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Volumn 6, Issue 5, 2011, Pages

C1 domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN 1; CELL CYCLE PROTEIN; CYCLIN A; CYCLIN B1; CYCLIN D1; CYCLIN E; DIACYLGLYCEROL; HMI 1A3; HMI 1B1; HMI 1B10; HMI 1B11; HMI 1B2; HMI 1B20; HMI 24A; HMP 27; NI 15E; PHORBOL 13 ACETATE 12 MYRISTATE; PHTHALIC ACID DERIVATIVE; PROTEIN KINASE C; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; ISOPHTHALATE;

EID: 79956341731     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020053     Document Type: Article
Times cited : (25)

References (40)
  • 1
    • 0035413601 scopus 로고    scopus 로고
    • Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
    • Newton AC, (2001) Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101: 2353-2364.
    • (2001) Chem Rev , vol.101 , pp. 2353-2364
    • Newton, A.C.1
  • 2
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y, (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614.
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 3
    • 0021227676 scopus 로고
    • The role of protein kinase C in cell surface signal transduction and tumour promotion
    • Nishizuka Y, (1984) The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308: 693-698.
    • (1984) Nature , vol.308 , pp. 693-698
    • Nishizuka, Y.1
  • 4
    • 33947603008 scopus 로고    scopus 로고
    • Protein kinase C and other diacylglycerol effectors in cancer
    • Griner EM, Kazanietz MG, (2007) Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7: 281-294.
    • (2007) Nat Rev Cancer , vol.7 , pp. 281-294
    • Griner, E.M.1    Kazanietz, M.G.2
  • 5
    • 1542619344 scopus 로고    scopus 로고
    • Protein kinase C isozymes as potential targets for anticancer therapy
    • Hofmann J, (2004) Protein kinase C isozymes as potential targets for anticancer therapy. Curr Cancer Drug Targets 4: 125-146.
    • (2004) Curr Cancer Drug Targets , vol.4 , pp. 125-146
    • Hofmann, J.1
  • 7
    • 77952468064 scopus 로고    scopus 로고
    • Activation of protein kinase C isoforms and its impact on diabetic complications
    • Geraldes P, King GL, (2010) Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res 106: 1319-1331.
    • (2010) Circ Res , vol.106 , pp. 1319-1331
    • Geraldes, P.1    King, G.L.2
  • 8
    • 77953543762 scopus 로고    scopus 로고
    • Pharmacology of protein kinase C activators: Cognition-enhancing and antidementic therapeutics
    • Sun MK, Alkon DL, (2010) Pharmacology of protein kinase C activators: Cognition-enhancing and antidementic therapeutics. Pharmacol Ther 127: 66-77.
    • (2010) Pharmacol Ther , vol.127 , pp. 66-77
    • Sun, M.K.1    Alkon, D.L.2
  • 9
    • 44849083233 scopus 로고    scopus 로고
    • Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta
    • Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, et al. (2008) Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. J Biol Chem 283: 10543-10549.
    • (2008) J Biol Chem , vol.283 , pp. 10543-10549
    • Choi, S.H.1    Czifra, G.2    Kedei, N.3    Lewin, N.E.4    Lazar, J.5
  • 10
    • 33748764383 scopus 로고    scopus 로고
    • C1 domains exposed: From diacylglycerol binding to protein-protein interactions
    • Colon-Gonzalez F, Kazanietz MG, (2006) C1 domains exposed: From diacylglycerol binding to protein-protein interactions. Biochim Biophys Acta 1761: 827-837.
    • (2006) Biochim Biophys Acta , vol.1761 , pp. 827-837
    • Colon-Gonzalez, F.1    Kazanietz, M.G.2
  • 11
    • 52449093812 scopus 로고    scopus 로고
    • Wealth of opportunity - the C1 domain as a target for drug development
    • Blumberg PM, Kedei N, Lewin NE, Yang D, Czifra G, et al. (2008) Wealth of opportunity- the C1 domain as a target for drug development. Curr Drug Targets 9: 641-652.
    • (2008) Curr Drug Targets , vol.9 , pp. 641-652
    • Blumberg, P.M.1    Kedei, N.2    Lewin, N.E.3    Yang, D.4    Czifra, G.5
  • 14
    • 67649921434 scopus 로고    scopus 로고
    • Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C
    • Boije af Gennäs G, Talman V, Aitio O, Ekokoski E, Finel M, et al. (2009) Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem 52: 3969-3981.
    • (2009) J Med Chem , vol.52 , pp. 3969-3981
    • Boije af Gennäs, G.1    Talman, V.2    Aitio, O.3    Ekokoski, E.4    Finel, M.5
  • 15
    • 77955295373 scopus 로고    scopus 로고
    • Protein kinase C - A family of protein kinases, allosteric effectors or both?
    • Cameron AJ, Parker PJ, (2010) Protein kinase C- A family of protein kinases, allosteric effectors or both? Adv Enzyme Regul 50: 169-77.
    • (2010) Adv Enzyme Regul , vol.50 , pp. 169-177
    • Cameron, A.J.1    Parker, P.J.2
  • 16
    • 47049109143 scopus 로고    scopus 로고
    • PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival
    • Cameron AJ, Procyk KJ, Leitges M, Parker PJ, (2008) PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. Int J Cancer 123: 769-779.
    • (2008) Int J Cancer , vol.123 , pp. 769-779
    • Cameron, A.J.1    Procyk, K.J.2    Leitges, M.3    Parker, P.J.4
  • 17
    • 0033577576 scopus 로고    scopus 로고
    • PKCepsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells
    • Zeidman R, Lofgren B, Pahlman S, Larsson C, (1999) PKCepsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells. J Cell Biol 145: 713-726.
    • (1999) J Cell Biol , vol.145 , pp. 713-726
    • Zeidman, R.1    Lofgren, B.2    Pahlman, S.3    Larsson, C.4
  • 18
    • 24044470631 scopus 로고    scopus 로고
    • Identification of conserved amino acids N-terminal of the PKC epsilon C1b domain crucial for protein kinase C epsilon-mediated induction of neurite outgrowth
    • Ling M, Troller U, Zeidman R, Stensman H, Schultz A, et al. (2005) Identification of conserved amino acids N-terminal of the PKC epsilon C1b domain crucial for protein kinase C epsilon-mediated induction of neurite outgrowth. J Biol Chem 280: 17910-17919.
    • (2005) J Biol Chem , vol.280 , pp. 17910-17919
    • Ling, M.1    Troller, U.2    Zeidman, R.3    Stensman, H.4    Schultz, A.5
  • 19
    • 29144529161 scopus 로고    scopus 로고
    • Targeting protein kinase C and "non-kinase" phorbol ester receptors: Emerging concepts and therapeutic implications
    • Kazanietz MG, (2005) Targeting protein kinase C and "non-kinase" phorbol ester receptors: Emerging concepts and therapeutic implications. Biochim Biophys Acta 1754: 296-304.
    • (2005) Biochim Biophys Acta , vol.1754 , pp. 296-304
    • Kazanietz, M.G.1
  • 20
    • 0026628279 scopus 로고
    • Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1
    • Basu A, Lazo JS, (1992) Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1. Cancer Res 52: 3119-3124.
    • (1992) Cancer Res , vol.52 , pp. 3119-3124
    • Basu, A.1    Lazo, J.S.2
  • 21
    • 57649221172 scopus 로고    scopus 로고
    • Discriminative cytotoxicity assessment based on various cellular damages
    • Kim H, Yoon SC, Lee TY, Jeong D, (2009) Discriminative cytotoxicity assessment based on various cellular damages. Toxicol Lett 184: 13-17.
    • (2009) Toxicol Lett , vol.184 , pp. 13-17
    • Kim, H.1    Yoon, S.C.2    Lee, T.Y.3    Jeong, D.4
  • 22
    • 54949152716 scopus 로고    scopus 로고
    • Caspase-independent cell death: Leaving the set without the final cut
    • Tait SW, Green DR, (2008) Caspase-independent cell death: Leaving the set without the final cut. Oncogene 27: 6452-6461.
    • (2008) Oncogene , vol.27 , pp. 6452-6461
    • Tait, S.W.1    Green, D.R.2
  • 23
    • 0031033274 scopus 로고    scopus 로고
    • Inhibition of ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the bcl-2 homologue bak
    • McCarthy NJ, Whyte MK, Gilbert CS, Evan GI, (1997) Inhibition of ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the bcl-2 homologue bak. J Cell Biol 136: 215-227.
    • (1997) J Cell Biol , vol.136 , pp. 215-227
    • McCarthy, N.J.1    Whyte, M.K.2    Gilbert, C.S.3    Evan, G.I.4
  • 24
    • 77958539005 scopus 로고    scopus 로고
    • Prohibitins are required for cancer cell proliferation and adhesion
    • Sievers C, Billig G, Gottschalk K, Rudel T, (2010) Prohibitins are required for cancer cell proliferation and adhesion. PLoS ONE 5: e12735.
    • (2010) PLoS ONE , vol.5
    • Sievers, C.1    Billig, G.2    Gottschalk, K.3    Rudel, T.4
  • 25
    • 77956632914 scopus 로고    scopus 로고
    • The role of prohibitin in cell signaling
    • Mishra S, Ande SR, Nyomba BL, (2010) The role of prohibitin in cell signaling. FEBS J 277: 3937-3946.
    • (2010) FEBS J , vol.277 , pp. 3937-3946
    • Mishra, S.1    Ande, S.R.2    Nyomba, B.L.3
  • 26
    • 26444524061 scopus 로고    scopus 로고
    • A global but stable change in HeLa cell morphology induces reorganization of DNA structural loop domains within the cell nucleus
    • Martinez-Ramos I, Maya-Mendoza A, Gariglio P, Aranda-Anzaldo A, (2005) A global but stable change in HeLa cell morphology induces reorganization of DNA structural loop domains within the cell nucleus. J Cell Biochem 96: 79-88.
    • (2005) J Cell Biochem , vol.96 , pp. 79-88
    • Martinez-Ramos, I.1    Maya-Mendoza, A.2    Gariglio, P.3    Aranda-Anzaldo, A.4
  • 27
    • 0031962372 scopus 로고    scopus 로고
    • Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization
    • Leung T, Chen XQ, Tan I, Manser E, Lim L, (1998) Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. Mol Cell Biol 18: 130-140.
    • (1998) Mol Cell Biol , vol.18 , pp. 130-140
    • Leung, T.1    Chen, X.Q.2    Tan, I.3    Manser, E.4    Lim, L.5
  • 28
    • 17644401743 scopus 로고    scopus 로고
    • The biology and biochemistry of diacylglycerol signalling. meeting on molecular advances in diacylglycerol signalling
    • Toker A, (2005) The biology and biochemistry of diacylglycerol signalling. meeting on molecular advances in diacylglycerol signalling. EMBO Rep 6: 310-314.
    • (2005) EMBO Rep , vol.6 , pp. 310-314
    • Toker, A.1
  • 29
    • 52449088793 scopus 로고    scopus 로고
    • The life and death of protein kinase C
    • Gould CM, Newton AC, (2008) The life and death of protein kinase C. Curr Drug Targets 9: 614-625.
    • (2008) Curr Drug Targets , vol.9 , pp. 614-625
    • Gould, C.M.1    Newton, A.C.2
  • 30
    • 0028055160 scopus 로고
    • Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
    • Szallasi Z, Smith CB, Pettit GR, Blumberg PM, (1994) Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J Biol Chem 269: 2118-2124.
    • (1994) J Biol Chem , vol.269 , pp. 2118-2124
    • Szallasi, Z.1    Smith, C.B.2    Pettit, G.R.3    Blumberg, P.M.4
  • 31
    • 38549161152 scopus 로고    scopus 로고
    • Cell fate determination during G1 phase progression
    • Blomen VA, Boonstra J, (2007) Cell fate determination during G1 phase progression. Cell Mol Life Sci 64: 3084-3104.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 3084-3104
    • Blomen, V.A.1    Boonstra, J.2
  • 32
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ, (1996) Cancer cell cycles. Science 274: 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 33
    • 70350371736 scopus 로고    scopus 로고
    • Nutlin-3 affects expression and function of retinoblastoma protein: Role of retinoblastoma protein in cellular response to nutlin-3
    • Du W, Wu J, Walsh EM, Zhang Y, Chen CY, et al. (2009) Nutlin-3 affects expression and function of retinoblastoma protein: Role of retinoblastoma protein in cellular response to nutlin-3. J Biol Chem 284: 26315-26321.
    • (2009) J Biol Chem , vol.284 , pp. 26315-26321
    • Du, W.1    Wu, J.2    Walsh, E.M.3    Zhang, Y.4    Chen, C.Y.5
  • 34
    • 29144468980 scopus 로고    scopus 로고
    • Aberrant cell cycle regulation in cervical carcinoma
    • Kim YT, Zhao M, (2005) Aberrant cell cycle regulation in cervical carcinoma. Yonsei Med J 46: 597-613.
    • (2005) Yonsei Med J , vol.46 , pp. 597-613
    • Kim, Y.T.1    Zhao, M.2
  • 36
    • 64449084409 scopus 로고    scopus 로고
    • A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses abeta-induced biomarker abnormality on cultured fibroblasts
    • Khan TK, Nelson TJ, Verma VA, Wender PA, Alkon DL, (2009) A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses abeta-induced biomarker abnormality on cultured fibroblasts. Neurobiol Dis 34: 332-339.
    • (2009) Neurobiol Dis , vol.34 , pp. 332-339
    • Khan, T.K.1    Nelson, T.J.2    Verma, V.A.3    Wender, P.A.4    Alkon, D.L.5
  • 37
    • 15444345629 scopus 로고    scopus 로고
    • Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity
    • Kozikowski AP, Wang S, Ma D, Yao J, Ahmad S, et al. (1997) Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity. J Med Chem 40: 1316-1326.
    • (1997) J Med Chem , vol.40 , pp. 1316-1326
    • Kozikowski, A.P.1    Wang, S.2    Ma, D.3    Yao, J.4    Ahmad, S.5
  • 38
    • 51849101594 scopus 로고    scopus 로고
    • Conformationally constrained analogues of diacylglycerol. 29. cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
    • Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, et al. (2008) Conformationally constrained analogues of diacylglycerol. 29. cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem 51: 5198-5220.
    • (2008) J Med Chem , vol.51 , pp. 5198-5220
    • Duan, D.1    Sigano, D.M.2    Kelley, J.A.3    Lai, C.C.4    Lewin, N.E.5
  • 39
    • 66149158200 scopus 로고    scopus 로고
    • PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo
    • Truman JP, Rotenberg SA, Kang JH, Lerman G, Fuks Z, et al. (2009) PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther 8: 54-63.
    • (2009) Cancer Biol Ther , vol.8 , pp. 54-63
    • Truman, J.P.1    Rotenberg, S.A.2    Kang, J.H.3    Lerman, G.4    Fuks, Z.5
  • 40
    • 0346096818 scopus 로고    scopus 로고
    • Bryostatin-1: A novel PKC inhibitor in clinical development
    • Kortmansky J, Schwartz GK, (2003) Bryostatin-1: A novel PKC inhibitor in clinical development. Cancer Invest 21: 924-936.
    • (2003) Cancer Invest , vol.21 , pp. 924-936
    • Kortmansky, J.1    Schwartz, G.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.