Apoptogenic activity of 2α,3α-dihydroxyurs-12-ene-28-oic acid from Prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by Bcl-2 in human acute leukemia Jurkat T cells

Journal of Ethnopharmacology

Volumn 135, Issue 3, 2011, Pages 626-635

  Woo, Hyun Ju ^a   Jun, Do Youn ^a   Lee, Ji Young ^a   Woo, Mi Hee ^b   Yang, Chae Ha ^c   Kim, Young Ho ^a  

^a Kyungpook National University   (South Korea)

^b Catholic University of Daegu   (South Korea)

^c Daegu Haany University   (South Korea)

Author keywords

2 ,3 Dihydroxyurs 12 en 28 oic acid; Apoptosis; Caspase cascade; Human Jurkat T cells; Mitochondrial damage; Prunella vulgaris var. lilacina

Indexed keywords

2ALPHA,3ALPHA DIHYDROXYURS 12 ENE 28 OIC ACID; ANTINEOPLASTIC AGENT; CASPASE 12; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PRUNELLA VULGARIS EXTRACT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL VIABILITY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG ACTIVITY; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; T LYMPHOCYTE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CYTOCHROMES C; DNA FRAGMENTATION; ENZYME INHIBITORS; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; INFLORESCENCE; INHIBITORY CONCENTRATION 50; JURKAT CELLS; LEUKEMIA, T-CELL; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHYTOTHERAPY; PLANT EXTRACTS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; PRUNELLA; SAPONINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

LAMIACEAE; PRUNELLA VULGARIS;

EID: 79957496848     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.03.067     Document Type: Article

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