Inflammatory gene variants in the tsimane, an indigenous bolivian population with a high infectious load

Biodemography and Social Biology

Volumn 57, Issue 1, 2011, Pages 33-52

  Vasunilashorn, Sarinnapha ^a   Finch, Caleb E ^b   Crimmins, Eileen M ^b   Vikman, Suvi A ^c   Stieglitz, Jonathan ^d   Gurven, Michael ^e   Kaplan, Hillard ^d   Allayee, Hooman ^c  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF NEW MEXICO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; C REACTIVE PROTEIN; INTERLEUKIN 6;

ADOLESCENT; ADULT; AMERICAN INDIAN; BLOOD; BOLIVIA; CASE CONTROL STUDY; CHILD; COMMUNICABLE DISEASE; CONFERENCE PAPER; ETHNOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; LIFE EXPECTANCY; MALE; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PRESCHOOL CHILD; REGRESSION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; APOLIPOPROTEINS E; BOLIVIA; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COMMUNICABLE DISEASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INDIANS, SOUTH AMERICAN; INTERLEUKIN-6; LEAST-SQUARES ANALYSIS; LIFE EXPECTANCY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79956227332     PISSN: 19485565     EISSN: 19485573     Source Type: Journal    
DOI: 10.1080/19485565.2011.564475     Document Type: Conference Paper

References (110)

1. Aceves, D, B. Ruiz, P. Nuño, S. Roman, E. Zepeda, and A. Panduro. 2006. Heterogenity of apolipoprotein E polymorphism in different Mexican populations. Hum Biol 78:65-75. (Pubitemid 44087147)
2. Aiello, A. E., H.-O. Nguyen, and M. N Haan. 2008. C-reactive protein mediates the effect of apolipoprotein E on cytomegalorvirus infection. J Infect Dis 197:34-41. (Pubitemid 351263463)
3. Asakawa J., N. Takahashi, B. B. Rosenblum, and J. V. Neel. 1985. Two-dimensional gel studies of genetic variation in the plasma proteins of Amerindians and Japanese. Hum Genet 70: 222-230. (Pubitemid 15234375)
4. Austin, M. A., C. Zhang, S. E. Humphries, W. L. Chadler, P. J. Talmud, K. L. Edwards, D. L. Leonetti, M. J. McNeely, and W. Y. Fujimoto. 2004. Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans. Ann Hum Genet 68:179-188. (Pubitemid 39162730)
5. Balding, J. C., M. Healy, W. J. Livingstone, B. White, L. Mynett-Johnson, M. Cafferkey, and O. P. Simth. 2003. Genomic polymorphic profiles in an Irish population with meningococaemia: Is it possible to predict severity and outcome of disease? Genes Immun 4:533-540. (Pubitemid 38961148)
6. Bamouldi, J, C. Courivaud, M. Deschamps, P. Mercier, C. Ferrand, A. Penfornis, P. Tiberghien, J. M. Chaolpin, P. Saas, and D. Ducloux. 2006. IL-6 promoter polymorphism -174 is associated with new-onset of diabetes after transplantation. J Am Soc Nephrol 17:2333-2340. (Pubitemid 44141925)
7. Bizzarro, A., D. Seripa, A. Acciarri, M. G. Matera, A. Pilotto, F. D. Tiziano, C. Brahe, and C. Masullo. 2009. The complex interaction between APOE promoter and AD: an Italian case-control study. Eur J Hum Genet 17:938-945.
8. Brull, D., N. Serrano, F. Zito, L. Jones, H. E. Montgomery, A. Rumley, P. Sharma, G. D. Lowe, M. J. World, S. E. Humphries, et al. 2003. Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arterioscler Thromb Vasc Biol 23:2063-2069. (Pubitemid 37433201)
9. Carlson, C. S, S. F. Aldred, P. K. Lee, R. P. Tracy, S. M. Schwartz, M. Rieder, K. Liu, D. Williams, C. Iribarren, E. C. Lewis, et al. 2005. Polymorphisms with the C-reactive protein promoter region are associated with plasma CRP levels. Am J Hum Genet 77:64-77. (Pubitemid 40848037)
10. Charlesworth, B. 1994. Evolution in age-structured populations. Cambridge: Cambridge University Press.
11. Charlesworth, B. 1996. Evolution of senescence: Alzheimer's disease and evolution. Curr Biol 6: 20-22. (Pubitemid 126663429)
12. Chiappelli, M, C. Tampieri, E. Tumini, E. Porcellini, C. M. Caldarera, S. Nanni, A. Branzi, D. Lio, M. Caruso M, E. Hoffmann, et al. 2005. Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. J Immunogenet 32:349-353. (Pubitemid 41735572)
13. Collins, F. S., M. S Guyer, and A. Charkravarti. 1997. Variations on a theme: Cataloging human DNA sequence variation. Science 278:1580-1581. (Pubitemid 27516268)
14. Corbo, R. M., and R. Scacchi. 1999. Apolipoprotein E (APOE) allele distribution in the world. Is APOE4 a 'thrifty' allele? Ann Hum Genet 63:301-310. (Pubitemid 30021229)
15. Corder, E. H., L. Lannfelt, M. Viitanen, L. S. Corder, K. G. Manton, B. Winblad, and H. Basun. 1996. Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition. Arch Neurol 53:418-422. (Pubitemid 26143640)
16. Crawford, D. C., C. L. Sanders, X. Qin, J. D. Smith, C. Shephard, M. Wong, L. Witrak, M. J. Rieder, and D. A. Nickerson. 2006. Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Circulation 114: 2458-2465. (Pubitemid 44901518)
17. Crews, D. E., M. I. Kamboh, J. J. Mancilha-Carvalho, and B. Kottke. 1993. Population genetics of apolipoprotein A-4, E, and H polymorphisms in Yanomami Indians of Northwestern Brazil: Associations with lipids, lipoproteins, and carbohydrate metabolism. Hum Biol 65:211-224.
18. Das, M, S. Pal, and A. Ghosh. 2008. Apolipoprotein E gene polymorphism and dyslipidaemia in adult Asian Indians: A population based study from Calcutta, India. Indian J Hum Genet 14:87-91.
19. De Craen, A. J. M., D. Posthuma, E. J. Remarque, A. H. J. van den Biggelaar, R. G. J. Westendorp, and D. I. Boomsma. 2005. Heritability estimates of innate immunity: An extended twin study. Genes Immun 6:167-170. (Pubitemid 40439544)
20. Demarchi, D. A., F. M. Salzano, M. E. Altuna, M. Fiegenbaum, K. Hill, A. M. Hurtado, L. T. Tsunetto, M. L. Petzl-Erler, and M. H. Hutz. 2005. APOE polymorphism distribution among Native Americans and related populations. Ann Hum Biol 32:351-365. (Pubitemid 40995690)
21. Drabe, N, G. Zund, J. Grunenfelder, M. Sprenger, S. P. Hoerstrup, I. Bestmann, F. E. Maly, and M. Turina. 2001. Genetic predisposition in patients undergoing cardiopulmonary bypass surgery is associated with an increase of inflammatory cytokines. Eur J Cardio-Thorac Surg 20:609-613. (Pubitemid 32743347)
22. Drenos, F., and T. B. L. Kirkwood. 2010. Selection on alleles affecting human longevity and late-life disease: The example of Apolipoprotein E. PLoS One 5:10022.
23. Drenos, F., R. Westendorp, and T. B. L. Kirkwood. 2006. Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions. Biogerontology 7:287-295.
24. Dupuis, J., M. G. Larson, R. S. Vasan, J. M. Massaro, P. W. Wilson, I. Lipinska, D. Corey, J. A. Vita, J. F. Keaney Jr., and E. J. Benjamin. 2005. Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q. Atherosclerosis 182:307-314. (Pubitemid 41267199)
25. Eichner, J. E., S. T. Dunn, G. Perveen, D. M .Thompson, K. E. Stewart, and B. C. Stroehla. 2002. Apolipoprotein E polymorphism and cardiovascular disease: A HuGE Review. Am J Epidemiol 155:487-495. (Pubitemid 34208040)
26. Eiriksdottir, G., A. V. Smith, T. Aspelund, S. H Hafsteinsdottir, E. Olafsdottir, L. J. Launer, T. B. Harris, and V. Gudnason. 2009. The interaction of adiposity with the CRP gene affects CRP levels: Age, Gene/Environment Susceptibility-Reykjavik Study. Int J Obesity 33:267-272.
27. Erlinger, T. P., E. A. Platz, N. Rifai, and K. J. Helzlsouer. 2004. C-reactive protein and the risk of incident colorectal cancer. JAMA 291:585-590. (Pubitemid 38500312)
28. Ewbank, D. C. 2004. The APOE gene and differences in life expectancy in Europe. J Gerontol Biol Sci Med Sci 59:16-20. (Pubitemid 38087949)
29. Ewbank, D. C. 2007. Differences in the association between apolipoprotein E genotype and mortality across populations. J Gerontol Biol Sci Med Sci 62:899-907. (Pubitemid 350131676)
30. Fabris, C., P. Toniutto, D. Bitetto, R. Minisini, C. Smirne, M. Caldato, and M. Pirisi. 2005. Low fibrosis progression of recurrent hepatitis C in apolipoprotein E epsilon4 carriers: Relationship with the blood lipid profile. Liver Int 25:1128-1135. (Pubitemid 41782555)
31. Finch, C. E. 2007. The biology of human longevity. Burlington, MA: Elsevier.
32. Finch, C. E., and E. M. Crimmins. 2004. Inflammatory exposure and historical changes in human life-spans. Science 305:1736-1739. (Pubitemid 39249633)
33. Finch, C. E., and T. E. Morgan. 2007. Systemic inflammation, infection, apoE alleles, and Alzheimer disease: A position paper. Curr Alzheimer Res 4:185-189. (Pubitemid 46562393)
34. Finch, C. E., and C. B. Stanford. 2004. Meat-adaptive genes and the evolution of slower aging in humans. Q Rev Biol 79:3-50. (Pubitemid 38394029)
35. Flint, J., R. M. Harding, A. J. Boyce, and B. B. Clegg. 1998. The population genetics of the haemoglobinopathies. Baillieres Clin Haematol 11:1-51. (Pubitemid 29039017)
36. Franceschi, C., M. Bonafe, S. Valensin, F. Olivieri, M. De Luca, E. Ottavini, and G. Benedictis. 2000. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244-254. (Pubitemid 30462008)
37. Franceschi, C., F. Olivieri, F. Marchegiani, M. Cardelli, L. Cavallone, M. Capri, S. Salvioli, S. Valensin, G. De Bendicitis, A. Di Iorio, et al. 2005. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Aging Develop 126: 351-361. (Pubitemid 40038357)
38. Friedman, G. E., A. L. Klatsky, and A. B. Siegelaub. 1974. The leukocyte count as a predictor of myocardial infarction. N Engl J Med 290:1275-1278.
39. Gajra, B., J. K. Candlish, N. Sha, J. W. Mak, and J. S. H. Tay. 1994. Effect of apolipoprotein E variants on plasma lipids and apolipoproteins in the Orang Asli ('Aborigines') of Malaysia. Hum Hered 44:209-213. (Pubitemid 24172298)
40. Genest, J. 2003. Lipoprotein disorders and cardiovascular risk. J Inherit Metab Dis 26:267-287. (Pubitemid 36889747)
41. Gerdes, L. U., I. C. Klausen, I. Sihm, and O. Faergeman. 1992. Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Genet Epidemiol 9:155-167.
42. Gerdes, L. U., C. Gerdes, P. S. Hansen, I. C. Klausen, O. Faergaeman, and J. Dyerberg. 1996. The apolipoprotein E polymorphism in Greenland Inuit in its global perspective. Hum Genet 98: 546-550. (Pubitemid 26394833)
43. Gerdes, L. U., B. Jeune, K. A. Ranberg, H. Nybo, and J. W. Vaupel. 2000. Estimation of apolipopro-tein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: Apolipoprotein E genes is a "frailty gene," not a "longevity gene." Genet Epidemiol 19:202-210.
44. Goldstein, D. B. 2009. Common genetic variation and human traits. N Engl J Med 360:1696-1698.
45. Grunenfelder, J., M. Umbehr, A. Plass, L. Bestmann, F. E. Maly, G. Zèund, and M. Turina. 2004. Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass. J Thorac Cardiovasc Surg 128:92-97. (Pubitemid 38881201)
46. Gurven, M., H. Kaplan, and A. Z. Supa. 2007. Mortality experience of Tsimane Amerindians of Bolivia: Regional variation and temporal trends. Am J Hum Biol 19:376-398. (Pubitemid 46839448)
47. Gurven, M., H. Kaplan, J. Winking, C. Finch, and E. M. Crimmins. 2008. Aging and inflammation in two epidemiological worlds. J Gerontol Biol Sci Med Sci 63:196-199. (Pubitemid 351738452)
48. Hage, F. G., and A. J. Szalai. 2007. C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. J Am Coll Cardiol 50:1115-1122. (Pubitemid 47375011)
49. Hage, F. G., and A. J. Szalai. 2009. The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk. Curr Atheroscler Rep 11:124-130.
50. HapMap Website http://hapmap.ncbi.nlm.nih.gov/cgi-perl/gbrowse/hapmap27- B36/#search (accessed April 15, 2010).
51. Hardy, J., and A. Singleton. 2009. Genomewide association studies and human disease. N Engl J Med 360:1759-1768.
52. Harpending, H., and G. Cochran. 2006. Genetic diversity and genetic burden in humans. Infect Genet Evol 6:154-162. (Pubitemid 43285822)
53. Huang, H.-Y., L. Thuita, P. Strickland, S. C. Hoffman, G. W. Comstock, and K. Helzlsouer. 2007. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. BMC Genet 8:7.
54. Huang, Y. D. 2006. Apolipoprotein E and Alzheimer disease. Neurology 66:79-85. International Still's Disease Foundation Web site: http://www.stillsdisease.org/lab-tests/cbc (accessed January 21, 2008).
55. Kamboh, M. I., B. Sepehrnia, and R. E. Ferrell. 1989. Genetic studies of human apolipoproteins: VI. Common polymorphism of apolipoprotein E in blacks. Dis Markers 7:49-55. (Pubitemid 19068211)
56. Kamboh, M. I., K. K. Bhatia, and R. E. Ferrell. 1990. Genetic of human apolipoproteins: XII. Population genetics of apolipoproteins in Papua New Guinea. Am J Hum Biol 2:17-23.
57. Kamboh, M. I., S. W. Serjeantson, and R. E. Ferrell. 1991a. Genetic studies of human apolipopro-teins: XVIII. Apolipoprotein polymorphisms in Australian Aborigines. Hum Biol 63:179-186.
58. Kamboh, M. I., K. M. Weiss, and R. E. Ferrell. 1991b. Genetic studies of human apolipopro-teins: XVI. APOE polymorphism and cholesterol levels in the Mayans of the Yucatan peninsula, Mexico. Clin Genet 39:26-32.
59. Kathiresan, S., M. G. Larson, R. S. Vasan, C.-Y. Guo, P. Gona, J. F. Keaney Jr., P. W. F. Wilson, C. Newton-Cheh, S. L. A. L Musone, Camargo, et al. 2006. Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation 116:1415-1423. (Pubitemid 43739438)
60. Khor, C. C., F. O. Vannberg, S. J. Chapman, H. Guo, S. H. Wong, A. J. Walley, et al. 2010. CISH and susceptibility to infectious diseases. N Engl J Med 362:2092-2101.
61. Kovacs, A., F. Green, L. O. Hansson, P. Lundman, A. Samnegard, S. Boquist, C. G. Ericsson, H. Watkins, A. Hamsten, and P. Tornvall. 2005. A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein. Atherosclerosis 178:193-198. (Pubitemid 39600833)
62. Kuningas, M., L. May, Tamm R, D. van Bodegom, A. H. J. van den Biggelaar, J. J. Meij, M. Frölich, J. B. Ziem, H. E. D. Suchiman, A. Metspalu, et al 2009. Selection for genetic variation inducing pro-inflammatory response under adverse environmental conditions in a Ghanaian population. PLoS One 4:7795.
63. Lahoz, C., E. J. Schaefer, L. A. Cupples, P. W. F. Wilson, D. Levy, D. Osgood, S. Parpos, J. Pedro-Botet, J. A. Daly, and J. M. Ordovas. 2001. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis 154:529-537. (Pubitemid 32232149)
64. Lange, L. A., C. S. Carlson, L. A. Hindorff, E. M. Lange, J. Walston, J. P. Durda, M. Cushman, J. C. Bis, D. Zeng, D. Lin, et al 2006. Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA 296:2703-2711. (Pubitemid 44917547)
65. Lehtinen, S., P. Luoma, T. Lehtimäki, S. Näyhä, J. Hassi, and T. Nikkari. 1994. Differences in genetic variation of apolipoprotein E in Lapps and Finns [abstract]. Atherosclerosis 109:263.
66. Livak, K. J. 2003. SNP genotyping by the 5-nuclease reaction. Methods Mol Biol 212:129-147.
67. López, C., C. Saravia, A. Gomez, J. Hoebeke, and M. A. Patarroyo. 2010. Mechanisms of genetically-based resistance to malaria. Gene 467:1-12.
68. Mahley, R. W. 1988. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240:622-630.
69. Mahley, R. W., and S. C. Rall, Jr. 2000. Apolipoprotein E: Far more than a lipid transport protein. Annu Rev Ergon Hum Genet 1:507-537.
70. Marin, G. B., M. H. Tavella, J. F. Guerreiro, S. E. B. Santos, and M. A. Zago. 1997. Absence of the E2 allele of apolipoprotein in Amerindians. Brazilian J Genet 20:741-743. (Pubitemid 28014420)
71. May, L., A. H. J. van den Biggelaar, D. van Bodegom, H. J. Meij, A. J. M. de Craen, J. Amankwa, M. Frölich, M. Kuningas, and R. G. J. Westendorp. 2009. Adverse environmental conditions influence age-related innate immune responsiveness. Immun Aging 6:7.
72. May, L., D. van Bodegom, M. Frölich, L. van Lieshout, P. E. Slagboom, R.G. Westendorp, and M. Kuningas. 2010. Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana. Eur J Hum Genet 18:480-495.
73. McDade, T. W., W. R. Leonard, J. Burhop, V. V Reyes-Garciá, T. Huanca, and R. A. Godoy. 2005. Predictors of C-reactive protein in Tsimane' 2 to 15 year-olds in lowland Bolivia. Am J Phys Anthropol 128:906-913. (Pubitemid 41746207)
74. Nyholt, D. R., C.-E. Yu, and P. M. Visscher. 2009. On Jim Watson's APOE status: Genetic information is hard to hide. Eur J Hum Genetics 17:147-150.
75. Oligati, P., A. Politis, P. Malitas, D. Albani, S. Dusi, L. Polito, S. De Mauro, A. Zisaki, C. Piperi, E. Samouli, et al. 2010. APOE epsilon-4 allele and cytokine production in Alzheimer's disease. Int J Geriatr Psychiatry 25:338-344.
76. Oriá, R. B., P. D. Patrick, M. O. Oriá, B. Lorntz, M. R. Thompson, O. G. Azevedo, R. N. Lobo, F. Pinkerton, R. L. Guerrant, and A. A. Lima. 2010. ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children. Braz J Med Biol Res 43:249-256.
77. Pankow, J. S., A. R. Folsom, M. Cushman, I. B. Borecki, P. N. Hopkins, J. H. Eckfeldt, and R. P. Tracy. 2001. Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study. Atherosclerosis 154:681-689. (Pubitemid 32232166)
78. Panza, F., V. Solfrizzi, A. Colacicco, A. Basile, A. D'Introno, C. Capurso, M. Sabba, S. Capurso, and A. Capurso. 2003. Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians. Neuroreport 14:605-608. (Pubitemid 36528999)
79. Pennington, R., C. Gatenbee, B. Kennedy, H. Harpending, and G. Cochran. 2009. Group differences in proneness to inflammation. Infect Genet Evol 9:1371-1380.
80. Ridker, P. M., E. Danielson, F. A. H. Fonseca, J. Genest, A. M. Gotto Jr., J. J. P. Kastelein, W. Koenig, P. Libby, A. J. Lorenzatti, J. G. MacFadyen, et al for the JUPITER Study Group. 2008. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 359:2195-2207.
81. Ridker, P. M., E. Danielson, Fonseca FAH, J. Genest, J A. M. Gotto Jr., J. J. P. Kastelein, W. Koenig, P. Libby, A. J. Lorenzatti, J. G. MacFadyen, et al on behalf of the JUPITER Study Group. 2009. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial. Lancet 373:1175-1182.
82. Rizzello, V., G. Liuzzo, G. D. Giannuario, E. Trabetti, S. Brugaletta, M. Santamaria, M. Piro, P. F. Pignatti, A. Maseri, L. M. Biasucci, and F. Crea. 2007. 1059G/C polymorphism within the exon 2 of the C-reactive protein gene: relationship to C-reactive protein levels and prognosis in unstable angina. Coronary Artery Dis 18:533-538. (Pubitemid 47556384)
83. Rontu, R., P. Ojala, A. Hervonen, S. Goebeler, P. J. Karhunen, M. Nikkilèa, T. Kunnas, M. Jylhä, C. Eklund, M. Hurme, et al 2006. Apoplipoprotein E genotype is related to plasma levels of -reactive protein and lipids and to longevity in nonagenarians. Clin Endocrinol 64:265-270.
84. Rosvall, L., D. Rizzuto, H.-X. Wang, B. Winblad, C. Graff, and L. Fratiglioni. 2009. APOE-related mortality: Effect of dementia, cardiovascular disease and gender. Neurobiol Aging 20:1545-1551.
85. Russell, A. I., D. S. C. Graham, C. Shepherd, C. A. Robertson, J. Whittaker, J. Meeks, R. J. Powell, D. A. Isenberg, M. J. Walport, and T. J. Vyse. 2004. Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus. Hum Mol Genet 13:137-147. (Pubitemid 38072141)
86. Sakuma, N., S. Iwata, R. Ikeuchi, T. Ichikawa, T. Hibino, Y. Kamiya, N. Ohte, M. Kawaguchi, M. Kunimatsu, H. Kawahara, et al 1995. Coexisting type III hyperlipoproteinemia and familial hypercholesterolemia: a case report. Metabolism 44:460-465.
87. Sandholzer, C., R. Delport, H. Vermaa, and G. Utermann. 1995. High frequency of the apo epsilon 4 allele in Khoi San from South Africa. Hum Genet 95:46-48.
88. Schachter, F., L. Faure-DiDelanef, F. Guenot, H. Rouger, P. Froguel, L. Lesueur-Ginot L, and D. Cohen. 1994. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 6:29-32. (Pubitemid 24191909)
89. Scholz, W. 1996. Interleukin 6 in diseases: Cause or cure? Immunopharmacology 31:131-150. (Pubitemid 26122642)
90. Sepehrnia, B., M. I. Kamboh, L. L. Adams Campbell, M. Nwankwo, and R. E. Ferrell. 1988. Genetic studies of human apolipoproteins. VII. Population distribution of polymorphisms of apolipoproteins A-I, A-II, A-IV, C-II, E, and H in Nigeria. Am J Hum Genet 43:847-853. (Pubitemid 19018986)
91. Singh, P. P., M. Singh, and S. S. Mastana. 2006. APOE distribution in world populations with new data from India and the UK. Ann Hum Biol 33:279-308. (Pubitemid 44232589)
92. Slattery, M. L., R. K. Wolff, J. S. Herrick, B. J. Caan, and J. D. Potter. 2007. IL6 genotypes and colon and rectal cancer. Cancer Causes Control 18:1095-1105. (Pubitemid 47498159)
93. Smith, J. D. 2002. Apolipoproteins and aging: Emerging mechanisms. Aging Res 1:345-365. (Pubitemid 38340329)
94. Song, Y. Q., M. J. Stampfer, and S. M. Liu. 2004. Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med 141:137-147. (Pubitemid 38937836)
95. Szalai, A. J. 2002. The biological functions of C-reactive protein. Vascul Pharmacol 39:105-107. (Pubitemid 36398231)
96. Szalai, A. J., J. Wu, E. M. Lange, M. A. McCrory, C. D. Langefeld, A. Williams, S. O. Zakharkin, V. George, D. B. Allison, G. S. Cooper, et al. 2005. Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with difference in baseline serum CRP level. J Mol Med 83:440-447. (Pubitemid 40922166)
97. Tanner, S., W. R. Leonard, T. W. McDade, V. Reyes-Garcia, R. Godoy, and T. Huanca. 2009. Influence of helminth infections on childhood nutritional status in lowland Bolivia. Am J Hum Biol 21:651-656.
98. Teng, M.-S., L.-A Hsu, S. Wu, H.-H. Chang, H. H. Chou, and Y.-L. Ko. 2009. Association between C-reactive protein gene haplotypes and C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: Interaction with obesity. Atherosclerosis 204:64-69.
99. Van Bodegom, D., L. May, H. J. Meij, and R. G. J. Westendorp. 2007. Regulation of human life histories. The role of the inflammatory host response. Ann N Y Acad Sci 1100:84-97. (Pubitemid 47092641)
100. Vasunilashorn, S., C. E. Finch, J. K. Kim, J. Winking, M. Gurven, H. Kaplan, and E. M. Crimmins. 2010. Biomarkers of aging in two societies: The U.S. and the Tsimane of Bolivia (forthcoming).
101. Vasunilashorn, S., E. Crimmins, J. K. Kim, J. Winking, M. Gurven, H. Kaplan, and C. Finch. 2010. Blood lipids, infection and inflammatory markers in the Tsimane of Bolivia. Am J Hum Biol 22:731-740.
102. Visser, M., L. M. Bouter, G. M. McQuillan, M. H. Werner, and T. B. Harris. 1999. Elevated C-reactive protein levels in overweight and obese adults. JAMA 282:2131-2135.
103. Vitek, M. P., C. M. Brown, and C. A. Colton. 2009. APOE genotype-specific differences in the innate immune response. Neurobiol Aging 30:1350-1360.
104. Walston, J., D. E. Arking, D. Fallin, T. Li, B. Beamer, Q. Xue, L. Ferrucci, L. P. Fried, and A. Chakravarti. 2005. IL-6 gene variation is not associated with increased serum levels of IL-6 muscle, weakness, or frailty in older women. Exp Gerontol 40:344-352. (Pubitemid 40488203)
105. Wee, C. C., K. J. Mukamal, A. Huang, R. B. Davis, E. P. McCarthy, and M. A. Mittleman. 2008. Obesity and C-reactive protein levels among white, black, and Hispanic US adults. Obesity 16:875-880. (Pubitemid 351465646)
106. Wellems, T. E., K. Hayton, and R. M. Fairhurst. 2009. The impact of malaria parasitism: from corpuscles to communities. J Clin Invest 119:2496-2505.
107. Wilson, P. W. F., E. J. Schaefer, M. G. Larson, and J. M. Ordovas. 1996. Apolipoprotein E alleles and risk of coronary disease-a meta-analysis. Arterioscler Thromb Vascul Biol 16:1250-1255. (Pubitemid 26339712)
108. Wozniak, M. A., R. F. Itzhaki, E. B. Faragher, M. W. Jame, S. D. Ryder, and W. L. Irving. 2002. Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. Hepatology 36:456-463. (Pubitemid 34810367)
109. Yashin, A. I., G. De Benedictis, J. W. Vaupel, Q. Tan, K. F. Andreev, I. A. Iachine, M. Bonafe, S. Valensin, M. De Luc, L. Carotenuto, et al 2000. Genes and longevity: Lessons from studies of centenarians. J Gerontol Biol Sci 55:319-328.
110. Zee, R. Y., and P. M. Ridker. 2002. Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. Atherosclerosis 162: 217-219. (Pubitemid 34327361)