NK cell KIR heterogeneity and evolution

Natural Killer Cells

Volumn , Issue , 2010, Pages 79-94

  Yawata, Makoto ^a   Yawata, Nobuyo ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79957522486     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-370454-2.00006-5     Document Type: Chapter

References (131)

1. Alter G., Martin M.P., Teigen N., Carr W.H., Suscovich T.J., Schneidewind A., Streeck H., Waring M., Meier A., Brander C., Lifson J.D., Allen T.M., Carrington M., Altfeld M. Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med 2007, 204:3027-3036.
2. Anfossi N., Andre P., Guia S., Falk C.S., Roetynck S., Stewart C.A., Breso V., Frassati C., Reviron D., Middleton D., Romagne F., Ugolini S., Vivier E. Human NK cell education by inhibitory receptors for MHC class I. Immunity 2006, 25:331-342.
3. Averdam A., Kuhl H., Sontag M., Becker T., Hughes A.L., Reinhardt R., Walter L. Genomics and diversity of the common marmoset monkey NK complex. J Immunol 2007, 178:7151-7161.
4. Boyington J.C., Motyka S.A., Schuck P., Brooks A.G., Sun P.D. Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature 2000, 405:537-543.
5. Burshtyn D.N., Scharenberg A.M., Wagtmann N., Rajagopalan S., Berrada K., Yi T., Kinet J.P., Long E.O. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity 1996, 4:77-85.
6. Carr W.H., Pando M.J., Parham P. KIR3DL1 polymorphisms that affect NK cell inhibition by HLA-Bw4 ligand. J Immunol 2005, 175:5222-5229.
7. Chan H.W., Kurago Z.B., Stewart C.A., Wilson M.J., Martin M.P., Mace B.E., Carrington M., Trowsdale J., Lutz C.T. DNA methylation maintains allele-specific KIR gene expression in human natural killer cells. J Exp Med 2003, 197:245-255.
8. Chan H.W., Miller J.S., Moore M.B., Lutz C.T. Epigenetic control of highly homologous killer Ig-like receptor gene alleles. J Immunol 2005, 175:5966-5974.
9. Chapman T.L., Heikeman A.P., Bjorkman P.J. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity 1999, 11:603-613.
10. Chewning J.H., Gudme C.N., Hsu K.C., Selvakumar A., Dupont B. KIR2DS1-positive NK cells mediate alloresponse against the C2 HLA-KIR ligand group in vitro. J Immunol 2007, 179:854-868.
11. Colonna M., Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995, 268:405-408.
12. Colonna M., Navarro F., Bellon T., Llano M., Garcia P., Samaridis J., Angman L., Cella M., Lopez-Botet M. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 1997, 186:1809-1818.
13. Dam J., Guan R., Natarajan K., Dimasi N., Chlewicki L.K., Kranz D.M., Schuck P., Margulies D.H., Mariuzza R.A. Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b). Nat Immunol 2003, 4:1213-1222.
14. D'Andrea A., Chang C., Franz-Bacon K., McClanahan T., Phillips J.H., Lanier L.L. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J Immunol 1995, 155:2306-2310.
15. Davies G.E., Locke S.M., Wright P.W., Li H., Hanson R.J., Miller J.S., Anderson S.K. Identification of bidirectional promoters in the human KIR genes. Genes Immun 2007, 8:245-253.
16. De Tomaso A.W., Nyholm S.V., Palmeri K.J., Ishizuka K.J., Ludington W.B., Mitchel K., Weissman I.L. Isolation and characterization of a protochordate histocompatibility locus. Nature 2005, 438:454-459.
17. Dupont B., Hsu K.C. Inhibitory killer Ig-like receptor genes and human leukocyte antigen class I ligands in haematopoietic stem cell transplantation. Curr Opin Immunol 2004, 16:634-643.
18. Epling-Burnette P.K., Painter J.S., Chaurasia P., Bai F., Wei S., Djeu J.Y., Loughran T.P. Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes. Blood 2004, 103:3431-3439.
19. Fauriat C., Andersson S., Bjorklund A.T., Carlsten M., Schaffer M., Bjorkstrom N.K., Baumann B.C., Michaelsson J., Ljunggren H.G., Malmberg K.J. Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype. J Immunol 2008, 181:6010-6019.
20. Fehniger T.A., Cooper M.A., Nuovo G.J., Cella M., Facchetti F., Colonna M., Caligiuri M.A. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 2003, 101:3052-3057.
21. Fernandez N.C., Treiner E., Vance R.E., Jamieson A.M., Lemieux S., Raulet D.H. A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood 2005, 105:4416-4423.
22. Foley B., De Santis D., Lathbury L., Christiansen F., Witt C. KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals. Int Immunol 2008, 20:555-563.
23. Foley, B.A., De Santis, D., Van Beelen, E., Lathbury, L.J., Christiansen, F.T. and Witt, C.S. (2008b). The reactivity of Bw4-positive HLA-B and HLA-A alleles with KIR3DL1: implications for patient and donor suitability for haploidentical stem cell transplants. Blood.
24. Gardiner C.M., Guethlein L.A., Shilling H.G., Pando M., Carr W.H., Rajalingam R., Vilches C., Parham P. Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism. J Immunol 2001, 166:2992-3001.
25. Gedil M.A., Steiner N.K., Hurley C.K. Genomic characterization of KIR2DL4 in families and unrelated individuals reveals extensive diversity in exon and intron sequences including a common frameshift variation occurring in several alleles. Tissue Antigens 2005, 65:402-418.
26. Gedil M.A., Steiner N.K., Hurley C.K. KIR3DL2: diversity in a hematopoietic stem cell transplant population. Tissue Antigens 2007, 70:228-232.
27. Gendzekhadze K., Norman P.J., Abi-Rached L., Layrisse Z., Parham P. High KIR diversity in Amerindians is maintained using few gene-content haplotypes. Immunogenetics 2006, 58:474-480.
28. Gomez-Lozano N., Gardiner C.M., Parham P., Vilches C. Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B. Immunogenetics 2002, 54:314-319.
29. Goodridge J.P., Witt C.S., Christiansen F.T., Warren H.S. KIR2DL4 (CD158d) genotype influences expression and function in NK cells. J Immunol 2003, 171:1768-1774.
30. Guethlein L.A., Flodin L.R., Adams E.J., Parham P. NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the coevolution of killer cell Ig-like receptors with MHC-C. J Immunol 2002, 169:220-229.
31. Guma M., Angulo A., Vilches C., Gomez-Lozano N., Malats N., Lopez-Botet M. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood 2004, 104:3664-3671.
32. Gutierrez-Rodriguez M.E., Sandoval-Ramirez L., Diaz-Flores M., Marsh S.G., Valladares-Salgado A., Madrigal J.A., Mejia-Arangure J.M., Garcia C.A., Huerta-Zepeda A., Ibarra-Cortes B., Ortega-Camarillo C., Cruz M. KIR gene in ethnic and Mestizo populations from Mexico. Hum Immunol 2006, 67:85-93.
33. Hanke T., Takizawa H., McMahon C.W., Busch D.H., Pamer E.G., Miller J.D., Altman J.D., Liu Y., Cado D., Lemonnier F.A., Bjorkman P.J., Raulet D.H. Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 1999, 11:67-77.
34. Hansasuta P., Dong T., Thananchai H., Weekes M., Willberg C., Aldemir H., Rowland-Jones S., Braud V.M. Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific. Eur J Immunol 2004, 34:1673-1679.
35. Hao L., Nei M. Rapid expansion of killer cell immunoglobulin-like receptor genes in primates and their coevolution with MHC class I genes. Gene 2005, 347:149-159.
36. Held W., Raulet D.H. Expression of the Ly49A gene in murine natural killer cell clones is predominantly but not exclusively mono-allelic. Eur J Immunol 1997, 27:2876-2884.
37. Hiby S.E., Walker J.J., O'Shaughnessy K M., Redman C.W., Carrington M., Trowsdale J., Moffett A. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 2004, 200:957-965.
38. Horton R., Wilming L., Rand V., Lovering R.C., Bruford E.A., Khodiyar V.K., Lush M.J., Povey S., Talbot C.C., Wright M.W., Wain H.M., Trowsdale J., Ziegler A., Beck S. Gene map of the extended human MHC. Nat Rev Genet 2004, 5:889-899.
39. Hou L., Chen M., Steiner N.K., Belle I., Turino C., Ng J., Hurley C.K. Seventeen novel alleles add to the already extensive KIR3DL3 diversity. Tissue Antigens 2007, 70:449-454.
40. Hou L., Steiner N.K., Chen M., Belle I., Kubit A.L., Ng J., Hurley C.K. Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors. Hum Immunol 2008, 69:174-178.
41. Houchins J.P., Yabe T., McSherry C., Bach F.H. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med 1991, 173:1017-1020.
42. Hsu K.C., Chida S., Geraghty D.E., Dupont B. The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol Rev 2002, 190:40-52.
43. Hughes A.L. Evolution of the human killer cell inhibitory receptor family. Mol Phylogenet Evol 2002, 25:330-340.
44. Jiang K., Zhu F.M., Lv Q.F., Yan L.X. Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. Tissue Antigens 2005, 65:556-563.
45. Karlhofer F.M., Ribaudo R.K., Yokoyama W.M. MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells. Nature 1992, 358:66-70.
46. Karre K., Ljunggren H.G., Piontek G., Kiessling R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 1986, 319:675-678.
47. Khakoo S.I., Rajalingam R., Shum B.P., Weidenbach K., Flodin L., Muir D.G., Canavez F., Cooper S.L., Valiante N.M., Lanier L.L., Parham P. Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. Immunity 2000, 12:687-698.
48. Khakoo S.I., Thio C.L., Martin M.P., Brooks C.R., Gao X., Astemborski J., Cheng J., Goedert J.J., Vlahov D., Hilgartner M., Cox S., Little A.M., Alexander G.J., Cramp M.E., O'Brien S.J., Rosenberg W.M., Thomas D.L., Carrington M. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 2004, 305:872-874.
49. Kikuchi-Maki A., Yusa S., Catina T.L., Campbell K.S. KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production. J Immunol 2003, 171:3415-3425.
50. Kim S., Poursine-Laurent J., Truscott S.M., Lybarger L., Song Y.J., Yang L., French A.R., Sunwoo J.B., Lemieux S., Hansen T.H., Yokoyama W.M. Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 2005, 436:709-713.
51. Kollnberger S., Chan A., Sun M.Y., Chen L.Y., Wright C., di Gleria K., McMichael A., Bowness P. Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide. Eur J Immunol 2007, 37:1313-1322.
52. Kubota A., Kubota S., Lohwasser S., Mager D.L., Takei F. Diversity of NK cell receptor repertoire in adult and neonatal mice. J Immunol 1999, 163:212-216.
53. LaBonte M.L., Hershberger K.L., Korber B., Letvin N.L. The KIR and CD94/NKG2 families of molecules in the rhesus monkey. Immunol Rev 2001, 183:25-40.
54. Lanier L.L. NK cell recognition. Annu Rev Immunol 2005, 23:225-274.
55. Lanier L.L., Corliss B.C., Wu J., Leong C., Phillips J.H. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 1998, 391:703-707.
56. Li H., Pascal V., Martin M.P., Carrington M., Anderson S.K. Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression. PLoS Genet 2008, 4:e1000254.
57. Luo L., Du Z., Sharma S.K., Cullen R., Spellman S., Reed E.F., Rajalingam R. Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3. Immunogenetics 2007, 59:779-792.
58. Maenaka K., Juji T., Stuart D.I., Jones E.Y. Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I. Structure 1999, 7:391-398.
59. Martin M.P., Gao X., Lee J.H., Nelson G.W., Detels R., Goedert J.J., Buchbinder S., Hoots K., Vlahov D., Trowsdale J., Wilson M., O'Brien S.J., Carrington M. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 2002, 31:429-434.
60. Martin M.P., Bashirova A., Traherne J., Trowsdale J., Carrington M. Cutting edge: expansion of the KIR locus by unequal crossing over. J Immunol 2003, 171:2192-2195.
61. Matsumoto N., Mitsuki M., Tajima K., Yokoyama W.M., Yamamoto K. The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand. J Exp Med 2001, 193:147-158.
62. Maxwell L.D., Wallace A., Middleton D., Curran M.D. A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey. Tissue Antigens 2002, 60:254-258.
63. Maxwell L.D., Williams F., Gilmore P., Meenagh A., Middleton D. Investigation of killer cell immunoglobulin-like receptor gene diversity: II. KIR2DS4. Hum Immunol 2004, 65:613-621.
64. McQueen K.L., Wilhelm B.T., Harden K.D., Mager D.L. Evolution of NK receptors: a single Ly49 and multiple KIR genes in the cow. Eur J Immunol 2002, 32:810-817.
65. Meenagh A., Williams F., Sleator C., Halfpenny I.A., Middleton D. Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2. Tissue Antigens 2004, 64:226-234.
66. Mehta I.K., Wang J., Roland J., Margulies D.H., Yokoyama W.M. Ly49A allelic variation and MHC class I specificity. Immunogenetics 2001, 53:572-583.
67. Middleton D., Meenagh A., Gourraud P.A. KIR haplotype content at the allele level in 77 Northern Irish families. Immunogenetics 2007, 59:145-158.
68. Moesta A.K., Norman P.J., Yawata M., Yawata N., Gleimer M., Parham P. Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3. J Immunol 2008, 180:3969-3979.
69. Moretta A., Vitale M., Bottino C., Orengo A.M., Morelli L., Augugliaro R., Barbaresi M., Ciccone E., Moretta L. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J Exp Med 1993, 178:597-604.
70. Moretta A., Sivori S., Vitale M., Pende D., Morelli L., Augugliaro R., Bottino C., Moretta L. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J Exp Med 1995, 182:875-884.
71. Morvan, M., David, G., Sebille, V., Perrin, A., Gagne, K., Willem, C., Kerdudou, N., Denis, L., Clemenceau, B., Follea, G., Bignon, J.D. and Retiere, C. (2008). Autologous and allogeneic HLA KIR ligand environments and activating KIR control KIR NK-cell functions. Eur J Immunol.
72. Natarajan K., Dimasi N., Wang J., Mariuzza R.A., Margulies D.H. Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination. Annu Rev Immunol 2002, 20:853-885.
73. Nelson G.W., Martin M.P., Gladman D., Wade J., Trowsdale J., Carrington M. Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis. J Immunol 2004, 173:4273-4276.
74. Norman P.J., Stephens H.A., Verity D.H., Chandanayingyong D., Vaughan R.W. Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups. Immunogenetics 2001, 52:195-205.
75. Norman P.J., Carrington C.V., Byng M., Maxwell L.D., Curran M.D., Stephens H.A., Chandanayingyong D., Verity D.H., Hameed K., Ramdath D.D., Vaughan R.W. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun 2002, 3:86-95.
76. Norman P.J., Cook M.A., Carey B.S., Carrington C.V., Verity D.H., Hameed K., Ramdath D.D., Chandanayingyong D., Leppert M., Stephens H.A., Vaughan R.W. SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex. Immunogenetics 2004, 56:225-237.
77. Norman P.J., Abi-Rached L., Gendzekhadze K., Korbel D., Gleimer M., Rowley D., Bruno D., Carrington C.V., Chandanayingyong D., Chang Y.H., Crespi C., Saruhan-Direskeneli G., Fraser P.A., Hameed K., Kamkamidze G., Koram K.A., Layrisse Z., Matamoros N., Mila J., Park M.H., Pitchappan R.M., Ramdath D.D., Shiau M.Y., Stephens H.A., Struik S., Verity D.H., Vaughan R.W., Tyan D., Davis R.W., Riley E.M., Ronaghi M., Parham P. Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans. Nat Genet 2007, 39:1092-1099.
78. O'Connor G.M., Guinan K.J., Cunningham R.T., Middleton D., Parham P., Gardiner C.M. Functional polymorphism of the KIR3DL1/S1 receptor on human NK cells. J Immunol 2007, 178:235-241.
79. Pando M.J., Gardiner C.M., Gleimer M., McQueen K.L., Parham P. The protein made from a common allele of KIR3DL1 (3DL1*004) is poorly expressed at cell surfaces due to substitution at positions 86 in Ig domain 0 and 182 in Ig domain 1. J Immunol 2003, 171:6640-6649.
80. Parham P. MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 2005, 5:201-214.
81. Pascal V., Stulberg M.J., Anderson S.K. Regulation of class I major histocompatibility complex receptor expression in natural killer cells: one promoter is not enough!. Immunol Rev 2006, 214:9-21.
82. Pende, D., Marcenaro, S., Falco, M., Martini, S., Bernardo, M.E., Montagna, D., Romeo, E., Cognet, C., Martinetti, M., Maccario, R., Mingari, M.C., Vivier, E., Moretta, L., Locatelli, F. and Moretta, A. (2008). Antileukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and re-definition of inhibitory KIR specificity. Blood.
83. Ponte M., Cantoni C., Biassoni R., Tradori-Cappai A., Bentivoglio G., Vitale C., Bertone S., Moretta A., Moretta L., Mingari M.C. Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor. Proc Natl Acad Sci U S A 1999, 96:5674-5679.
84. Proteau M.F., Rousselle E., Makrigiannis A.P. Mapping of the BALB/c Ly49 cluster defines a minimal natural killer cell receptor gene repertoire. Genomics 2004, 84:669-677.
85. Rajagopalan S., Bryceson Y.T., Kuppusamy S.P., Geraghty D.E., van der Meer A., Joosten I., Long E.O. Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol 2006, 4:e9.
86. Rajalingam R., Hong M., Adams E.J., Shum B.P., Guethlein L.A., Parham P. Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes. J Exp Med 2001, 193:135-146.
87. Rajalingam R., Krausa P., Shilling H.G., Stein J.B., Balamurugan A., McGinnis M.D., Cheng N.W., Mehra N.K., Parham P. Distinctive KIR and HLA diversity in a panel of north Indian Hindus. Immunogenetics 2002, 53:1009-1019.
88. Rajalingam R., Du Z., Meenagh A., Luo L., Kavitha V.J., Pavithra-Arulvani R., Vidhyalakshmi A., Sharma S.K., Balazs I., Reed E.F., Pitchappan R.M., Middleton D. Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations. Immunogenetics 2008, 60:207-217.
89. Raulet D.H., Vance R.E., McMahon C.W. Regulation of the natural killer cell receptor repertoire. Annu Rev Immunol 2001, 19:291-330.
90. Rouhi A., Gagnier L., Takei F., Mager D.L. Evidence for epigenetic maintenance of Ly49a monoallelic gene expression. J Immunol 2006, 176:2991-2999.
91. Ruggeri L., Capanni M., Urbani E., Perruccio K., Shlomchik W.D., Tosti A., Posati S., Rogaia D., Frassoni F., Aversa F., Martelli M.F., Velardi A. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002, 295:2097-2100.
92. Saleh A., Davies G.E., Pascal V., Wright P.W., Hodge D.L., Cho E.H., Lockett S.J., Abshari M., Anderson S.K. Identification of probabilistic transcriptional switches in the Ly49 gene cluster: a eukaryotic mechanism for selective gene activation. Immunity 2004, 21:55-66.
93. Sambrook J.G., Bashirova A., Andersen H., Piatak M., Vernikos G.S., Coggill P., Lifson J.D., Carrington M., Beck S. Identification of the ancestral killer immunoglobulin-like receptor gene in primates. BMC Genomics 2006, 7:209.
94. Sanjanwala B., Draghi M., Norman P.J., Guethlein L.A., Parham P. Polymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1. J Immunol 2008, 181:6293-6300.
95. Santourlidis S., Trompeter H.I., Weinhold S., Eisermann B., Meyer K.L., Wernet P., Uhrberg M. Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells. J Immunol 2002, 169:4253-4261.
96. Santourlidis S., Graffmann N., Christ J., Uhrberg M. Lineage-specific transition of histone signatures in the killer cell Ig-like receptor locus from hematopoietic progenitor to NK cells. J Immunol 2008, 180:418-425.
97. Shilling H.G., Guethlein L.A., Cheng N.W., Gardiner C.M., Rodriguez R., Tyan D., Parham P. Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype. J Immunol 2002, 168:2307-2315.
98. Shilling H.G., Young N., Guethlein L.A., Cheng N.W., Gardiner C.M., Tyan D., Parham P. Genetic control of human NK cell repertoire. J Immunol 2002, 169:239-247.
99. Single R.M., Martin M.P., Gao X., Meyer D., Yeager M., Kidd J.R., Kidd K.K., Carrington M. Global diversity and evidence for coevolution of KIR and HLA. Nat Genet 2007, 39:1114-1119.
100. Stern M., Ruggeri L., Capanni M., Mancusi A., Velardi A. Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1. Blood 2008, 112:708-710.
101. Stewart C.A., Van Bergen J., Trowsdale J. Different and divergent regulation of the KIR2DL4 and KIR3DL1 promoters. J Immunol 2003, 170:6073-6081.
102. Stewart C.A., Laugier-Anfossi F., Vely F., Saulquin X., Riedmuller J., Tisserant A., Gauthier L., Romagne F., Ferracci G., Arosa F.A., Moretta A., Sun P.D., Ugolini S., Vivier E. Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci U S A 2005, 102:13224-13229.
103. Takahashi T., Yawata M., Raudsepp T., Lear T.L., Chowdhary B.P., Antczak D.F., Kasahara M. Natural killer cell receptors in the horse: evidence for the existence of multiple transcribed LY49 genes. Eur J Immunol 2004, 34:773-784.
104. Takei F., McQueen K.L., Maeda M., Wilhelm B.T., Lohwasser S., Lian R.H., Mager D.L. Ly49 and CD94/NKG2: developmentally regulated expression and evolution. Immunol Rev 2001, 181:90-103.
105. Thananchai H., Gillespie G., Martin M.P., Bashirova A., Yawata N., Yawata M., Easterbrook P., McVicar D.W., Maenaka K., Parham P., Carrington M., Dong T., Rowland-Jones S. Cutting edge: allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. J Immunol 2007, 178:33-37.
106. Thomas R., Yamada E., Alter G., Martin M.P., Bashirova A.A., Norman P.J., Altfeld M., Parham P., Anderson S.K., McVicar D.W., Carrington M. Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?. J Immunol 2008, 180:6743-6750.
107. Toneva M., Lepage V., Lafay G., Dulphy N., Busson M., Lester S., Vu-Trien A., Michaylova A., Naumova E., McCluskey J., Charron D. Genomic diversity of natural killer cell receptor genes in three populations. Tissue Antigens 2001, 57:358-362.
108. Trompeter H.I., Gomez-Lozano N., Santourlidis S., Eisermann B., Wernet P., Vilches C., Uhrberg M. Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3. J Immunol 2005, 174:4135-4143.
109. Trundley A.E., Hiby S.E., Chang C., Sharkey A.M., Santourlidis S., Uhrberg M., Trowsdale J., Moffett A. Molecular characterization of KIR3DL3. Immunogenetics 2006, 57:904-916.
110. Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P. Human diversity in killer cell inhibitory receptor genes. Immunity 1997, 7:753-763.
111. Uhrberg M., Parham P., Wernet P. Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes. Immunogenetics 2002, 54:221-229.
112. Valiante N.M., Uhrberg M., Shilling H.G., Lienert-Weidenbach K., Arnett K.L., D'Andrea A., Phillips J.H., Lanier L.L., Parham P. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity 1997, 7:739-751.
113. VandenBussche C.J., Dakshanamurthy S., Posch P.E., Hurley C.K. A single polymorphism disrupts the killer Ig-like receptor 2DL2/2DL3 D1 domain. J Immunol 2006, 177:5347-5357.
114. Velardi A. Role of KIRs and KIR ligands in hematopoietic transplantation. Curr Opin Immunol 2008, 20:581-587.
115. Velickovic M., Velickovic Z., Dunckley H. Diversity of killer cell immunoglobulin-like receptor genes in Pacific Islands populations. Immunogenetics 2006, 58:523-532.
116. Velickovic, M., Velickovic, Z., Panigoro, R. and Dunckley, H. (2008). Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. Tissue Antigens.
117. Verma S., King A., Loke Y.W. Expression of killer cell inhibitory receptors on human uterine natural killer cells. Eur J Immunol 1997, 27:979-983.
118. Vilches C., Parham P. KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu Rev Immunol 2002, 20:217-251.
119. Vilches C., Gardiner C.M., Parham P. Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene. J Immunol 2000, 165:6416-6421.
120. Voss S.D., Daley J., Ritz J., Robertson M.J. Participation of the CD94 receptor complex in costimulation of human natural killer cells. J Immunol 1998, 160:1618-1626.
121. Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995, 2:439-449.
122. Whang D.H., Park H., Yoon J.A., Park M.H. Haplotype analysis of killer cell immunoglobulin-like receptor genes in 77 Korean families. Hum Immunol 2005, 66:146-154.
123. Williams F., Maxwell L.D., Halfpenny I.A., Meenagh A., Sleator C., Curran M.D., Middleton D. Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals. Hum Immunol 2003, 64:729-732.
124. Wilson M.J., Torkar M., Haude A., Milne S., Jones T., Sheer D., Beck S., Trowsdale J. Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci U S A 2000, 97:4778-4783.
125. Winter C.C., Gumperz J.E., Parham P., Long E.O., Wagtmann N. Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J Immunol 1998, 161:571-577.
126. Yawata M., Yawata N., Abi-Rached L., Parham P. Variation within the human killer cell immunoglobulin-like receptor (KIR) gene family. Crit Rev Immunol 2002, 22:463-482.
127. Yawata M., Yawata N., McQueen K.L., Cheng N.W., Guethlein L.A., Rajalingam R., Shilling H.G., Parham P. Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. Immunogenetics 2002, 54:543-550.
128. Yawata M., Yawata N., Draghi M., Little A.M., Partheniou F., Parham P. Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function. J Exp Med 2006, 203:633-645.
129. Yawata M., Yawata N., Draghi M., Partheniou F., Little A.M., Parham P. MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response. Blood 2008, 112:2369-2380.
130. Yokoyama W.M., Jacobs L.B., Kanagawa O., Shevach E.M., Cohen D.I. A murine T lymphocyte antigen belongs to a supergene family of type II integral membrane proteins. J Immunol 1989, 143:1379-1386.
131. Yu J., Heller G., Chewning J., Kim S., Yokoyama W.M., Hsu K.C. Hierarchy of the human natural killer cell response is determined by class and quantity of inhibitory receptors for self-HLA-B and HLA-C ligands. J Immunol 2007, 179:5977-5989.