Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils

Stem Cells

Volumn 29, Issue 6, 2011, Pages 1001-1011

  Cassatella, Marco A ^a   Mosna, Federico ^b   Micheletti, Alessandra ^a   Lisi, Veronica ^b   Tamassia, Nicola ^a   Cont, Caterina ^b   Calzetti, Federica ^a   Pelletier, Martin ^a   Pizzolo, Giovanni ^b   Krampera, Mauro ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Mesenchymal stromal cells; Neutrophils; Toll like receptors

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD11B ANTIGEN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BONE MARROW CELL; CELL CONTACT; CELL FUNCTION; CELL ISOLATION; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MESENCHYME CELL; MOLECULAR MECHANICS; NEUTROPHIL; PROTEIN EXPRESSION; RESPIRATORY BURST; SPLEEN; STROMA CELL; SUBCUTANEOUS FAT; SUPERNATANT; THYMUS;

BONE MARROW CELLS; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON-BETA; INTERFERON-GAMMA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MESENCHYMAL STEM CELLS; NEUTROPHILS; PHENOTYPE; POLY I-C; TOLL-LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79957598130     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.651     Document Type: Article

References (49)

1. Prockop DJ. Marrow stromal cells as stem cells for nonhemopoietic tissues. Science 1997;276:71-74. (Pubitemid 27161245)
2. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147. (Pubitemid 29282067)
3. da Silva ML, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006;119:2204-2213. (Pubitemid 43960310)
4. Aggarwal S, Friedenstein MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005;105:1815-1822. (Pubitemid 40223708)
5. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008;8:726-736.
6. Siegel G, Schafer R, Dazzi F. The immunosuppressive properties of mesenchymal stem cells. Transplantation 2009;87:S45-S49.
7. Krampera M, Glennie S, Dyson J et al. Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide. Blood 2003;101:3722-3729. (Pubitemid 36857965)
8. Di Nicola M, Carlo-Stella C, Magni M et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or non-specific mitogenic stimuli. Blood 2002;99:3838-3843. (Pubitemid 34534559)
9. Traggiai E, Volpi S, Schena F et al. Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients. Stem Cells 2008;26:562-569. (Pubitemid 351413617)
10. Sotiropoulou PA, Perez SA, Gritzapis AD et al. Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells 2006;24:74-85.
11. Jiang XX, Zhang Y, Liu B et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005;105:4120-4126. (Pubitemid 40656164)
12. Jones S, Horwood N, Cope A et al. The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells. J Immunol 2007;179:2824-2831.
13. Ringden O, Uzunel M, Rasmusson I et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006;81:1390-1397. (Pubitemid 43847148)
14. Nemeth K, Leelahavanichkul A, Yuen PST et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009;15:42-49.
15. Krampera M, Cosmi L, Angeli R et al. Role for Interferon-γ in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006;24:386-398. (Pubitemid 44464808)
16. Liotta F, Angeli R, Cosmi L et al. Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing notch signaling. Stem Cells 2008;26:279-289.
17. Waterman RS, Tomchuck SL, Henkle SL et al. A new mesenchymal stem cell (MSC) paradigm: Polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype. Plos One 2010;5:e10088.
18. Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity 2005;23:344-346. (Pubitemid 41443435)
19. Cassatella MA. The neutrophil. In: Serhan CN, Ward PA, Gilroy DW, eds. Fundamentals of Inflammation. Cambridge, UK: Cambridge University Press, 2010:49-64.
20. Cassatella MA. The production of cytokines by polymorphonuclear neutrophils. Immunol Today 1995;16:21-26.
21. Muller I, Munder M, Kropf P et al. Polymorphonuclear neutrophils and T lymphocytes: Strange bedfellows or borthers in arms? Trends Immunol 2009;30:522-530.
22. Pelletier M, Maggi L, Micheletti A et al. Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 2010;115:335-343.
23. Costantini C, Calzetti F, Perbellini O et al. Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFNγ: Role of CD18, ICAM-1, and ICAM-3. Blood 2011;117:1677-1686.
24. Parkos CA, Colgan SP, Madara JL. Interactions of neutrophils with epithelial cells: Lessons from the intestine. J Am Soc Nephrol 1994;5:138-152. (Pubitemid 24977069)
25. Raffaghello L, Bianchi G, Bertolotto M et al. Human mesenchymal stem cells inhibit neutrophil apoptosis: A model for neutrophil preservation in the bone marrow niche. Stem Cells 2008;26:151-162.
26. Van Overstraeten-Schlogel N, Beguin Y, Gothot A. Role of stromal-derived factor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells. Eur J Haematol 2006;76:488-493.
27. Brandau S, Jakob M, Hemeda H et al. Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge. J Leukoc Biol 2010;88:1005-1015.
28. Krampera M, Sartoris S, Liotta F et al. Immune regulation by mesenchymal stem cells derived from adult spleen and thymus. Stem Cells Dev 2007;16:797-810. (Pubitemid 350125228)
29. Mosna F, Sensebé L, Krampera M. Human bone-marrow and adipose tissue mesenchymal stem cells: A user's guide. Stem Cells Dev 2010;19:1449-1470.
30. Tamassia N, Le Moigne V, Calzetti F et al. The MYD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4. J Immunol 2007;178:7344-7356. (Pubitemid 46847462)
31. Costantini C, Micheletti A, Calzetti F et al. Neutrophil activation and survival are modulated by interaction with NK cells. Int Immunol 2010;22:827-838.
32. Tomchuck SL, Zwezdaryk KJ, Coffelt SB et al. Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells 2008;26:99-107.
33. Romieu-Mourez R, Francois M, Boivin MN et al. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol 2009;182: 7963-7973.
34. Hayashi F, Means TK, Luster AD. Toll-like receptors stimulate human neutrophil function. Blood 2003;102:2660-2669. (Pubitemid 37193610)
35. Tamassia N, Le Moigne V, Rossato M et al. Activation of an immunoregulatory and antiviral gene expression program in poly (I:C)-transfected human neutrophils. J Immunol 2008;181:6563-6573.
36. Beutler B. Tlr4: Central component of the sole mammalian LPS sensor. Curr Opin Immunol 2000;12:20-26. (Pubitemid 30093446)
37. Dransfield I, Buckle A, Savill J et al. Neutrophil apoptosis is associated with a reduction in CD16 (FcγRIII) expression. J Immunol 1994; 153:1254-1263. (Pubitemid 24228517)
38. Pugin J, Stern-Voeffray S, Daubeuf B et al. Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood 2004; 104:4071-4079. (Pubitemid 39620158)
39. Toshchakov V, Jones BW, Perera PY et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol 2002;3:392-398. (Pubitemid 34308628)
40. Hemeda H, Jakob M, Ludwig AK et al. Interferon-γ and tumor necrosis factor-a differentially affect cytokine expression and migration properties of Mesenchymal Stem Cells. Stem Cells Dev 2010;19:693-706.
41. Pevsner-Fischer M, Morad V, Cohen-Sfady M et al. Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood 2007;109:1422-1432. (Pubitemid 46239573)
42. Opitz CA, Litzenburger UM, Lutz C et al. Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived Mesenchymal Stem Cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-β and protein kinase R. Stem Cells 2009; 27:909-919.
43. Cassatella MA, Flynn RM, Amezaga MA et al. Interferon gamma induces in human neutrophils and macrophages expression of the mRNA for the high affinity receptor for monomeric IgG (Fc gamma R-I or CD64). Biochem Biophys Res Commun 1990;170:582-588. (Pubitemid 20249459)
44. Tate MD, Deng YM, Jones JE et al. Neutrophils ameliorate lung injury and the development of severe disease during influenza infection. J Immunol 2009;183:7441-7450.
45. Costantini C, Cassatella MA. The defensive alliance between neutrophils and NK cells as a novel arm of innate immunity. J Leukoc Biol 2011;89:221-233.
46. Cavassani KA, Ishii M, Wen H et al. TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med 2008;205:2609-2621.
47. Karikò K, Houping N, Capodici J et al. mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 2004;279:12542-12550. (Pubitemid 38445825)
48. Bouffi C, Djouad F, Mathieu M et al. Multipotent mesenchymal stromal cells and rheumatoid arthritis: Risk or benefit? Rheumatology (Oxford) 2009;48:1185-1189.
49. Brentano F, Schorr O, Gay RE et al. RNA released from necrotic synovial fluid cells activated rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum 2005;52:2656-2665. (Pubitemid 41369093)