Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China

Genomics

Volumn 92, Issue 3, 2008, Pages 152-158

  Qin, Shengying ^a,b   Shen, Lu ^a,c   Zhang, Aiping ^a,c   Xie, Jing ^a,c   Shen, Wen ^a,c   Chen, Lingling ^a,c   Tang, Jimin ^a,c   Xiong, Yuyu ^a,c   Yang, Lun ^a,c   Shi, Yongyong ^a,c   Feng, Guoyin ^d   He, Lin ^c   Xing, Qinghe ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Wu Zhong Group   (China)

^c Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^d SHANGHAI MENTAL HEALTH CENTER   (China)

Author keywords

Chinese mainland; CYP2D6; Haplotype; Pharmacogenetics; Polymorphism

Indexed keywords

CYTOCHROME P450 2D6;

ADULT; ARTICLE; CHINA; CHINESE; EXON; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC SELECTION; GENETIC VARIABILITY; GEOGRAPHY; HAPLOTYPE; HUMAN; INTRON; MALE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PHARMACOGENETICS; POPULATION GENETICS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CYTOCHROME P-450 CYP2D6; FEMALE; GENE FREQUENCY; GENETICS, POPULATION; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 49349109652     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2008.05.004     Document Type: Article

References (28)

1. Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J. 5 (2005) 6-13
2. Zanger U.M., et al. Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6. Pharmacogenetics 11 (2001) 573-585
3. Leathart J.B., et al. CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics 8 (1998) 529-541
4. Masimirembwa C.M., and Hasler J.A. Genetic polymorphism of drug metabolising enzymes in African populations: implications for the use of neuroleptics and antidepressants. Brain Res. Bull. 44 (1997) 561-571
5. Bradford L.D. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 3 (2002) 229-243
6. Lee S.Y., et al. Sequence-based CYP2D6 genotyping in the Korean population. Ther. Drug Monit. 28 (2006) 382-387
7. Nishida Y., Fukuda T., Yamamoto I., and Azuma J. CYP2D6 genotypes in a Japanese population: low frequencies of CYP2D6 gene duplication but high frequency of CYP2D6*10. Pharmacogenetics 10 (2000) 567-570
8. Sachse C., Brockmoller J., Bauer S., and Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. 60 (1997) 284-295
9. McLellan R.A., Oscarson M., Seidegard J., Evans D.A., and Ingelman-Sundberg M. Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians. Pharmacogenetics 7 (1997) 187-191
10. Aklillu E., et al. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J. Pharmacol. Exp. Ther. 278 (1996) 441-446
11. Ingelman-Sundberg M. Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy. J. Intern. Med. 250 (2001) 186-200
12. Ji L., Pan S., Wu J., Marti-Jaun J., and Hersberger M. Genetic polymorphisms of CYP2D6 in Chinese mainland. Chin. Med. J. (Engl.) 115 (2002) 1780-1784
13. Garcia-Barcelo M., et al. Occurrence of CYP2D6 gene duplication in Hong Kong Chinese. Clin. Chem. 46 (2000) 1411-1413
14. Shi Y., et al. Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population. Genome Res. 14 (2004) 1345-1349
15. Murphy M.P., et al. Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial. Pharmacogenetics 10 (2000) 583-590
16. Guzey C., and Spigset O. Genotyping as a tool to predict adverse drug reactions. Curr. Top. Med. Chem. 4 (2004) 1411-1421
17. Gaedigk A., et al. Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. Pharmacogenomics J. 5 (2005) 173-182
18. Rogan P.K., Svojanovsky S., and Leeder J.S. Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations. Pharmacogenetics 13 (2003) 207-218
19. Kubota T., Yamaura Y., Ohkawa N., Hara H., and Chiba K. Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes. Br. J. Clin. Pharmacol. 50 (2000) 31-34
20. Griese E.U., et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics 8 (1998) 15-26
21. Agundez J.A., et al. Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations. Clin. Pharmacol. Ther. 55 (1994) 412-417
22. Menoyo A., del Rio E., and Baiget M. Characterization of variant alleles of cytochrome CYP2D6 in a Spanish population. Cell Biochem. Funct. 24 (2006) 381-385
23. Hersberger M., Marti-Jaun J., Rentsch K., and Hanseler E. Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR. Clin. Chem. 46 (2000) 1072-1077
24. Ishiguro A., Kubota T., Sasaki H., and Iga T. A long PCR assay to distinguish CYP2D6*5 and a novel CYP2D6 mutant allele associated with an 11-kb EcoRI haplotype. Clin. Chim. Acta 347 (2004) 217-221
25. Lovlie R., Daly A.K., Molven A., Idle J.R., and Steen V.M. Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene. FEBS Lett. 392 (1996) 30-34
26. Gabriel S.B., et al. The structure of haplotype blocks in the human genome. Science 296 (2002) 2225-2229
27. Carlson C.S., et al. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am. J. Hum. Genet. 74 (2004) 106-120
28. Wan Y.J.Y., et al. Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in Southern California. Pharmacogenetics 11 (2001) 489-499