FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells

Genes to Cells

Volumn 16, Issue 6, 2011, Pages 714-727

  Kitao, Hiroyuki ^a,b,c   Nanda, Indrajit ^d   Sugino, Ryuichi P ^e   Kinomura, Aiko ^b   Yamazoe, Mitsuyoshi ^f   Arakawa, Hiroshi ^g   Schmid, Michael ^d   Innan, Hideki ^e   Hiom, Kevin ^h   Takata, Minoru ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^f WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^g INSTITUTE OF EPIDEMIOLOGY   (Germany)

^h UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRIP1 HELICASE; FANCJ HELICASE; GENOMIC DNA; HELICASE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CANCER; CHICKEN; COMPARATIVE GENOMIC HYBRIDIZATION; FAMILIAL CANCER; FANCONI ANEMIA; GENE DELETION; GENE LOCUS; GENE REARRANGEMENT; GENOME; NONHUMAN; PRIORITY JOURNAL; VERTEBRATE;

ANIMALS; BASE SEQUENCE; CELL LINE; CHICKENS; COMPARATIVE GENOMIC HYBRIDIZATION; FANCONI ANEMIA COMPLEMENTATION GROUP C PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP L PROTEIN; G-QUADRUPLEXES; GENE AMPLIFICATION; GENE CONVERSION; GENE DELETION; GENE ORDER; GENE REARRANGEMENT; GENE TARGETING; GENOMIC INSTABILITY; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MOLECULAR SEQUENCE DATA; NUCLEOSIDE DEAMINASES; RNA HELICASES; SEQUENCE ALIGNMENT;

CAENORHABDITIS ELEGANS; VERTEBRATA;

EID: 79956308523     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2011.01523.x     Document Type: Article

References (41)

1. Arakawa, H. & Buerstedde, J.M. (2004) Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line. Dev. Dyn. 229, 458-464.
2. Arakawa, H., Hauschild, J. & Buerstedde, J.M. (2002) Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 295, 1301-1306.
3. Bridge, W.L., Vandenberg, C.J., Franklin, R.J. & Hiom, K. (2005) The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. Nat. Genet. 37, 953-957.
4. Buerstedde, J.M., Reynaud, C.A., Humphries, E.H., Olson, W., Ewert, D.L. & Weill, J.C. (1990) Light chain gene conversion continues at high rate in an ALV-induced cell line. EMBO J. 9, 921-927.
5. Cantor, S., Drapkin, R., Zhang, F., Lin, Y., Han, J., Pamidi, S. & Livingston, D.M. (2004) The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc. Natl Acad. Sci. USA 101, 2357-2362.
6. Cantor, S.B., Bell, D.W., Ganesan, S., Kass, E.M., Drapkin, R., Grossman, S., Wahrer, D.C., Sgroi, D.C., Lane, W.S., Haber, D.A. & Livingston, D.M. (2001) BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 105, 149-160.
7. Cheung, I., Schertzer, M., Rose, A. & Lansdorp, P.M. (2002) Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat. Genet. 31, 405-409.
8. D'Andrea, A.D. & Grompe, M. (2003) The Fanconi anaemia/BRCA pathway. Nat. Rev. Cancer 3, 23-34.
9. Dorsman, J.C., Levitus, M., Rockx, D., et al. (2007) Identification of the Fanconi anemia complementation group I gene, FANCI. Cell Oncol 29, 211-218.
10. Gong, Z., Kim, J.E., Leung, C.C., Glover, J.N. & Chen, J. (2010) BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol. Cell 37, 438-446.
11. Gupta, R., Sharma, S., Sommers, J.A., Jin, Z., Cantor, S.B. & Brosh, R.M.. Jr (2005) Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer. J. Biol. Chem. 280, 25450-25460.
12. Gupta, R., Sharma, S., Sommers, J.A., Kenny, M.K., Cantor, S.B. & Brosh, R.M. Jr (2007) FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein. Blood 110, 2390-2398.
13. Hirano, S., Yamamoto, K., Ishiai, M., Yamazoe, M., Seki, M., Matsushita, N., Ohzeki, M., Yamashita, Y.M., Arakawa, H., Buerstedde, J.M., Enomoto, T., Takeda, S., Thompson, L.H. & Takata, M. (2005) Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. EMBO J. 24, 418-427.
14. Ishiai, M., Kitao, H., Smogorzewska, A., Tomida, J., Kinomura, A., Uchida, E., Saberi, A., Kinoshita, E., Kinoshita-Kikuta, E., Koike, T., Tashiro, S., Elledge, S.J. & Takata, M. (2008) FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat. Struct. Mol. Biol. 15, 1138-1146.
15. Kitao, H., Arakawa, H., Kuma, K., Yamagishi, H., Nakamura, N., Furusawa, S., Matsuda, H., Yasuda, M., Ekino, S. & Shimizu, A. (2000) Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats. Int. Immunol. 12, 959-968.
16. Kitao, H., Kimura, M., Yamamoto, K., Seo, H., Namikoshi, K., Agata, Y., Ohta, K. & Takata, M. (2008) Regulation of histone H4 acetylation by transcription factor E2A in Ig gene conversion. Int. Immunol. 20, 277-284.
17. Kitao, H., Yamamoto, K., Matsushita, N., Ohzeki, M., Ishiai, M. & Takata, M. (2006) Functional interplay between BRCA2/FancD1 and FancC in DNA repair. J Biol Chem 281, 21312-21320.
18. Kratz, K., Schopf, B., Kaden, S., Sendoel, A., Eberhard, R., Lademann, C., Cannavo, E., Sartori, A.A., Hengartner, M.O. & Jiricny, J. (2010) Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell 142, 77-88.
19. Kruisselbrink, E., Guryev, V., Brouwer, K., Pontier, D.B., Cuppen, E. & Tijsterman, M. (2008) Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans. Curr. Biol. 18, 900-905.
20. Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P.R. & Cantor, S.B. (2005) BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell 8, 255-265.
21. Liu, T., Ghosal, G., Yuan, J., Chen, J. & Huang, J. (2010) FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science 329, 693-696.
22. London, T.B., Barber, L.J., Mosedale, G., Kelly, G.P., Balasubramanian, S., Hickson, I.D., Boulton, S.J. & Hiom, K. (2008) FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem 283, 36132-36139.
23. MacKay, C., Declais, A.C., Lundin, C., Agostinho, A., Deans, A.J., MacArtney, T.J., Hofmann, K., Gartner, A., West, S.C., Helleday, T., Lilley, D.M. & Rouse, J. (2010) Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell 142, 65-76.
24. Maizels, N. (2008) Genomic stability: FANCJ-dependent G4 DNA repair. Curr. Biol. 18, R613-R614.
25. Niedzwiedz, W., Mosedale, G., Johnson, M., Ong, C.Y., Pace, P. & Patel, K.J. (2004) The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol. Cell 15, 607-620.
26. Peng, M., Litman, R., Xie, J., Sharma, S., Brosh, R.M. Jr & Cantor, S.B. (2007) The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J. 26, 3238-3249.
27. Sale, J.E., Calandrini, D.M., Takata, M., Takeda, S. & Neuberger, M.S. (2001) Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature 412, 921-926.
28. Sims, A.E., Spiteri, E., Sims, R.J. III, Arita, A.G., Lach, F.P., Landers, T., Wurm, M., Freund, M., Neveling, K., Hanenberg, H., Auerbach, A.D. & Huang, T.T. (2007) FANCI is a second monoubiquitinated member of the Fanconi anemia pathway. Nat. Struct. Mol. Biol. 14, 564-567.
29. Smogorzewska, A., Desetty, R., Saito, T.T., Schlabach, M., Lach, F.P., Sowa, M.E., Clark, A.B., Kunkel, T.A., Harper, J.W., Colaiacovo, M.P. & Elledge, S.J. (2010) A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol. Cell 39, 36-47.
30. Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E.R. III, Hurov, K.E., Luo, J., Ballif, B.A., Gygi, S.P., Hofmann, K., D'Andrea, A.D. & Elledge, S.J. (2007) Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell 129, 289-301.
31. Sommers, J.A., Rawtani, N., Gupta, R., Bugreev, D.V., Mazin, A.V., Cantor, S.B. & Brosh, R.M. Jr (2009) FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem 284, 7505-7517.
32. Walsh, T. & King, M.C. (2007) Ten genes for inherited breast cancer. Cancer Cell 11, 103-105.
33. Wang, W. (2007) Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat. Rev. Genet. 8, 735-748.
34. Ward, J.D., Barber, L.J., Petalcorin, M.I., Yanowitz, J. & Boulton, S.J. (2007) Replication blocking lesions present a unique substrate for homologous recombination. EMBO J. 26, 3384-3396.
35. Wu, Y., Shin-Ya, K. & Brosh, R.M. Jr (2008) FANCJ helicase defective in fanconia anemia and breast cancer unwinds G-Quadruplex DNA to defend genomic stability. Mol. Cell. Biol. 28, 4116-4128.
36. Wu, Y., Sommers, J.A., Suhasini, A.N., Leonard, T., Deakyne, J.S., Mazin, A.V., Shin-Ya, K., Kitao, H. & Brosh, R.M. Jr (2010) Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood 116, 3780-3791.
37. Xie, J., Litman, R., Wang, S., Peng, M., Guillemette, S., Rooney, T. & Cantor, S.B. (2010) Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass. Oncogene 29, 2499-2508.
38. Yamamoto, K., Hirano, S., Ishiai, M., Morishima, K., Kitao, H., Namikoshi, K., Kimura, M., Matsushita, N., Arakawa, H., Buerstedde, J.M., Komatsu, K., Thompson, L.H. & Takata, M. (2005) Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. Mol. Cell. Biol. 25, 34-43.
39. Yamamoto, K., Ishiai, M., Matsushita, N., Arakawa, H., Lamerdin, J.E., Buerstedde, J.M., Tanimoto, M., Harada, M., Thompson, L.H. & Takata, M. (2003) Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Mol. Cell. Biol. 23, 5421-5430.
40. Youds, J.L., Barber, L.J., Ward, J.D., Collis, S.J., O'Neil, N.J., Boulton, S.J. & Rose, A.M. (2008) DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair. Mol. Cell. Biol. 28, 1470-1479.
41. Zhao, J., Bacolla, A., Wang, G. & Vasquez, K.M. (2010) Non-B DNA structure-induced genetic instability and evolution. Cell. Mol. Life Sci. 67, 43-62.