Orchestrated downregulation of genes involved in oxidative metabolic pathways in obese vs. lean high-fat young male consumers

Journal of Physiology and Biochemistry

Volumn 67, Issue 1, 2011, Pages 141-144

  Marrades, M Pilar ^a   González Muniesa, Pedro ^a   Arteta, David ^b   Martínez, J Alfredo ^a   Moreno Aliaga, Maria Jesus ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b IMG Pharma Biotech S L Parque Tecnologico de Zamudio   (Spain)

Author keywords

Genetic susceptibility; High fat diet; Metabolic pathways; Microarray; Obesity

Indexed keywords

ADULT STEM CELL; AMYOTROPHIC LATERAL SCLEROSIS; EMBRYONIC STEM CELL; HUMAN; PIGMENT EPITHELIUM; PLURIPOTENT STEM CELL; RETINA MACULA DEGENERATION; SHORT SURVEY; SPINAL CORD INJURY; ADIPOSE TISSUE; ADULT; ARTICLE; BIOSYNTHESIS; BODY WEIGHT; CITRIC ACID CYCLE; DOWN REGULATION; ELECTRON TRANSPORT; EVALUATION; FAT INTAKE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; MALE; METABOLISM; MITOCHONDRION; OBESITY; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN MICROARRAY; STANDARD; VALIDATION STUDY;

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACYL COENZYME A DEHYDROGENASE; ACYL COENZYME A DESATURASE; ELECTRON TRANSFERRING FLAVOPROTEIN; ELECTRON TRANSFERRING FLAVOPROTEIN DEHYDROGENASE; ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE; FATTY ACID; FATTY ACID SYNTHASE; IRON SULFUR PROTEIN; OXIDOREDUCTASE;

3-HYDROXYACYL COA DEHYDROGENASES; ACYL-COA DEHYDROGENASES; ADIPOSE TISSUE; ADULT; CITRIC ACID CYCLE; DIETARY FATS; DOWN-REGULATION; ELECTRON TRANSPORT; ELECTRON-TRANSFERRING FLAVOPROTEINS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IRON-SULFUR PROTEINS; MALE; MITOCHONDRIA; OBESITY; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMERASE CHAIN REACTION; PROTEIN ARRAY ANALYSIS; STEAROYL-COA DESATURASE; THINNESS;

EID: 79956363932     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-010-0064-0     Document Type: Short Survey

References (40)

1. Andersson CX, Gustafson B, Hammarstedt A, Hedjazifar S, Smith U (2008) Inflamed adipose tissue, insulin resistance and vascular injury. Diab Metab Res Rev 24:595-603
2. Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Bruning JC (2010) Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance. J Biol Chem 285:6198-6207
3. Beale EG, Hammer RE, Antoine B, Forest C (2004) Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene. Trends Endocrinol Metab 15:129-135 (Pubitemid 38445067)
4. Blaak EE, Hul G, Verdich C, Stich V, Martinez A, Petersen M, Feskens EFM, Patel K, Oppert JM, Barbe P, Toubro S, Anderson I, Polak J, Astrup A, Macdonald IA, Langin D, Holst C, Sorensen TI, Saris WHM, the Consortium for Nutrient-Gene Interactions in Human Obesity-Implications for Dietary Guidelines (2006) Fat oxidation before and after a high fat load in the obese insulin-resistant state. J Clin Endocrinol Metab 91:1462-1469
5. Bray GA, Popkin BM (1998) Dietary fat intake does affect obesity! Am J Clin Nutr 68:1157-1173
6. Castro-Chavez F, Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O'Connell P, Taegtmeyer H, Chan L (2003) Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes 52:2666-2674 (Pubitemid 37339695)
7. Colombo M, Kruhoeffer M, Gregersen S, Agger A, Jeppesen P, Oerntoft T, Hermansen K (2006) Energy restriction prevents the development of type 2 diabetes in Zucker diabetic fatty rats: coordinated patterns of gene expression for energy metabolism in insulin-sensitive tissues and pancreatic islets determined by oligonucleotide microarray analysis. Metabolism 55:43-52 (Pubitemid 41736245)
8. Corpeleijn E, Petersen L, Holst C, Saris WH, Astrup A, Langin D, MacDonald I, Martinez JA, Oppert JM, Polak J, Pedersen O, Froguel P, Arner P, Sorensen TI, Blaak EE (2010) Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. Obesity (Silver Spring) 18:1369-1377
9. Chang TJ, Lee WJ, Chang HM, Lee KC, Chuang LM (2008) Expression of subcutaneous adipose tissue phosphoenolpyruvate carboxykinase correlates with body mass index in nondiabetic women. Metabolism 57:367-372
10. Diraison F, Dusserre E, Vidal H, Sothier M, Beylot M (2002) Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am J Physiol Endocrinol Metab 282:E46-E51 (Pubitemid 34654105)
11. Gerbitz K, Gempel K, Brdiczka D (1996) Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes 45:113-126
12. Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J (2007) PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci USA 104:15466-15471 (Pubitemid 47502940)
13. Heilbronn LK, Gan SK, Turner N, Campbell LV, ChisholmDJ (2007) Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects. J Clin Endocrinol Metab 92:1467-1473
14. Hill MJ, Metcalfe D, McTernan PG (2009) Obesity and diabetes: lipids, 'nowhere to run to'. Clin Sci (Lond) 116:113-123
15. Hirabara SM, Curi R, Maechler P (2010) Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. J Cell Physiol 222:187-194
16. Huo Y, Guo X, Li H, Wang H, Zhang W, Wang Y, Zhou H, Gao Z, Telang S, Chesney J, Chen YE, Ye J, Chapkin RS, Wu C (2010) Disruption of inducible 6-phosphofructo-2- kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response. J Biol Chem 285:3713-3721
17. Inadera H (2008) The usefulness of circulating adipokine levels for the assessment of obesity-related health problems. Int J Med Sci 5:248-262
18. Kerner J, Hoppel C (2000) Fatty acid import into mitochondria. Biochim Biophys Acta 1486:1-17 (Pubitemid 30336788)
19. Koza RA, Nikonova L, Hogan J, Rim J-S, Mendoza T, Faulk C, Skaf J, Kozak LP (2006) Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet 2:e81
20. Leroyer SN, Tordjman J, Chauvet G, Quette J, Chapron C, Forest C, Antoine B (2006) Rosiglitazone controls fatty acid cycling in human adipose tissue by means of glyceroneogenesis and glycerol phosphorylation. J Biol Chem 281:13141-13149 (Pubitemid 43855225)
21. Lin RY, Vera JC, Chaganti RS, Golde DW (1998) Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem 273:28959-28965 (Pubitemid 28507590)
22. Lopez IP, Marti A, Milagro FI, Zulet Md Mde L, Moreno- Aliaga MJ, Martinez JA, De Miguel C (2003) DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats. Obes Res 11:188-194 (Pubitemid 41127385)
23. Marinou K, Tousoulis D, Antonopoulos AS, Stefanadi E, Stefanadis C (2010) Obesity and cardiovascular disease: from pathophysiology to risk stratification. Int J Cardiol 138:3-8
24. Marrades MP, Milagro FI, Martinez JA, Moreno-Aliaga MJ (2006) Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers. Biochem Biophys Res Commun 339:785-789 (Pubitemid 41772882)
25. Marrades MP, Martinez JA, Moreno-Aliaga MJ (2007) Differences in short-term metabolic responses to a lipid load in lean (resistant) vs obese (susceptible) young male subjects with habitual high-fat consumption. Eur J Clin Nutr 61:166-174
26. Martinez-Cruz LA, Rubio A, Martinez-Chantar ML, Labarga A, Barrio I, Podhorski A, Segura V, Sevilla Campo JL, Avila MA,Mato JM(2003) GARBAN: genomic analysis and rapid biological annotation of cDNA microarray and proteomic data. Bioinformatics 19:2158-2160 (Pubitemid 37408172)
27. Martinez-Gonzalez MA, Lopez-Fontana C, Varo JJ, Sanchez-Villegas A, Martinez JA (2005) Validation of the Spanish version of the physical activity questionnaire used in the Nurses' Health Study and the Health Professionals' Follow-up Study. Public Health Nutr 8:920-927
28. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267-273 (Pubitemid 36792858)
29. Moreno-Aliaga MJ, Marti A, Garcia-Foncillas J, Alfredo Martinez J (2001) DNA hybridization arrays: a powerful technology for nutritional and obesity research. Br J Nutr 86:119-122 (Pubitemid 32780615)
30. Neel JV (1962) Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 14:353-362
31. Obici S, Wang J, Chowdury R, Feng Z, Siddhanta U, Morgan K, Rossetti L (2002) Identification of a biochemical link between energy intake and energy expenditure. J Clin Invest 109:1599-1605 (Pubitemid 34663522)
32. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 100:8466-8471 (Pubitemid 36842568)
33. Perez-Echarri N, Perez-Matute P, Martinez JA, Marti A, Moreno-Aliaga MJ (2005) Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity. J Physiol Biochem 61:333-342 (Pubitemid 41269257)
34. Rognstad R, Katz J (1969) The effect of 2, 4-dinitrophenol on adipose-tissue metabolism. Biochem J 111:431-444
35. Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ (2010) Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol 30:106-115
36. Segura V, Podhorski A, Guruceaga E, Sevilla JL, Corrales FJ, Rubio A (2006) GARBAN II: An integrative frame- work for extracting biological information from proteomic and genomic data. Proteomics 6(Suppl 1):S12-S15
37. Wang ZG, White PS, Ackerman SH (2001) Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria. J Biol Chem 276:30773-30778 (Pubitemid 37384935)
38. WHO (2000) Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 894:i-xii, 1-253
39. Yvan-Charvet L, Even P, Bloch-Faure M, Guerre-Millo M, Moustaid-Moussa N, Ferre P, Quignard-Boulange A (2005) Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. Diabetes 54:991-999 (Pubitemid 40446313)
40. Zhang B, Kirov S, Snoddy J (2005) WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res 33:W741-W748 (Pubitemid 44530021)