Effect of the p38 MAPK inhibitor SB-239063 on Lipopolysaccharide-induced psychomotor retardation and peripheral biomarker alterations in rats

European Journal of Pharmacology

Volumn 661, Issue 1-3, 2011, Pages 49-56

  Bison, Silvia ^a   Razzoli, Maria ^a   Arban, Roberto ^a   Michielin, Francesca ^a   Bertani, Simone ^a   Carboni, Lucia ^a  

^a GSK   (Italy)

Author keywords

Cytokine; Lipopolysaccharide; Locomotor activity; p38 MAPK inhibitor; Sickness behavior; Stress hormone

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CORTICOSTERONE; CORTICOTROPIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH HORMONE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROLACTIN; TUMOR NECROSIS FACTOR ALPHA;

ACUTE DRUG ADMINISTRATION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG TARGETING; ILLNESS BEHAVIOR; LOCOMOTION; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR RETARDATION; RAT;

ANIMALS; BIOLOGICAL MARKERS; HORMONES; IMIDAZOLES; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MOTOR ACTIVITY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PSYCHOMOTOR DISORDERS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PHYSIOLOGICAL; TIME FACTORS;

EID: 79956221796     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.04.020     Document Type: Article

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