Physiologically based pharmacokinetic modeling of a homologous series of barbiturates in the rat: A sensitivity analysis

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 25, Issue 4, 1997, Pages 413-447

  Nestorov, Ivan A ^a,b   Aarons, Leon J ^b   Rowland, Malcolm ^b  

^a Acad G Bonchev   (Bulgaria)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Compartmental system; Matrix perturbation analysis; Physiologically based pharmacokinetic model; Sensitivity analysis; Simulation

Indexed keywords

BARBITURIC ACID DERIVATIVE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BOLUS INJECTION; BONE; BRAIN; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; HEART; HUMAN; INTESTINE; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; LUNG; MALE; MUSCLE; PANCREAS; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; SKIN; SPLEEN; STOMACH; TESTIS; TISSUE BLOOD FLOW;

ANIMALS; BARBITURATES; MODELS, BIOLOGICAL; RATS; SENSITIVITY AND SPECIFICITY;

EID: 0031412578     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025740909016     Document Type: Article

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