A single amino acid residue constitutes the third dimerization domain essential for the assembly and function of the Tetrameric Polycystin-2 (TRPP2) channel

Journal of Biological Chemistry

Volumn 286, Issue 21, 2011, Pages 18994-19000

  Feng, Shuang ^a,c   Rodat Despoix, Lise ^b   Delmas, Patrick ^b   Ong, Albert C M ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b University of Mediterranée   (France)

^c Sheffield Kidney Institute   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; AUTOSOMAL DOMINANTS; C-TERMINAL DOMAINS; CALCIUM CHANNELS; CO-EXPRESSION; COILED-COIL DOMAINS; DIMER FORMATION; DIMERIZATION DOMAIN; DISULFIDE BOND FORMATION; ENDOPLASMIC RETICULUM; HEK293 CELLS; HETEROTETRAMERS; HOMODIMERIZATION; N-TERMINALS; POLYCYSTIC KIDNEY DISEASE; SINGLE CYSTEINE RESIDUE; TRANSIENT RECEPTOR POTENTIALS; TRP CHANNELS; TRUNCATION MUTANTS; WILD TYPES;

AMINO ACIDS; CALCIUM; COVALENT BONDS; DIMERS; TISSUE;

DIMERIZATION;

AMINO TERMINAL TELOPEPTIDE; CALCIUM ION; CARBOXY TERMINAL TELOPEPTIDE; CYSTEINE; ISOLEUCINE; LEUCINE; METHIONINE; MONOMER; POLYCYSTIN 1; POLYCYSTIN 2; VALINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RESIDUE ANALYSIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; CALCIUM; DISULFIDES; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; MUTATION, MISSENSE; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; TRPC CATION CHANNELS; TRPP CATION CHANNELS; TRPV CATION CHANNELS;

EID: 79956300184     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.192286     Document Type: Article

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