Skp2 knockout reduces cell proliferation and mouse body size: And prevents cancer?

Cell Research

Volumn 20, Issue 6, 2010, Pages 605-607

  Zhu, Liang ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; GROWTH INHIBITOR; S PHASE KINASE ASSOCIATED PROTEIN;

ANIMAL; ARTICLE; BODY SIZE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; NEOPLASM; PHYSIOLOGY; UBIQUITINATION;

ANIMALS; BODY SIZE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH INHIBITORS; MICE; MICE, KNOCKOUT; NEOPLASMS; S-PHASE KINASE-ASSOCIATED PROTEINS; UBIQUITINATION;

EID: 77953293194     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.71     Document Type: Article

References (15)

1. Hao B, Zheng N, Schulman BA, et al. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell 2005; 20:9-19.
2. Frescas D, Pagano M. Deregulated proteolysis by the F-box proteins SKP2 and -TrCP: tipping the scales of cancer. Nat Rev Cancer 2008; 8:438-449.
3. Nakayama K, Nagahama H, Minamishima YA, et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 2000; 19:2069-2081.
4. Lin HK, Chen Z, Wang G, et al. Skp2 targeting suppresses tumorigenesis by Arfp53-independent cellular senescence. Nature 2010; 464:374-379.
5. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007; 8:729-740.
6. Wang H, Bauzon F, Ji P, et al. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice. Nat Genet 2010; 42:83-88.
7. Old JB, Kratzat S, Hoellein A, et al. Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis. Mol Cancer Res 2010; 8:353-362.
8. Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001; 411:1017-1021.
9. Ji P, Jiang H, Rekhtman K, et al. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell 2004; 16:47-58.
10. Binne UK, Classon MK, Dick FA, et al. Retinoblastoma protein and anaphasepromoting complex physically interact and functionally cooperate during cellcycle exit. Nat Cell Biol 2007; 9:225-232.
11. Zhang L, Wang C. F-box protein Skp2: a novel transcriptional target of E2F. Oncogene 2005; 25:2615-2627.
12. Ji P, Goldin L, Ren H, et al. Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. J Biol Chem 2006; 281:24058-24069.
13. Kitagawa M, Lee SH, McCormick F. Skp2 Suppresses p53-Dependent Apoptosis by Inhibiting p300. Mol Cell 2008; 29:217-231.
14. Malek NP, Sundberg H, McGrew S, et al. A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 2001; 413:323-327.
15. Soucy TA, Smith PG, Milhollen MA, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009; 458:732-736.