Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma

OMICS A Journal of Integrative Biology

Volumn 15, Issue 5, 2011, Pages 273-280

  Coco, Simona ^a   Valdora, Francesca ^b   Bonassi, Stefano ^c   Scaruffi, Paola ^a   Stigliani, Sara ^a   Oberthuer, André ^d   Berthold, Frank ^d   Andolfo, Immacolata ^e   Servidei, Tiziana ^f   Riccardi, Riccardo ^f   Basso, Eleonora ^g   Iolascon, Achille ^e   Tonini, Gian Paolo ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

^d UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^e CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^f CATHOLIC UNIVERSITY   (Italy)

^g UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER SURVIVAL; CHILD; CHROMOSOME 10Q; CHROMOSOME 16Q; CHROMOSOME 17P; CHROMOSOME 17Q; CHROMOSOME 1Q; CHROMOSOME 8P; CHROMOSOME 9Q; CHROMOSOME LOSS; CHROMOSOME NUMBER; FEMALE; GENOTYPE PHENOTYPE CORRELATION; HUMAN; ISOCHROMOSOME; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; MONOSOMY; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL;

ADOLESCENT; CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 9; FEMALE; GENETIC ASSOCIATION STUDIES; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MEDULLOBLASTOMA; MULTIVARIATE ANALYSIS; SURVIVAL ANALYSIS;

EID: 79956140754     PISSN: 15362310     EISSN: 15362310     Source Type: Journal    
DOI: 10.1089/omi.2010.0103     Document Type: Article

References (43)

1. Albright, A., Wisoff, J., Zeltzer, P., Boyett, J.M., Rorke, L.B., and Stanley, P. (1996). Effects of medulloblastoma resections on outcome in children: a report from the Children's Cancer Group. Neurosurgery 38, 265-271. (Pubitemid 26030705)
2. Bailey, C.C., Gnekow, A., Wellek, S., Jones, M., Round, C., Brown, J., et al. (1995). Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II. Med Pediatr Oncol 25, 166-178.
3. Batra, S.K., McLendon, R.E., Koo, J.S., Castelino-Prabhu, S., Fuchs, H.E., Krischer, J.P., et al. (1995). Prognostic implications of chromosome 17p deletions in human medulloblastomas. J Neurooncol 24:39-45.
4. Brown, H.G., Kepner, J.L., Perlman, E.J., Friedman, H.S., Strother, D.R., Duffner, P.K., et al. (2000). ''Large cell/anaplastic'' medulloblastomas: a Pediatric Oncology Group Study. J Neuropathol Exp Neurol 59, 857-865.
5. Chang, C.H., Houseplan, E.M., and Herbert, C. (1969). An operative staging system for a megavoltage radiotherapeutic technique for cerebellar medulloblastomas. Radiology 93: 1351-1359.
6. Clifford, S.C., Lusher, M.E., Lindsey, J.C., Langdon, J.A., Gilbertson, R.J., Straughton, D., et al. (2006). Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis. Cell Cycle 5, 2666-2670.
7. Cogen, P.H., and McDonald, J.D. (1996). Tumor soppressor genes and medulloblastoma. J Neurooncol 29:103-111.
8. Crawford, J.R., MacDonald, T.J., and Packer, R.J. (2007). Medulloblastoma in childhood: new biological advances. Lancet Neurol 6, 1073-1085. (Pubitemid 350116703)
9. Eberhart, C.G., Kratz, J., Wang, Y., Summers, K., Stearns, D., Cohen, K., et al. (2004). Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.J Neuropathol Exp Neurol 63, 441-449. (Pubitemid 38669665)
10. Ellison, D.W., Onilude, O.E., Lindsey, J.C., Lusher, M.E., Weston, C.L., and Taylor, R.E. (2005). beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J Clin Oncol 23, 7951-7957. (Pubitemid 46657395)
11. Gajjar, A., Chintagumpala, M., Ashley, D., Kellie, S., Kun, L.E., Merchant, T.E., et al. (2006). Risk-adapted craniospinal ra-diotherapy followed by high-dose chemotherapy and stemcell rescue in children with newly diagnosed medulloblastoma (St. Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol 7, 813-820. (Pubitemid 44464063)
12. Giangaspero, F., Eberhart, C., Haapasalo, H., Pietsch, T., Wiestler, O.D., and Ellison, D.W. (2007). Medulloblastoma. In: WHO Classification of Tumours of the Central Nervous System. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. (IARC Press, Lyon, France).
13. Gilbertson, R., Wickramasinghe, C., Hernan, R., Balaji, V., Hunt, D., Jones-Wallace, D., et al. (2001). Clinical and molecular stratification of disease risk in medulloblastoma. Br J Cancer 85, 705-712. (Pubitemid 32929469)
14. Herms, J., Neidt, I., Lüscher, B., Sommer, A., Schürmann, P., Schröder, T., et al. (2000). C-MYC expression in medulloblastoma and its prognostic value. Int J Cancer 89, 395-402.
15. Hui, A.B., Takano, H., Lo, K.W., Kuo, W.L., Lam, C.N., Tong, C.Y., et al. (2005). Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using highresolution array comparative genomic hybridization analysis. Clin Cancer Res 11, 4707-4716. (Pubitemid 41557189)
16. Jung, H.L., Wang, K.C., Kim, S.K., Sung, K.W., Koo, H.H., Shin, H.Y., et al. (2004). Loss of heterozygosity analysis of chromosome 17p13.1-13.3 and its correlation with clinical outcome in medulloblastomas. J Neurooncol 67:41-46. (Pubitemid 38418247)
17. Kool, M., Koster, J., Bunt, J., Hasselt, N.E., Lakeman, A., Vansluis, P., et al. (2008). Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 3, e3088.
18. Korshunov, A., Remke, M., Werft, W., Benner, A., Ryzhova, M., Witt, H., et al. (2010). Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification. J Clin Oncol 28, 3054-3060.
19. Lamont, J.M., McManamy, C.S., Pearson, A.D., Clifford, S.C., and Ellison, D.W. (2004). Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin Cancer Res 10, 5482-5493. (Pubitemid 39100486)
20. Langdon, J.A., Lamont, J.M., Scott, D.K., Dyer, S., Prebble, E., Bown, N., et al. (2006). Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma. Genes Chromosomes Cancer 45, 47-60. (Pubitemid 46930861)
21. Lo, K.C., Ma, C., Bundy, B.N., Pomeroy, S.L., Eberhart, C.G., and Cowell, J.K. (2007a). Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma. Clin Cancer Res 13, 7022-7028. (Pubitemid 350276883)
22. Lo, K.C., Rossi, M.R., Burkhardt, T., Pomeroy, S.L., and Cowell, J.K. (2007b). Overlay analysis of the oligonucleotide array gene expression profiles and copy number abnormalities as determined by array comparative genomic hybridization in medulloblastomas. Genes Chromosomes Cancer 46, 53-66. (Pubitemid 44772872)
23. Lo, K.C., Rossi, M.R., Eberhart, C.G., and Cowell, J.K. (2007c). Genome wide copy number abnormalities in pediatric medulloblastomas as assessed by array comparative genome hybridization. Brain Pathol 17, 282-296. (Pubitemid 47000637)
24. Maw, M.A., Grundy, P.E., Millow, L.J., Eccles, M.R., Dunn, R.S., Smith, P.J., et al. (1992). A third Wilms' tumor locus on chromosome 16q. Cancer Res 52, 3094-3098.
25. Michiels, E.M., Weiss, M.M., Hoovers, J.M., Baak, J.P., Voûte, P.A., Baas, F., et al. (2002). Genetic alterations in childhood medulloblastoma analyzed by comparative genomic hybridization. J Pediatr Hematol Oncol 24, 205-210. (Pubitemid 34297564)
26. Mollenhauer, J., Wiemann, S., Scheurlen, W., Korn, B., Hayashi, Y., Wilgenbus, K.K., et al. (1997). DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet 17, 32-39. (Pubitemid 27377529)
27. Nicholson, J., Wickramasinghe, C., Ross, F., Crolla, J., and Ellison, D. (2000). Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridization and fluorescence in situ hybridisation. Mol Pathol 53, 313-319.
28. Oyharcabal-Bourden, V., Kalifa, C., Gentet, J.C., Frappaz, D., Edan, C., Chastagner, P., et al. (2005). Standard-risk medulloblastoma treated by adjuvant chemotherapy followed by reduced-dose craniospinal radiation therapy: a French Society of Pediatric Oncology Study. J Clin Oncol 23, 4726-4734. (Pubitemid 46224076)
29. Packer, R.J., Goldwein, J., Nicholson, H.S., Vezina, L.G., Allen, J.C., Ris, M.D., et al. (1999). Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study. J Clin Oncol 17, 2127-2136. (Pubitemid 29318845)
30. Packer, R.J., Rood, B.R., and MacDonald, T.J. (2003). Medulloblastoma: present concepts of stratification into risk groups. Pediatr Neurosurg 39, 60-67. (Pubitemid 36829097)
31. Patterson, R., and Farr, R.F. (1953). Cerebellar medulloblastomas: treatment by irradiation of the whole central nervous system. Acta Radiol 39. 323-336.
32. Pfister, S., Remke, M., Benner, A., Mendrzyk, F., Toedt, G., Felsberg, J., et al. (2009). Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J Clin Oncol 27, 1627-1636.
33. Piao, Z., Park, C., Kim, J.J., and Kim, H. (1999). Deletion mapping of chromosome 16q in hepatocellular carcinoma. Br J Cancer 80, 850-854. (Pubitemid 29209850)
34. Pietsch, T., Waha, A., Koch, A., Kraus, J., Albrecht, S., Tonn, J., et al. (1997). Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 57, 2085-2088. (Pubitemid 27247016)
35. Roylance, R., Gorman, P., Papior, T., Wan, Y.L., Ives, M., Watson, J.E., et al. (2006). A comprehensive study of chromosome 16q in invasive ductal and lobular breast carcinoma using array CGH. Oncogene 25, 6544-6553. (Pubitemid 44607087)
36. Scaruffi, P., Valent, A., Schramm, A., Astrahantseff, K., Eggert, A., and Tonini, G.P. (2005). Application of microarray-based technology to neuroblastoma. Cancer Lett 228:13-20. (Pubitemid 41188420)
37. Schofield, D., West, D.C., Anthony, D.C., Marshal, R., and Sklar, J. (1995). Correlation of loss of heterozygosity at chromosome 9q with histological subtype in medulloblastomas. Am J Pathol 146, 472-480.
38. Segal, R.A., Goumnerova, L.C., Kwon, Y.K., Stiles, C.D., and Pomeroy, S.L. (1994). Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci USA 91, 12867-12871.
39. Shlomit, R., Ayala, A.G., Michal, D., Ninett, A., Frida, S., Boleslaw, G., et al. (2000). Gains and losses of DNA sequences in childhood brain tumors analyzed by comparative genomic hybridization. Cancer Genet Cytogenet 121, 67-72. (Pubitemid 30665744)
40. Stanton, S.E., Shin, S.W., Johnson, B.E., and Meyerson, M. (2000). Recurrent allelic deletions of chromosome arms 15q and 16q in human small cell lung carcinomas. Genes Chromosomes Cancer 27, 323-331. (Pubitemid 30067463)
41. Thompson, M.C., Fuller, C., Hogg, T.L., Dalton, J., Finkelstein, D., Lau, C.C., et al. (2006). Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 24, 1924-1931. (Pubitemid 46638992)
42. Yin, X.L., Pang, J.C., Liu, Y.H., Chong, E.Y., Cheng, Y., Poon, W.S., et al. (2001). Analysis of loss of heterozygosity on chromosomes 10q, 11, and 16 in medulloblastomas. J Neurosurg 94, 799-805. (Pubitemid 32799630)
43. Zeltzer, P.M., Boyett, J.M., Finlay, J.L., Albright, A.L., Rorke, L.B., Milstein, J.M., et al. (1999).Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: Conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol 17, 832-845. (Pubitemid 29109313)