6*31 allele in Spanish, Puerto Rican, and US Hispanic populations
-
GaedigkA, Isidoro-Garcia M, Pearce RE, et al. Discovery of the nonfunctional CYP2D6*31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur. J. Clin. Pharmacol. 66, 859-864 (2010).
-
(2010)
Eur. J. Clin. Pharmacol.
, vol.66
, pp. 859-864
-
-
Gaedigk, A.1
Isidoro-Garcia, M.2
Pearce, R.E.3
-
56
-
-
0038069498
-
Common mutant alleles of CYP2D6 causing the defect of CYP2D6 enzyme activity in a Japanese population [2]
-
DOI 10.1046/j.1365-2125.2003.01782.x
-
Ishiguro A, Kubota T, Sasaki H, Yamada Y, Iga T: Common mutant alleles of CYP2D6 causing the defect of CYP2D6 enzyme activity in a Japanese population. Br. J. Clin. Pharmacol. 55, 414-415 (2003). (Pubitemid 36535374)
-
(2003)
British Journal of Clinical Pharmacology
, vol.55
, Issue.4
, pp. 414-415
-
-
Ishiguro, A.1
Kubota, T.2
Sasaki, H.3
Yamada, Y.4
Iga, T.5
-
57
-
-
0035721949
-
Pharmacogenetics: An opportunity for a safer and more efficient pharmacotherapy
-
DOI 10.1046/j.1365-2796.2001.00879.x
-
Ingelman-Sundberg M: Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy. J. Intern. Med. 250, 186-200 (2001). (Pubitemid 34205685)
-
(2001)
Journal of Internal Medicine
, vol.250
, Issue.3
, pp. 186-200
-
-
Ingelman-Sundberg, M.1
-
58
-
-
34447269513
-
Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population
-
DOI 10.1111/j.1472-8206.2007.00510.x
-
Arvanitidis K, Ragia G, Iordanidou M, et al. Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population. Fundam. Clin. Pharmacol. 21, 419-426 (2007). (Pubitemid 47084032)
-
(2007)
Fundamental and Clinical Pharmacology
, vol.21
, Issue.4
, pp. 419-426
-
-
Arvanitidis, K.1
Ragia, G.2
Iordanidou, M.3
Kyriaki, S.4
Xanthi, A.5
Tavridou, A.6
Manolopoulos, V.G.7
-
59
-
-
11144226236
-
Polymorphisms of CYP2C19 and CYP2D6 in Israeli ethnic groups
-
DOI 10.2165/00129785-200404060-00006
-
Luo HR, Aloumanis V, Lin KM, Gurwitz D, Wan YJ: Polymorphisms of CYP2C19 and CYP2D6in Israeli ethnic groups. Am. J. Pharmacogenomics A, 395-401 (2004). (Pubitemid 40052848)
-
(2004)
American Journal of PharmacoGenomics
, vol.4
, Issue.6
, pp. 395-401
-
-
Luo, H.-R.1
Aloumanis, V.2
Lin, K.-M.3
Gurwitz, D.4
Wan, Y.-J.Y.5
-
60
-
-
34548743476
-
Gene conversion: Mechanisms, evolution and human disease
-
DOI 10.1038/nrg2193, PII NRG2193
-
SI Chen JM, Cooper DN, Chuzhanova N, Ferec C, Patrinos GP: Gene conversion: mechanisms, evolution and human disease. Nat. Rev. Genet. 8, 762-775 (2007). (Pubitemid 47429210)
-
(2007)
Nature Reviews Genetics
, vol.8
, Issue.10
, pp. 762-775
-
-
Chen, J.-M.1
Cooper, D.N.2
Chuzhanova, N.3
Ferec, C.4
Patrinos, G.P.5
-
61
-
-
0027136288
-
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
-
DOI 10.1073/pnas.90.24.11825
-
Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjoqvist F, Ingelman-Sundberg M: Inherited amplification of an active gene in the cytochrome p450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. NatlAcad. Sci. USA 90, 11825-11829 (1993). (Pubitemid 24008732)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.24
, pp. 11825-11829
-
-
Johansson, I.1
Lundqvist, E.2
Bertilsson, L.3
Dahl, M.-L.4
Sjoqvist, F.5
Ingelman-Sundberg, M.6
-
62
-
-
33646092472
-
Crystal structure of human cytochrome P450 2D6
-
DOI 10.1074/jbc.M511232200
-
Rowland P, Blaney FE, Smyth MG, et al. Crystal structure of human cytochrome P450 2D6.J. Biol. Chem. 281,7614-7622 (2006). (Pubitemid 43847532)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.11
, pp. 7614-7622
-
-
Rowland, P.1
Blaney, F.E.2
Smyth, M.G.3
Jones, J.J.4
Leydon, V.R.5
Oxbrow, A.K.6
Lewis, C.J.7
Tennant, M.G.8
Modi, S.9
Eggleston, D.S.10
Chenery, R.J.11
Bridges, A.M.12
-
63
-
-
0029816947
-
Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family
-
DOI 10.1074/jbc.271.41.25269
-
Cairns W, Smith CA, McLaren AW, Wolf CR: Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family J. Biol. Chem. 271, 25269-25276 (1996). (Pubitemid 26337893)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.41
, pp. 25269-25276
-
-
Cairns, W.1
Smith, C.A.D.2
McLaren, A.W.3
Wolf, C.R.4
-
64
-
-
49649091997
-
Genetic polymorphism of hepatocyte nuclear factor-4a influences human cytochrome P450 2D6 activity
-
Lee SS, Cha EY, Jung HJ, et al. Genetic polymorphism of hepatocyte nuclear factor-4a influences human cytochrome P450 2D6 activity. Hepatology 48, 635-645 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 635-645
-
-
Lee, S.S.1
Cha, E.Y.2
Jung, H.J.3
|