Extremolytes: Natural compounds from extremophiles for versatile applications

Applied Microbiology and Biotechnology

Volumn 72, Issue 4, 2006, Pages 623-634

  Lentzen, Georg ^a   Schwarz, Thomas ^a  

^a BITOP AG   (Germany)

Author keywords

Compatible solutes; Cytoprotection; Ectoine; Extremolytes; Extremophiles; Osmolytes

Indexed keywords

EXTREMOLYTES; EXTREMOPHILES; NATURAL COMPOUNDS; OSMOLYTES;

BIOPOLYMERS; CONCENTRATION (PROCESS); LOW TEMPERATURE EFFECTS; MACROMOLECULES; PRESSURE EFFECTS; PROTEINS; STRESSES;

MICROORGANISMS;

ALPHA DIGLYCEROL PHOSPHATE; BIOPOLYMER; CYCLIC 2,3 DIPHOSPHOGLYCERIC ACID; DIMYOINOSITOL 1,1 PHOSPHATE; ECTOIN; ECTOINE; EXTREMOLYTE; FIROIN; FIROIN A; HYDROXYECTOINE; PROTEIN; STABILIZING AGENT; UNCLASSIFIED DRUG;

EXTREMOPHILE;

BIOMEDICINE; CELL PROTECTION; CONCENTRATION RESPONSE; DENATURATION; ENVIRONMENTAL CHANGE; EXTRACELLULAR FLUID; EXTREMOPHILE; MACROMOLECULE; MICROORGANISM; MOLECULAR WEIGHT; NONHUMAN; NUCLEIC ACID ANALYSIS; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STABILITY; SHORT SURVEY; SKIN CARE; SOLUTE; STRESS; TEMPERATURE SENSITIVITY; WATER STRESS;

ADAPTATION, PHYSIOLOGICAL; BACTERIA; BACTERIAL PHYSIOLOGICAL PHENOMENA; BACTERIAL PHYSIOLOGY; BIOLOGICAL PRODUCTS; BIOTECHNOLOGY; ENZYME STABILITY; SALTS; TEMPERATURE;

EID: 33749031257     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-006-0553-9     Document Type: Short Survey

References (73)

1. Andersson MM, Breccia JD, Hatti-Kaul R (2000) Stabilizing effect of chemical additives against oxidation of lactate dehydrogenase. Biotechnol Appl Biochem 32(Pt 3):145-153
2. Arakawa T, Timasheff SN (1985) The stabilization of proteins by osmolytes. Biophys J 47:411-414
3. Arora A, Ha C, Park CB (2004) Inhibition of insulin amyloid formation by small stress molecules. FEBS Lett 564:121-125
4. Baliarda A, Robert H, Jebbar M, Blanco C, Deschamps A, Marrec C (2002) Potential osmoprotectants for the lactic acid bacteria Pediococcus pentosaceus and Tetragenococcus halophila. Int J Food Microbiol 2607:1-8
5. Baluna R, Vitetta ES (1997) Vascular leak syndrome: a side effect of immunotherapy. Immunopharmacology 37:117-132
6. Barth S (2000) Pharmaceutical preparation. European Patent EP000001183047
7. Barth S, Huhn MF, Matthey B, Klimka A, Galinski EA, Engert A (2000) Compatible-solute-supported periplasmic expression of functional recombinant proteins under stress conditions. Appl Environ Microbiol 66:1572-1579
8. Bersch S, Vangala M, Schwarz T, Kaufmann M (2000) Protection of antibodies against proteolytic degradation by compatible solutes. In: 2nd international conference on protein stabilisation/biomolecule stabilisation, Lissabon
9. Beyer N, Driller H, Bünger J (2000) Ectoin - a innovative, multifunctional active substance for the cosmetic industry. SÖFW-J 126:27-29
10. Borges N, Ramos A, Raven ND, Sharp RJ, Santos H (2002) Comparative study of the thermostabilizing properties of mannosylglycerate and other compatible solutes on model enzymes. Extremophiles 6:209-216
11. Brown AD (1976) Microbial water stress. Bacteriol Rev 40:803-846
12. Bünger J (1999) Ectoine added protection and care for the skin. Eurocosmetics 7:22-24
13. Bünger J, Driller H (2004) Ectoin: an effective natural substance to prevent UVA-induced premature photoaging. Skin Pharmacol Physiol 17:232-237
14. Bünger J, Degwert J, Driller H (2001) The protective function of compatible solute ectoine on the skin cells and its biomolecules with respect to UV-radiation, immunosuppression and membrane damage. IFSCC Mag 4:1-6
15. Buommino E, Schiraldi C, Baroni A, Paoletti I, Lamberti M, De Rosa M, Tufano MA (2005) Ectoine from halophilic microorganisms induces the expression of hsp70 and hsp70B′ in human keratinocytes modulating the proinflammatory response. Cell Stress Chaperones 10:197-203
16. Chen L, Roberts MF (1998) Cloning and expression of the inositol monophosphatase gene from Methanococcus jannaschii and characterization of the enzyme. Appl Environ Microbiol 64:2609-2615
17. Chen L, Spiliotis ET, Roberts MF (1998) Biosynthesis of di-myoinositol-1,1′-phosphate, a novel osmolyte in hyperthermophilic archaea. J Bacteriol 180:3785-3792
18. Ciulla RA, Diaz MR, Taylor BF, Roberts MF (1997) Organic Osmolytes in Aerobic Bacteria from Mono Lake, an Alkaline, Moderately Hypersaline Environment. Appl Environ Microbiol 63:220-226
19. Cruz PE, Silva AC, Roldao A, Carmo M, Carrondo MJ, Alves PM (2006) Screening of novel excipients for improving the stability of retroviral and adenoviral vectors. Biotechnol Prog 22:568-576
20. Dobson CM (2003) Protein folding and disease: a view from the first Horizon Symposium. Nat Rev Drug Discov 2:154-160
21. Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MA, Santos H, da Costa MS (2004) A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase. J Bacteriol 186:4075-4084
22. Faria TQ, Lima JC, Bastos M, Macanita AL, Santos H (2004) Protein stabilization by osmolytes from hyperthermophiles: effect of mannosylglycerate on the thermal unfolding of recombinant nuclease a from Staphylococcus aureus studied by picosecond time-resolved fluorescence and calorimetry. J Biol Chem 279:48680-48691
23. Flock S, Labarbe R, Houssier C (1996) 23Na NMR study of the effect of organic osmolytes on DNA counterion atmosphere. Biophys J 71:1519-1529
24. Foord RL, Leatherbarrow RJ (1998) Effect of osmolytes on the exchange rates of backbone amide protons in proteins. Biochemistry 37:2969-2978
25. Frings E, Sauer T, Galinski EA (1995) Production of hydroxyectoine: high cell-density cultivation and osmotic downshock of Marinococcus strain M52. J Biotechnol 43:53-61
26. Furusho K, Yoshizawa T, Shoji S (2005) Ectoine alters subcellular localization of inclusions and reduces apoptotic cell death induced by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch. Neurobiol Dis 20:170-178
27. Galinski EA, Pfeiffer HP, Truper HG (1985) 1,4,5,6-Tetrahydro-2-methyl-4- pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira. Eur J Biochem 149:135-139
28. Galinski EA, Stein M, Amendt B, Kinder M (1997) The kosmotropic (structure-forming) effect of compensatory solutes. Comp Biochem Physiol 117A:357-365
29. Göller K, Galinski EA (1999) Protection of a model enzyme (lactate dehydrogenase) against heat, urea and freeze-thaw treatment by compatible solute additives. J Mol Catal B Enzym 7:37-45
30. Grammann K, Volke A, Kunte HJ (2002) New type of osmoregulated solute transporter identified in halophilic members of the bacteria domain: TRAP transporter TeaABC mediates uptake of ectoine and hydroxyectoine in Halomonas elongata DSM 2581 (T). J Bacteriol 184:3078-3085
31. Grether-Beck S, Timmer A, Felsner I, Brenden H, Brammertz D, Krutmann J (2005) Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis. J Invest Dermatol 125:545-553
32. Harjes S, Scheidig A, Bayer P (2004) Expression, purification and crystallization of human 3′-phosphoadenosine-5′-phosphosulfate synthetase 1. Acta Crystallogr D Biol Crystallogr 60:350-352
33. Hensel R, Jakob I (1994) Stability of Glyceraldehyde-3-Phosphate Dehydrogenases from Hyperthermophilic Archaea at High Temperature. Syst Appl Microbiol 16:742-745
34. Hinrichsen LL, Montel MC, Talon R (1994) Proteolytic and lipolytic activities of Micrococcus roseus (65), Halomonas elongata (16) and Vibrio sp. (168) isolated from Danish bacon curing brines. Int J Food Microbiol 22:115-126
35. Inbar L, Lapidot A (1988) The structure and biosynthesis of new tetrahydropyrimidine derivatives in actinomycin D producer Streptomyces parvulus. Use of 13C- and 15N-labeled L-glutamate and 13C and 15N NMR spectroscopy. J Biol Chem 263:16014-16022
36. Jebbar M, Talibart R, Gloux K, Bernard T, Blanco C (1992) Osmoprotection of Escherichia coli by ectoine: uptake and accumulation characteristics. J Bacteriol 174:5027-5035
37. Jebbar M, von Blohn C, Bremer E (1997) Ectoine functions as an osmoprotectant in Bacillus subtilis and is accumulated via the ABC-transport system OpuC. FEMS Microbiol Lett 154:325-330
38. Jebbar M, Sohn-Bosser L, Bremer E, Bernard T, Blanco C (2005) Ectoine-induced proteins in Sinorhizobium meliloti include an Ectoine ABC-Type transporter involved in osmoprotection and ectoine catabolism. J Bacteriol 187:1293-1304
39. Kanapathipillai M, Lentzen G, Sierks M, Park CB (2005) Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's beta-amyloid. FEBS Lett 579:4775-4780
40. Kanodia S, Roberts MF (1983) Methanophosphagen: Unique cyclic pyrophosphate isolated from Methanobacterium thermoautotrophicum. Proc Natl Acad Sci USA 80:5217-5221
41. Karsten U, West JA, Ganesan EK (1993) Comparative physiological ecology of Bostrychia moritziana (Ceramiales, Rhodophyta) from freshwater and marine habitats. Phycologia 32:401-409
42. Kolp S, Pietsch M, Galinski EA, Gütschow M (2003) Protection against proteolytic cleavage by compatible solutes. In: Polish-Austrian-German- Hungarian-Italian joint meeting on medicinal chemistry, Krakow
43. Kraegeloh A, Kunte HJ (2002) Novel insights into the role of potassium for osmoregulation in Halomonas elongata. Extremophiles 6:453-462
44. Lamosa P, Burke A, Peist R, Huber R, Liu MY, Silva G, Rodrigues-Pousada C, LeGall J, Maycock C, Santos H (2000) Thermostabilization of proteins by diglycerol phosphate, a new compatible solute from the hyperthermophile Archaeoglobus fulgidus. Appl Environ Microbiol 66:1974-1979
45. Lamosa P, Turner DL, Ventura R, Maycock C, Santos H (2003) Protein stabilization by compatible solutes. Effect of diglycerol phosphate on the dynamics of Desulfovibrio gigas rubredoxin studied by NMR. Eur J Biochem 270:4606- 4614
46. Lapidot A, Iakobashvili R, Malin G (1999) Methods for DNA amplification and sequencing. Patent WO1999041410
47. Lentzen G, Schwarz T (2005) Kompatible Solute: Mikrobielle Herstellung und Anwendung. In: Anthranikian G (ed) Angewandte Mikrobiologie. Springer, Berlin Heidelberg New York, pp 355-372
48. Lippert K, Galinski EA (1992) Enzyme stabilization by ectoine-type compatible solutes: protection against heating, freezing and drying. Appl Microbiol Biotechnol 37:61-65
49. Louis P, Trüper HG, Galinski EA (1994) Survival of Escherichia coli during drying and storage in the presence of compatible solutes. Appl Microbiol Biotechnol 41:684-688
50. Malin G, Lapidot A (1996) Induction of synthesis of tetrahydropyrimidine derivatives in Streptomyces strains and their effect on Escherichia coli in response to osmotic and heat stress. J Bacteriol 178:385-395
51. Manzanera M, Garcia de Castro A, Tondervik A, Rayner-Brandes M, Strom AR, Tunnacliffe A (2002) Hydroxyectoine is superior to trehalose for anhydrobiotic engineering of Pseudomonas putida KT2440. Appl Environ Microbiol 68:4328-4333
52. Manzanera M, Vilchez S, Tunnacliffe A (2004) High survival and stability rates of Escherichia coli dried in hydroxyectoine. FEMS Microbiol Lett 233:347-352
53. Martins LO, Santos H (1995) Accumulation of mannosylglycerate and di-myo-inositol-phosphate by Pyrococcus furiosus in response to salinity and temperature. Appl Environ Microbiol 61:3299-3303
54. Martins LO, Carreto LS, Da Costa MS, Santos H (1996) New compatible solutes related to di-myo-inositol-phosphate in members of the order Thermotogales. J Bacteriol 178:5644-5651
55. Matussek K, Moritz P, Brunner N, Eckerskorn C, Hensel R (1998) Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus. J Bacteriol 180:5997-6004
56. Melo EP, Faria TQ, Martins LO, Gonçalves AM, Cabral JMS (2001) Cutinase unfolding and stabilization by trehalose and mannosylglycerate. Proteins 42:542-552
57. Moritz P (2003) Die Bedeutung der cyclischen 2,3-Diphosphoglycerat Synthetase für die temperaturabhänige Regulation der intrazellulären Konzentration von cyclischem 2,3-Diphosphoglycerat im hyperthermophilen Archaeum Methanothermus fervidus. Ph. D. thesis, Universität Duisburg-Essen
58. Nakayama H, Yoshida K, Ono H, Murooka Y, Shinmyo A (2000) Ectoine, the compatible solute of Halomonas elongata, confers hyperosmotic tolerance in cultured tobacco cells. Plant Physiol 122:1239-1247
59. Pais TM, Lamosa P, dos Santos W, Legall J, Turner DL, Santos H (2005) Structural determinants of protein stabilization by solutes. The important of the hairpin loop in rubredoxins. Febs J 272:999-1011
60. Ramos A, Raven ND, Sharp RJ, Bartolucci S, Rossi M, Cannio R, Lebbink J, Oost Jvd, Vos WMd, Santos H (1997) Stabilization of enzymes against thermal stress and freeze-drying by mannosylglycerate. Appl Environ Microbiol 63:4020-4025
61. Rattray FP, Fox PF (1999) Aspects of enzymology and biochemical properties of brevibacterium linens relevant to cheese ripening: a review. J Dairy Sci 82:891-909
62. Rothschild LJ, Mancinelli RL (2001) Life in extreme environments. Nature 409:1092-1101
63. Santos H, da Costa MS (2002) Compatible solutes of organisms that live in hot saline environments. Environ Microbiol 4:501-509
64. Santos H, Lamosa P, Burke A, Maycock C (1998) Thermostabilization, osmoprotection and protection against desiccation of enzymes, cell components and cells by di-glycerol-phosphate. European Patent EP0965268
65. Sauer T, Galinski EA (1998) Bacterial milking: a novel bioprocess for production of compatible solutes. Biotechnol Bioeng 57:306-313
66. Scholz S, Sonnenbichler J, Schafer W, Hensel R (1992) Di-myoinositol-1,1′-phosphate: a new inositol phosphate isolated from Pyrococcus woesei. FEBS Lett 306:239-242
67. Silva Z, Borges N, Martins LO, Wait R, da Costa MS, Santos H (1999) Combined effect of the growth temperature and salinity of the medium on the accumulation of compatible solutes by Rhodothermus marinus and Rhodothermus obamensis. Extremophiles 3:163-172
68. Steger R, Weinand M, Kramer R, Morbach S (2004) LcoP, an osmoregulated betaine/ectoine uptake system from Corynebacterium glutamicum. FEBS Lett 573:155-160
69. Valentao P, Fernandes E, Carvalho F, Andrade PB, Seabra RM, de Lourdes Bastos M (2002) Antioxidant activity of Hypericum androsaemum infusion: scavenging activity against superoxide radical, hydroxyl radical and hypochlorous acid. Biol Pharm Bull 25:1320-1323
70. Vermeulen V, Kunte HJ (2004) Marinococcus halophilus DSM 20408T encodes two transporters for compatible solutes belonging to the betaine-carnitine- choline transporter family: identification and characterization of ectoine transporter EctM and glycine betaine transporter BetM. Extremophiles 8:175-184
71. Vreeland RH, Litchfield CD, Martin EL, Elliot E (1980) Halomonas elongata, a new genus and species of extremely salt-tolerant bacteria. Int J Syst Bacteriol 30:485-495
72. Yasuhiko Y, Yoshio K, Eiichiro K, Yasuhiro T, Seichi S (1997) Production of l-amino acid by fermentation method using ectoine. Japanese Patent JP9271382, 21 Oct 1997
73. Yu I, Nagaoka M (2004) Slowdown of water diffusion around protein in aqueous solution with ectoine. Chem Phys Lett 388:316-321