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Volumn 5, Issue 3, 2011, Pages 222-226

Combined azithromycin and metronidazole therapy is effective in inducing remission in pediatric Crohn's disease

Author keywords

Antibiotics; Apoptosis; Azithromycin; Child; Crohn's disease; Inflammatory bowel disease; Therapy

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; IMMUNOMODULATING AGENT; METRONIDAZOLE;

EID: 79955950438     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2011.01.006     Document Type: Article
Times cited : (40)

References (33)
  • 1
    • 0030830553 scopus 로고    scopus 로고
    • Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases
    • Sartor J.B. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. Am J Gastroenterol 1997, 92:S5-S11.
    • (1997) Am J Gastroenterol , vol.92
    • Sartor, J.B.1
  • 2
    • 3242737791 scopus 로고    scopus 로고
    • Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    • J
    • Martin H.M., Campbell B.J., Hart C.A., Mpofu C., Nayar M., Singh R., et al. Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology 2004 Jul, 127(1):80-93.
    • (2004) Gastroenterology , vol.127 , Issue.1 , pp. 80-93
    • Martin, H.M.1    Campbell, B.J.2    Hart, C.A.3    Mpofu, C.4    Nayar, M.5    Singh, R.6
  • 3
    • 4444306100 scopus 로고    scopus 로고
    • Bacterial DNA within granulomas of patients with Crohn's disease - detection by laser capture microdissection and PCR
    • A
    • Ryan P., Kelly R.G., Lee G., et al. Bacterial DNA within granulomas of patients with Crohn's disease - detection by laser capture microdissection and PCR. Am J Gastroenterol 2004 Aug, 99(8):1539-1543.
    • (2004) Am J Gastroenterol , vol.99 , Issue.8 , pp. 1539-1543
    • Ryan, P.1    Kelly, R.G.2    Lee, G.3
  • 4
    • 4444349841 scopus 로고    scopus 로고
    • High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study
    • Mow W.S., Landers C.J., Steinhart A.H., et al. High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study. Dig Dis Sci 2004, 49:1280-1286.
    • (2004) Dig Dis Sci , vol.49 , pp. 1280-1286
    • Mow, W.S.1    Landers, C.J.2    Steinhart, A.H.3
  • 5
    • 0034873344 scopus 로고    scopus 로고
    • Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death
    • S
    • Glasser A.L., Boudeau J., Branch N., Perruchot M.H., Colombel J.F., Darfeuille-Michaud A. Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death. Infect Immun 2001 Sep, 69(9):5529-5537.
    • (2001) Infect Immun , vol.69 , Issue.9 , pp. 5529-5537
    • Glasser, A.L.1    Boudeau, J.2    Branch, N.3    Perruchot, M.H.4    Colombel, J.F.5    Darfeuille-Michaud, A.6
  • 6
    • 33644831090 scopus 로고    scopus 로고
    • The Crohn's disease-associated adherent-invasive Escherichia coli strain LF82 replicates in mature phagolysosomes within J774 macrophages
    • Bringer M.A., Glasser A.L., Tung C.H., Meresse S., Darfeuille-Michaud A. The Crohn's disease-associated adherent-invasive Escherichia coli strain LF82 replicates in mature phagolysosomes within J774 macrophages. Cell Microbiol 2006, 8:471-484.
    • (2006) Cell Microbiol , vol.8 , pp. 471-484
    • Bringer, M.A.1    Glasser, A.L.2    Tung, C.H.3    Meresse, S.4    Darfeuille-Michaud, A.5
  • 7
    • 70449707658 scopus 로고    scopus 로고
    • Biofilm formation as a novel phenotypic feature of adherent-invasive Escherichia coli (AIEC)
    • Martinez-Medina M., Naves P., Blanco J., et al. Biofilm formation as a novel phenotypic feature of adherent-invasive Escherichia coli (AIEC). BMC Microbiol 2009, 21(9):202.
    • (2009) BMC Microbiol , vol.21 , Issue.9 , pp. 202
    • Martinez-Medina, M.1    Naves, P.2    Blanco, J.3
  • 9
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • M 31
    • Hugot J.P., Chamaillard M., Zouali H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001 May 31, 411(6837):599-603.
    • (2001) Nature , vol.411 , Issue.6837 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 10
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • M 31
    • Ogura Y., Bonen D.K., Inohara N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001 May 31, 411(6837):603-606.
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 11
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett J.C., Hansoul S., Nicolae D.L., et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008, 40:955-962.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 12
    • 39649120107 scopus 로고    scopus 로고
    • Muramyl dipeptide-induced gene expression in NOD2 mutant and wild type Crohn's disease patient-derived dendritic cells
    • Zelinkova Z., Van Beelen A.J., Dekort S., et al. Muramyl dipeptide-induced gene expression in NOD2 mutant and wild type Crohn's disease patient-derived dendritic cells. Inflamm Bowel Dis 2008, 14:186-194.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 186-194
    • Zelinkova, Z.1    Van Beelen, A.J.2    Dekort, S.3
  • 13
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux J.D., Xavier R.J., Taylor K.D., et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007, 39:596-604.
    • (2007) Nat Genet , vol.39 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3
  • 14
    • 54849421128 scopus 로고    scopus 로고
    • Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
    • Kuballa P., Huett A., Rioux J.D., Daly M.J., Xavier R.J. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE 2008, 3(10):e3391.
    • (2008) PLoS ONE , vol.3 , Issue.10
    • Kuballa, P.1    Huett, A.2    Rioux, J.D.3    Daly, M.J.4    Xavier, R.J.5
  • 15
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal {alpha}-defensin expression
    • N
    • Wehkamp J., Harder J., Weichenthal M., et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal {alpha}-defensin expression. Gut 2004 Nov, 53(11):1658-1664.
    • (2004) Gut , vol.53 , Issue.11 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 16
    • 0033565302 scopus 로고    scopus 로고
    • Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance
    • Ina K., Itoh J., Fukushima K., et al. Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol 1999, 163:1081-1090.
    • (1999) J Immunol , vol.163 , pp. 1081-1090
    • Ina, K.1    Itoh, J.2    Fukushima, K.3
  • 17
    • 0344457371 scopus 로고    scopus 로고
    • A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn's disease. Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID)
    • M
    • Colombel J.F., Lemann M., Cassagnou M., et al. A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn's disease. Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID). Am J Gastroenterol 1999 Mar, 94(3):674-678.
    • (1999) Am J Gastroenterol , vol.94 , Issue.3 , pp. 674-678
    • Colombel, J.F.1    Lemann, M.2    Cassagnou, M.3
  • 18
  • 19
    • 34548663890 scopus 로고    scopus 로고
    • Medical management of mild to moderate Crohn's disease: evidence-based treatment algorithms for induction and maintenance of remission
    • Sandborn W.J., Feagan B.G., Lichtenstein G.R. Medical management of mild to moderate Crohn's disease: evidence-based treatment algorithms for induction and maintenance of remission. Aliment Pharmacol Ther 2007, 26:987-1003.
    • (2007) Aliment Pharmacol Ther , vol.26 , pp. 987-1003
    • Sandborn, W.J.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 20
    • 33144459948 scopus 로고    scopus 로고
    • European evidence based consensus on the diagnosis and management of Crohn's disease:current management
    • Travis S.P.L., Stange E.F., Lemann M., et al. European evidence based consensus on the diagnosis and management of Crohn's disease:current management. Gut 2006, 55:6-35.
    • (2006) Gut , vol.55 , pp. 6-35
    • Travis, S.P.L.1    Stange, E.F.2    Lemann, M.3
  • 22
    • 3142574652 scopus 로고    scopus 로고
    • Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL
    • S
    • Mizunoe S., Kadota J., Tokimatsu I., Kishi K., Nagai H., Nasu M. Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL. Int Immunopharmacol 2004 Sep, 4(9):1201-1207.
    • (2004) Int Immunopharmacol , vol.4 , Issue.9 , pp. 1201-1207
    • Mizunoe, S.1    Kadota, J.2    Tokimatsu, I.3    Kishi, K.4    Nagai, H.5    Nasu, M.6
  • 23
    • 0037199689 scopus 로고    scopus 로고
    • Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects
    • A 30
    • Culic O., Erakovic V., Cepelak I., Barisic K., Brajsa K., Ferencic Z., et al. Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects. Eur J Pharmacol 2002 Aug 30, 450(3):277-289.
    • (2002) Eur J Pharmacol , vol.450 , Issue.3 , pp. 277-289
    • Culic, O.1    Erakovic, V.2    Cepelak, I.3    Barisic, K.4    Brajsa, K.5    Ferencic, Z.6
  • 24
    • 34247624035 scopus 로고    scopus 로고
    • Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America
    • M
    • Bousvaros A., Antonioli D.A., Colletti R.B., et al. Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America. J Pediatr Gastroenterol Nutr 2007 May, 44(5):653-674.
    • (2007) J Pediatr Gastroenterol Nutr , vol.44 , Issue.5 , pp. 653-674
    • Bousvaros, A.1    Antonioli, D.A.2    Colletti, R.B.3
  • 25
    • 33646778482 scopus 로고    scopus 로고
    • The Montreal classification of inflammatory bowel diseases; controversies, consensus and implications
    • Satsangi J., Silverberg M., Vermiere S., Colombel J.F. The Montreal classification of inflammatory bowel diseases; controversies, consensus and implications. Gut 2006, 55:749-753.
    • (2006) Gut , vol.55 , pp. 749-753
    • Satsangi, J.1    Silverberg, M.2    Vermiere, S.3    Colombel, J.F.4
  • 26
    • 77956344492 scopus 로고    scopus 로고
    • Appraisal of the Pediatric Crohn's Disease Activity Index on four prospectively collected datasets: recommended cutoff values and clinimetric properties
    • Turner D., Griffiths A.M., Walters T.D., et al. Appraisal of the Pediatric Crohn's Disease Activity Index on four prospectively collected datasets: recommended cutoff values and clinimetric properties. Am J Gastroenterol 2010, 105:2085-2092.
    • (2010) Am J Gastroenterol , vol.105 , pp. 2085-2092
    • Turner, D.1    Griffiths, A.M.2    Walters, T.D.3
  • 27
    • 53049110159 scopus 로고    scopus 로고
    • Natural history of pediatric Crohn's disease: a population based study
    • Vernier-Massouille G., Balde M., Salleron J., et al. Natural history of pediatric Crohn's disease: a population based study. Gastroenterology 2008, 135:1106-1113.
    • (2008) Gastroenterology , vol.135 , pp. 1106-1113
    • Vernier-Massouille, G.1    Balde, M.2    Salleron, J.3
  • 28
    • 33646884826 scopus 로고    scopus 로고
    • Antibiotic treatment of Crohn's disease: results of a multicentre, double blind, randomized, placebo-controlled trial with rifaximin
    • A 15
    • Prantera C., Lochs H., Campieri M., et al. Antibiotic treatment of Crohn's disease: results of a multicentre, double blind, randomized, placebo-controlled trial with rifaximin. Aliment Pharmacol Ther 2006 Apr 15, 23(8):1117-1125.
    • (2006) Aliment Pharmacol Ther , vol.23 , Issue.8 , pp. 1117-1125
    • Prantera, C.1    Lochs, H.2    Campieri, M.3
  • 29
    • 0031011327 scopus 로고    scopus 로고
    • Disposition of oral azithromycin in humans
    • Luke D.R., Foulds G. Disposition of oral azithromycin in humans. Clin Pharmacol Ther 1997, 61(6):641-648.
    • (1997) Clin Pharmacol Ther , vol.61 , Issue.6 , pp. 641-648
    • Luke, D.R.1    Foulds, G.2
  • 30
    • 38649143210 scopus 로고    scopus 로고
    • Replication of colonic Crohn's disease mucosal Escherichia coli isolates within macrophages and their susceptibility to antibiotics
    • F
    • Subramanian S., Roberts C., Hart C.A., et al. Replication of colonic Crohn's disease mucosal Escherichia coli isolates within macrophages and their susceptibility to antibiotics. Antimicrob Agents Chemother 2008 February, 52(2):427-434.
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.2 , pp. 427-434
    • Subramanian, S.1    Roberts, C.2    Hart, C.A.3
  • 31
    • 77951887288 scopus 로고    scopus 로고
    • Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial
    • M 5
    • Saiman L., Anstead M., Mayer-Hamblett N., et al. Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA 2010 May 5, 303(17):1707-1715.
    • (2010) JAMA , vol.303 , Issue.17 , pp. 1707-1715
    • Saiman, L.1    Anstead, M.2    Mayer-Hamblett, N.3
  • 33
    • 73449113632 scopus 로고    scopus 로고
    • Long-term daily high and low doses of azithromycin in children with cystic fibrosis: a randomized controlled trial
    • J
    • Kabra S.K., Pawaiya R., Lodha R., et al. Long-term daily high and low doses of azithromycin in children with cystic fibrosis: a randomized controlled trial. J Cyst Fibros 2010 Jan, 9(1):17-23.
    • (2010) J Cyst Fibros , vol.9 , Issue.1 , pp. 17-23
    • Kabra, S.K.1    Pawaiya, R.2    Lodha, R.3


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