The potential tumour suppressor role for caspase-9 (CASP9) in the childhood malignancy, neuroblastoma

European Journal of Cancer

Volumn 37, Issue 17, 2001, Pages 2217-2221

  Catchpoole, D R ^a,b,c   Lock, R B ^a,b  

^a CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

Apoptosis; Caspase 9 (CASP9); Mutation; Neuroblastoma; Polymorphism; Tumorigenesis; Tumour suppressor gene

Indexed keywords

CASPASE 9; COMPLEMENTARY DNA;

ARTICLE; CANCER INHIBITION; CANCER SCREENING; CANCER STAGING; CARCINOGENESIS; CHILDHOOD CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE ISOLATION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; NEUROBLASTOMA; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CASPASE 9; CASPASES; CELL TRANSFORMATION, NEOPLASTIC; CHILD; DNA, COMPLEMENTARY; DNA, NEOPLASM; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEUROBLASTOMA; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 0034783359     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(01)00273-8     Document Type: Article

References (22)

1. International criteria for diagnosis, staging and response to treatment in patients with neuroblastoma
2. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
3. Why does stage 4s neuroblastoma regress spontaneously?
4. A proposed staging for children with neuroblastoma
5. Caspase, killer proteases
6. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
7. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
8. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
9. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
10. Mutations of the p53 gene are involved in Ewing's sarcoma but not in neuroblastoma
11. Clinical categories of neuroblastoma are associated with different patterns of loss of heterozygosity on chromosome arm 1p
12. A physical map of 30000 human genes
13. Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma
14. NCBI's LocusLink and RefSeq
15. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype
16. A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma
17. Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
18. Interleukin-1 β converting enzyme (ICE) is preferentially expressed in neuroblastoma with favourable prognosis
19. High levels of expression and nuclear localization of interleukin-1 β converting enzyme (ICE) and CPP32 in favourable human neuroblastomas
20. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of N-MYC
21. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
22. Regulation of cell death protease caspase-9 by phosphorylation