Use of a local sensitivity analysis to inform study design based on a mechanistic toxicokinetic model for γ-hydroxybutyric acid

AAPS Journal

Volumn 13, Issue 2, 2011, Pages 240-254

  Felmlee, Melanie A ^a   Krzyzanski, Wojciech ^a   Morse, Bridget L ^a   Morris, Marilyn E ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

active renal reabsorption; gamma hydroxybutyric acid; monocarboxylate transporters; sensitivity analysis

Indexed keywords

4 HYDROXYBUTYRIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG OVERDOSE; DRUG URINE LEVEL; KIDNEY TUBULE ABSORPTION; MALE; MECHANISTIC MODEL; METHODOLOGY; MODEL; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PREDICTION; RAT; SENSITIVITY ANALYSIS; SIMULATION; TISSUE DISTRIBUTION; TOXICOKINETICS; VALIDATION PROCESS;

ANIMALS; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROXYBUTYRATES; KIDNEY; MALE; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 79957519725     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9264-y     Document Type: Article

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