Cellular and molecular characteristics of scarless versus fibrotic wound healing

Dermatology Research and Practice

Volumn 2010, Issue 1, 2010, Pages

  Satish, Latha ^a   Kathju, Sandeep ^a,b  

^a ALLEGHENY GENERAL HOSPITAL   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79956259993     PISSN: None     EISSN: 16876113     Source Type: Journal    
DOI: 10.1155/2010/790234     Document Type: Review

References (112)

1. Clark R. A. F., Clark R. A. F., Wound repair: overview and general considerations. The Molecular and Cellular Biology of Wound Repair 1996 2nd New York, NY, USA Plenum Press 3 50
2. Maragakis G. M., Garcia-Tempone M., Microstomia following facial burns. Journal of Clinical Pediatric Dentistry 1998 23 1 69 74 2-s2.0-0032150974 (Pubitemid 128708143)
3. La Trenta G. S., Grant R. T., Haworth R. D., Madden M., Hoffman L. A., Functional reconstruction for severe postburn microstomia. Annals of Plastic Surgery 1992 29 2 178 181 2-s2.0-0026722052
4. Staley M., Richard R., Billmire D., Warden G., Head/face/neck burns: therapist considerations for the pediatric patient. Journal of Burn Care and Rehabilitation 1997 18 2 164 171 2-s2.0-0030931013 10.1097/00004630-199703000- 00013 (Pubitemid 27149243)
5. Fricke N. B., Omnell M. L., Dutcher K. D., Hollender L. G., Engrav L. H., Skeletal and dental disturbances after facial burns and pressure garments. Journal of Burn Care and Rehabilitation 1996 17 4 338 345 2-s2.0-0029817565 (Pubitemid 26286644)
6. Tower I., Lasko L. A., Kathju S., Secondary surgery for cicatricial complications of facial injury. Journal of Oral and Maxillofacial Surgery 2010 68 4 751 755 2-s2.0-77949642538 10.1016/j.joms.2009.09.026
7. Colwell A. S., Longaker M. T., Lorenz H. P., Mammalian fetal organ regeneration. Advances in Biochemical Engineering/Biotechnology 2005 93 83 100 2-s2.0-17144408728 (Pubitemid 44617148)
8. Wilgus T. A., Continuing education information: regenerative healing in fetal skin: a review of the literature. Ostomy Wound Management 2007 53 6 16 31 2-s2.0-34547526317
9. Hantash B. M., Zhao L., Knowles J. A., Lorenz H. P., Adult and fetal wound healing. Frontiers in Bioscience 2008 13 1 51 61 2-s2.0-38449113933 10.2741/2559 (Pubitemid 351594762)
10. Hess A., Reactions of mammalian fetal tissues to injury. II. Skin. The Anatomical Record 1954 119 1 435 447
11. Rowlatt U., Intrauterine wound healing in a 20 week human fetus. Virchows Archiv Abteilung A Pathologische Anatomie 1979 381 3 353 361 2-s2.0-0018357624 (Pubitemid 9212849)
12. Armstrong J. R., Ferguson M. W. J., Ontogeny of the skin and the transition from scar-free to scarring phenotype during wound healing in the pouch young of a marsupial, Monodelphis domestica. Developmental Biology 1995 169 1 242 260 2-s2.0-0029049524 10.1006/dbio.1995.1141
13. Ihara S., Motobayashi Y., Nagao E., Kistler A., Ontogenetic transition of wound healing pattern in rat skin occurring at the fetal stage. Development 1990 110 3 671 680 2-s2.0-0025224225
14. Longaker M. T., Whitby D. J., Adzick N. S., Crombleholme T. M., Langer J. C., Duncan B. W., Bradley S. M., Stern R., Ferguson M. W. J., Harrison M. R., Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. Journal of Pediatric Surgery 1990 25 1 63 69 2-s2.0-0025117567 10.1016/S0022-3468(05)80165- 4 (Pubitemid 20027336)
15. Lorenz H. P., Adzick N. S., Scarless skin wound repair in the fetus. Western Journal of Medicine 1993 159 3 350 355 (Pubitemid 23321605)
16. Longaker M. T., Whitby D. J., Ferguson M. W. J., Lorenz H. P., Harrison M. R., Adzick N. S., Adult skin wounds in the fetal environment heal with scar formation. Annals of Surgery 1994 219 1 65 72 2-s2.0-0028089015 (Pubitemid 24032239)
17. Longaker M. T., Whitby D. J., Ferguson M. W. J., Lorenz H. P., Harrison M. R., Adzick N. S., Adult skin wounds in the fetal environment heal with scar formation. Annals of Surgery 1994 219 1 65 72 2-s2.0-0028089015 (Pubitemid 24032239)
18. Mast B. A., Cohen K., Diegelmann R. F., Lindblad W. J., The skin. Wound Healing: Biochemical and Clinical Aspects 1992 Philadelphia, Pa, USA WB Saunders 344 355
19. Moulin V., Lawny F., Barritault D., Caruelle J. P., Platelet releasate treatment improves skin healing in diabetic rats through endogenous growth factor secretion. Cellular and Molecular Biology 1998 44 6 961 971 2-s2.0-0032159996
20. Ross R., Raines E. W., Bowen-Pope D. F., The biology of platelet-derived growth factor. Cell 1986 46 2 155 169 2-s2.0-0022457822 (Pubitemid 16031684)
21. Sporn M. B., Roberts A. B., Transforming growth factor- β: recent progress and new challenges. Journal of Cell Biology 1992 119 5 1017 1022 2-s2.0-0026445528 10.1083/jcb.119.5.1017
22. Muller-Eberhard H., Complement: chemistry and pathways. Inflammation Basic Principles and Clinical Correlates 1992 New York, NY, USA Raven Press
23. Diegelmann R. F., Cohen I. K., Kaplan A. M., The role of macrophages in wound repair: a review. Plastic and Reconstructive Surgery 1981 68 1 107 113 2-s2.0-0019831447 (Pubitemid 11075544)
24. Shaw R. J., Doherty D. E., Ritter A. G., Benedict S. H., Clark R. A. F., Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR2 mRNA. Journal of Cell Biology 1990 111 5 2139 2148 2-s2.0-0025155349
25. Juliano R. L., Haskill S., Signal transduction from the extracellular matrix. Journal of Cell Biology 1993 120 3 577 585 2-s2.0-0027459771 10.1083/jcb.120.3.577 (Pubitemid 23035126)
26. Robson M. C., Barnett R. A., Leitch I. O. W., Hayward P. G., Prevention and treatment of postburn scars and contracture. World Journal of Surgery 1992 16 1 87 96 2-s2.0-0026506985
27. Trabucchi E., Radaelli E., Marazzi M., Foschi D., Musazzi M., Veronesi A. M., Montorsi W., The role of mast cells in wound healing. International Journal of Tissue Reactions 1988 10 6 367 372 2-s2.0-0024154728 (Pubitemid 19205247)
28. Noli C., Miolo A., The mast cell in wound healing. Veterinary Dermatology 2001 12 6 303 313 2-s2.0-0035749441 10.1046/j.0959-4493.2001.00272.x (Pubitemid 33686158)
29. Egozi E. I., Ferreira A. M., Burns A. L., Gamelli R. L., DiPietro L. A., Mast cells modulate the inflammatory but not the proliferative response in healing wounds. Wound Repair and Regeneration 2003 11 1 46 54 2-s2.0-0037282778 10.1046/j.1524-475X.2003.11108.x (Pubitemid 36268608)
30. Weller K., Foitzik K., Paus R., Syska W., Maurer M., Mast cells are required for normal healing of skin wounds in mice. FASEB Journal 2006 20 13 E1628 E1635 2-s2.0-33845613484 10.1096/fj.06-5837fje (Pubitemid 44953829)
31. Grinnell F., Fibronectin and wound healing. Journal of Cellular Biochemistry 1984 26 2 107 116 2-s2.0-0021742978 (Pubitemid 15180965)
32. Chiquet-Ehrismann R., Kalla P., Pearson C. A., Beck K., Chiquet M., Tenascin interferes with fibronectin action. Cell 1988 53 3 383 390 2-s2.0-0024279848
33. Szpaderska A. M., Egozi E. I., Gamelli R. L., DiPietro L. A., The effect of thrombocytopenia on dermal wound healing. Journal of Investigative Dermatology 2003 120 6 1130 1137 2-s2.0-0038129398 10.1046/j.1523-1747.2003. 12253.x (Pubitemid 36702927)
34. Dovi J. V., He L. K., DiPietro L. A., Accelerated wound closure in neutrophil-depleted mice. Journal of Leukocyte Biology 2003 73 4 448 455 2-s2.0-0037983059 10.1189/jlb.0802406 (Pubitemid 38040090)
35. Martin P., D'Souza D., Martin J., Grose R., Cooper L., Maki R., McKercher S. R., Wound healing in the PU.1 null mouse-tissue repair is not dependent on inflammatory cells. Current Biology 2003 13 13 1122 1128 2-s2.0-0038348096 10.1016/S0960-9822(03)00396-8 (Pubitemid 36815260)
36. Xu J., Clark R. A. F., Extracellular matrix alters PDGF regulation of fibroblast integrins. Journal of Cell Biology 1996 132 1-2 239 249 2-s2.0-0030023905 (Pubitemid 26035088)
37. Hunt T. K., Wound Healing and Wound Infection: Theory and Surgical Practice 1980 New York, NY, USA Appleton-Century-Crofts
38. Roberts A. B., Sporn M. B., Transforming growth factor- β The Molecular Basis of Wound Repair 1996 New York, NY, USA RAF Clark
39. Ferguson M. W., Duncan J., Bond J., Bush J., Durani P., So K., Taylor L., Chantrey J., Mason T., James G., Laverty H., Occleston N. L., Sattar A., Ludlow A., O'Kane S., Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies. The Lancet 2009 373 9671 1264 1274 2-s2.0-64049103218 10.1016/S0140-6736(09)60322-6
40. Desmouliere A., Gabbiani G., The role of the myofibroblast in wound healing and fibrocontractive diseases. The Molecular Basis of Wound Repair 1996 New York, NY, USA Clark RAF
41. Montesano R., Orci L., Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proceedings of the National Academy of Sciences of the United States of America 1988 85 13 4894 4897 2-s2.0-0024043131
42. Hinz B., Formation and function of the myofibroblast during tissue repair. Journal of Investigative Dermatology 2007 127 3 526 537 2-s2.0-33847084614 10.1038/sj.jid.5700613
43. Wong P., Coulombe P. A., Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair. Journal of Cell Biology 2003 163 2 327 337 2-s2.0-0242298585 10.1083/jcb.200305032 (Pubitemid 37363133)
44. Nanney L. B., King L. Jr., Clark R. A. F., Epidermal growth factor and transforming growth factor- α The Molecular and Cellular Basis of Wound Repair 1996 New York, NY, USA Plenum Press
45. Werner S., Smola H., Liao X., Longaker M. T., Krieg T., Hofschneider P. H., Williams L. T., The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science 1994 266 5186 819 822 2-s2.0-0028053872 (Pubitemid 24359294)
46. Draper B. K., Komurasaki T., Davidson M. K., Nanney L. B., Epiregulin is more potent than EGF or TGF α in promoting in vitro wound closure due to enhanced ERK/MAPK activation. Journal of Cellular Biochemistry 2003 89 6 1126 1137 2-s2.0-0042570776 10.1002/jcb.10584 (Pubitemid 36959380)
47. Mast B. A., Cohen K., Diegelmann R. F., Lindblad W. J., The skin. Wound Healing: Biochemical and Chemical Aspects 1992 Philadelphia, Pa, USA WB Saunders 344 355
48. Parks W. C., Matrix metalloproteinases in repair. Wound Repair and Regeneration 1999 7 6 423 432 2-s2.0-0033380154 10.1046/j.1524-475X.1999.00423.x (Pubitemid 30027564)
49. Desmoulière A., Redard M., Darby I., Gabbiani G., Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. American Journal of Pathology 1995 146 1 56 66 2-s2.0-0028851160
50. Peacock E. E., Madden J. W., Trier W. C., Biologic basis for the treatment of keloids and hypertrophic scars. Southern Medical Journal 1970 63 7 755 760 2-s2.0-0014815854
51. Haverstock B. D., Hypertrophic scars and keloids. Clinics in Podiatric Medicine and Surgery 2001 18 1 147 159 2-s2.0-0035027711 (Pubitemid 32385209)
52. van der Veer W. M., Bloemen M. C. T., Ulrich M. M. W., Molema G., van Zuijlen P. P., Middelkoop E., Niessen F. B., Potential cellular and molecular causes of hypertrophic scar formation. Burns 2009 35 1 15 29 2-s2.0-58149127508 10.1016/j.burns.2008.06.020
53. Shih B., Bayat A., Genetics of keloid scarring. Archives of Dermatological Research 2010 302 5 319 339 2-s2.0-77953198604 10.1007/s00403-009-1014-y
54. Wu J., Ma B., Yi S., Wang Z., He W., Luo G., Chen X., Wang X., Chen A., Barisoni D., Gene expression of early hypertrophic scar tissue screened by means of cDNA microarrays. Journal of Trauma 2004 57 6 1276 1286 2-s2.0-19944428538 10.1097/01.TA.0000108997.49513.DC (Pubitemid 40053825)
55. Naitoh M., Kubota H., Ikeda M., Tanaka T., Shirane H., Suzuki S., Nagata K., Gene expression in human keloids is altered from dermal to chondrocytic and osteogenic lineage. Genes to Cells 2005 10 11 1081 1091 2-s2.0-27644527952 10.1111/j.1365-2443.2005.00902.x (Pubitemid 41556076)
56. Satish L., Lyons-Weiler J., Hebda P. A., Wells A., Gene expression patterns in isolated keloid fibroblasts. Wound Repair and Regeneration 2006 14 4 463 470 2-s2.0-33747590974 10.1111/j.1743-6109.2006.00135.x (Pubitemid 44266604)
57. Lane A. T., Human fetal skin development. Pediatric Dermatology 1986 3 6 487 491 2-s2.0-0022896156 (Pubitemid 17054674)
58. Coolen N. A., Schouten K. C. W. M., Middelkoop E., Ulrich M. M. W., Comparison between human fetal and adult skin. Archives of Dermatological Research 2010 302 1 47 55 2-s2.0-77949270345 10.1007/s00403-009-0989-8
59. Dang C. M., Beanes S. R., Lee H., Zhang X., Soo C., Ting K., Scarless fetal wounds are associated with an increased matrix metalloproteinase-to- tissue-derived inhibitor of metalloproteinase ratio. Plastic and Reconstructive Surgery 2003 111 7 2273 2285 2-s2.0-0037981628 10.1097/01.PRS.0000060102.57809. DA (Pubitemid 36676806)
60. Beanes S. R., Dang C., Soo C., Wang Y., Urata M., Ting K., Fonkalsrud E. W., Benhaim P., Hedrick M. H., Atkinson J. B., Lorenz H. P., Down-regulation of decorin, a transforming growth factor-beta modulator, is associated with scarless fetal wound healing. Journal of Pediatric Surgery 2001 36 11 1666 1671 10.1053/jpsu.2001.27946 (Pubitemid 33021988)
61. Soo C., Hu F.-Y., Zhang X., Wang Y., Beanes S. R., Lorenz H. P., Hedrick M. H., Mackool R. J., Plaas A., Kim S.-J., Longaker M. T., Freymiller E., Ting K., Differential expression of fibromodulin, a transforming growth factor- β modulator, in fetal skin development and scarless repair. American Journal of Pathology 2000 157 2 423 433 (Pubitemid 30626906)
62. Krummel T. M., Nelson J. M., Diegelmann R. F., Fetal response to injury in the rabbit. Journal of Pediatric Surgery 1987 22 7 640 644 (Pubitemid 17096972)
63. Cowin A. J., Brosnan M. P., Holmes T. M., Ferguson M. W.J., Endogenous inflammatory response to dermal wound healing in the fetal and adult mouse. Developmental Dynamics 1998 212 3 385 393 10.1002/(SICI)1097-0177(199807)212: 3<385::AID-AJA6>3.0.CO;2-D (Pubitemid 28294867)
64. Stelnicki E. J., Bullard K. M., Harrison M. R., Cass D. L., Scott Adzick N., A new in vivo model for the study of fetal wound healing. Annals of Plastic Surgery 1997 39 4 374 380 10.1097/00000637-199710000-00008 (Pubitemid 27433261)
65. Wilgus T. A., Bergdall V. K., Tober K. L., Hill K. J., Mitra S., Flavahan N. A., Oberyszyn T. M., The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing. American Journal of Pathology 2004 165 3 753 761 2-s2.0-4344643930 (Pubitemid 39129283)
66. Olutoye O. O., Yager D. R., Cohen I. K., Diegelmann R. F., Lower cytokine release by fetal porcine platelets: a possible explanation for reduced inflammation after fetal wounding. Journal of Pediatric Surgery 1996 31 1 91 95 2-s2.0-0030021251 10.1016/S0022-3468(96)90326-7 (Pubitemid 26044256)
67. Hopkinson-Woolley J., Hughes D., Gordon S., Martin P., Macrophage recruitment during limb development and wound healing in the embryonic and foetal mouse. Journal of Cell Science 1994 107 5 1159 1167 2-s2.0-0028306029 (Pubitemid 24177317)
68. Jennings R. W., Adzick N. S., Longaker M. T., Duncan B. W., Scheuenstuhl H., Hunt T. K., Ontogeny of fetal sheep polymorphonuclear leukocyte phagocytosis. Journal of Pediatric Surgery 1991 26 7 853 855 2-s2.0-0025734040 10.1016/0022-3468(91)90155-M
69. Roberts A. B., Sporn M. B., Assoian R. K., Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proceedings of the National Academy of Sciences of the United States of America 1986 83 12 4167 4171 (Pubitemid 16057012)
70. Krummel T. M., Michna B. A., Thomas B. L., Sporn M. B., Nelson J. M., Salzberg A. M., Cohen I. K., Diegelmann R. F., Transforming growth factor beta (TGF- β) induces fibrosis in a fetal wound model. Journal of Pediatric Surgery 1988 23 7 647 652 2-s2.0-0023910131
71. Sullivan K. M., Lorenz H. P., Meuli M., Lin R. Y., Adzick N. S., Crombleholme T., Lally K., Fonkalsrud E., Vane D., A model of scarless human fetal wound repair is deficient in transforming growth factor beta. Journal of Pediatric Surgery 1995 30 2 198 203 2-s2.0-0028893942
72. Lin R. Y., Sullivan K. M., Argenta P. A., Meuli M., Lorenz H. P., Adzick N. S., Exogenous transforming growth factor-beta amplifies its own expression and induces scar formation in a model of human fetal skin repair. Annals of Surgery 1995 222 2 146 154 2-s2.0-0029135303
73. Cowin A. J., Holmes T. M., Brosnan P., Ferguson M. W. J., Expression of TGF- β and its receptors in murine fetal and adult dermal wounds. European Journal of Dermatology 2001 11 5 424 431 2-s2.0-0034878046 (Pubitemid 32801338)
74. Nath R. K., LaRegina M., Markham H., Ksander G. A., Weeks P. M., The expression of transforming growth factor type beta in fetal and adult rabbit skin wounds. Journal of Pediatric Surgery 1994 29 3 416 421 2-s2.0-0028219896 10.1016/0022-3468(94)90582-7 (Pubitemid 24094910)
75. Shah M., Foreman D. M., Ferguson M. W. J., Neutralisation of TGF- β and TGF- β or exogenous addition of TGF- β to cutaneous rat wounds reduces scarring. Journal of Cell Science 1995 108 3 985 1002 2-s2.0-0028986030
76. Haynes J. H., Johnson D. E., Mast B. A., Diegelmann R. F., Salzberg D. A., Cohen I. K., Krummel T. M., Platelet-derived growth factor induces fetal wound fibrosis. Journal of Pediatric Surgery 1994 29 11 1405 1408 2-s2.0-0027960409 10.1016/0022-3468(94)90130-9 (Pubitemid 24356230)
77. Dang C. M., Beanes S. R., Soo C., Ting K., Benhaim P., Hedrick M. H., Lorenz H. P., Decreased expression of fibroblast and keratinocyte growth factor isoforms and receptors during scarless repair. Plastic and Reconstructive Surgery 2003 111 6 1969 1979 2-s2.0-0038753847 10.1097/01.PRS.0000054837.47432. E7 (Pubitemid 36532353)
78. Wilgus T. A., Ferreira A. M., Oberyszyn T. M., Bergdall V. K., DiPietro L. A., Regulation of scar formation by vascular endothelial growth factor. Laboratory Investigation 2008 88 6 579 590 2-s2.0-44349149183 10.1038/labinvest.2008.36 (Pubitemid 351733282)
79. Colwell A. S., Beanes S. R., Soo C., Dang C., Ting K., Longaker M. T., Atkinson J. B., Lorenz H. P., Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair. Plastic and Reconstructive Surgery 2005 115 1 204 212 2-s2.0-13244262625 10.1097/01.PRS.0000138252.51581.22 (Pubitemid 40187816)
80. Liechty K. W., Adzick N. S., Crombleholme T. M., Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair. Cytokine 2000 12 6 671 676 2-s2.0-0033948707 10.1006/cyto.1999.0598 (Pubitemid 30453496)
81. Liechty K. W., Kim H. B., Adzick N. S., Crombleholme T. M., Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair. Journal of Pediatric Surgery 2000 35 6 866 873 2-s2.0-0034121872 (Pubitemid 30346180)
82. Peranteau W. H., Zhang L., Muvarak N., Badillo A. T., Radu A., Zoltick P. W., Liechty K. W., IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation. Journal of Investigative Dermatology 2008 128 7 1852 1860 2-s2.0-45349091820 10.1038/sj.jid.5701232 (Pubitemid 351847365)
83. Gordon A., Kozin E. D., Keswani S. G., Vaikunth S. S., Katz A. B., Zoltick P. W., Favata M., Radu A. P., Soslowsky L. J., Herlyn M., Crombleholme T. M., Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound Repair and Regeneration 2008 16 1 70 79 2-s2.0-38349168948 10.1111/j.1524-475X.2007.00326.x
84. Lorenz H. P., Lin R. Y., Longaker M. T., Whitby D. J., Adzick N. S., The fetal fibroblast: the effector cell of scarless fetal skin repair. Plastic and Reconstructive Surgery 1995 96 6 1251 1259 2-s2.0-0028881014
85. McCluskey J., Martin P., Analysis of the tissue movements of embryonic wound healing-DiI studies in the limb bud stage mouse embryo. Developmental Biology 1995 170 1 102 114 2-s2.0-0029090422 10.1006/dbio.1995.1199
86. Skalli O., Gabbiani G., Clark R. A. F., Henson P. M., The biology of the myofibroblast. Relationship to wound contraction and fibrocontractive diseases. The Molecular and Cellular Biology of Wound Repair 1988 New York, NY, USA Plenum
87. Chen J., Li H., SundarRaj N., Wang J. H. C., Alpha-smooth muscle actin expression enhances cell traction force. Cell Motility and the Cytoskeleton 2007 64 4 248 257 2-s2.0-33947392959 10.1002/cm.20178 (Pubitemid 46452034)
88. Desmouliere A., Geinoz A., Gabbiani F., Gabbiani G., Transforming growth factor- β 1 induces α -smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. Journal of Cell Biology 1993 122 1 103 111 2-s2.0-0027212686 (Pubitemid 23188802)
89. Lanning D. A., Diegelmann R. F., Yager D. R., Wallace M. L., Bagwell C. E., Haynes J. H., Myofibroblast induction with transforming growth factor- β and-β in cutaneous fetal excisional wounds. Journal of Pediatric Surgery 2000 35 2 183 188 2-s2.0-0033974339 (Pubitemid 30082567)
90. Satish L., Johnson S., Wang J. H.-C., Post J. C., Ehrlich G. D., Kathju S., skathju@wpahs.org Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) is a specific regulator of fibroblast motility and contractility. PLoS One 2010 5 4 e10063 10.1371/journal.pone.0010063
91. Stern M., Dodson T. B., Longaker M. T., Fetal cleft lip repair in lambs: histologic characteristics of the healing wound. International Journal of Oral and Maxillofacial Surgery 1993 22 6 371 374
92. Whitby D. J., Ferguson M. W. J., The extracellular matrix of lip wounds in fetal, neonatal and adult mice. Development 1991 112 2 651 668 2-s2.0-0025847137
93. Whitby D. J., Longaker M. T., Harrison M. R., Adzick N. S., Ferguson M. W. J., Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin. Journal of Cell Science 1991 99 3 583 586 2-s2.0-0025813411
94. McCluskey J., Hopkinson-Woolley J., Luke B., Martin P., A study of wound healing in the E11.5 mouse embryo by light and electron microscopy. Tissue and Cell 1993 25 2 173 181 2-s2.0-0027255769 10.1016/0040-8166(93)90017-F
95. Martin P., Lewis J., Actin cables and epidermal movement in embryonic wound healing. Nature 1992 360 6400 179 183 10.1038/360179a0
96. Buck R. C., Cell migration in repair of mouse corneal epithelium. Investigative Ophthalmology and Visual Science 1979 18 8 767 784 2-s2.0-0018354586 (Pubitemid 9212706)
97. Brock J., Midwinter K., Lewis J., Martin P., Healing of incisional wounds in the embryonic chick wing bud: characterization of the actin purse-string and demonstration of a requirement for Rho activation. Journal of Cell Biology 1996 135 4 1097 1107 2-s2.0-0029807433 (Pubitemid 26403781)
98. Cowin A. J., Hatzirodos N., Teusner J. T., Belford D. A., Differential effect of wounding on actin and its associated proteins, paxillin and gelsolin, in fetal skin explants. Journal of Investigative Dermatology 2003 120 6 1118 1129 2-s2.0-0038806276 10.1046/j.1523-1747.2003.12231.x (Pubitemid 36702926)
99. Cass D. L., Bullard K. M., Sylvester K. G., Yang E. Y., Sheppard D., Herlyn M., Adzick N. S., Epidermal integrin expression is upregulated rapidly in human fetal wound repair. Journal of Pediatric Surgery 1998 33 2 312 316 2-s2.0-0031891864 10.1016/S0022-3468(98)90453-5 (Pubitemid 28093720)
100. Clark R. A. F., Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin. Journal of Investigative Dermatology 1990 94 6 128S 134S 2-s2.0-0025329404 (Pubitemid 20213081)
101. Zambruno G., Cavani A., Manca V., Integrin expression during wound healing in human skin transplanted onto nude mice. Journal of Investigative Dermatology 1991 96, article 1015
102. Juhasz I., Murphy G. F., Yan H. C., Herlyn M., Albelda S. M., Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo. American Journal of Pathology 1993 143 5 1458 1469 2-s2.0-0027744501 (Pubitemid 24057116)
103. Martin P., Nobes C. D., An early molecular component of the wound healing response in rat embryos-induction of c-fos protein in cell at the epidermal wound margin. Mechanisms of Development 1992 38 3 209 216 2-s2.0-0026787263 10.1016/0925-4773(92)90054-N
104. Colwell A. S., Krummel T. M., Longaker M. T., Lorenz H. P., Early-gestation fetal scarless wounds have less lysyl oxidase expression. Plastic and Reconstructive Surgery 2006 118 5 1125 1129 2-s2.0-33749439757 10.1097/01.prs.0000221056.27536.db (Pubitemid 44511405)
105. Stelnicki E. J., Kömúves L. G., Holmes D., Clavin W., Harrison M. R., Adzick N. S., Largman C., The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin. Differentiation 1997 62 1 33 41 2-s2.0-0030810349 10.1046/j.1432-0436.1997.6210033.x (Pubitemid 27482856)
106. Chen W., Fu X., Ge S., Sun T., Zhou G., Han B., Li H., Sheng Z., Profiling of genes differentially expressed in a rat of early and later gestational ages with high-density oligonucleotide DNA array. Wound Repair and Regeneration 2007 15 1 147 155 2-s2.0-33846426443 10.1111/j.1524-475X.2006. 00195.x (Pubitemid 46146672)
107. Colwell A. S., Longaker M. T., Lorenz H. P., Identification of differentially regulated genes in fetal wounds during regenerative repair. Wound Repair and Regeneration 2008 16 3 450 459 2-s2.0-43349092410 10.1111/j.1524-475X.2008.00383.x (Pubitemid 351661581)
108. Antony A. K., Kong W., Lorenz H. P., Upregulation of neurodevelopmental genes during scarless healing. Annals of Plastic Surgery 2010 64 2 247 250 2-s2.0-77649092840 10.1097/SAP.0b013e3181a20af8
109. Darden D. L., Hu F. Z., Ehrlich M. D., Gorry M. C., Dressman D., Li HA. S., Whitcomb D. C., Hebda P. A., Dohar J. E., Ehrlich G. D., RNA differential display of scarless wound healing in fetal rabbit indicates downregulation of a CCT chaperonin subunit and upregulation of a glycophorin-like gene transcript. Journal of Pediatric Surgery 2000 35 3 406 419 2-s2.0-12944301117 (Pubitemid 30131601)
110. Kathju S., Satish L., Rabik C., Rupert T., Oswald D., Johnson S., Hu F. Z., Christopher Post J., Ehrlich G. D., Identification of differentially expressed genes in scarless wound healing utilizing polymerase chain reaction-suppression subtractive hybridization. Wound Repair and Regeneration 2006 14 4 413 420 2-s2.0-33747620718 10.1111/j.1743-6109.2006.00140.x (Pubitemid 44266597)
111. Satish L., Abdulally A., Oswald D., Johnson S., Hu F. Z., Post J. C., Ehrlich G. D., Kathju S., Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healing. Cell Stress and Chaperones 2008 13 4 527 533 2-s2.0-59649124624 10.1007/s12192-008-0040-6
112. Shilo S., Roy S., Khanna S., Sen C. K., MicroRNA in cutaneous wound healing: a new paradigm. DNA and Cell Biology 2007 26 4 227 237 2-s2.0-34248679582 10.1089/dna.2006.0568 (Pubitemid 46776607)