Gene expression in human keloids is altered from dermal to chondrocytic and osteogenic lineage

Genes to Cells

Volumn 10, Issue 11, 2005, Pages 1081-1091

  Naitoh, Motoko ^a,b   Kubota, Hiroshi ^a   Ikeda, Mika ^b   Tanaka, Toshinori ^c   Shirane, Hirofumi ^c   Suzuki, Shigehiko ^b   Nagata, Kazuhiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9;

ADOLESCENT; AGED; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL LINEAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; FIBROBLAST; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KELOID; LIGAMENT; MARKER GENE; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CELL; TENDON; UPREGULATION;

ADOLESCENT; ADULT; AGED; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARTILAGE; CELL LINEAGE; CHONDROCYTES; COLLAGEN TYPE XI; CORE BINDING FACTOR ALPHA 1 SUBUNIT; EXTRACELLULAR MATRIX PROTEINS; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HIGH MOBILITY GROUP PROTEINS; HUMANS; KELOID; MIDDLE AGED; OSTEOBLASTS; RNA, MESSENGER; SKIN; TRANSCRIPTION FACTORS;

EID: 27644527952     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2005.00902.x     Document Type: Article

References (50)

1. Abergel, R.P., Pizzurro, D., Meeker, C.A., et al. (1985) Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures. J. Invest. Dermatol. 84, 384-390.
2. Akasaka, Y., Ishikawa, Y., Ono, I., et al. (2000) Enhanced expression of caspase-3 in hypertrophic scars and keloid: induction of caspase-3 and apoptosis in keloid fibroblasts in vitro. Lab. Invest. 80, 345-357.
3. Benjamin, M. & Ralphs, J.R. (2004) Biology of fibrocartilage cells. Int. Rev. Cytol. 233, 1-45.
4. Bentz, H., Nathan, R.M., Rosen, D.M., et al. (1989) Purification and characterization of a unique osteoinductive factor from bovine bone. J. Biol. Chem. 264, 20805-20810.
5. Bi, W., Deng, J.M., Zhang, Z., Behringer, R.R. & de Crombrugghe, B. (1999) Sox9 is required for cartilage formation. Nature Genet. 22, 85-89.
6. Botchkarev, V.A. & Kisimono, J. (2003) Molecular control of epithelial-mesenchymal interactions furing hair follicle cycling. J. Investig. Dermatol. Symp. Proc. 8, 46-55.
7. Bridgewater, L.C., Lefebvre, V. & de Crombrugghe, B. (1998) Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J. Biol. Chem. 273, 14998-15006.
8. Chakravarti, S., Magnuson, T., Lass, J.H., et al. (1998) Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. J. Cell Biol. 141, 1277-1286.
9. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
10. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L. & Karsenty, G. (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747-754.
11. Enomoto, H., Emoto-Iwamoto, M., Iwamoto, M., et al. (2000) Cbfa1 is a positive regulatory factor in chondrocyte maturation. J. Biol. Chem. 275, 8695-8702.
12. Foster, J.W., Dominguez-Steglich, M.A., Guioli, S., et al. (1994) Campomelic dysplasia and autosomal sex reversal caused by mutations roan SRY-related gene. Nature 372, 525-530.
13. Funayama, E., Chondon, T., Oyama, A. & Sugihara, T. (2003) Keratinocytes promote proliferation and inhibit apoptosis of the underlying fibroblasts: an important role in the pathogenesis of keloid. J. Invest. Dermatol. 121, 1326-1331.
14. Heenan, P.J. (1997) Tumors of the fibrous tissue involving the skin. In: Lever's Histopathology of the Skin (eds D. Elder, R. Elenitsas, C. Jaworsky & B. Johnson Jr), pp. 847-887. Philadelphia, Pennsylvania: Lippincott-Raven Publishers.
15. Horiuchi, K., Amizuka, N., Takeshita, S., et al. (1999) Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J. Bone Miner. Res. 14, 1239-1249.
16. Kahai, S., Vary, C.P., Gao, Y. & Seth, A. (2004) Collagen, type V, alpha1 (COL5A1) is regulated by TGF-beta in osteoblasts. Matrix Biol. 23, 445-455.
17. Kassner, A., Tiedemann, K., Notbohm, H., et al. (2004) Molecular structure and interaction of recombinant human type XVI collagen. J. Mol. Biol. 339, 835-853.
18. Kern, B., Shen, J., Starbuck, M. & Karsenty, G. (2001) Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes. J. Biol. Chem. 276, 7101-7107.
19. Kiani, K., Chen, L., Wu, Y.J., Yee, A.J. & Yang, B.B. (2002) Structure and function of aggrecan. Cell Res. 12, 19-32.
20. Kishimoto, J., Ehama, R., Wu, L., Jiang, S., Jiang, N. & Burgeson, R.E. (1999) Selective activation of versican promoter by epithelial-mesenchmal interactions during hair follicle development. Proc. Natl. Acad. Sci. USA 96, 736-741.
21. Komori, T., Yagi, H., Nomura, S., et al. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764.
22. Lee, B., Thirunavukkarasu, K., Zhou, L., et al. (1997) Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nature Genet. 16, 307-310.
23. Makay, A.M., Beck, S.C., Murphy, J.M., et al. (1998) Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng. 4, 415-428.
24. Mariani, L., McDonough, W.S., Hoelzinger, D.B., et al. (2001) Identification and validation of P311 as a glioblastoma invasion gene using laser capture microdissection. Cancer Res. 61, 4190-4196.
25. Mendler, M., Eich-Bender, S.G., Vaughan, L., Winterhalter, K.H. & Bruckner, P. (1989) Cartilage contains mixed fibrils of collagen types II, IX, and XI. J. Cell Biol. 108, 191-197.
26. Mouna, A., Eklund, L., Vaisanen, T. & Pihlajaniemi, T. (2004) Developmentally regulated expression of type XV collagen correlates with abnormalities in Col15a1 (-/-) mice. Matrix Biol. 21, 89-102.
27. Mundlos, S., Otto, F., Mundlos, C., et al. (1997) Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89, 773-779.
28. Naitoh, M., Hosokawa, N., Kubota, H., et al. (2001) Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid. Biochem. Biophys. Res. Commun. 280, 1316-1322.
29. Nerlich, A.G., Kirsch, T., Wiest, I., Betz, P. & von der Mark, K. (1992) Localization of collagen X in human fetal and juvenile articular cartilage and bone. Histochemistry 98, 275-281.
30. Oka, C., Tsujimoto, R., Kajikawa, M., et al. (2004) HtrA1 serine prtoease inhibits signaling mediated by Tgfbeta family proteins. Development 131, 1041-1053.
31. Okazaki, M., Takeshita, S., Kawai, S., et al. (1994) Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J. Biol. Chem. 269, 12092-12098.
32. Otto, F., Thornell, A.P., Crompton, T., et al. (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89, 765-771.
33. Park, J.E., Lenter, M.C., Zimmermann, R.N., Garin-Chesa, P., Old, L.J. & Rettig, W.J. (1999) Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J. Biol. Chem. 274, 36505-36512.
34. Peltonen, J., Hsiao, L.L., Jaakkola, S., et al. (1991) Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1 mRNA. J. Invest. Dermatol. 97, 240-248.
35. Raouf, A., Ganss, B., McMahon, C., Vary, C., Roughley, P.J. & Seth, A. (2002) Lumican is a major proteoglycan component of the bone matrix. Matrix Biol. 21, 361-367.
36. Saito, Y., Yoshizawa, T., Takizawa, F., et al. (2002) A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. J. Cell Sci. 115, 4191-4200.
37. Salingcarnboriboon, R., Yoshitake, H., Tsuji, K., et al. (2003) Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property. Exp. Cell Res. 287, 289-300.
38. Schweitzer, R., Chyung, J.H., Murtaugh, L.C., et al. (2001) Analysis of tendon cell fate using Scleraxis, a specific marker for tendon and ligaments. Development 128, 3855-3866.
39. Seo, B.M., Miura, M., Gronthos, S., et al. (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 364, 149-155.
40. Shibata, S., Fukuda, K., Imai, H., Abe, T. & Yamashita, Y. (2003) In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage. J. Anat. 203, 425-432.
41. Takeshita, S., Kikuno, R., Tezuka, K. & Amann, E. (1993) Osteoblast-specific factor 2: cloning of a putative cone adhesion protein with homology with the insect protein fasciclin I. Biochem. J. 294, 271-278.
42. Tasheva, E.S., Koester, A., Palsen, A.Q., et al. (2002) Miemecan/osoteoglycin-deficient mice have collagen fibril abnormalities. Mol. Vis. 31, 407-415.
43. Tsukifuji, R., Sakai, Y., Hatamochi, A. & Shinkai, H. (1997) Gene expression of matrix metalloproteinase-1 (interstitial collagenase) and matrix metalloproteinase-3 (stromelysin-1) in basal cell carcinoma by in situ hybridization using chondroitin ABC lyase. Histochem. J. 29, 401-407.
44. Tucker, R.P., Adams, J.C. & Lawler, J. (1995) Thrombospondin-4 is expressed by early osteogenic tissues in the chick embryo. Dev. Dyn. 203, 477-490.
45. Wagner, T., Wirth, J., Meyer, J., et al. (1994) Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell 79, 1111-1120.
46. Webb, P.P., Moxham, B.J., Ralphs, J.R. & Benjamin, M. (1998) Immunolocalisation of collagens in the developing rat molar tooth. Eur. J. Oral. Sci. 106 (Suppl. 1), 147-155.
47. Wight, T.N. (2002) Versican: a versatile extracellular matrix proteoglycan in cell biology. Curr. Opin. Cell Biol. 14, 617-623.
48. Yoshida, A., Kobayashi, K., Manya, H., et al. (2001) Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev. Cell 1, 717-724.
49. Zimmermann, D.R., Dours-Zimmermann, M.T., Schubert, M. & Bruckner-Tudrman. L. (1994) Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the derimis. J. Cell Biol. 124, 817-825.
50. Zumbrunn, J. & Trueb, B. (1996) Primary structure of a putative serine protease specific for IGF-binding proteins. FEBS Lett. 398, 187-192.