-
1
-
-
27544490377
-
+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
DOI 10.1038/ni1254, PII N1254
-
Harrington LE, Hatton RD, Mangan PR et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6(11), 1123-1132 (2005). (Pubitemid 41541790)
-
(2005)
Nature Immunology
, vol.6
, Issue.11
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
Turner, H.4
Murphy, T.L.5
Murphy, K.M.6
Weaver, C.T.7
-
2
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
DOI 10.1038/ni1261, PII N1261
-
Park H, Li Z, Yang XO et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nat. Immunol. 6(11), 1133-1141 (2005). (Pubitemid 41541791)
-
(2005)
Nature Immunology
, vol.6
, Issue.11
, pp. 1133-1141
-
-
Park, H.1
Li, Z.2
Yang, X.O.3
Chang, S.H.4
Nurieva, R.5
Wang, Y.-H.6
Wang, Y.7
Hood, L.8
Zhu, Z.9
Tian, Q.10
Dong, C.11
-
3
-
-
67349234068
-
IL-17 and Th17 cells in human inflammatory diseases
-
Miossec P. IL-17 and Th17 cells in human inflammatory diseases. Microbes Infect. 11(5), 625-630 (2009).
-
(2009)
Microbes Infect.
, vol.11
, Issue.5
, pp. 625-630
-
-
Miossec, P.1
-
4
-
-
68849125507
-
Type 17 T helper cells-origins features and possible roles in rheumatic disease
-
Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Type 17 T helper cells-origins, features and possible roles in rheumatic disease. Nat. Rev. Rheumatol. 5(6), 325-331 (2009).
-
(2009)
Nat. Rev. Rheumatol.
, vol.5
, Issue.6
, pp. 325-331
-
-
Annunziato, F.1
Cosmi, L.2
Liotta, F.3
Maggi, E.4
Romagnani, S.5
-
5
-
-
77950535421
-
LY2439821 a humanized anti-interleukin-17 monoclonal antibody in the treatment of patients with rheumatoid arthritis: A Phase I randomized double-blind placebo-controlled proof-of-concept study
-
Genovese MC, Van den Bosch F, Roberson SA et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 62(4), 929-939 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, Issue.4
, pp. 929-939
-
-
Genovese, M.C.1
Van Den Bosch, F.2
Roberson, S.A.3
-
6
-
-
0037449737
-
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
-
DOI 10.1074/jbc.M207577200
-
Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 J. Biol. Chem. 278(3), 1910-1914 (2003). (Pubitemid 36801431)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.3
, pp. 1910-1914
-
-
Aggarwal, S.1
Ghilardi, N.2
Xie, M.-H.3
De Sauvage, F.J.4
Gurney, A.L.5
-
7
-
-
32244442562
-
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
DOI 10.1016/j.immuni.2006.01.001, PII S1074761306000045
-
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFb in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24(2), 179-189 (2006). (Pubitemid 43214587)
-
(2006)
Immunity
, vol.24
, Issue.2
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
8
-
-
33750142276
-
Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
-
DOI 10.1038/ni1391, PII NI1391
-
Veldhoen M, Hocking RJ, Flavell RA, Stockinger B. Signals mediated by transforming growth factor-b initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7(11), 1151-1156 (2006). (Pubitemid 44594310)
-
(2006)
Nature Immunology
, vol.7
, Issue.11
, pp. 1151-1156
-
-
Veldhoen, M.1
Hocking, R.J.2
Flavell, R.A.3
Stockinger, B.4
-
9
-
-
33748588423
-
+ T helper cells
-
DOI 10.1016/j.cell.2006.07.035, PII S0092867406011056
-
Ivanov, II, McKenzie BS, Zhou L et al. The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 126(6), 1121-1133 (2006). (Pubitemid 44380299)
-
(2006)
Cell
, vol.126
, Issue.6
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
Cua, D.J.7
Littman, D.R.8
-
10
-
-
34547188748
-
H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
DOI 10.1038/ni1488, PII NI1488
-
Zhou L, Ivanov, II, Spolski R et al. IL-6 programs T(h)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8(9), 967-974 (2007). (Pubitemid 47300011)
-
(2007)
Nature Immunology
, vol.8
, Issue.9
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
Levy, D.E.7
Leonard, W.J.8
Littman, D.R.9
-
11
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells. Nature 441(7090), 235-238 (2006).
-
(2006)
Nature
, vol.441
, Issue.7090
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
12
-
-
34548125305
-
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
-
DOI 10.1038/ni1496, PII NI1496
-
Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1b and 6 but not transforming growth factor-b are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8(9), 942-949 (2007). (Pubitemid 47300008)
-
(2007)
Nature Immunology
, vol.8
, Issue.9
, pp. 942-949
-
-
Acosta-Rodriguez, E.V.1
Napolitani, G.2
Lanzavecchia, A.3
Sallusto, F.4
-
13
-
-
77958584113
-
Generation of pathogenic Th17 cells in the absence TGF-b signalling
-
Ghoreschi K, Laurence A, Yang XP et al. Generation of pathogenic T(h)17 cells in the absence TGF-b signalling. Nature 467(7318), 967-971 (2010).
-
(2010)
Nature
, vol.467
, Issue.7318
, pp. 967-971
-
-
Ghoreschi, K.1
Laurence, A.2
Yang, X.P.3
-
14
-
-
36248965294
-
H-17 cell-mediated pathology
-
DOI 10.1038/ni1539, PII NI1539
-
McGeachy MJ, Bak-Jensen KS, Chen Y et al. TGF-b and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(h)-17 cell-mediated pathology. Nat. Immunol. 8(12), 1390-1397 (2007). (Pubitemid 350138974)
-
(2007)
Nature Immunology
, vol.8
, Issue.12
, pp. 1390-1397
-
-
McGeachy, M.J.1
Bak-Jensen, K.S.2
Chen, Y.3
Tato, C.M.4
Blumenschein, W.5
McClanahan, T.6
Cua, D.J.7
-
15
-
-
34848821989
-
Distinct regulation of interleukin-17 in human T helper lymphocytes
-
DOI 10.1002/art.22866
-
Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 56(9), 2936-2946 (2007). (Pubitemid 47502740)
-
(2007)
Arthritis and Rheumatism
, vol.56
, Issue.9
, pp. 2936-2946
-
-
Chen, Z.1
Tato, C.M.2
Muul, L.3
Laurence, A.4
O'Shea, J.J.5
-
16
-
-
3142724732
-
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
-
DOI 10.1084/jem.20031819
-
Bettelli E, Sullivan B, Szabo SJ et al. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 200(1), 79-87 (2004). (Pubitemid 38924730)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.1
, pp. 79-87
-
-
Bettelli, E.1
Sullivan, B.2
Szabo, S.J.3
Sobel, R.A.4
Glimcher, L.H.5
Kuchroo, V.K.6
-
17
-
-
33751071052
-
Polyfunctional analysis of human t cell responses: Importance in vaccine immunogenicity and natural infection
-
DOI 10.1007/s00281-006-0025-4
-
Makedonas G, Betts MR. Polyfunctional analysis of human T cell responses: importance in vaccine immunogenicity and natural infection. Springer Semin. Immunopathol. 28(3), 209-219 (2006). (Pubitemid 44764277)
-
(2006)
Springer Seminars in Immunopathology
, vol.28
, Issue.3
, pp. 209-219
-
-
Makedonas, G.1
Betts, M.R.2
|