Synthesis and in vitro antimalarial activity of tetraoxane-amine/amide conjugates

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 2816-2827

  Kumar, Nitin ^a   Khan, Shabana I ^b   Atheaya, Himanshu ^a   Mamgain, Ritu ^a   Rawat, Diwan S ^a  

^a UNIVERSITY OF DELHI   (India)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Amine conjugates; Artemisinin; Plasmodium falciparum; Tetraoxane

Indexed keywords

(4 BROMOPHENYL)[4 [6 (4 TOLYL) [1,2,4,5]TETRAOXAN 3 YL]BENZYLIDENE]AMINE; (4 CHLOROPHENYL)[4 [6 (4 TOLYL) [1,2,4,5]TETRAOXAN 3 YL]BENZYLIDENE]AMINE; 2[4 [6 (4 TOLYL) 1,2,4,5 TETRAOXAN 3 YL]BENZYLIDENEAMINO]BENZENETHIOL; 2[4 [6 (4 TOLYL) 1,2,4,5TETRAOXAN 3 YL]BENZYLAMINO]BENZENETHIOL; 2[[4 [6 (4 TOLYL) 1,2,4,5 TETRAOXAN 3 YL]BENZYLIDENE]AMINO]ETHANOL; 4 (6 PHENYL[1,2,4,5]TETROXAN 3 YL)BENZALDEHYDE; 4 [6 (2 TOLYL)[1,2,4,5]TETROXAN 3 YL]BENZALDEHYDE; 4 [6 (3 TOLYL)[1,2,4,5]TETROXAN 3 YL]BENZALDEHYDE; 4 [6 (4 ETHYLPHENYL)[1,2,4,5]TETROXAN 3 YL]BENZALDEHYDE; 4 [6 (4 ISOPROPYLPHENYL)[1,2,4,5]TETROXAN 3 YL]BENZALDEHYDE; 4 [6 (4 TOLYL)[1,2,4,5]TETROXAN 3 YL]BENZALDEHYDE; [4 [6 (4 TOLYL) [1,2,4,5]TETRAOXAN 3 YL]BENZYLIDENE]HYDRAZINE; ADAMANTAN 1 YL[4 [6 (4 TOLYL) [1,2,4,5]TETRAOXAN 3 YL]BENZYL]AMINE; ADAMANTAN 1 YL[4 [6 (4 TOLYL) [1,2,4,5]TETRAOXAN 3 YL]BENZYLIDENE]AMINE; ANTIMALARIAL AGENT; ARTEMISININ; BENZYL[4 [6 (4 TOLYL) [1,2,4,5]TETRAOXAN 3 YL]BENZYL]AMINE; BENZYL[4 [6 (4 TOLYL)[1,2,4,5]TETROXAN 3 YL]BENZYLIDENE]AMINE; CHLOROQUINE; N (7 CHLOROQUINOLIN 4 YL) N' [4 [6 (4 TOLYL) [1,2,4,5]TETRAOXAN 3 YL]BENZYLIDENE]ETHANE 1,2 DIAMINE; N [4 [6 (4 TOLYL) 1,2,4,5 TETRAOXAN 3 YL]BENZYL]PYRIDIN 3 AMINE; N [4 [6 (4 TOLYL) 1,2,4,5 TETRAOXAN 3 YL]BENZYLIDENE]ANILINE; N [4 [6 (4 TOLYL) 1,2,4,5 TETRAOXAN 3 YL]BENZYLIDENE]CYCLOHEXANAMINE; N [4 [6 (4 TOLYL) 1,2,4,5 TETRAOXAN 3 YL]BENZYLIDENE]PYRIDIN 3 AMINE; PHENETHYL[4 [6 (4 TOLYL) [1,2,4,5]TETRAOXAN 3 YL]BENZY]AMINE; PHENETHYL[4 [6 (4 TOLYL)[1,2,4,5]TETROXAN 3 YL]BENZYLIDENE]AMINE; TETRAOXANE AMIDE; TETRAOXANE AMINE; TETRAOXANE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; AMIDE; AMINE; ARTEMISININ DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG CONJUGATION; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; PLASMODIUM FALCIPARUM; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; DRUG RESISTANCE; HUMAN; IC50; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; VERO CELL LINE;

AMIDES; AMINES; ANIMALS; ANTIMALARIALS; ARTEMISININS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CHLOROQUINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG RESISTANCE; HUMANS; INHIBITORY CONCENTRATION 50; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAOXANES; VERO CELLS;

EID: 79957461484     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.002     Document Type: Article

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