Genetically modified adipose tissue-derived mesenchymal stem cells overexpressing CXCR4 display increased motility, invasiveness, and homing to bone marrow of NOD/SCID mice

Experimental Hematology

Volumn 39, Issue 6, 2011, Pages

  Bobis Wozowicz, Sylwia ^a   Miekus, Katarzyna ^a   Wybieralska, Ewa ^b   Jarocha, Danuta ^a   Zawisz, Artur ^c   Madeja, Zbigniew ^b   Majka, Marcin ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c Private Clinic of Plastic Surgery   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN; PROTEIN KINASE B; RETROVIRUS VECTOR; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADULT; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL HOMING; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CHEMOTAXIS; CONTROLLED STUDY; DNA MODIFICATION; ENGRAFTMENT; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; NORMAL HUMAN; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCID MOUSE; STEM CELL TRANSPLANTATION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

MUS;

EID: 79956279508     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2011.03.004     Document Type: Article

References (39)

1. Cavarretta I.T., Altanerova V., Matuskova M., Kucerova L., Culig Z., Altaner C. Adipose tissue-derived mesenchymal stem cells expressing prodrug-converting enzyme inhibit human prostate tumor growth. Mol Ther 2010, 18:223-231.
2. Chuah M.K., Van Damme A., Zwinnen H., et al. Long term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice. Human Gene Ther 2000, 11:729-738.
3. Lane J.M., Yasko A.W., Tomin E., et al. Bone marrow and recombinant human bone morphogenic protein-2 in osseous repair. Clin Orthop Relat Res 1999, 361:216-227.
4. Shake J.G., Gruber P.J., Baumgartner W.A., et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg 2002, 73:1919-1956.
5. Chen Y., Xiang L.X., Shao J.Z., et al. Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver. J Cell Mol Med 2010, 14:1494-1508.
6. Bobis S., Jarocha D., Majka M. Mesenchymal stem cells: characteristics and clinical application. Folia Histochem Cytobiol 2006, 44:215-230.
7. Horwitz E.M., Prockop D.J., Gordon P.L., et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 2001, 7:1227-1231.
8. Ratajczak M.Z., Majka M., Kucia M., et al. Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem/progenitor cells in muscles. Stem Cells 2003, 21:363-371.
9. Honczarenko M., Le Y., Glodek A.M., et al. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. Blood 2002, 100:2321-2329.
10. Kucia M., Wojakowski W., Reca R., et al. The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner. Arch Immunol Ther Exp (Warsz) 2006, 54:121-135.
11. Ratajczak M.Z., Kucia M., Reca R., Majka M., Janowska-Wieczorek A., Ratajczak J. Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells 'hide out' in the bone marrow. Leukemia 2004, 18:29-40.
12. Cheng Z., Ou L., Zhou X., et al. Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther 2008, 16:571-579.
13. Ponte A.L., Marais E., Gallay N., et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells 2007, 25:1737-1745.
14. Shi M., Li J., Liao L., et al. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica 2007, 92:897-904.
15. Son B.R., Marquez-Curtis L.A., Kucia M., et al. Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells 2006, 24:1254-1264.
16. Wynn R.F., Hart C.A., Corradi-Perini C., et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood 2004, 104:2643-2645.
17. Kortesidis A., Zannettino A., Isenmann S., Shi S., Lapidot T., Gronthos S. Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells. Blood 2005, 105:3793-3801.
18. Honczarenko M., Le Y., Swierkowski M., Ghiran I., Glodek A.M., Silberstein L.E. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells 2006, 24:1030-1041.
19. Von Lüttichau I., Notohamiprodjo M., Wechselberger A., et al. Human adult CD34- progenitor cells functionally express the chemokine receptors CCR1, CCR4, CCR7, CXCR5, and CCR10 but not CXCR4. Stem Cells Dev 2005, 14:329-336.
20. Tögel F., Isaac J., Hu Z., Weiss K., Westenfelder C. Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury. Kidney Int 2005, 67:1772-1784.
21. Ceradini D.J., Kulkarni A.R., Callaghan M.J., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004, 10:858-864.
22. Wang Y., Deng Y., Zhou G.Q. SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model. Brain Res 2008, 1195:104-112.
23. Gronthos S., Franklin D.M., Leddy H.A., Robey P.G., Storms R.W., Gimble J.M. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol 2001, 189:54-63.
24. Noël D., Caton D., Roche S., et al. Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials. Exp Cell Res 2008, 314:1575-1584.
25. Lee R.H., Kim B., Choi I., et al. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem 2004, 14:311-324.
26. Miekus K., Czernik M., Sroka J., Czyz J., Madeja Z. Contact stimulation of prostate cancer cell migration: the role of gap junctional coupling and migration stimulated by heterotypic cell-to-cell contacts in determination of the metastatic phenotype of Dunning rat prostate cancer cells. Biol Cell 2005, 97:893-903.
27. Kang S.K., Lee D.H., Bae Y.C., Kim H.K., Baik S.Y., Jung J.S. Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp Neurol 2003, 183:355-366.
28. Katz A.J., Tholpady A., Tholpady S.S., Shang H., Ogle R.C. Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells. Stem Cells 2005, 23:412-423.
29. Wagner W., Wein F., Seckinger A., et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005, 33:1402-1416.
30. Libura J., Drukala J., Majka M., et al. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Blood 2002, 100:2597-2606.
31. Kyriakou C., Rabin N., Pizzey A., Nathwani A., Yong K. Factors that influence short-term homing of human bone marrow-derived mesenchymal stem cells in a xenogeneic animal model. Haematologica 2008, 93:1457-1465.
32. Ries C., Egea V., Karow M., Kolb H., Jochum M., Neth P. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood 2007, 109:4055-4063.
33. Majka M., Ratajczak J., Kowalska M.A., Ratajczak M.Z. Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. Eur J Haematol 2000, 64:164-172.
34. Potapova I.A., Brink P.R., Cohen I.S., Doronin S.V. Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells. J Biol Chem 2008, 283:13100-13107.
35. Kitaori T., Ito H., Schwarz E.M., et al. Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum 2009, 60:813-823.
36. Lien C.Y., Chih-Yuan Ho K., Lee O.K., Blunn G.W., Su Y. Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cells. J Bone Miner Res 2009, 24:837-848.
37. Vieira N.M., Brandalise V., Zucconi E., et al. Human multipotent adipose-derived stem cells restore dystrophin expression of Duchenne skeletal-muscle cells in vitro. Biol Cell 2008, 100:231-241.
38. Ivanova-Todorova E., Bochev I., Mourdjeva M., et al. Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells. Immunol Lett 2009, 126:37-42.
39. Rebelatto C.K., Aguiar A.M., Moretão M.P., et al. Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp Biol Med (Maywood) 2008, 233:901-913.