Mutation of the elongin C binding domain of human respiratory syncytial virus non-structural protein 1 (NS1) results in degradation of NS1 and attenuation of the virus

Virology Journal

Volumn 8, Issue , 2011, Pages

  Straub, Claire P ^a,b   Lau, Wei Har ^a,b   Preston, Faith M ^a,b   Headlam, Madeleine J ^c   Gorman, Jeffery J ^c   Collins, Peter L ^d   Spann, Kirsten M ^a,b,c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Sir Albert Sakzewski Virus Research Centre   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

attenuation; NS1; RSV

Indexed keywords

AMINO ACID; BETA INTERFERON; ELONGIN C; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NONSTRUCTURAL PROTEIN 1; ELONGIN; MUTANT PROTEIN; TRANSCRIPTION FACTOR; VIRULENCE FACTOR; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; AUTOPHAGY; GENE DELETION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VIRUS ATTENUATION; VIRUS REPLICATION; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; CERCOPITHECUS; GENETIC RECOMBINATION; GENETICS; METABOLISM; PATHOGENICITY; PROTEIN BINDING;

HUMAN RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; HUMANS; MUTANT PROTEINS; PROTEIN BINDING; RECOMBINATION, GENETIC; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; TRANSCRIPTION FACTORS; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE FACTORS; VIRUS REPLICATION;

EID: 79956201003     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-8-252     Document Type: Article

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