-
1
-
-
0742286803
-
Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
-
Summarizes important aspects and essential knowledge of CYP2D6
-
Zanger UM, Raimundo S, Eichelbaum M: Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn-Schmiedeberg's Arch. Pharmacol. 369, 23-37 (2004). Summarizes important aspects and essential knowledge of CYP2D6.
-
(2004)
Naunyn-Schmiedeberg's Arch. Pharmacol
, vol.369
, pp. 23-37
-
-
Zanger, U.M.1
Raimundo, S.2
Eichelbaum, M.3
-
2
-
-
36148976077
-
Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
-
Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C: Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther. 116, 496-526(2007).
-
(2007)
Pharmacol. Ther
, vol.116
, pp. 496-526
-
-
Ingelman-Sundberg, M.1
Sim, S.C.2
Gomez, A.3
Rodriguez-Antona, C.4
-
3
-
-
54949144309
-
-
Zanger UM, Turpeinen M, Klein K, Schwab M: Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal. Bioanal. Chem. 392, 1093-1108 (2008). Provides a comprehensive review of P450 pharmacogenetics including CYP2D6.
-
Zanger UM, Turpeinen M, Klein K, Schwab M: Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal. Bioanal. Chem. 392, 1093-1108 (2008). Provides a comprehensive review of P450 pharmacogenetics including CYP2D6.
-
-
-
-
4
-
-
33847031732
-
CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
-
Provides genotyping data and allele frequencies for numerous populations and ethnic groups across continents
-
Sistonen J, Sajantila A, Lao O, Corander J, Barbujani G, Fuselli S: CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet. Genomics 17, 93-101 (2007). Provides genotyping data and allele frequencies for numerous populations and ethnic groups across continents.
-
(2007)
Pharmacogenet. Genomics
, vol.17
, pp. 93-101
-
-
Sistonen, J.1
Sajantila, A.2
Lao, O.3
Corander, J.4
Barbujani, G.5
Fuselli, S.6
-
5
-
-
33846643134
-
-
Gaedigk A, Ndjountché L, Divakaran K et al.: Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events. Clin. Pharmacol. Ther. 81, 242-251 (2007). Provides additional detailed information for CYP2D6 gene duplications.
-
Gaedigk A, Ndjountché L, Divakaran K et al.: Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events. Clin. Pharmacol. Ther. 81, 242-251 (2007). Provides additional detailed information for CYP2D6 gene duplications.
-
-
-
-
6
-
-
33645109079
-
CYP2D6*36 gene arrangements with in the CYP2D6 locus: Association of CYP2D6*36 with poor metabolizer status
-
Gaedigk A, Bradford LD, Alander SW, Leeder JS: CYP2D6*36 gene arrangements with in the CYP2D6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab. Dispos. 34, 563-569 (2006).
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 563-569
-
-
Gaedigk, A.1
Bradford, L.D.2
Alander, S.W.3
Leeder, J.S.4
-
7
-
-
0028846090
-
An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype
-
Panserat S, Mura C, Gerard N et al.: An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype. Br. J. Clin. Pharmacol. 40, 361-367 (1995).
-
(1995)
Br. J. Clin. Pharmacol
, vol.40
, pp. 361-367
-
-
Panserat, S.1
Mura, C.2
Gerard, N.3
-
8
-
-
0029736710
-
Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype
-
Daly AK, Fairbrother KS, Andreassen OA, London SJ, Idle JR, Steen VM: Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype. Pharmacogenetics 6, 319-328 (1996).
-
(1996)
Pharmacogenetics
, vol.6
, pp. 319-328
-
-
Daly, A.K.1
Fairbrother, K.S.2
Andreassen, O.A.3
London, S.J.4
Idle, J.R.5
Steen, V.M.6
-
9
-
-
0033461165
-
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
-
Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS: Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 9, 669-682 (1999).
-
(1999)
Pharmacogenetics
, vol.9
, pp. 669-682
-
-
Gaedigk, A.1
Gotschall, R.R.2
Forbes, N.S.3
Simon, S.D.4
Kearns, G.L.5
Leeder, J.S.6
-
10
-
-
41149086705
-
-
Gaedigk A, Coetsee C: The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements. Eur. J. Clin. Pharmacol. 64, 465-475 (2008). Describes the detection and characterization of'single' CYP2D6 hybrids adding complementary information to the current report.
-
Gaedigk A, Coetsee C: The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements. Eur. J. Clin. Pharmacol. 64, 465-475 (2008). Describes the detection and characterization of'single' CYP2D6 hybrids adding complementary information to the current report.
-
-
-
-
11
-
-
38349132802
-
The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype
-
Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, Leeder JS: The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clin. Pharmacol. Ther. 83, 234-242 (2008).
-
(2008)
Clin. Pharmacol. Ther
, vol.83
, pp. 234-242
-
-
Gaedigk, A.1
Simon, S.D.2
Pearce, R.E.3
Bradford, L.D.4
Kennedy, M.J.5
Leeder, J.S.6
-
12
-
-
0032421471
-
CYP2D6 phenotype -genotype relationships in African-Americans and Caucasians in Los Angeles
-
Leathart JBS, London SJ, Steward A, Adams JD, Idle JR, Daly AK: CYP2D6 phenotype -genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics 8, 529-541 (1998).
-
(1998)
Pharmacogenetics
, vol.8
, pp. 529-541
-
-
Leathart, J.B.S.1
London, S.J.2
Steward, A.3
Adams, J.D.4
Idle, J.R.5
Daly, A.K.6
-
13
-
-
0345492218
-
Molecular drive in multigene families: How biological novelties arise, spread and are assimilated
-
Summarizes Southern-blot and long-range PCR data for gene duplications and offers mechanistic models that may explain duplication and deletion formation
-
Dover GA: Molecular drive in multigene families: how biological novelties arise, spread and are assimilated. Trends Genet. 2, 159-165 (1986). Summarizes Southern-blot and long-range PCR data for gene duplications and offers mechanistic models that may explain duplication and deletion formation.
-
(1986)
Trends Genet
, vol.2
, pp. 159-165
-
-
Dover, G.A.1
-
14
-
-
67651098662
-
Mechanisms of change in gene copy number
-
Summarizes mechanisms leading to copy-number variation
-
Hastings PJ, Lupski JR, Rosenberg SM, Ira G: Mechanisms of change in gene copy number. Nat. Rev. Genet. 10, 551-564 (2009). Summarizes mechanisms leading to copy-number variation.
-
(2009)
Nat. Rev. Genet
, vol.10
, pp. 551-564
-
-
Hastings, P.J.1
Lupski, J.R.2
Rosenberg, S.M.3
Ira, G.4
-
15
-
-
0033590590
-
Genetic mechanism for duplication and multiduplication of the CYP2D6 gene
-
Lundqvist E, Johansson I, Ingelman-Sundberg M: Genetic mechanism for duplication and multiduplication of the CYP2D6 gene. Gene 226, 327-338 (1999).
-
(1999)
Gene
, vol.226
, pp. 327-338
-
-
Lundqvist, E.1
Johansson, I.2
Ingelman-Sundberg, M.3
-
16
-
-
0007293059
-
Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene
-
Løvlie R, Daly AK, Molven A, Idle JR, Steen VM: Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene. FEBS Letters 392, 30-34 (1996).
-
(1996)
FEBS Letters
, vol.392
, pp. 30-34
-
-
Løvlie, R.1
Daly, A.K.2
Molven, A.3
Idle, J.R.4
Steen, V.M.5
-
17
-
-
0028844757
-
Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of the cytochrome P450 CYP2D6 gene
-
Steen VM, Molven A, Aarskog NK, Gulbrandsen AK: Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of the cytochrome P450 CYP2D6 gene. Hum. Mol. Genet. 4, 2251-2257 (1995).
-
(1995)
Hum. Mol. Genet
, vol.4
, pp. 2251-2257
-
-
Steen, V.M.1
Molven, A.2
Aarskog, N.K.3
Gulbrandsen, A.K.4
-
18
-
-
0027965620
-
Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes in subjects with diminished capacity for debrisoquine hydroxylation
-
Johansson I, Oscarson M, Q-Yue Y, Bertilsson L, Sjöqvist F, Ingelman-Sundberg M: Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes in subjects with diminished capacity for debrisoquine hydroxylation. Mol. Pharmacol. 46, 452-459 (1994).
-
(1994)
Mol. Pharmacol
, vol.46
, pp. 452-459
-
-
Johansson, I.1
Oscarson, M.2
Q-Yue, Y.3
Bertilsson, L.4
Sjöqvist, F.5
Ingelman-Sundberg, M.6
-
19
-
-
33645129348
-
Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: In vitro functional analysis of recombinant proteins expressed in Saccharomyces cervisiae
-
Hanioka N, Okumura Y, Saito Y et al.: Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: In vitro functional analysis of recombinant proteins expressed in Saccharomyces cervisiae. Biochem. Pharmacol. 71, 1386-1395 (2006).
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 1386-1395
-
-
Hanioka, N.1
Okumura, Y.2
Saito, Y.3
-
20
-
-
33747134323
-
Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
-
Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder SJ: Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 368, 704 (2006).
-
(2006)
Lancet
, vol.368
, pp. 704
-
-
Koren, G.1
Cairns, J.2
Chitayat, D.3
Gaedigk, A.4
Leeder, S.J.5
-
21
-
-
57749180179
-
Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: A case-control study
-
Madadi P, Ross CJR, Hayden MR et al.: Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin. Pharmacol. Ther. 85, 31-35 (2009).
-
(2009)
Clin. Pharmacol. Ther
, vol.85
, pp. 31-35
-
-
Madadi, P.1
Ross, C.J.R.2
Hayden, M.R.3
-
22
-
-
55649094298
-
Pharmacogenetic insights into codeine analgesia: Implications to pediatric codeine use
-
Madadi P, Koren G: Pharmacogenetic insights into codeine analgesia: implications to pediatric codeine use. Pharmacogenomics 9, 1267-1284 (2008).
-
(2008)
Pharmacogenomics
, vol.9
, pp. 1267-1284
-
-
Madadi, P.1
Koren, G.2
-
23
-
-
73549119899
-
-
Home Page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee www.cypalleles.ki.se/ (Accessed 07 April 2009)
-
Home Page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee www.cypalleles.ki.se/ (Accessed 07 April 2009)
-
-
-
|