Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 3058-3065

  Dolušić, Eduard ^a   Larrieu, Pierre ^b   Blanc, Sébastien ^c   Sapunaric, Frédéric ^d   Pouyez, Jenny ^a   Moineaux, Laurence ^a   Colette, Delphine ^c   Stroobant, Vincent ^b   Pilotte, Luc ^b   Colau, Didier ^b   Ferain, Thierry ^c   Fraser, Graeme ^c   Galleni, Moreno ^d   Frre, Jean Marie ^d   Masereel, Bernard ^a   Van Den Eynde, Benoît ^b   Wouters, Johan ^a   Frédérick, Raphaël ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c Euroscreen SA   (Belgium)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Enzyme inhibitors; IDO; Indoleamine 2,3 dioxygenase; Keto indoles; Structure activity relationships; Structure based drug discovery

Indexed keywords

INDOLE DERIVATIVE; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; KETO INDOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; INDOLEAMINE 2,3 DIOXYGENASE; RECOMBINANT PROTEIN; TRYPTOPHAN; TUMOR PROTEIN;

ANIMAL CELL; ARTICLE; DRUG BINDING; DRUG STRUCTURE; ENZYME INHIBITION; MOLECULAR DOCKING; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL DATABASE; CHEMISTRY; DRUG DEVELOPMENT; ENZYME ASSAY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DATABASES, CHEMICAL; DRUG DISCOVERY; ENZYME ASSAYS; ENZYME INHIBITORS; ESCHERICHIA COLI; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INDOLES; MICE; MOLECULAR DOCKING SIMULATION; NEOPLASM PROTEINS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 79957472526     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.049     Document Type: Article

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