The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1] octane-3-carboxamide (SCH 655842): Comparison of efficacy and side effects across rodent species

European Journal of Pharmacology

Volumn 661, Issue 1-3, 2011, Pages 63-71

  Lu, Sherry X ^a   Higgins, Guy A ^a,b,c   Hodgson, Robert A ^a   Hyde, Lynn A ^a   Del Vecchio, Robert A ^a   Guthrie, Donald H ^a   Kazdoba, Tatiana ^a   McCool, Martha F ^a   Morgan, Cynthia A ^a   Bercovici, Ana ^a   Ho, Ginny D ^a   Tulshian, Deen ^a   Parker, Eric M ^a   Hunter, John C ^a   Varty, Geoffrey B ^a,d  

^a MERCK RESEARCH LABORATORIES   (United States)

^b InterVivo Solutions Inc   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d SANOFI   (France)

Author keywords

(Guinea pig); (Mouse); (Rat); Anxiety; ORL opioid receptor

Indexed keywords

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; ANXIOLYTIC AGENT; ENDO 8 [BIS(2 CHLOROPHENYL)METHYL] 3 PHENYL 8 AZABICYCLO[3.2.1]OCTANE 3 CARBOXAMIDE; SCH 655842; UNCLASSIFIED DRUG;

ADVERSE OUTCOME; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TOLERABILITY; EXPERIMENTAL GUINEA PIG; FEMALE; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; ROTAROD TEST; TEMPERATURE SENSITIVITY; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; AZABICYCLO COMPOUNDS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; BRAIN; CONDITIONING (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; FEAR; FEMALE; GENE KNOCKOUT TECHNIQUES; GUINEA PIGS; MALE; MICE; MOTOR ACTIVITY; RATS; RECEPTORS, OPIOID; ROTAROD PERFORMANCE TEST; SPECIES SPECIFICITY; VOCALIZATION, ANIMAL;

EID: 79956199777     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.04.034     Document Type: Article

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