Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects

Journal of Applied Physiology

Volumn 110, Issue 5, 2011, Pages 1204-1210

  Long, Yun Chau ^a   Kostovski, Emil ^b   Boon, Hanneke ^a   Hjeltnes, Nils ^b   Krook, Anna ^a   Widegren, Ulrika ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SUNNAAS REHABILITATION HOSPITAL   (Norway)

Author keywords

Glycogen storage; Metabolism; Oxidation; Physical inactivity; Tetraplegia

Indexed keywords

GLUCOSE; MUSCLE PROTEIN;

ADULT; ARTICLE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIPID METABOLISM; MALE; METABOLISM; MUSCLE; SPINAL CORD INJURY;

ADULT; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; LIPID METABOLISM; MALE; MUSCLE PROTEINS; MUSCLES; SPINAL CORD INJURIES;

EID: 79956108795     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00686.2010     Document Type: Article

References (45)

1. Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117: 421-426, 2004. (Pubitemid 38610228)
2. Aksnes AK, Brundin T, Hjeltnes N, Wahren J. Metabolic, thermal and circulatory effects of intravenous infusion of amino acids in tetraplegic patients. Clin Physiol 15: 377-396, 1995.
3. Aksnes AK, Hjeltnes N, Wahlstrom EO, Katz A, Zierath JR, Wallberg-Henriksson H. Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients. Am J Physiol Endocrinol Metab 271: E593-E600, 1996.
4. Andersen JL, Aagaard P. Myosin heavy chain IIX overshoot in human skeletal muscle. Muscle Nerve 23: 1095-1104, 2000. (Pubitemid 30437120)
5. Andres R, Cader G, Zierler KL. The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state; measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. J Clin Invest 35: 671-682, 1956.
6. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab 1: 259-271, 2005. (Pubitemid 43960608)
7. Bassel-Duby R, Olson EN. Signaling pathways in skeletal muscle remodeling. Annu Rev Biochem 75: 19-37, 2006. (Pubitemid 44118024)
8. Burnham R, Martin T, Stein R, Bell G, MacLean I, Steadward R. Skeletal muscle fibre type transformation following spinal cord injury. Spinal Cord 35: 86-91, 1997. (Pubitemid 27084735)
9. Castro MJ, Apple DF Jr, Hillegass EA, Dudley GA. Influence of complete spinal cord injury on skeletal muscle cross-sectional area within the first 6 months of injury. Eur J Appl Physiol Occup Physiol 80: 373-378, 1999. (Pubitemid 29405672)
10. de Lange P, Ragni M, Silvestri E, Moreno M, Schiavo L, Lombardi A, Farina P, Feola A, Goglia F, Lanni A. Combined cDNA array/RT-PCR analysis of gene expression profile in rat gastrocnemius muscle: relation to its adaptive function in energy metabolism during fasting. FASEB J 18: 350-352, 2004.
11. Ennion S, Sant=ana Pereira J, Sargeant AJ, Young A, Goldspink G. Characterization of human skeletal muscle fibres according to the myosin heavy chains they express. J Muscle Res Cell Motil 16: 35-43, 1995.
12. Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. A potential link between muscle peroxisome proliferator-activated receptor-[alpha] signaling and obesity-related diabetes. Cell Metab 1: 133-144, 2005. (Pubitemid 43960595)
13. Frayn KN. The glucose-fatty acid cycle: a physiological perspective. Biochem Soc Trans 31: 1115-1119, 2003.
14. Fueger PT, Shearer J, Krueger TM, Posey KA, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse. J Physiol 566: 533-541, 2005. (Pubitemid 41030558)
15. Giangregorio L, McCartney N. Bone loss and muscle atrophy in spinal cord injury: epidemiology, fracture prediction, and rehabilitation strategies. J Spinal Cord Med 29: 489-500, 2006.
16. Gross DN, Wan M, Birnbaum MJ. The role of FOXO in the regulation of metabolism. Curr Diab Rep 9: 208-214, 2009.
17. Hildebrandt AL, Neufer PD. Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle. Am J Physiol Endocrinol Metab 278: E1078-E1086, 2000. (Pubitemid 30439146)
18. Hjeltnes N, Aksnes AK, Birkeland KI, Johansen J, Lannem A, Wallberg-Henriksson H. Improved body composition after 8 wk of electrically stimulated leg cycling in tetraplegic patients. Am J Physiol Regul Integr Comp Physiol 273: R1072-R1079, 1997.
19. Hjeltnes N, Fernstrom M, Zierath JR, Krook A. Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects. Diabetologia 42: 826-830, 1999. (Pubitemid 29325072)
20. Hjeltnes N, Galuska D, Bjornholm M, Aksnes AK, Lannem A, Zierath JR, Wallberg-Henriksson H. Exercise-induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons: molecular mechanism for improved glucose homeostasis. FASEB J 12: 1701-1712, 1998. (Pubitemid 28553665)
21. Holloszy JO, Kohrt WM. Regulation of carbohydrate and fat metabolism during and after exercise. Annu Rev Nutr 16: 121-138, 1996. (Pubitemid 26286849)
22. Hribal ML, Nakae J, Kitamura T, Shutter JR, Accili D. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J Cell Biol 162: 535-541, 2003. (Pubitemid 37022932)
23. Ihmels J, Levy R, Barkai N. Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae. Nat Biotechnol 22: 86-92, 2004. (Pubitemid 38057961)
24. Jeukendrup AE. Regulation of fat metabolism in skeletal muscle. Ann NY Acad Sci 967: 217-235, 2002. (Pubitemid 34721908)
25. Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, Ezaki O. Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, downregulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem 279: 41114-41123, 2004. (Pubitemid 39287713)
26. Kannus P, Alosa D, Cook L, Johnson RJ, Renstrom P, Pope M, Beynnon B, Yasuda K, Nichols C, Kaplan M. Effect of one-legged exercise on the strength, power and endurance of the contralateral leg. A randomized, controlled study using isometric and concentric isokinetic training. Eur J Appl Physiol Occup Physiol 64: 117-126, 1992.
27. Kelley D, Mandarino L. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49: 677-683, 2000. (Pubitemid 30339979)
28. Kiens B, Roepstorff C, Glatz JFC, Bonen A, Schjerling P, Knudsen J, Nielsen JN. Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender. J Appl Physiol 97: 1209-1218, 2004. (Pubitemid 39302660)
29. Kramer DK, Ahlsen M, Norrbom J, Jansson E, Hjeltnes N, Gustafsson T, Krook A. Human skeletal muscle fibre type variations correlate with PPAR alpha, PPAR delta and PGC-1 alpha mRNA. Acta Physiol (Oxf) 188: 207-216, 2006. (Pubitemid 44622368)
30. Leger B, Senese R, Al-Khodairy AW, Deriaz O, Gobelet C, Giacobino JP, Russell AP. Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients. Muscle Nerve 40: 69-78, 2009.
31. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha ) in the cellular fasting response: The PPARalpha -null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 96: 7473-7478, 1999. (Pubitemid 29299686)
32. Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1[alpha] drives the formation of slow-twitch muscle fibres. Nature 418: 797-801, 2002.
33. Long YC, Barnes BR, Mahlapuu M, Steiler TL, Martinsson S, Leng Y, Wallberg-Henriksson H, Andersson L, Zierath JR. Role of AMPactivated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle. Diabetologia 48: 2354-2364, 2005. (Pubitemid 41618928)
34. Lotta S, Scelsi R, Alfonsi E, Saitta A, Nicolotti D, Epifani P, Carraro U. Morphometric and neurophysiological analysis of skeletal muscle in paraplegic patients with traumatic cord lesion. Paraplegia 29: 247-252, 1991.
35. Mandard S, Muller M, Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 61: 393-416, 2004. (Pubitemid 38316578)
36. Monroe MB, Tataranni PA, Pratley R, Manore MM, Skinner JS, Ravussin E. Lower daily energy expenditure as measured by a respiratory chamber in subjects with spinal cord injury compared with control subjects. Am J Clin Nutr 68: 1223-1227, 1998. (Pubitemid 28550952)
37. Pette D, Staron RS. Transitions of muscle fiber phenotypic profiles. Histochem Cell Biol 115: 359-372, 2001. (Pubitemid 32467749)
38. Pilegaard H, Saltin B, Neufer PD. Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle. Diabetes 52: 657-662, 2003. (Pubitemid 36323571)
39. Plomgaard P, Penkowa M, Leick L, Pedersen BK, Saltin B, Pilegaard H. The mRNA expression profile of metabolic genes relative to MHC isoform pattern in human skeletal muscles. J Appl Physiol 101: 817-825, 2006. (Pubitemid 44352295)
40. Sacheck JM, Hyatt JP, Raffaello A, Jagoe RT, Roy RR, Edgerton VR, Lecker SH, Goldberg AL. Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. FASEB J 21: 140-155, 2007. (Pubitemid 46052553)
41. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117: 399-412, 2004. (Pubitemid 38534545)
42. Seip RL, Angelopoulos TJ, Semenkovich CF. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. Am J Physiol Endocrinol Metab 268: E229-E236, 1995.
43. Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S. Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle. Am J Physiol Cell Physiol 267: C1723-C1728, 1994.
44. Tunstall RJ, Mehan KA, Wadley GD, Collier GR, Bonen A, Hargreaves M, Cameron-Smith D. Exercise training increases lipid metabolism gene expression in human skeletal muscle. Am J Physiol Endocrinol Metab 283: E66-E72, 2002. (Pubitemid 34686669)
45. Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H, Evans RM. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol 2: e294, 2004.