Role of 11β-OH-C19 and C21 steroids in the coupling of 11β-HSD1 and 17β-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells

Steroids

Volumn 76, Issue 7, 2011, Pages 682-689

  Latif, Syed A ^a   Shen, Mae ^a   Ge, Ren Shan ^b   Sottas, Chantal M ^b   Hardy, Matthew P ^b   Morris, David J ^a  

^a BROWN UNIVERSITY   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

11 Hydroxysteroid dehydrogenase; 17 Hydroxysteroid dehydrogenase; Adrenal; Enzymatic coupling; Testis

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA OH C19 STEROID; 17BETA HYDROXYSTEROID DEHYDROGENASE 3; ANDROSTENEDIONE; C 21 STEROID; CORTICOSTERONE; OXIDOREDUCTASE; STEROID; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; LEYDIG CELL; MALE; NONHUMAN; RAT; STEROID RELEASE; TESTOSTERONE SYNTHESIS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 17-HYDROXYSTEROID DEHYDROGENASES; ANDROSTENEDIONE; ANIMALS; CORTICOSTERONE; LEYDIG CELLS; MALE; NADP; OXIDATION-REDUCTION; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; STEROIDS; TESTOSTERONE;

RATTUS;

EID: 79956204146     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.03.007     Document Type: Article

References (39)

1. S.A. Berger, T.J. Cole, W. Schmid, and G. Schutz Molecular genetic analysis of glucocorticoid and mineralocorticoid signaling in development and physiological processes Steroids 61 1996 236 239 (Pubitemid 26144429)
2. P. Gass, H.M. Reichardt, T. Strekalova, F. Henn, and F. Tronche Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: models for depression and anxiety? Physiol Behav 73 2001 811 825 (Pubitemid 32885569)
3. M.R. Yudt, and J.A. Cidlowski The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene Mol Endocrinol 16 2002 1719 1726 (Pubitemid 34828083)
4. R.C. Andrews, and B.R. Walker Glucocorticoids and insulin resistance: old hormones, new targets Clin Sci 96 1999 513 523 (Pubitemid 29237902)
5. R.V. Andrews Influence of the adrenal gland on gonadal function Adv Sex Horm Res 3 1977 197 215
6. J.W. Tomlinson, E.A. Walker, I.J. Bujalska, N. Draper, G.G. Lavery, and M.S. Cooper 11β-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocr Rev 25 2005 831 866
7. J.R. Seckl, and B.R. Walker 11β-hydroxysteroid dehydrogenase type 1 - A Tissue-specific amplifier of glucocorticoid action Endocrinology 142 2001 1371 1376 (Pubitemid 32299662)
8. R.S. Ge, and M.P. Hardy Initial predominance of the oxidative activity of type I 11β-hydroxysteroid dehydrogenase in primary rat Leydig cells and transfected cell lines J Androl 21 2000 303 310 (Pubitemid 30123712)
9. R.S. Ge, D.O. Hardy, J.F. Catterall, and M.P. Hardy Developmental changes in glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase oxidative and reductive activities in rat Leydig cells Endocrinology 138 1997 5089 5095 (Pubitemid 27509664)
10. N. Draper, E.A. Walker, I.J. Bujalska, J.W. Tomlinson, S.M. Chalder, and W. Arlt Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency Nat Genet 34 2003 434 439 (Pubitemid 36935337)
11. G.G. Lavery, E.A. Walker, N. Draper, P. Jeyasuria, J. Marcos, and C.H.L. Shackleton Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation J Biol Chem 281 2006 6546 6551 (Pubitemid 43847588)
12. G. Banhegyi, A. Benedetti, R. Fulceri, and S. Senesi Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum J Biol Chem 279 2004 27017 27021 (Pubitemid 38812537)
13. E.P. Gomez-Sanchez, D.G. Romero, A.F. de Rodriguez, M.P. Warden, Z. Krozowski, and C.E. Gomez-Sanchez Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat Endocrinology 149 2008 523 533
14. Gomez-Sanchez CE, de Rodriguez AF, Romero DG, Warden MP, Fonfara G, Krozowski Z, Gomez-Sanchez EP. Immunohistochemical distribution of hexose-6-phosphate dehydrogenase and 11b-hydroxysteroid dehydrogenase. Endocrinol. Soc. Mtg June 2005. Poster P1-335.
15. G.-X. Hu, Q.-Q. Lian, H. Lin, S.A. Latif, D.J. Morris, and M.P. Hardy Rapid mechanisms of glucocorticoid signaling in the Leydig cell Steroids 73 2008 1018 1024
16. C.R. Zerez, S.J. Lee, and K.R. Tanaka Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure Anal Biochem 164 1987 367 373 (Pubitemid 17123608)
17. I.E. Bush, S.A. Hunter, and R.A. Meigs Metabolism of 11-oxygenated steroids Biochem J 107 1968 239 257
18. C. Monder, and P.C. White 11β-Hydroxysteroid dehydrogenase Vitam Horm 47 1993 187 269
19. E. Rusvai, and A. Naray-Fejes-Toth A new isoform of 11β- hydroxysteroid dehydrogenase in aldosterone target cells J Biol Chem 268 1993 10717 10720 (Pubitemid 23162245)
20. D.J. Morris, A.S. Brem, R. Ge, H.P. Jellinck, R.R. Sakai, and M.P. Hardy The functional roles of 11β-HSD1: vascular tissue, testis and brain, Mol Cell Endocrinol 203 2003 1 12 (Pubitemid 36627583)
21. I.J. Bujalska, E.A. Walker, M. Hewison, and P.M. Stewart A switch in dehydrogenase to reductase activity of 11ß -hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells J Clin Endocrinol Metab 87 2002 1205 1210 (Pubitemid 36121089)
22. A.S. Brem, R.B. Bina, T. King, and D.J. Morris 11β-OH-Progesterone affects vascular glucocorticoid metabolism and contractile response Hypertension 30 I 1997 449 454 (Pubitemid 27446107)
23. C.M. Leckie, L.A.M. Welberg, and J.R. Seckl 11β-Hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells J Endocrinol 159 1998 233 238 (Pubitemid 28520175)
24. R.-S. Ge, Q. Dong, E.-M. Niu, C.M. Sottas, D.O. Hardy, and J.F. Catterall 11β-Hydroxysteroid dehydrogenase 2 in rat Leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate Endocrinology 146 2005 2657 2664 (Pubitemid 40695568)
25. A.G. Atanasov, L.G. Nashev, R.A. Schweizer, C. Frick, and A. Odermatt Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase FEBS Lett 571 2004 129 133 (Pubitemid 38992936)
26. A.G. Atanasov, L.G. Nashev, L. Gelman, B. Legeza, R. Sack, and R. Portmann Direct protein-protein interaction of 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen Biochim Biophys Acta 1783 2008 1536 1543
27. S. Andersson, and N. Moghrabi Physiological and molecular genetics of 17β-hydroxysteroid dehydrogenases Steroids 62 1997 143 147 (Pubitemid 27066998)
28. J. Sha, P. Baker, and P.J. O'Shaughnessy Both reductase forms of 17β-hydroxysteroid dehydrogenase (types 1 and 3) are expressed during development in the mouse testis Biochem Biophys Res Commun 222 1996 90 94 (Pubitemid 26152209)
29. C. Prehn, G. Moller, and J. Adamski Recent advances in 17β-hydroxysteroid dehydrogenases J Steroid Biochem Mol Biol 114 2009 72 77
30. C. Huang, B. Wan, B. Gao, S. Hexige, and L. Yu Isolation and characterization of novel human short-chain dehydrogenase/reductase SCDR10B which is highly expressed in the brain and acts as a dehydrogenase Acta Biochim Pol 56 2009 279 289
31. E.P. Gomez-Sanchez, V. Ganjam, Y.J. Chen, D.L. Cox, M.Y. Zhou, and S. Thanigaraj The sheep kidney contains a novel unidirectional, high affinity NADP(+)-dependent 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD-3) Steroids 62 1997 444 450 (Pubitemid 27257946)
32. N. Pollack, M. Niere, and M. Zeigler NAD kinase levels control the NADPH concentration in human cells J Biol Chem 282 2007 33562 33571 (Pubitemid 350159523)
33. A.A. Dzyakanchuk, Z. Balazs, L.G. Nashev, K.E. Amrein, and A. Odermatt 11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose Mol Cell Endocrinol 301 2009 137 141
34. Y.L. Zhang, X. Zhong, Z. Gjoka, Y. Li, W. Stochaj, and M. Stahl H6PDH interacts directly with 11β-HSD1: implications for determining directionality of glucocorticoid catalysis Arch Biochem Biophys 483 2009 45 54
35. C. Betterle, C.D. Pra, F. Mantero, and R. Zanchetta Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction Endocr Rev 23 2002 327 364 (Pubitemid 34651950)
36. G. Lescoat, D. Lescoat, and D.H. Garnier Influence on adrenalectomy on maturation of gonadotrophin function in the male rat J Endocrinol 95 1982 1 6 (Pubitemid 12029753)
37. C. Parthasarathy, and K. Balasuramanian Effects of corticosterone deficiency and its replacement on leydig cell steroidogenesis J Cell Biochem 104 2008 1671 1683
38. S.B. Seminara, J.C. Achermann, M. Genel, J.L. Jameson, and W.F. Crowley X-Linked adrenal hypoplasia congenita: a mutation in DAX1 expands the phenotypic spectrum in males and females J Clin Endocrinol Metab 84 1999 4501 4509
39. Y. Sugino, T. Usui, K. Okubo, K. Nagahama, T. Takahashi, and H. Okuno Genotyping of congenital adrenal hyperplasia due to 21-hydroxylase deficiency presenting as male infertility: case report and literature review J Assist Reprod Genet 23 2006 377 380 (Pubitemid 44922383)