Differential effect of wounding on actin and its associated proteins, paxillin and gelsolin, in fetal skin explants

Journal of Investigative Dermatology

Volumn 120, Issue 6, 2003, Pages 1118-1129

  Cowin, Allison J ^a,b,c   Hatzirodos, Nicholas ^a,b   Teusner, Jacqueline T ^a,b   Belford, David A ^d  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^b Div of Hlth Sciences and Nutrition   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d GroPep Ltd   (Australia)

Author keywords

Actin; Fetal; Gelsolin; Paxillin; Wound healing

Indexed keywords

ACTIN; GELSOLIN; MESSENGER RNA; PAXILLIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIVISION; EPITHELIZATION; EXPLANT; FETUS; GESTATIONAL AGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SCAR FORMATION; SKIN INCISION; TENSILE STRENGTH; TISSUE CULTURE; WOUND CLOSURE; WOUND HEALING;

EID: 0038806276     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12231.x     Document Type: Article

References (36)

1. Arora PD, McCulloch CA: Dependence of fibroblast migration on actin severing activity of gelsolin. J Biol Chem 271:20516-20523, 1996
2. Belford DA: The mechanism of excisional fetal wound repair in vitro is responsive to growth factors. Endocrinology 138:3987-3996, 1997
3. Brock J, Midwinter K, Lewis J, Martin P: Healing of incisional wounds in the embryonic chick wing bud. Characterization of the actin purse-string and demonstration of a requirement for Rho activation. J Cell Biol 135:1097-1107, 1996
4. Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS: Epidermal integrin expression is upregulated rapidly in human fetal wound repair. J Pediatr Surg 33:312-316, 1998
5. Chang Lin D, Tobin KD, Grumet M, Lin S: Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongation. J Cell Biol 84:455-460, 1980
6. Clark RAF: Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin. J Invest Dermatol 94:128S-134S, 1990
7. Cowin AJ, Brosnan MP, Holmes TM, Ferguson MWJ: Endogenous inflammatory response to dermal wound healing in the fetal and adult mouse. Dev Dyn 212:383-393, 1998
8. Cowin AJ, Holmes TM, Brosnan P, Ferguson MWJ: Expression of TGF-β and its receptors in murine fetal and adult dermal wounds. Eur J Dermatol 11:424-431, 2001
9. Ferguson MWJ, Whitby DJ, Shah M, Armstrong J, Siebert JW, Longaker MT: Scar formation. The spectral nature of fetal and adult wound repair. Plast Reconstr Surg 97:854-860, 1996
10. Gosiewska A, Yi CF, Brown LJ, Cullen B, Silcock D, Geesin JC: Differential expression of extracellular matrix-associated genes in fetal and neonatal fibroblasts. Wound Rep Reg 9:213-222, 2001
11. Grinnell F: Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol 124:401-404, 1994
12. Hagel M, George EL, Kim A, et al: The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol 22:901-915, 2002
13. Hopkinson-Woolley J, Hughes D, Gordon S, Martin P: Macrophage recruitment during limb development and wound healing in the embryonic and fetal mouse. J Cell Sci 107:1159-1167, 1994
14. Ihara S, Motobayashi Y: Wound closure in fetal rat skin. Development 114:573-582, 1992
15. Ihara S, Motobayashi Y, Nagao E, Kistler A: Ontogenetic transition of wound healing pattern in rat skin occurring at the fetal stage. Development 110:671-680, 1990
16. Kiehart DP: Wound healing. The power of the purse string. Curr Biol 9:R602-R605, 1999
17. Longaker MT, Whitby DJ, Adzick NS, et al: Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg 25:63-68, 1990
18. Longaker MT, Chiu ES, Adzick NS, Stern M, Harrison MR, Stern R: Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid. Ann Surg 213:292-296, 1991
19. Longaker MT, Peled ZM, Chang J, Krummel TM: Fetal wound healing: Progress report and future directions. Surgery 130:785-787, 2001
20. Lorenz HP, Whitby DJ, Longaker MT, Adzick NS: Fetal wound healing. The ontogeny of scar formation in the non-human primate. Ann Surg 217:391-396, 1993
21. Martin P: Wound healing - Aiming for perfect skin regeneration. Science 276:75-81, 1997
22. Martin P, Lewis J: Actin cables and epidermal movement in embryonic wound healing. Nature 360:179-183, 1992
23. McCallion RL, Ferguson MWJ: Fetal wound healing and the development of antiscarring therapies for adult wound healing. In: Clark RAF (ed). The Molecular and Cellular Biology of Wound Repair. New York: Plenum Press, 1996: p 561-600
24. McCluskey J, Martin P: Analysis of the tissue movements of embryonic wound healing - Dil studies in the limb bud stage mouse embryo. Dev Biol 170:102-114, 1995
25. O'Kane S: Mechanistic insights into wound healing and scarring through the use of transgenic mice. The Wound Healing Society Seventh Annual Meeting S21, 1997; p 40
26. Rudolph R, Vande Berg J, Ehrlich HP: Wound contraction and scar contracture. In: Cohen IK, Diegelmann RF, Lindblad WJ (eds). Wound Healing Biochemical and Clinical Aspects. Philadelphia: WB Saunders, 1992; p 96-114
27. Spooner BS, Wessells NK: Effects of cytochalasin B upon microfilaments involved in morphogenesis of salivary epithelium. Proc Natl Acad Sci USA 6:360-364, 1970
28. Stelnicki EJ, Chin GS, Gittes GK, Longaker MT: Fetal wound repair. Where do we go from here? Semin Pediatr Surg 8:124-130, 1999
29. Sun HQ, Yamamoto M, Mejillano M, Yin HL: Gelsolin, a multifunctional actin regulatory protein. J Biol Chem 274:33179-33182, 1999
30. Turner CE: Molecules in focus Paxillin. Int J Biochem Cell Biol 30:955-959, 1998
31. Turner CE: Paxillin interactions. J Cell Sci 113:4139-4140, 2000
32. Wade R, Bohl J, Vande Pol S: Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase. Oncogene 21:96-107, 2002
33. West DC, Shaw DM, Lorenz P, Adzick NS, Longaker MT: Fibrotic healing of adult and late gestation fetal wounds correlates with increased hyaluronidase activity and removal of hyaluronan. Int J Biochem Cell Biol 29:201-210, 1997
34. Whitby DJ, Ferguson MW: Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 147:207-215, 1991
35. Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ: Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell 81:41-51, 1995
36. Young CW, Hodas S: Hydroxyurea: Inhibitory effect on DNA metabolism. Science 146:1172-1174, 1964