Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Wang, Sih han ^a   Martin, Sean M ^a   Harris, Peter S ^a,b   Knudson, C Michael ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSOME; BECLIN 1; CASPASE 9; DEXAMETHASONE; PROTEIN BAX; PROTEIN BAX38; PROTEIN KINASE LCK; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, MOUSE; CASPASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE DOSAGE; HAPLOINSUFFICIENCY; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; T CELL LYMPHOMA; THYMOCYTE; THYMUS LYMPHOMA; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CELL CULTURE; CELL SEPARATION; DOMINANT GENE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PATHOLOGY; THYMUS; TRANSGENIC MOUSE; ULTRASTRUCTURE;

MUS; MUS MUSCULUS;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL DEATH; CELL PROLIFERATION; CELL SEPARATION; CELLS, CULTURED; DEXAMETHASONE; GENE DOSAGE; GENES, DOMINANT; HAPLOINSUFFICIENCY; LYMPHOMA, T-CELL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; THYMUS GLAND;

EID: 79956146245     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019786     Document Type: Article

References (41)

1. Adams JM, Cory S, (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26: 1324-1337.
2. Bakhshi A, Jensen JP, Goldman P, Wright JJ, McBride OW, et al. (1985) Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41: 899-906.
3. McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, et al. (1989) bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57: 79-88.
4. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, et al. (1997) Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275: 967-969.
5. Brimmell M, Mendiola R, Mangion J, Packham G, (1998) BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability. Oncogene 16: 1803-1812.
6. Yamamoto H, Sawai H, Weber TK, Rodriguezbigas MA, Perucho M, (1998) Somatic Frameshift Mutations in Dna Mismatch Repair and Proapoptosis Genes in Hereditary Nonpolyposis Colorectal Cancer. Cancer Research 58: 997-1003.
7. Egle A, Harris AW, Bouillet P, Cory S, (2004) Bim is a suppressor of Myc-induced mouse B cell leukemia. PNAS 101: 6164-6169.
8. Knudson CM, Johnson GM, Lin Y, Korsmeyer SJ, (2001) Bax accelerates tumorigenesis in p53-deficient mice. Cancer Research 61: 659-665.
9. Luke JJ, Van de Wetering CI, Knudson CM, (2003) Lymphoma development in Bax transgenic mice is inhibited by Bcl-2 and associated with chromosomal instability. Cell Death & Differentiation 10: 740-748.
10. Tamm I, Kornblau SM, Segall H, Krajewski S, Welsh K, et al. (2000) Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res 6: 1796-1803.
11. Soengas MS, Capodieci P, Polsky D, Mora J, Esteller M, et al. (2001) Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409: 207-211.
12. Furukawa Y, Sutheesophon K, Wada T, Nishimura M, Saito Y, et al. (2005) Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res 3: 325-334.
13. Ferreira CG, van der Valk P, Span SW, Ludwig I, Smit EF, et al. (2001) Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients. Clin Cancer Res 7: 2468-2474.
14. Krajewska M, Krajewski S, Banares S, Huang X, Turner B, et al. (2003) Elevated expression of inhibitor of apoptosis proteins in prostate cancer. Clin Cancer Res 9: 4914-4925.
15. Strater J, Herter I, Merkel G, Hinz U, Weitz J, et al. (2010) Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: caspase-8 and caspase-9 is associated with poor prognosis. Int J Cancer 127: 873-880.
16. Scott CL, Schuler M, Marsden VS, Egle A, Pellegrini M, et al. (2004) Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation. J Cell Biol 164: 89-96.
17. Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, et al. (2002) Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1: 289-298.
18. Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, et al. (1999) Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 59: 59-65.
19. Qu XP, Yu J, Bhagat G, Furuya N, Hibshoosh H, et al. (2003) Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. Journal of Clinical Investigation 112: 1809-1820.
20. Yue ZY, Jin SK, Yang CW, Levine AJ, Heintz N, (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America 100: 15077-15082.
21. Karantza-Wadsworth V, Patel S, Kravchuk O, Chen GH, Mathew R, et al. (2007) Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes & Development 21: 1621-1635.
22. Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, et al. (2007) Autophagy suppresses tumor progression by limiting chromosomal instability. Genes & Development 21: 1367-1381.
23. Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, et al. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137: 1062-1075.
24. Brown NM, Martin SM, Maurice N, Kuwana T, Knudson CM, (2007) Caspase inhibition blocks cell death and results in cell cycle arrest in cytokine-deprived hematopoietic cells. J Biol Chem 282: 2144-2155.
25. Colell A, Ricci J-E, Tait S, Milasta S, Maurer U, et al. (2007) GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation. Cell 129: 983-997.
26. Mukhopadhyay P, Rajesh M, Yoshihiro K, Hasko G, Pacher P, (2007) Simple quantitative detection of mitochondrial superoxide production in live cells. Biochem Biophys Res Commun 358: 203-208.
27. Wei YJ, Pattingre S, Sinha S, Bassik M, Levine B, (2008) JNK1-mediated phosphorylation of BcI-2 regulates starvation-induced autophagy. Molecular Cell 30: 678-688.
28. Pattingre S, Tassa A, Qu XP, Garuti R, Liang XH, et al. (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122: 927-939.
29. Lum JJ, Bauer DE, Kong M, Harris MH, Li C, et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248.
30. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, et al. (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337.
31. Soengas MS, Alarcon RM, Yoshida H, Giaccia AJ, Hakem R, et al. (1999) Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284: 156-159.
32. Tait SW, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, et al. (2010) Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell 18: 802-813.
33. Soung YH, Lee JW, Kim SY, Park WS, Nam SW, et al. (2006) Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas. APMIS 114: 292-297.
34. Kim MS, Kim SS, An CH, Yoo NJ, Lee SH, (2008) Frameshift mutation at mononucleotide repeat in Apaf-1 is rare in gastric carcinomas. Dig Liver Dis 40: 599-600.
35. van de Wetering CI, Coleman MC, Spitz DR, Smith BJ, Knudson CM, (2008) Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma. Free Radic Biol Med 44: 1677-1686.
36. Cheng Y, Deshmukh M, D'Costa A, Demaro JA, Gidday JM, et al. (1998) Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J Clin Invest 101: 1992-1999.
37. Deshmukh M, Vasilakos J, Deckwerth TL, Lampe PA, Shivers BD, et al. (1996) Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J Cell Biol 135: 1341-1354.
38. Werth JL, Deshmukh M, Cocabo J, Johnson EM, Rothman SM, (2000) Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion. Experimental Neurology 161: 203-211.
39. Catchpoole DR, Lock RB, (2001) The potential tumour suppressor role for caspase-9 (CASP9) in the childhood malignancy, neuroblastoma. Eur J Cancer 37: 2217-2221.
40. Cheng N, van de Wetering CI, Knudson CM, (2008) p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma. PLoS ONE 3: e1911.
41. Du J, Martin SM, Levine M, Wagner BA, Buettner GR, et al. (2010) Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clin Cancer Res 16: 509-520.