Prognostic significance of FTO genotype in the development of obesity in Japanese: The J-SHIPP study

International Journal of Obesity

Volumn 33, Issue 11, 2009, Pages 1243-1248

  Tabara, Y ^a,c   Osawa, H ^a,c   Guo, H ^a   Kawamoto, R ^a   Onuma, H ^a,c   Shimizu, I ^b   Takara, Y ^a   Nishida, W ^a   Yamamoto, M ^a   Makino, H ^a   Kohara, K ^a,c   Miki, T ^a,c  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Ehime Prefectural Hospital   (Japan)

^c EHIME UNIVERSITY   (Japan)

Author keywords

FTO; Gene polymorphism; Longitudinal study; MC4R; Retrospective analysis

Indexed keywords

MELANOCORTIN 4 RECEPTOR; FTO PROTEIN, HUMAN; PROTEIN;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FAT MASS AND OBESITY ASSOCIATED GENE; FEMALE; FOLLOW UP; GENE; GENE FREQUENCY; GENOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; JAPAN; MIDDLE AGED; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; JAPAN; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 4; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 70450285199     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2009.161     Document Type: Article

References (35)

1. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
2. Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39: 724-726.
3. Loos RJ, Bouchard C. FTO: the first gene contributing to common forms of human obesity. Obes Rev 2008; 9: 246-250.
4. Cornes BK, Lind PA, Medland SE, Montgomery GW, Nyholt DR, Martin NG. Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction. Int J Obes (Lond) 2009; 33: 75-79.
5. Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R et al. Variations in the FTO gene are associated with severe obesity in the Japanese. JHum Genet 2008; 53: 546-553.
6. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-775.
7. Stutzmann F, Cauchi S, Durand E, Calvacanti-Proenca C, Pigeyre M, Hartikainen AL et al. Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. IntJ Obes (Lond) 2009; 33: 373-378.
8. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. NEnglJMed 2008; 359: 2558-2566.
9. Berentzen T, Kring SI, Holst C, Zimmermann E, Jess T, Hansen T et al. Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity. J Clin Endocrinol Metab 2008; 93: 2904-2908.
10. Qi L, Kraft P, Hunter DJ, Hu FB. The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet 2008; 17: 3502-3508.
11. Wardle J, Llewellyn C, Sanderson S, Plomin R. The FTO gene and measured food intake in children. Int J Obes (Lond) 2009; 33: 42-45.
12. Jess T, Zimmermann E, Kring SI, Berentzen T, Holst C, Toubro S et al. Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study. Int J Obes (Lond) 2008; 32: 1388-1394.
13. Qi L, Kang K, Zhang C, van Dam RM, Kraft P, Hunter D et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes 2008; 57: 3145-3151.
14. Frayling TM. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 2007; 8: 657-662.
15. Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Miki T et al. Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes 2009; 58: 493-498
16. Expert Committee on the Diagnosis Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26: S5-S20.
17. Osawa H, Yamada K, Onuma H, Murakami A, Ochi M, Kawata H et al. The G/G genotype of a resistin single-nucleotide polymorphism at-420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am J Hum Genet 2004; 75: 678-686.
18. Grundy SM, Brewer Jr HB, Cleeman JI, Smith Jr SC, Lenfant C, American Heart Association; National Heart Lung Blood Institute. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004; 109: 433-438 (Pubitemid 38133916)
19. Examination Committee of Criteria for 'Obesity Disease' in Japan; Japan Society for the Study of Obesity New criteria for 'obesity disease' in Japan CircJ 2002 66 987-992
20. Horikawa Y, Miyake K, Yasuda K, Enya M, Hirota Y, Yamagata K et al. Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab 2008; 93: 3136-3141.
21. Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K et al. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 2007; 50: 2461-2466. (Pubitemid 350060646)
22. Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K et al. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 2008; 57: 791-795.
23. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719-748.
24. Prentice RL, Thomas DB. On the epidemiology of oral contraceptives and disease. Adv Cancer Res 1987; 49: 285-401.
25. Greenland S. Quantitative methods in the review of epidemio-logic literature. Epidemiol Rev 1987; 9: 1-30.
26. Zhou BF, Stamler J, Dennis B, Moag-Stahlberg A, Okuda N, Robertson C et al. Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: the INTERMAP study. J Hum Hypertens 2003; 17: 623-630. (Pubitemid 37265100)
27. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008; 57: 95-101.
28. Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, O'Connell JR et al. Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med 2008; 168: 1791-1797.
29. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
30. Wang LY, Chyen D, Lee S, Lowry R. The association between body mass index in adolescence and obesity in adulthood. J Adolesc Health 2008; 42: 512-518.
31. Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. The relation of childhood BMI to adult adiposity: the Bogalusa Heart Study. Pediatrics 2005; 115: 22-27.
32. Siervogel RM, Wisemandle W, Maynard LM, Guo SS, Chumlea WC, Towne B. Lifetime overweight status in relation to serial changes in body composition and risk factors for cardiovascular disease: The Fels Longitudinal Study. Obes Res 2000; 8: 422-430.
33. Rong R, Hanson RL, Ortiz D, Wiedrich C, Kobes S, Knowler WC et al. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 2009; 58: 478-488.
34. Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes 2008; 57: 1419-1426.
35. Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, Strachan DP et al. Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 2009; 58: 505-510