Functional analysis of PKD1 transgenic lines reveals a direct role for polycystin-1 in mediating cell-cell adhesion

Journal of the American Society of Nephrology

Volumn 14, Issue 7, 2003, Pages 1804-1815

  Streets, Andrew J ^a   Newby, Linda J ^a   O'Hare, Michael J ^b   Bukanov, Nikolay O ^c   Ibraghimov Beskrovnaya, Oxana ^c   Ong, Albert C M ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; POLYCYSTIN; POLYCYSTIN 1; POLYCYSTIN 2; PROTEIN ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL AGGREGATION; CELL IMMORTALIZATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE; MORPHOGENESIS; PKD1 GENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSGENICS;

EID: 0037868262     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000076075.49819.9B     Document Type: Article

References (41)

1. Ong AC, Harris PC: Molecular basis of renal cyst formation-one hit or two? Lancet 349: 1039-1040, 1997
2. Newby LJ, Streets AJ, Zhao Y, Harris PC, Ward CJ, Ong AC: Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J Biol Chem 277: 20763-20773, 2002
3. Hughes J, Ward CJ, Peral B, Aspinwall R, Clark K, San Millan JL, Gamble V, Harris PC: The polycystic kidney disease 1 (PKDI) gene encodes a novel protein with multiple cell recognition domains. Nat Genet 10: 151-160, 1995
4. Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas RL, Chothia C: The structure of a PKD domain from polycystin-1: Implications for polycystic kidney disease. Embo J 18: 297-305, 1999
5. van Adelsberg J: Peptides from the PKD repeats of polycystin, the PKD1 gene product, modulate pattern formation in the developing kidney. Dev Genet 24: 299-308, 1999
6. Ibraghimov-Beskrovnaya O, Bukanov NO, Donohue LC, Dackowski WR, Klinger KW, Landes GM: Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1. Hum Mol Genet 9: 1641-1649, 2000
7. Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG: Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 408: 990-994, 2000
8. Boletta A, Qian F, Onuchic LF, Bhunia AK, Phakdeekitcharoen B, Hanaoka K, Guggino W, Monaco L, Germino GG: Polycystin-1, the gene product of PKD 1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells. Mol Cell 6: 1267-1273, 2000
9. Nickel C, Benzing T, Sellin L, Gerke P, Karihaloo A, Liu ZX, Cantley LG, Walz G: The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest 109: 481-489, 2002
10. Bhunia AK, Piontek K, Boletta A, Liu L, Qian F, Xu PN, Germino FJ, Germino GG: PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109: 157-168, 2002
11. Delmas P, Nomura H, Li X, Lakkis M, Luo Y, Segal Y, Fernandez-Fernandez JM, Harris P, Frischauf AM, Brown DA, Zhou J: Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem 277: 11276-11283, 2002
12. Gonzalez-Perret S, Kim K, Ibarra C, Damiano AE, Zotta E, Batelli M, Harris PC, Reisin IL, Arnaout MA, Cantiello HF: Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. Proc Natl Acad Sci USA 98: 1182-1187, 2001
13. Vassilev PM, Guo L, Chen XZ, Segal Y, Peng JB, Basora N, Babakhanlou H, Cruger G, Kanazirska M, Ye C, Brown EM, Hediger MA, Zhou J: Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease. Biochem Biophys Res Commun 282: 341-350, 2001
14. Koulen P, Cai Y, Geng L, Maeda Y, Nishimura S, Witzgall R, Ehrlich BE, Somlo S: Polycystin-2 is an intracellular calcium release channel. Nat Cell Biol 4, 191-197, 2002
15. Ong AC, Moorhead JF: Tubular lipidosis: Epiphenomenon or pathogenetic lesion in human renal disease? Kidney Int 45: 753-762, 1994
16. O'Hare MJ, Bond J, Clarke C, Takeuchi Y, Atherton AJ, Berry C, Moody J, Silver AR, Davies DC, Alsop AE, Neville AM, Jat PS: Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc Natl Acad Sci USA 98: 646-651, 2001
17. Ong AC, Harris PC, Davies DR, Pritchard L, Rossetti S, Biddolph S, Vaux DJ, Migone N, Ward CJ: Polycystin-1 expression in PKDI, early-onset PKDI, and TSC2/PKDI cystic tissue. Kidney Int 56: 1324-1333, 1999
18. Ong AC, Ward CJ, Butler RJ, Biddolph S, Bowker C, Torra R, Pei Y, Harris PC: Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue. Am J Pathol 154: 1721-1729, 1999
19. Wheelock MJ, Buck CA, Bechtol KB, Damsky CH: Soluble 80-kd fragment of cell-CAM 120/80 disrupts cell-cell adhesion. J Cell Biochem 34: 187-202, 1987
20. Runswick SK, O'Hare MJ, Jones L, Streuli CH, Garrod DR: Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol 3: 823-830, 2001
21. Pritchard L, Sloane-Stanley JA, Sharpe JA, Aspinwall R, Lu W, Buckle V, Strmecki L, Walker D, Ward CJ, Alpers CE, Zhou J, Wood WG, Harris PC: A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype. Hum Mol Genet 9: 2617-2627, 2000
22. Malhas AN, Abuknesha RA, Price RG: Interaction of the leucine-rich repeats of polycystin-I with extracellular matrix proteins: Possible role in cell proliferation. J Am Soc Nephrol 13: 19-26, 2002
23. Weston BS, Bagneris C, Price RG, Stirling JL: The polycystin-I C-type lectin domain binds carbohydrate in a calcium-dependent manner, and interacts with extracellular matrix proteins in vitro. Biochim Biophys Acta 1536: 161-76, 2001
24. Ong AC: Polycystin expression in the kidney and other tissues: Complexity, consensus and controversy. Exp Nephrol 8: 208-214, 2000
25. Kim K, Drummond I, Ibraghimov-Beskrovnaya O, Klinger K, Arnaout MA: Polycystin-1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci USA 97: 1731-1736, 2000
26. Huan Y, van Adelsberg J: Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. J Clin Invest 104: 1459-1468, 1999
27. Scheffers MS, van der Bent P, Prins F, Spruit L, Breuning MH, Litvinov SV, de Heer E, Peters DJ: Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells. Hum Mol Genet 9: 2743-2750, 2000
28. Wilson PD, Geng L, Li X, Burrow CR: The PKD1 gene product, "polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia. Lab Invest 79: 1311-1323, 1999
29. Palsson R, Sharma CP, Kim K, McLaughlin M, Brown D, Arnaout MA: Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1. Mol Med 2: 702-711, 1996
30. Yoder BK, Hou X, Guay-Woodford LM: The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol 13: 2508-2516, 2002
31. Bukanov NO, Husson H, Dackowski WR, Lawrence BD, Clow PA, Roberts BL, Klinger KW, Ibraghimov-Beskrovnaya O: Functional polycystin-1 expression is developmentally regulated during epithelial morphogenesis in vitro: downregulation and loss of membrane localization during cystogenesis. Hum Mol Genet 11: 923-936, 2002
32. Vicart P, Schwartz B, Vandewalle A, Bens M, Delouis C, Panthier JJ, Pournin S, Babinet C, Paulin D: Immortalization of multiple cell types from transgenic mice using a transgene containing the vimentin promoter and a conditional oncogene. Exp Cell Res 214: 35-45, 1994
33. Seshimo K, Miyazaki M, Mori M, Orita K, Namba M: Establishment and characterization of a SV40 T-antigen immortalized epithelial-like cell line derived from the newborn rat colorectum and its malignant transformation by the ras oncogene. Cell Struct Funct 18: 345-354, 1993
34. Stein LS, Stein DW, Echols J, Burghardt RC: Concomitant alterations of desmosomes, adhesiveness, and diffusion through gap junction channels in a rat ovarian transformation model system. Exp Cell Res 207: 19-32, 1993
35. Xu GM, Sikaneta T, Sullivan BM, Zhang Q, Andreucci M, Stehle T, Drummond I, Arnaout MA: Polycystin-1 interacts with intermediate filaments. J Biol Chem 276: 46544-46552, 2001
36. Charron AJ, Nakamura S, Bacallao R, Wandinger-Ness A: Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells. J Cell Biol 149: 111-124, 2000
37. Shimazui T, Giroldi LA, Bringuier PP, Oosterwijk E, Schalken JA: Complex cadherin expression in renal cell carcinoma. Cancer Res 56: 3234-3237, 1996
38. St Croix B, Sheehan C, Rak JW, Florenes VA, Slingerland JM, Kerbel RS: E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J Cell Biol 142: 557-571, 1998
39. Stockinger A, Eger A, Wolf J, Beug H, Foisner R: E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol 154: 1185-1196, 2001
40. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J: Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33: 129-137, 2003
41. Ong AC, Wheatley DN: Polycystic kidney disease - The ciliary connection. Lancet 361: 774-776, 2003