Characterization of hydroxycinnamic acid glucuronide and sulfate conjugates by HPLC-DAD-MS2: Enhancing chromatographic quantification and application in Caco-2 cell metabolism

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 5, 2011, Pages 1245-1254

  Farrell, Tracy ^a   Poquet, Laure ^b   Dionisi, Fabiola ^b   Barron, Denis ^b   Williamson, Gary ^a,b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Bioavailability; Caco 2; LC MS MS; Phase II metabolism; Phenolic acid; Sulfation

Indexed keywords

AGLYCONE; CAFFEIC ACID; COUMARIC ACID; FERULIC ACID; GLUCURONIDE; SULFATE;

ACCURACY; ARTICLE; AUTORADIOGRAPHY; BIOAVAILABILITY; CELL METABOLISM; CELL STRAIN CACO 2; DIFFERENTIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ISOMERIZATION; LIMIT OF DETECTION; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; ULTRAVIOLET RADIATION;

CACO-2 CELLS; CAFFEIC ACIDS; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARIC ACIDS; DRUG STABILITY; GLUCURONIDES; HUMANS; HYDROLYSIS; MODELS, CHEMICAL; REPRODUCIBILITY OF RESULTS; SOLVENTS; SPECIMEN HANDLING; SULFATES; TEMPERATURE;

EID: 79956081851     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.03.023     Document Type: Article

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