메뉴 건너뛰기




Volumn 124, Issue 10, 2011, Pages 1635-1643

p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels

Author keywords

Keratinocyte; p63; Proliferation

Indexed keywords

ACTIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; ISOPROTEIN; MESSENGER RNA; PROTEIN P107; PROTEIN P130; PROTEIN P21; PROTEIN P53; PROTEIN P63; PROTEIN P63 ALPHA; PROTEIN P63 BETA; RETINOBLASTOMA PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 79956088481     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.084723     Document Type: Article
Times cited : (22)

References (53)
  • 1
    • 77952559255 scopus 로고    scopus 로고
    • The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis
    • Barre, B. and Perkins, N. D. (2010). The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis. Mol. Cell 38, 524-538.
    • (2010) Mol. Cell , vol.38 , pp. 524-538
    • Barre, B.1    Perkins, N.D.2
  • 2
    • 77953575202 scopus 로고    scopus 로고
    • Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality
    • Bauzon, F. and Zhu, L. (2010). Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality. Cell Cycle 9, 2118-2123.
    • (2010) Cell Cycle , vol.9 , pp. 2118-2123
    • Bauzon, F.1    Zhu, L.2
  • 3
    • 27744597937 scopus 로고    scopus 로고
    • Regulation of the cyclin-dependent kinase inhibitor p57Kip2 expression by p63
    • Beretta, C., Chiarelli, A., Testoni, B., Mantovani, R. and Guerrini, L. (2005). Regulation of the cyclin-dependent kinase inhibitor p57Kip2 expression by p63. Cell Cycle 4, 1625-1631.
    • (2005) Cell Cycle , vol.4 , pp. 1625-1631
    • Beretta, C.1    Chiarelli, A.2    Testoni, B.3    Mantovani, R.4    Guerrini, L.5
  • 4
    • 0038708117 scopus 로고    scopus 로고
    • SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells
    • Bhattacharya, S., Garriga, J., Calbo, J., Yong, T., Haines, D. S. and Grana, X. (2003). SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells. Oncogene 22, 2443-2451.
    • (2003) Oncogene , vol.22 , pp. 2443-2451
    • Bhattacharya, S.1    Garriga, J.2    Calbo, J.3    Yong, T.4    Haines, D.S.5    Grana, X.6
  • 8
    • 4444306013 scopus 로고    scopus 로고
    • The Rb network
    • DeGregori, J. (2004). The Rb network. J. Cell Sci. 117, 3411-3413.
    • (2004) J. Cell Sci. , vol.117 , pp. 3411-3413
    • DeGregori, J.1
  • 9
    • 34547753615 scopus 로고    scopus 로고
    • p63 and p73 in human cancer: defining the network
    • Deyoung, M. P. and Ellisen, L. W. (2007). p63 and p73 in human cancer: defining the network. Oncogene 26, 5169-5183.
    • (2007) Oncogene , vol.26 , pp. 5169-5183
    • Deyoung, M.P.1    Ellisen, L.W.2
  • 11
    • 44349122993 scopus 로고    scopus 로고
    • Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
    • Frescas, D. and Pagano, M. (2008). Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat. Rev. Cancer 8, 438-449.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 438-449
    • Frescas, D.1    Pagano, M.2
  • 13
    • 33846629387 scopus 로고    scopus 로고
    • Tumor suppressor dosage regulates stem cell dynamics during aging
    • Gatza, C., Moore, L., Dumble, M. and Donehower, L. A. (2007). Tumor suppressor dosage regulates stem cell dynamics during aging. Cell Cycle 6, 52-55.
    • (2007) Cell Cycle , vol.6 , pp. 52-55
    • Gatza, C.1    Moore, L.2    Dumble, M.3    Donehower, L.A.4
  • 16
    • 70349693968 scopus 로고    scopus 로고
    • Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence
    • Helmbold, H., Komm, N., Deppert, W. and Bohn, W. (2009). Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence. Oncogene 28, 3456-3467.
    • (2009) Oncogene , vol.28 , pp. 3456-3467
    • Helmbold, H.1    Komm, N.2    Deppert, W.3    Bohn, W.4
  • 17
    • 0029036491 scopus 로고
    • The pRb-related protein p130 is a possible effector of transforming growth factor beta 1 induced cell cycle arrest in keratinocytes
    • Herzinger, T., Wolf, D. A., Eick, D. and Kind, P. (1995). The pRb-related protein p130 is a possible effector of transforming growth factor beta 1 induced cell cycle arrest in keratinocytes. Oncogene 10, 2079-2084.
    • (1995) Oncogene , vol.10 , pp. 2079-2084
    • Herzinger, T.1    Wolf, D.A.2    Eick, D.3    Kind, P.4
  • 19
    • 33646124023 scopus 로고    scopus 로고
    • Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6
    • Incassati, A., Patel, D. and McCance, D. J. (2006). Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6. Oncogene 25, 2444-2451.
    • (2006) Oncogene , vol.25 , pp. 2444-2451
    • Incassati, A.1    Patel, D.2    McCance, D.J.3
  • 20
    • 0035082243 scopus 로고    scopus 로고
    • Role of the newer p53 family proteins in malignancy
    • Irwin, M. S. and Kaelin, W. G., Jr (2001). Role of the newer p53 family proteins in malignancy. Apoptosis 6, 17-29.
    • (2001) Apoptosis , vol.6 , pp. 17-29
    • Irwin, M.S.1    Kaelin W.G. Jr2
  • 23
    • 0036114018 scopus 로고    scopus 로고
    • A dominant-negative form of p63 is required for epidermal proliferation in zebrafish
    • Lee, H. and Kimelman, D. (2002). A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Dev. Cell 2, 607-616.
    • (2002) Dev. Cell , vol.2 , pp. 607-616
    • Lee, H.1    Kimelman, D.2
  • 26
    • 1842343575 scopus 로고
    • Human papillomavirus type 16 alters human epithelial cell differentiation in vitro
    • McCance, D. J., Kopan, R., Fuchs, E. and Laimins, L. A. (1988). Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc. Natl. Acad. Sci. USA 85, 7169-7173.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 7169-7173
    • McCance, D.J.1    Kopan, R.2    Fuchs, E.3    Laimins, L.A.4
  • 27
    • 76449099717 scopus 로고    scopus 로고
    • The role of p63 in epidermal morphogenesis and neoplasia
    • McDade, S. S. and McCance, D. J. (2010). The role of p63 in epidermal morphogenesis and neoplasia. Biochem. Soc. Trans. 38, 223-228.
    • (2010) Biochem. Soc. Trans. , vol.38 , pp. 223-228
    • McDade, S.S.1    McCance, D.J.2
  • 28
    • 77957195647 scopus 로고    scopus 로고
    • MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6
    • McKenna, D. J., McDade, S. S., Patel, D. and McCance, D. J. (2010). MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6. J. Virol. 84, 10644-10652.
    • (2010) J. Virol. , vol.84 , pp. 10644-10652
    • McKenna, D.J.1    McDade, S.S.2    Patel, D.3    McCance, D.J.4
  • 29
    • 0033594491 scopus 로고    scopus 로고
    • p63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R. and Bradley, A. (1999). p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398, 708-713.
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1    Zheng, B.2    Wang, X.J.3    Vogel, H.4    Roop, D.R.5    Bradley, A.6
  • 30
    • 59949100164 scopus 로고    scopus 로고
    • Candidate housekeeping genes require evaluation before their selection for studies of human epidermal keratinocytes
    • Minner, F. and Poumay, Y. (2009). Candidate housekeeping genes require evaluation before their selection for studies of human epidermal keratinocytes. J. Invest. Dermatol. 129, 770-773.
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 770-773
    • Minner, F.1    Poumay, Y.2
  • 31
    • 0029020945 scopus 로고
    • Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1Aassociated p300 protein in terminal differentiation
    • Missero, C., Calautti, E., Eckner, R., Chin, J., Tsai, L. H., Livingston, D. M. and Dotto, G. P. (1995). Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1Aassociated p300 protein in terminal differentiation. Proc. Natl. Acad. Sci. USA 92, 5451-5455.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5451-5455
    • Missero, C.1    Calautti, E.2    Eckner, R.3    Chin, J.4    Tsai, L.H.5    Livingston, D.M.6    Dotto, G.P.7
  • 33
    • 0034234312 scopus 로고    scopus 로고
    • Frequent alteration of p63 expression in human primary bladder carcinomas
    • Park, B. J., Lee, S. J., Kim, J. I., Lee, C. H., Chang, S. G., Park, J. H. and Chi, S. G. (2000). Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res. 60, 3370-3374.
    • (2000) Cancer Res. , vol.60 , pp. 3370-3374
    • Park, B.J.1    Lee, S.J.2    Kim, J.I.3    Lee, C.H.4    Chang, S.G.5    Park, J.H.6    Chi, S.G.7
  • 36
    • 34548671621 scopus 로고    scopus 로고
    • p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest. DNA repair and apoptosis
    • Schavolt, K. L. and Pietenpol, J. A. (2007). p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis. Oncogene 26, 6125-6132.
    • (2007) Oncogene , vol.26 , pp. 6125-6132
    • Schavolt, K.L.1    Pietenpol, J.A.2
  • 37
    • 10044266819 scopus 로고    scopus 로고
    • Dominant negative p63 isoform expression in head and neck squamous cell carcinoma
    • Sniezek, J. C., Matheny, K. E., Westfall, M. D. and Pietenpol, J. A. (2004). Dominant negative p63 isoform expression in head and neck squamous cell carcinoma. Laryngoscope 114, 2063-2072.
    • (2004) Laryngoscope , vol.114 , pp. 2063-2072
    • Sniezek, J.C.1    Matheny, K.E.2    Westfall, M.D.3    Pietenpol, J.A.4
  • 39
    • 0033529790 scopus 로고    scopus 로고
    • p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential
    • Topley, G. I., Okuyama, R., Gonzales, J. G., Conti, C. and Dotto, G. P. (1999). p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential. Proc. Natl. Acad. Sci. USA 96, 9089-9094.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9089-9094
    • Topley, G.I.1    Okuyama, R.2    Gonzales, J.G.3    Conti, C.4    Dotto, G.P.5
  • 40
    • 0031828874 scopus 로고    scopus 로고
    • p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes
    • Tron, V. A., Trotter, M. J., Tang, L., Krajewska, M., Reed, J. C., Ho, V. C. and Li, G. (1998). p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes. Am. J. Pathol. 153, 579-585.
    • (1998) Am. J. Pathol. , vol.153 , pp. 579-585
    • Tron, V.A.1    Trotter, M.J.2    Tang, L.3    Krajewska, M.4    Reed, J.C.5    Ho, V.C.6    Li, G.7
  • 41
    • 33751230475 scopus 로고    scopus 로고
    • p63 regulates proliferation and differentiation of developmentally mature keratinocytes
    • Truong, A. B., Kretz, M., Ridky, T. W., Kimmel, R. and Khavari, P. A. (2006). p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev. 20, 3185-3197.
    • (2006) Genes Dev. , vol.20 , pp. 3185-3197
    • Truong, A.B.1    Kretz, M.2    Ridky, T.W.3    Kimmel, R.4    Khavari, P.A.5
  • 43
    • 73349139851 scopus 로고    scopus 로고
    • Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice
    • Wang, H., Bauzon, F., Ji, P., Xu, X., Sun, D., Locker, J., Sellers, R. S., Nakayama, K., Nakayama, K. I., Cobrinik, D. et al. (2010). Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice. Nat. Genet. 42, 83-88.
    • (2010) Nat. Genet. , vol.42 , pp. 83-88
    • Wang, H.1    Bauzon, F.2    Ji, P.3    Xu, X.4    Sun, D.5    Locker, J.6    Sellers, R.S.7    Nakayama, K.8    Nakayama, K.I.9    Cobrinik, D.10
  • 44
    • 85074914953 scopus 로고    scopus 로고
    • A PCR primer bank for quantitative gene expression analysis
    • Wang, X. and Seed, B. (2003). A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res. 31, e154.
    • (2003) Nucleic Acids Res. , vol.31
    • Wang, X.1    Seed, B.2
  • 45
    • 0036787917 scopus 로고    scopus 로고
    • E7 abolishes raf-induced arrest via mislocalization of p21(Cip1)
    • Westbrook, T. F., Nguyen, D. X., Thrash, B. R. and McCance, D. J. (2002). E7 abolishes raf-induced arrest via mislocalization of p21(Cip1). Mol. Cell. Biol. 22, 7041-7052.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7041-7052
    • Westbrook, T.F.1    Nguyen, D.X.2    Thrash, B.R.3    McCance, D.J.4
  • 46
    • 0037377761 scopus 로고    scopus 로고
    • The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations
    • Westfall, M. D., Mays, D. J., Sniezek, J. C. and Pietenpol, J. A. (2003). The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol. Cell. Biol. 23, 2264-2276.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2264-2276
    • Westfall, M.D.1    Mays, D.J.2    Sniezek, J.C.3    Pietenpol, J.A.4
  • 47
    • 77952472239 scopus 로고    scopus 로고
    • p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1)
    • Wong, P. P., Pickard, A. and McCance, D. J. (2010). p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1). PLoS ONE 5, e8369.
    • (2010) PLoS ONE , vol.5
    • Wong, P.P.1    Pickard, A.2    McCance, D.J.3
  • 48
    • 0032161624 scopus 로고    scopus 로고
    • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M. D., Dotsch, V., Andrews, N. C., Caput, D. and McKeon, F. (1998). p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2, 305-316.
    • (1998) Mol. Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6    Andrews, N.C.7    Caput, D.8    McKeon, F.9
  • 50
    • 33847057887 scopus 로고    scopus 로고
    • Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells
    • Yang, A., Zhu, Z., Kapranov, P., McKeon, F., Church, G. M., Gingeras, T. R. and Struhl, K. (2006). Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol. Cell 24, 593-602.
    • (2006) Mol. Cell , vol.24 , pp. 593-602
    • Yang, A.1    Zhu, Z.2    Kapranov, P.3    McKeon, F.4    Church, G.M.5    Gingeras, T.R.6    Struhl, K.7
  • 51
    • 40749111551 scopus 로고    scopus 로고
    • A skin microRNA promotes differentiation by repressing 'stemness'
    • Yi, R., Poy, M. N., Stoffel, M. and Fuchs, E. (2008). A skin microRNA promotes differentiation by repressing 'stemness'. Nature 452, 225-229.
    • (2008) Nature , vol.452 , pp. 225-229
    • Yi, R.1    Poy, M.N.2    Stoffel, M.3    Fuchs, E.4
  • 52
    • 0032530151 scopus 로고    scopus 로고
    • Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
    • Yu, Z. K., Gervais, J. L. and Zhang, H. (1998). Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc. Natl. Acad. Sci. USA 95, 11324-11329.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11324-11329
    • Yu, Z.K.1    Gervais, J.L.2    Zhang, H.3
  • 53
    • 77953293194 scopus 로고    scopus 로고
    • Skp2 knockout reduces cell proliferation and mouse body size: and prevents cancer?
    • Zhu, L. (2010). Skp2 knockout reduces cell proliferation and mouse body size: and prevents cancer? Cell Res. 20, 605-607.
    • (2010) Cell Res. , vol.20 , pp. 605-607
    • Zhu, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.