Cytokines, p38 MAP kinase and the pathophysiology of depression

Neuropsychopharmacology

Volumn 31, Issue 10, 2006, Pages 2089-2090

  Miller, Andrew H ^a   Raison, Charles L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AMITRIPTYLINE; CELL ADHESION MOLECULE; CHEMOKINE; DEXAMETHASONE; GLUCOCORTICOID; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 1; INTERLEUKIN 6; KYNURENINE; MITOGEN ACTIVATED PROTEIN KINASE P38; QUINOLINIC ACID; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CYTOKINE PRODUCTION; DEPRESSION; EDITORIAL; ENZYME MECHANISM; HUMAN; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; INFLAMMATION; MAJOR DEPRESSION; MOOD DISORDER; MOUSE; NERVE CELL PLASTICITY; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE;

CYTOKINES; DEPRESSION; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 33748774125     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301032     Document Type: Editorial

References (7)

1. Capuron L, Miller AH (2004). Cytokines and psychopathology: lessons from interferon-alpha. Biol Psychiatry 56: 819-824.
2. Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R (2002). Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol Psychiatry 7: 468-473.
3. Lanquillon S, Krieg JC, Bening-Abu-Shach U, Vedder H (2000). Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 22: 370-379.
4. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J et al (2004). Gene regulation and DNA damage in the ageing human brain. Nature 429: 883-891.
5. Raison CL, Capuron L, Miller AH Cytokines sing the blues: Inflammation and the pathogenesis of major depression. Trend Immunol (in press).
6. Wang X, Wu H, Miller AH (2004). Interleukin-1 alpha-induced activation of p38 mitogen-activated kinase inhibits glucocorticoid receptor function. Mol Psychiatry 9: 65-75.
7. Won JS, Lee JK, Suh HW (2001). Forskolin inhibits expression of inducible nitric oxide synthase mRNA via inhibiting the mitogen activated protein kinase in C6 cells. Molecular Brain Res 89: 1-10.