4-Aminothiazolyl analogs of GE2270 A: Design, synthesis and evaluation of imidazole analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3210-3215

  Lamarche, Matthew J ^a   Leeds, Jennifer A ^a   Dzink Fox, Joanne ^a   Mullin, Steve ^a   Patane, Michael A ^a   Rann, Elin M ^a   Tiamfook, Stacey ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Antibacterial; Antibiotic; Curtius; Drug discovery; Elongation factor Tu; GE2270 A; Imidazole; Natural product

Indexed keywords

4 THIAZOLYL IMIDAZOLE DERIVATIVE; COPPER; GE 2270A; IMIDAZOLE DERIVATIVE; NATURAL PRODUCT; NOCATHIACIN; THIOMURACIN; THIOSTREPTON; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINES; ANTI-BACTERIAL AGENTS; COPPER; ESCHERICHIA COLI; GRAM-POSITIVE BACTERIA; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

POSIBACTERIA;

EID: 79956061227     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.048     Document Type: Article

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