Multi-stage high cell continuous fermentation for high productivity and titer

Bioprocess and Biosystems Engineering

Volumn 34, Issue 4, 2011, Pages 419-431

  Chang, Ho Nam ^a   Kim, Nag Jong ^a,c   Kang, Jongwon ^a   Jeong, Chang Moon ^a   Choi, Jin Dal Rae ^a   Fei, Qiang ^a   Kim, Byoung Jin ^a,d   Kwon, Sunhoon ^a,e   Lee, Sang Yup ^a   Kim, Jungbae ^b  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea University   (South Korea)

^c Samsung Petrochemical   (South Korea)

^d Samsung Advanced Institute of Technology (SAIT)   (South Korea)

^e BINEX   (South Korea)

Author keywords

Antibody; Ethanol; High cell density; Lactic acid; Multi stage continuous fermentation

Indexed keywords

BATCH CULTIVATION; BATCH SYSTEMS; CELL DENSITY; CONTINUOUS FERMENTATION; CONTINUOUS STIRRED TANK REACTOR; CYCLE TIME; DILUTION RATE; FED BATCHES; FERMENTATION KINETICS; FERMENTATION PRODUCTS; HIGH CELL DENSITY; HIGH CELL DENSITY CULTURES; HIGH PRODUCTIVITY; HOLLOW FIBER; LACTIC ACID FERMENTATION; MULTI-STAGE; PENICILLIN PRODUCTION; PRODUCTIVITY RATIOS;

BATCH CELL CULTURE; BODY FLUIDS; CELLS; CONTINUOUS CELL CULTURE; DRILLING PLATFORMS; ETHANOL; FERMENTATION; GLUCOSE; LACTIC ACID; MONOCLONAL ANTIBODIES; PRODUCTION PLATFORMS; PRODUCTIVITY;

CELL IMMOBILIZATION;

ALCOHOL; LACTIC ACID; MONOCLONAL ANTIBODY; PENICILLIN G;

ARTICLE; BATCH FERMENTATION; BIOMASS; BIOREACTOR; CELL CULTURE; CELL DENSITY; CONTINOUS HIGH CELL DENSITY CULTURE; CONTROLLED STUDY; CULTURE TECHNIQUE; FED BATCH CULTURE; FERMENTATION; MULTI STAGE CONTINOUS HIGH CELL DENSITY CULTURE; NONHUMAN; OXYGEN SUPPLY; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; BIOMASS; BIOREACTORS; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; CULTURE MEDIA; ETHANOL; FERMENTATION; GLUCOSE; KINETICS; LACTIC ACID; MODELS, STATISTICAL; PENICILLINS; SUBSTRATE SPECIFICITY; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 79956208508     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-010-0485-8     Document Type: Article

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