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Volumn 10, Issue 5, 2011, Pages 874-882

2-Methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; ENMD 1198; RISEDRONIC ACID; UNCLASSIFIED DRUG;

EID: 79955989699     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-10-0997     Document Type: Article
Times cited : (16)

References (41)
  • 1
    • 26944459975 scopus 로고    scopus 로고
    • Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone
    • DOI 10.1677/erc.1.00543
    • Clines GA, Guise TA. Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone. Endocr Relat Cancer 2005;12:549-83. (Pubitemid 41482993)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.3 , pp. 549-583
    • Clines, G.A.1    Guise, T.A.2
  • 3
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • DOI 10.1038/nrc867
    • Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002;2:584-93. (Pubitemid 37328925)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.8 , pp. 584-593
    • Mundy, G.R.1
  • 4
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • DOI 10.1172/JCI31537
    • Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 2007;117:1175-83. (Pubitemid 46718402)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.5 , pp. 1175-1183
    • Lin, W.-W.1    Karin, M.2
  • 5
    • 56749107194 scopus 로고    scopus 로고
    • The tumor microenvironment and its contribution to tumor evolution toward metastasis
    • Lorusso G, Ruegg C. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol 2008;130:1091-103.
    • (2008) Histochem Cell Biol , vol.130 , pp. 1091-1103
    • Lorusso, G.1    Ruegg, C.2
  • 6
    • 33747181617 scopus 로고    scopus 로고
    • Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: A crossectional and longitudinal evaluation
    • DOI 10.1038/sj.bjc.6603285, PII 6603285
    • Voorzanger-Rousselot N, Juillet F, Mareau E, Zimmermann J, Kalebic T, Garnero P. Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: a cross-sectional and longitudinal evaluation. Br J Cancer 2006;95:506-14. (Pubitemid 44232560)
    • (2006) British Journal of Cancer , vol.95 , Issue.4 , pp. 506-514
    • Voorzanger-Rousselot, N.1    Juillet, F.2    Mareau, E.3    Zimmermann, J.4    Kalebic, T.5    Garnero, P.6
  • 7
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • + regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22:531-62.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 8
    • 0028221238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells
    • 41994
    • Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, et al. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem 41994;269:6271-4.
    • J Biol Chem , vol.269 , pp. 6271-6274
    • Pertovaara, L.1    Kaipainen, A.2    Mustonen, T.3    Orpana, A.4    Ferrara, N.5    Saksela, O.6
  • 9
    • 40649090942 scopus 로고    scopus 로고
    • Molecular mechanisms and treatment of bone metastasis
    • Clines GA, Guise TA. Molecular mechanisms and treatment of bone metastasis. Expert Rev Mol Med 2008;10:e7.
    • (2008) Expert Rev Mol Med , vol.10
    • Clines, G.A.1    Guise, T.A.2
  • 11
    • 0142250340 scopus 로고    scopus 로고
    • Transforming growth factor-beta in osteolytic breast cancer bone metastases
    • Guise TA, Chirgwin JM. Transforming growth factor-beta in osteolytic breast cancer bone metastases. Clin Orthop Relat Res 2003;415 Suppl:S32-8.
    • (2003) Clin Orthop Relat Res , vol.415 , Issue.SUPPL.
    • Guise, T.A.1    Chirgwin, J.M.2
  • 13
    • 0036897097 scopus 로고    scopus 로고
    • Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs
    • Bocci G, Nicolaou KC, Kerbel RS. Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res 2002;62:6938-43. (Pubitemid 35424084)
    • (2002) Cancer Research , vol.62 , Issue.23 , pp. 6938-6943
    • Bocci, G.1    Nicolaou, K.C.2    Kerbel, R.S.3
  • 16
    • 77953730756 scopus 로고    scopus 로고
    • + regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels
    • + regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels. Cancer Res 2010;70:4850-8.
    • (2010) Cancer Res , vol.70 , pp. 4850-4858
    • Zhao, J.1    Cao, Y.2    Lei, Z.3    Yang, Z.4    Zhang, B.5    Huang, B.6
  • 17
    • 0842269204 scopus 로고    scopus 로고
    • Mechanism of action of 2-methoxyestradiol: New developments
    • DOI 10.1016/j.drup.2003.10.001
    • Mooberry SL. Mechanism of action of 2-methoxyestradiol: new developments. Drug Resist Updat 2003;6:355-61. (Pubitemid 38173586)
    • (2003) Drug Resistance Updates , vol.6 , Issue.6 , pp. 355-361
    • Mooberry, S.L.1
  • 18
    • 0742269867 scopus 로고    scopus 로고
    • New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent
    • DOI 10.1097/00001622-200311000-00004
    • Mooberry SL. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr Opin Oncol 2003;15:425-30. (Pubitemid 38147037)
    • (2003) Current Opinion in Oncology , vol.15 , Issue.6 , pp. 425-430
    • Mooberry, S.L.1
  • 19
    • 71049183916 scopus 로고    scopus 로고
    • Synthesis, antiproliferative, and pharmacokinetic properties of 3-and 17-double-modified analogs of 2-methoxyestradiol
    • Agoston GE, Shah JH, Suwandi L, Hanson AD, Zhan X, LaVallee TM, et al. Synthesis, antiproliferative, and pharmacokinetic properties of 3-and 17-double-modified analogs of 2-methoxyestradiol. Bioorg Med Chem Lett 2009;19:6241-4.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 6241-6244
    • Agoston, G.E.1    Shah, J.H.2    Suwandi, L.3    Hanson, A.D.4    Zhan, X.5    LaVallee, T.M.6
  • 20
    • 48949095975 scopus 로고    scopus 로고
    • Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198
    • LaVallee TM, Burke PA, Swartz GM, Hamel E, Agoston GE, Shah J, et al. Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198. Mol Cancer Ther 2008;7:1472-82.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1472-1482
    • LaVallee, T.M.1    Burke, P.A.2    Swartz, G.M.3    Hamel, E.4    Agoston, G.E.5    Shah, J.6
  • 21
    • 48949087080 scopus 로고    scopus 로고
    • ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo
    • Moser C, Lang SA, Mori A, Hellerbrand C, Schlitt HJ, Geissler EK, et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer 2008;8:206.
    • (2008) BMC Cancer , vol.8 , pp. 206
    • Moser, C.1    Lang, S.A.2    Mori, A.3    Hellerbrand, C.4    Schlitt, H.J.5    Geissler, E.K.6
  • 22
    • 77952123093 scopus 로고    scopus 로고
    • ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties
    • Pasquier E, Sinnappan S, Munoz MA, Kavallaris M. ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Mol Cancer Ther 2010;9:1408-18.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1408-1418
    • Pasquier, E.1    Sinnappan, S.2    Munoz, M.A.3    Kavallaris, M.4
  • 23
    • 79955986877 scopus 로고    scopus 로고
    • A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer
    • Zhou Q, Gustafson D, Nallapareddy S, Diab S, Leong S, Lewis K, et al. A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer. Invest New Drugs 2011;2:340-6.
    • (2011) Invest New Drugs , vol.2 , pp. 340-346
    • Zhou, Q.1    Gustafson, D.2    Nallapareddy, S.3    Diab, S.4    Leong, S.5    Lewis, K.6
  • 24
    • 58249121577 scopus 로고    scopus 로고
    • Inhibition of bone resorption and growth of breast cancer in the bone microenvironment
    • Buijs JT, Que I, Lowik CW, Papapoulos SE, Van Der Pluijm G. Inhibition of bone resorption and growth of breast cancer in the bone microenvironment. Bone 2009;44:380-6.
    • (2009) Bone , vol.44 , pp. 380-386
    • Buijs, J.T.1    Que, I.2    Lowik, C.W.3    Papapoulos, S.E.4    Van Der Pluijm, G.5
  • 25
    • 51349163043 scopus 로고    scopus 로고
    • Bisphosphonates: Mechanism of action and role in clinical practice
    • Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc 2008;83:1032-45.
    • (2008) Mayo Clin Proc , vol.83 , pp. 1032-1045
    • Drake, M.T.1    Clarke, B.L.2    Khosla, S.3
  • 28
    • 1942501727 scopus 로고    scopus 로고
    • Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: Results from two randomised, placebo-controlled phase III studies
    • DOI 10.1038/sj.bjc.6601663
    • Body JJ, Diel IJ, Lichinitzer M, Lazarev A, Pecherstorfer M, Bell R, et al. Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studies. Br J Cancer 2004;90:1133-7. (Pubitemid 38496803)
    • (2004) British Journal of Cancer , vol.90 , Issue.6 , pp. 1133-1137
    • Body, J.J.1    Diel, I.J.2    Liehinitzer, M.3    Lazarev, A.4    Pecherstorfer, M.5    Bell, R.6    Tripathy, D.7    Bergstrom, B.8
  • 29
    • 0034783467 scopus 로고    scopus 로고
    • Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: Application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions
    • Peyruchaud O, Winding B, Pecheur I, Serre CM, Delmas P, Clezardin P. Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions. J Bone Miner Res 2001;16:2027-34. (Pubitemid 32995393)
    • (2001) Journal of Bone and Mineral Research , vol.16 , Issue.11 , pp. 2027-2034
    • Peyruchaud, O.1    Winding, B.2    Pecheur, I.3    Serre, C.-M.4    Delmas, P.5    Clezardin, P.6
  • 32
    • 73449097423 scopus 로고    scopus 로고
    • An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: Actions of TNP-470, marimastat and the tubulin-binding agent Ang-510
    • van Wijngaarden J, Snoeks TJ, van Beek ER, Bloys H, Kaijzel EL, van Hinsbergh V, et al. An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510. Biochem Biophys Res Commun 2010;391:1161-5.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1161-1165
    • Van Wijngaarden, J.1    Snoeks, T.J.2    Van Beek, E.R.3    Bloys, H.4    Kaijzel, E.L.5    Van Hinsbergh, V.6
  • 33
    • 0345161422 scopus 로고    scopus 로고
    • The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates
    • DOI 10.1359/jbmr.1999.14.5.722
    • van Beek ER, Lowik CW, Van Der Pluijm G, Papapoulos S. The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: a clue to the mechanism of action of nitrogen-containing bisphosphonates. J Bone Miner Res 1999;14:722-9. (Pubitemid 29210598)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.5 , pp. 722-729
    • Van Beek, E.1    Lowik, C.2    Van Der, P.G.3    Papapoulos, S.4
  • 35
    • 0037434841 scopus 로고    scopus 로고
    • Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- Or 2-methoxyestradiol-induced apoptosis
    • DOI 10.1016/S0014-5793(03)00131-5
    • Basu A, Haldar S. Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS Lett 2003;538:41-7. (Pubitemid 36287422)
    • (2003) FEBS Letters , vol.538 , Issue.1-3 , pp. 41-47
    • Basu, A.1    Haldar, S.2
  • 36
    • 70249108848 scopus 로고    scopus 로고
    • Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment
    • Dunn LK, Mohammad KS, Fournier PG, McKenna CR, Davis HW , Niewolna M , et al. Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS One 2009;4:e6896.
    • (2009) PLoS One , vol.4
    • Dunn, L.K.1    Mohammad, K.S.2    Fournier, P.G.3    McKenna, C.R.4    Davis, H.W.5    Niewolna, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.