Polycystin-1 activates and stabilizes the polycystin-2 channel

Journal of Biological Chemistry

Volumn 278, Issue 3, 2003, Pages 1457-1462

  Xu, G Mark ^a   González Perrett, Silvia ^b   Essafi, Makram ^a   Timpanaro, Gustavo A ^b   Montalbetti, Nicolás ^b   Arnaout, M Amin ^a   Cantiello, Horacio F ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; DISEASES; MUTAGENS; PROTEINS;

MUTATIONS;

GENETIC ENGINEERING;

CATION CHANNEL; POLYCYSTIN; POLYCYSTIN 1; POLYCYSTIN 2; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; PRIMER DNA; PROTEIN;

ARTICLE; AUTOSOMAL DOMINANT DISORDER; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; GENE; GENE ACTIVATION; GENE MUTATION; GENETIC CODE; KIDNEY POLYCYSTIC DISEASE; NONHUMAN; PKD1 GENE; PKD2 GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; AMINO ACID SEQUENCE; CHEMISTRY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN SYNTHESIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; DNA PRIMERS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; PROTEINS; TRPP CATION CHANNELS;

EID: 0037449709     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209996200     Document Type: Article

References (19)

1. Arnaout, M. A. (2001) Annu. Rev. Med. 52, 93-123
2. Scheffers, M. S., van der Bent, P., Prins, F., Spruit, L., Breuning, M. H., Litvinov, S. V., de Heer, E., and Peters, D. J. (2000) Hum. Mol. Genet. 9, 2743-2750
3. Xu, G. M., Sikaneta, T., Sullivan, B. M., Zhang, Q., Andreucci, M., Stehle, T., Drummond, I., and Arnaout, M. A. (2001) J. Biol. Chem. 276, 46544-46552
4. Bhunia, A. K., Piontek, K., Boletta, A., Liu, L., Qian, F., Xu, P. N., Germino, F. J., and Germino, G. G. (2002) Cell 109, 157-168
5. Mochizuki, T., Wu, G., Hayashi, T., Xenophontos, S. L., Veldhuisen, B., Saris, J. J., Reynolds, D. M., Cai, Y., Gabow, P. A., Pierides, A., Kimberling, W. J., Breuning, M. H., Deltas, C. C., Peters, D. J., and Somlo, S. (1996) Science 272, 1339-1342
6. Clapham, D. E., Runnels, L. W., and Strubing, C. (2001) Nat. Rev. Neurosci. 2, 387-396
7. González-Perret, S., Kim, K., Ibarra, C., Damiano, A. E., Zotta, E., Batelli, M., Harris, P. C., Reisin, I. L., Arnaout, M. A., and Cantiello, H. F. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 1182-1187
8. Vassilev, P. M., Guo, L., Chen, X. Z., Segal, Y., Peng, J. B., Basora, N., Babakhanlou, H., Cruger, G., Kanazirska, M., Ye, C., Brown, E. M., Hediger, M. A., and Zhou, J. (2001) Biochem. Biophys. Res. Commun. 282, 341-350
9. Koulen, P., Cai, Y., Geng, L., Maeda, Y., Nishimura, S., Witzgall, R., Ehrlich, B. E., and Somlo, S. (2002) Nat. Cell Biol. 4, 191-197
10. Qian, F., Germino, F. J., Cai, Y., Zhang, X., Somlo, S., and Germino, G. G. (1997) Nat. Genet. 16, 179-183
11. Tsiokas, L., Kim, E., Arnould, T., Sukhatme, V. P., and Walz, G. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6965-6970
12. Newby, L. J., Streets, A. J., Zhao, Y., Harris, P. C., Ward, C. J., and Ong, A. C. (2002) J. Biol. Chem. 277, 20763-20773
13. Hanaoka, K., Qian, F., Boletta, A., Bhunia, A. K., Piontek, K., Tsiokas, L., Sukhatme, V. P., Guggino, W. B., and Germino, G. G. (2000) Nature 408, 990-994
14. Delmas, P., Nomura, H., Li, X., Lakkis, M., Luo, Y., Segal, Y., Fernandez-Fernandez, J. M., Harris, P., Frischauf, A. M., Brown, D. A., and Zhou, J. (2002) J. Biol. Chem. 277, 11276-11283
15. Chen, X. Z., Segal, Y., Basora, N., Guo, L., Peng, J. B., Babakhanlou, H., Vassilev, P. M., Brown, E. M., Hediger, M. A., and Zhou, J. (2001) Biochem. Biophys. Res. Commun. 282, 1251-1256
16. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
17. González-Perrett, S., Batelli, M., Kim, K., Essafi, M., Timpanaro, G. A., Montalbetti, N., Reisin, I. L., Arnaout, M. A., and Cantiello, H. F. (2002) J. Biol. Chem. 277, 24959-24966
18. Snedecor, M. M., and Cochran, W. G. (1973) Statistical Methods, pp. 104-106, The Iowa State University Press, Ames, Iowa
19. Badenas, C., Torra, R., San Millan, J. L., Lucero, L., Mila, M., Estivill, X., and Darnell, A. (1999) Kidney Int. 55, 1225-1233