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Volumn 63, Issue 2, 2011, Pages 337-347

Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions

Author keywords

Alopecia; Anemia; Cancer; Cepharanthine; Leukopenia; Multiple myeloma; Sarcoidosis; Snakebites

Indexed keywords

8 DIFLUOROMETHOXY 1 ETHYL 6 FLUORO 1,4 DIHYDRO 7 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 4 OXO 3 QUINOLINECARBOXYLIC ACID; ALPHA TOCOPHEROL; BUTYLATED HYDROXYANISOLE; CEPHARANTHINE; DEXAMETHASONE; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; KALLIKREIN; KETOTIFEN; MEMBRANE LIPID; METHYLGLYOXAL; METHYLPREDNISOLONE; PACLITAXEL; PROTEIN KINASE C; SQUARIC ACID DIBUTYL ESTER; TROLOX C; TUMOR NECROSIS FACTOR ALPHA; VENOM ANTISERUM; VINBLASTINE; VINCRISTINE; VINDESINE;

EID: 79955940323     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(11)70500-X     Document Type: Review
Times cited : (94)

References (79)
  • 1
    • 0029150003 scopus 로고
    • Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1
    • Abe T, Koike K, Ohga T, Kubo T, Wada M, Kohno K: Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1. Br J Cancer, 1995, 72, 418-423.
    • (1995) Br J Cancer , vol.72 , pp. 418-423
    • Abe, T.1    Koike, K.2    Ohga, T.3    Kubo, T.4    Wada, M.5    Kohno, K.6
  • 2
    • 0026651805 scopus 로고
    • Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells
    • Akiba S, Kato E, Sato T, Fujii T: Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells. Biochem Pharmacol, 1992, 44, 45-50.
    • (1992) Biochem Pharmacol , vol.44 , pp. 45-50
    • Akiba, S.1    Kato, E.2    Sato, T.3    Fujii, T.4
  • 3
    • 0029064975 scopus 로고
    • Direct antitumor effect of cepharanthin and combined effect with adriamycin against Ehrlich ascites tumor in mice
    • Asaumi J, Nishikawa K, Matsuoka H, Iwata M, Kawasaki S, Hiraki Y: Direct antitumor effect of cepharanthin and combined effect with adriamycin against Ehrlich ascites tumor in mice Anticancer Res, 1995, 15, 67-70.
    • (1995) Anticancer Res , vol.15 , pp. 67-70
    • Asaumi, J.1    Nishikawa, K.2    Matsuoka, H.3    Iwata, M.4    Kawasaki, S.5    Hiraki, Y.6
  • 5
    • 0036272696 scopus 로고    scopus 로고
    • Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor kappaB: A possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjögren's syndrome patients
    • DOI 10.1002/art.10315
    • Azuma M, Aota K, Tamatani T, Motegi K, Yamashita T, Ashida Y: Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor kappaB: a possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjögren's syndrome patients. Arthritis Rheum, 2002, 46, 1585-1594. (Pubitemid 34620206)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.6 , pp. 1585-1594
    • Azuma, M.1    Aota, K.2    Tamatani, T.3    Motegi, K.4    Yamashita, T.5    Ashida, Y.6    Hayashi, Y.7    Sato, M.8
  • 6
    • 0035718925 scopus 로고    scopus 로고
    • Anti-HIV-1 activity and structure-activity relationship of cepharanoline derivatives in chronically infected cells
    • Baba M, Okamoto M, Kashiwaba N, Ono M: Anti-HIV-1 activity and structure-activity relationship of cepharanoline derivatives in chronically infected cells. Antivir Chem Chemother, 2001, 12, 307-312. (Pubitemid 34168779)
    • (2001) Antiviral Chemistry and Chemotherapy , vol.12 , Issue.5 , pp. 307-312
    • Baba, M.1    Okamoto, M.2    Kashiwaba, N.3    Ono, M.4
  • 8
    • 85031249235 scopus 로고    scopus 로고
    • Cepharanthine reverses multidrug resistance sensitizing neuroblastoma cell lines to vincristine-induced cell death
    • Presented at
    • Graham RM, Guest JD, Thompson JW, Webster KA, Vanni S: Cepharanthine reverses multidrug resistance sensitizing neuroblastoma cell lines to vincristine-induced cell death. Presented at AACR, 2010.
    • (2010) AACR
    • Graham, R.M.1    Guest, J.D.2    Thompson, J.W.3    Webster, K.A.4    Vanni, S.5
  • 10
    • 0026007746 scopus 로고
    • Inhibition of 12-O-tetradecanoyl phorbol-13-acetate promoted tumorigenesis by cepharanthine, a biscoclaurine alkaloid, in relation to the inhibitory effect on protein kinase C
    • Edashige K, Utsumi T, Utsumi K: Inhibition of 12-O-tetradecanoyl phorbol-13-acetate promoted tumorigenesis by cepharanthine, a biscoclaurine alkaloid, in relation to the inhibitory effect on protein kinase C. Biochem Pharmacol, 1991, 41, 71-78.
    • (1991) Biochem Pharmacol , vol.41 , pp. 71-78
    • Edashige, K.1    Utsumi, T.2    Utsumi, K.3
  • 12
    • 0019821631 scopus 로고
    • Effect of cepharanthine on neuro-humoral excitatory responses of gastric movement in dog
    • Fujii K, Takasugi S, Toki N: Effect of cepharanthine on neuro-humoral excitatory responses of gastric movement in dog. Jpn J Physiol, 1981,31, 613-623. (Pubitemid 12219841)
    • (1981) Japanese Journal of Physiology , vol.31 , Issue.5 , pp. 613-623
    • Fujii, K.1    Takasugi, S.2    Toki, N.3
  • 15
    • 33846940700 scopus 로고    scopus 로고
    • The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: Implications for cancer, shock, and inflammatory diseases
    • DOI 10.1016/j.lfs.2006.12.001, PII S0024320506009490
    • Furusawa S, Wu J: The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: implications for cancer, shock, and inflammatory diseases. Life Sci, 2007, 80, 1073-1079. (Pubitemid 46241220)
    • (2007) Life Sciences , vol.80 , Issue.12 , pp. 1073-1079
    • Furusawa, S.1    Wu, J.2
  • 16
    • 0025824159 scopus 로고
    • Cepharanthine (biscoclaurine alkaloid) treatment in endotoxic shock of suckling rats
    • Goto M, Zeller WP, Hurley RM: Cepharanthine (biscoclaurine alkaloid) treatment in endotoxic shock of suckling rats. J Pharm Pharmacol, 1991, 43, 589-591.
    • (1991) J Pharm Pharmacol , vol.43 , pp. 589-591
    • Goto, M.1    Zeller, W.P.2    Hurley, R.M.3
  • 17
    • 85031241422 scopus 로고    scopus 로고
    • Cepharanthine reverses multidrug resistance sensitizing neuroblastoma cell lines to vincristine-induced cell death
    • Graham R: Cepharanthine reverses multidrug resistance sensitizing neuroblastoma cell lines to vincristine-induced cell death. AAOR 101st Annual Meeting 2010.
    • AAOR 101st Annual Meeting 2010
    • Graham, R.1
  • 18
    • 74349130587 scopus 로고    scopus 로고
    • Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: Cepharanthine and fangchinoline
    • Gülçin I, Elias R, Gepdiremen A, Chea A, Topal F: Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline. J Enzyme Inhib Med Chem, 2010, 25, 44-53.
    • (2010) J Enzyme Inhib Med Chem , vol.25 , pp. 44-53
    • Gülçin, I.1    Elias, R.2    Gepdiremen, A.3    Chea, A.4    Topal, F.5
  • 19
    • 42549096557 scopus 로고    scopus 로고
    • Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage
    • Halicka D, Ita M, Tanaka T, Kurose A, Darzynkiewicz Z: Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage. Pharmacol Rep, 2008, 60, 93-100. (Pubitemid 351586547)
    • (2008) Pharmacological Reports , vol.60 , Issue.1 , pp. 93-100
    • Halicka, H.D.1    Ita, M.2    Tanaka, T.3    Kurose, A.4    Darzynkiewicz, Z.5
  • 21
    • 70449563093 scopus 로고    scopus 로고
    • Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8
    • Harada K, Ferdous T, Itashiki Y, Takii M, Mano T, Mori Y: Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8. Int J Oncol, 2009, 35, 1025-1035.
    • (2009) Int J Oncol , vol.35 , pp. 1025-1035
    • Harada, K.1    Ferdous, T.2    Itashiki, Y.3    Takii, M.4    Mano, T.5    Mori, Y.6
  • 22
    • 0025968791 scopus 로고
    • Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets
    • Hashizume T, Yamaguchi H, Sato T, Fujii T: Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets. Biochem Pharmacol, 1991, 41, 419-423.
    • (1991) Biochem Pharmacol , vol.41 , pp. 419-423
    • Hashizume, T.1    Yamaguchi, H.2    Sato, T.3    Fujii, T.4
  • 23
    • 0025720594 scopus 로고
    • Cepharanthine potentiates the antitumor effect of methyl-glyoxal bis (cyclopentylamidinohydrazone) on human leukemia cells
    • Hibasami H, Takaji S, Murata T, Nakashima K: Cepharanthine potentiates the antitumor effect of methyl-glyoxal bis (cyclopentylamidinohydrazone) on human leukemia cells. Anticancer Res, 1991, 11, 1543-1547.
    • (1991) Anticancer Res , vol.11 , pp. 1543-1547
    • Hibasami, H.1    Takaji, S.2    Murata, T.3    Nakashima, K.4
  • 24
    • 47949117680 scopus 로고    scopus 로고
    • Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines
    • Ita M, Halicka HD, Tanaka T, Kurose A, Ardelt B, Shogen K: Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines. Cancer Biol Ther, 2008, 7, 1104-1108.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1104-1108
    • Ita, M.1    Halicka, H.D.2    Tanaka, T.3    Kurose, A.4    Ardelt, B.5    Shogen, K.6
  • 25
    • 0028061740 scopus 로고
    • Intraarterial chemotherapy for metastatic renal cell carcinomas: Combination with MDR-overcoming agents
    • Kakehi Y, Yoshida O, Segawa T, Kanematsu A, Hiura M, Shichiri Y: Intraarterial chemotherapy for metastatic renal cell carcinomas: combination with MDR-overcoming agents. Hinyokika Kiyo, 1994, 40, 925-929. (Pubitemid 24353541)
    • (1994) Acta Urologica Japonica , vol.40 , Issue.10 , pp. 925-929
    • Kakehi, Y.1    Yoshida, O.2    Segawa, T.3    Kanematsu, A.4    Hiura, M.5    Shichiri, Y.6    Arai, Y.7
  • 26
    • 0023227445 scopus 로고
    • Potentiation of antitumor activity of vincristine by the biscoclaurine alkaloid cepharanthine
    • Kato T, Suzumura Y: Potentiation of antitumor activity of vincristine by the biscoclaurine alkaloid cepharanthine. J Natl Cancer Inst, 1987, 79, 527-532. (Pubitemid 17126591)
    • (1987) Journal of the National Cancer Institute , vol.79 , Issue.3 , pp. 527-532
    • Kato, T.1    Suzumura, Y.2
  • 27
    • 21644459020 scopus 로고    scopus 로고
    • Cepharanthin enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR
    • Katsui K, Kuroda M, Wang Y, Komatsu M, Himei K, Takemoto M: Cepharanthin enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR. Int J Oncol, 2004, 25, 47-56.
    • (2004) Int J Oncol , vol.25 , pp. 47-56
    • Katsui, K.1    Kuroda, M.2    Wang, Y.3    Komatsu, M.4    Himei, K.5    Takemoto, M.6
  • 28
    • 0034630167 scopus 로고    scopus 로고
    • Induction of apoptosis by cancer chemotherapy
    • DOI 10.1006/excr.2000.4838
    • Kaufmann SH, Earnshaw WC: Induction of apoptosis by cancer chemotherapy. Exp Cell Res, 2000, 256, 42-49. (Pubitemid 30211165)
    • (2000) Experimental Cell Research , vol.256 , Issue.1 , pp. 42-49
    • Kaufmann, S.H.1    Earnshaw, W.C.2
  • 29
    • 54049087378 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid
    • Kikukawa Y, Okuno Y, Tatetsu H, Nakamura M, Harada N, Ueno S: Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid. Int J Oncol, 2008, 33, 807-814.
    • (2008) Int J Oncol , vol.33 , pp. 807-814
    • Kikukawa, Y.1    Okuno, Y.2    Tatetsu, H.3    Nakamura, M.4    Harada, N.5    Ueno, S.6
  • 30
    • 0031371323 scopus 로고    scopus 로고
    • Therapeutic experience of venomous snakebites by the Japanese viper (Agkistrodon halys Blomhoffii) with low dose of antivenin: Report of 43 consecutive cases
    • Kimoto T, Suemitsu K, Nakayama H, Komori E, Ohtani M, Ando S: Therapeutic experience of venomous snakebites by the Japanese viper (Agkistrodon halys Blomhoffii) with low dose of antivenin: report of 43 consecutive cases. Nippon Geka Hokan, 1997, 66, 71-77. (Pubitemid 28410969)
    • (1997) Archiv fur Japanische Chirurgie , vol.66 , Issue.2 , pp. 71-77
    • Kimoto, T.1    Suemitsu, K.2    Nakayama, H.3    Komori, E.4    Ohtani, M.5    Ando, S.6
  • 31
    • 0027074340 scopus 로고
    • Assay of flow cytometry for the effect of cepharanthine on resistance to doxorubicin
    • Kisara S, Hayashi A, Maekawa I, Furusawa S, Takayanagi Y, Sasaki K: Assay of flow cytometry for the effect of cepharanthine on resistance to doxorubicin. Yakugaku Zasshi, 1992, 112, 837-845. (Pubitemid 23022529)
    • (1992) Yakugaku Zasshi , vol.112 , Issue.11 , pp. 837-845
    • Kisara, S.1    Hayashi, A.2    Maekawa, I.3    Furusawa, S.4    Takayanagi, Y.5    Sasaki, K.6
  • 33
    • 0032929699 scopus 로고    scopus 로고
    • Potent antiperoxidation activity of the bisbenzylisoquinoline alkaloid cepharanthine: The amine moiety is responsible for its pH-dependent radical scavenge activity
    • DOI 10.1016/S0304-4165(98)00146-9, PII S0304416598001469
    • Kogure K, Goto S, Abe K, Ohiwa C, Akasu M, Terada H: Potent antiperoxidation activity of the bisbenzylisoquinoline alkaloid cepharanthine: the amine moiety is responsible for its pH-dependent radical scavenge activity. Biochim Biophys Acta, 1999, 1426, 133-142. (Pubitemid 29027876)
    • (1999) Biochimica et Biophysica Acta - General Subjects , vol.1426 , Issue.1 , pp. 133-142
    • Kogure, K.1    Goto, S.2    Abe, K.3    Ohiwa, C.4    Akasu, M.5    Terada, H.6
  • 35
    • 0022971350 scopus 로고
    • Effects of cepharanthine on experimental nasal allergy
    • Kohno H, Seyama Y, Yamashita S, Akasu M, Inoue H: Effects of cepharanthine on experimental nasal allergy. Nippon Yakurigaku Zasshi, 1986, 88, 71-76. (Pubitemid 17182940)
    • (1986) Folia Pharmacologica Japonica , vol.88 , Issue.2 , pp. 71-76
    • Kohno, H.1    Seyama, Y.2    Yamashita, S.3
  • 36
    • 0023574608 scopus 로고
    • Mode of the anti-allergic action of cepharanthine on an experimental model of allergic rhinitis
    • Kohno H, Inoue H, Seyama Y, Yamashita S, Akasu M: Mode of the anti-allergic action of cepharanthine on an experimental model of allergic rhinitis. Nippon Yakurigaku Zasshi, 1987, 90, 205-211. (Pubitemid 18083863)
    • (1987) Folia Pharmacologica Japonica , vol.90 , Issue.4 , pp. 205-211
    • Kohno, H.1    Inoue, H.2    Seyama, Y.3    Yamashita, S.4    Akasu, M.5
  • 37
    • 0021957065 scopus 로고
    • Inhibitory effect of cepharanthine on collagen-induced activation in rabbit platelets
    • DOI 10.1016/0014-2999(85)90117-7
    • Kometani M, Kanaho Y, Sato T, Fujii T: Inhibitory effect of cepharanthine on collagen-induced activation in rabbit platelets. Eur J Pharmacol, 1985, 111, 97-105. (Pubitemid 15097845)
    • (1985) European Journal of Pharmacology , vol.111 , Issue.1 , pp. 97-105
    • Kometani, M.1    Kanaho, Y.2    Sato, T.3    Fujii, T.4
  • 38
    • 0026670777 scopus 로고
    • Selective inhibition of T-cell-dependent immune responses by bisbenzylisoquinoline alkaloids in vivo
    • Kondo Y, Imai Y, Hojo H, Hashimoto Y, Nozoe S: Selective inhibition of T-cell-dependent immune responses by bisbenzylisoquinoline alkaloids in vivo. Int J Immunopharmacol, 1992, 14, 1181-1186.
    • (1992) Int J Immunopharmacol , vol.14 , pp. 1181-1186
    • Kondo, Y.1    Imai, Y.2    Hojo, H.3    Hashimoto, Y.4    Nozoe, S.5
  • 39
    • 0036204777 scopus 로고    scopus 로고
    • Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines
    • DOI 10.1023/A:1014548618440
    • Kono K, Takahashi JA, Ueba T, Mori H, Hashimoto N, Fukumoto M: Effects of combination chemotherapy with biscoclaurine-derived alkaloid (cepharanthine) and nimustine hydrochloride on malignant glioma cell lines. J Neurooncol, 2002, 56, 101-108. (Pubitemid 34272300)
    • (2002) Journal of Neuro-Oncology , vol.56 , Issue.2 , pp. 101-108
    • Kono, K.1    Takahashi, J.A.2    Ueba, T.3    Mori, H.4    Hashimoto, N.5    Fukumoto, M.6
  • 40
    • 79955933435 scopus 로고
    • Bisbenzylisoquinoline alkaloids
    • Ed. Manske R, Academic Press, London, New York
    • Kulka M: Bisbenzylisoquinoline alkaloids. In: The Alkaloids. Chemistry and Physiology, Ed. Manske R, Vol. 4. Academic Press, London, New York, 1965, 233.
    • (1965) The Alkaloids. Chemistry and Physiology , vol.4 , pp. 233
    • Kulka, M.1
  • 41
    • 13844289126 scopus 로고    scopus 로고
    • Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-κB activation in RAW 264.7 cells
    • DOI 10.1016/j.bcp.2004.11.013
    • Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S: Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-κB activation in RAW 264.7 cells. Biochem Pharmacol, 2005, 69, 791-799. (Pubitemid 40248621)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.5 , pp. 791-799
    • Lee, S.H.1    Lee, S.Y.2    Son, D.J.3    Lee, H.4    Yoo, H.S.5    Song, S.6    Oh, K.W.7    Han, D.C.8    Kwon, B.M.9    Hong, J.T.10
  • 42
    • 0027665201 scopus 로고
    • Clinical assessment of complement activation and leukocyte kinetics during cardiopulmonary bypass: The effect of cepharanthine
    • Masuda M, Tominaga R, Nokashima A, Mayumi H, Morita S, Kono H: Clinical assessment of complement activation and leukocyte kinetics during cardiopulmonary bypass: the effect of cepharanthine. Kyobu Geka, 1993, 46, 845-849.
    • (1993) Kyobu Geka , vol.46 , pp. 845-849
    • Masuda, M.1    Tominaga, R.2    Nokashima, A.3    Mayumi, H.4    Morita, S.5    Kono, H.6
  • 43
    • 0036808027 scopus 로고    scopus 로고
    • Seventeen cases of alopecia areata: Combination of SADBE topical immunotherapy with other therapies
    • Morita K, Nakamura M, Nagamachi M, Kishi T, Miyachi Y: Seventeen cases of alopecia areata: combination of SADBE topical immunotherapy with other therapies. J Dermatol, 2002, 29, 661-664. (Pubitemid 35334015)
    • (2002) Journal of Dermatology , vol.29 , Issue.10 , pp. 661-664
    • Morita, K.1    Nakamura, M.2    Nagamachi, M.3    Kishi, T.4    Miyachi, Y.5
  • 45
    • 0042386664 scopus 로고    scopus 로고
    • Cepharanthin, an alkaloid from Stephania cepharantha, inhibits increased pulmonary vascular permeability in an ovine model of sepsis
    • Murakami K, Cox RA, Hawkins HK, Schmalstieg FC, McGuire RW, Jodoin JM, Traber LD, Traber DL: Cepharanthin, an alkaloid from Stephania cepharantha, inhibits increased pulmonary vascular permeability in an ovine model of sepsis. Shock, 2003, 20, 46-51.
    • (2003) Shock , vol.20 , pp. 46-51
    • Murakami, K.1    Cox, R.A.2    Hawkins, H.K.3    Schmalstieg, F.C.4    McGuire, R.W.5    Jodoin, J.M.6    Traber, L.D.7    Traber, D.L.8
  • 47
    • 0020457023 scopus 로고
    • Effects of membrane-stabilizing agents, cholesterol and cepharanthin, on radiation-induced lipid peroxidation and permeability in liposomes
    • Nagatsuka S, Nakazawa T: Effect of membrane-stabilizing agents, cholesterol and cepharanthine, on radiation-induced lipid peroxidation and permeability in liposomes. Biochim Biophys Acta, 1982, 691, 171-177. (Pubitemid 13232481)
    • (1982) Biochimica et Biophysica Acta , vol.691 , Issue.1 , pp. 171-177
    • Nagatsuka, S.1    Nakazawa, T.2
  • 48
    • 6044228068 scopus 로고    scopus 로고
    • Beneficial effect of cepharanthine on overcoming drug-resistance of hepatocellular carcinoma
    • Nakajima A, Yamamoto Y, Taura K, Hata K, Fukumoto M, Uchinami H: Beneficial effect of cepharanthine on overcoming drug-resistance of hepatocellular carcinoma. Int J Oncol, 2004, 24, 635-645.
    • (2004) Int J Oncol , vol.24 , pp. 635-645
    • Nakajima, A.1    Yamamoto, Y.2    Taura, K.3    Hata, K.4    Fukumoto, M.5    Uchinami, H.6
  • 49
    • 0028926967 scopus 로고
    • A study on the effect of cepharanthin, a biscoclaurine alkaloid, on enhancement of mitogen-induced histidine decarboxylase activity in mice spleens and the effect of histamine on the production of cytokines
    • Nakatsu T: A study on the effect of cepharanthin, a biscoclaurine alkaloid, on enhancement of mitogen-induced histidine decarboxylase activity in mice spleens and the effect of histamine on the production of cytokines. Nippon Yakurigaku Zasshi, 1995, 105, 209-219.
    • (1995) Nippon Yakurigaku Zasshi , vol.105 , pp. 209-219
    • Nakatsu, T.1
  • 50
    • 0026825728 scopus 로고
    • Clinical evaluation of cepharanthin for chronic idiopathic thrombocytopenic purpura
    • Nakayama S, Matsushita A, Ichiba S, Nagai K: Clinical evaluation of cepharanthin for chronic idiopathic thrombocytopenic purpura. Rinsho Ketsueki, 1992, 33, 408-409.
    • (1992) Rinsho Ketsueki , vol.33 , pp. 408-409
    • Nakayama, S.1    Matsushita, A.2    Ichiba, S.3    Nagai, K.4
  • 51
    • 79955932062 scopus 로고    scopus 로고
    • Nodular muscular sarcoidosis vanished during oral cepharanthine treatment
    • Nishida H, Tsuchiya H: Nodular muscular sarcoidosis vanished during oral cepharanthine treatment. Cent Jap J Orthopaed Surg Traum, 2007, 50, 1133-1134.
    • (2007) Cent Jap J Orthopaed Surg Traum , vol.50 , pp. 1133-1134
    • Nishida, H.1    Tsuchiya, H.2
  • 52
    • 0014475317 scopus 로고
    • Effect of cepharanthine on alopecia areata
    • Niwa Y: Effect of cepharanthine on alopecia areata. Hifuka Kiyo, 1969, 64, 47-52.
    • (1969) Hifuka Kiyo , vol.64 , pp. 47-52
    • Niwa, Y.1
  • 53
    • 3242698788 scopus 로고    scopus 로고
    • Effect of cepharanthin in preventing radiation induced normal tissue damage in prostate cancer
    • Nomoto S, Imada H, Ohguri T, Yahara K, Kato F, Morioka T: Effect of cepharanthin in preventing radiation induced normal tissue damage in prostate cancer. Gan To Kagaku Ryoho, 2004, 31, 1063-1066.
    • (2004) Gan to Kagaku Ryoho , vol.31 , pp. 1063-1066
    • Nomoto, S.1    Imada, H.2    Ohguri, T.3    Yahara, K.4    Kato, F.5    Morioka, T.6
  • 55
    • 0025337656 scopus 로고
    • Effect of cepharanthin on radiotherapy induced leukopenia
    • Ohta T, Morita K: Effect of cepharanthin on radiotherapy induced leukopenia. Rinsho Hoshasen, 1990, 35, 471-474. (Pubitemid 20213108)
    • (1990) Japanese Journal of Clinical Radiology , vol.35 , Issue.4 , pp. 471-474
    • Ohta, T.1
  • 56
    • 0032749192 scopus 로고    scopus 로고
    • Prevention of lung metastasis by intra-tumoral injection of cepharanthin and staphylococcal enterotoxin B in transplantable rat osteosarcoma
    • Okada K, Sakusabe N, Kobayashi A, Hoshi N, Sato K: Prevention of lung metastasis by intra-tumoral injection of cepharanthin and staphylococcal enterotoxin B in transplantable rat osteosarcoma. Jpn J Cancer Res, 1999, 90, 928-933. (Pubitemid 29500430)
    • (1999) Japanese Journal of Cancer Research , vol.90 , Issue.9 , pp. 928-933
    • Okada, K.1    Sakusabe, N.2    Kobayashi, A.3    Hoshi, N.4    Sato, K.5
  • 57
    • 0032552469 scopus 로고    scopus 로고
    • Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells
    • Okamoto M, Ono M, Baba M: Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells. AIDS Res Hum Retroviruses, 1998, 14, 1239-1245. (Pubitemid 28488934)
    • (1998) AIDS Research and Human Retroviruses , vol.14 , Issue.14 , pp. 1239-1245
    • Okamoto, M.1    Ono, M.2    Baba, M.3
  • 58
    • 0033016647 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells
    • Okamoto M, Okamoto T, Baba M: Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. Antimicrob Agents Chemother, 1999, 43, 492-497. (Pubitemid 29109508)
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , Issue.3 , pp. 492-497
    • Okamoto, M.1    Okamoto, T.2    Baba, M.3
  • 60
    • 0030745543 scopus 로고    scopus 로고
    • Positive interaction of bisbenzylisoquinoline alkaloid, cepharanthin, with vinca alkaloid agents against human tumors
    • Ono M, Tanaka N: Positive interaction of bisbenzylisoquinoline alkaloid, cepharanthin, with vinca alkaloid agents against human tumors. In Vivo, 1997, 11, 233-241. (Pubitemid 27348109)
    • (1997) In Vivo , vol.11 , Issue.3 , pp. 233-241
    • Ono, M.1    Tanaka, N.2
  • 62
    • 0023194703 scopus 로고
    • Certain membrane-interacting amphiphiles inhibit aggregation and reverse shape change of rabbit platelets pre-activated with arachidonic acid through dissociation of cytoskeletal assembly
    • DOI 10.1016/0049-3848(87)90159-9
    • Sato T, Kometani M, Fujii T: Certain membrane-interacting amphiphiles inhibit aggregation and reverse shape change of rabbit platelets pre-activated with arachidonic acid through dissociation of cytoskeletal assembly. Thromb Res, 1987, 46, 587-592. (Pubitemid 17096472)
    • (1987) Thrombosis Research , vol.46 , Issue.4 , pp. 587-592
    • Sato, T.1    Kometani, M.2    Fujii, T.3
  • 63
    • 0035053728 scopus 로고    scopus 로고
    • Pharmacological characterization of cepharanthin in chronic idiopathic thrombocytopenic purpura
    • DOI 10.1080/09537100120039334
    • Sato T, Morita I, Fujita H, Ono M, Kimishima A, Tomiyama J, Murota S: Pharmacological characterization of cepharanthin in chronic idiopathic thrombocytopenic purpura. Platelets, 2001, 12, 156-162. (Pubitemid 32299584)
    • (2001) Platelets , vol.12 , Issue.3 , pp. 156-162
    • Sato, T.1    Morita, I.2    Fujita, H.3    Ono, M.4    Kimishima, A.5    Tomiyama, J.6    Murota, S.-I.7
  • 64
    • 71049155835 scopus 로고    scopus 로고
    • Cepharanthin effect on radiation-induced xerostomia and taste disorder in patients with head and neck cancer
    • Shimazu R, Tanaka G, Tomiyama R, Kuratomi Y, Inokuchi A: Cepharanthin effect on radiation-induced xerostomia and taste disorder in patients with head and neck cancer. Nippon Jibiinkoka Gakkai Kaiho, 2009, 112, 648-655.
    • (2009) Nippon Jibiinkoka Gakkai Kaiho , vol.112 , pp. 648-655
    • Shimazu, R.1    Tanaka, G.2    Tomiyama, R.3    Kuratomi, Y.4    Inokuchi, A.5
  • 66
    • 0023275159 scopus 로고
    • Effect of bisbenzylisoquinoline (Biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells
    • Shiraishi N, Akiyama S, Nakagawa M, Kobayashi M, Kuwano M: Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells. Cancer Res, 1987, 47, 2413-2416. (Pubitemid 17099206)
    • (1987) Cancer Research , vol.47 , Issue.9 , pp. 2413-2416
    • Shiraishi, N.1    Akiyama, S.-I.2    Nakagawa, M.3
  • 67
    • 18244390938 scopus 로고    scopus 로고
    • Reversal of multidrug resistance in drug-resistant cell line EAC/ADR by cepharanthine hydrochloride and its mechanism
    • 0513-4870(2005)03-02
    • Song Y, Xia W, Jiang J, Wang Q: Reversal of multidrug resistance in drug-resistant cell line EAC/ADR by cepharanthine hydrochloride and its mechanism. Yao Xue Xue Bao, 2005, 40, 204-207. (Pubitemid 40627128)
    • (2005) Yaoxue Xuebao , vol.40 , Issue.3 , pp. 204-207
    • Song, Y.-C.1    Xia, W.2    Jiang, J.-H.3    Wang, Q.-D.4
  • 68
    • 0025053357 scopus 로고
    • Efficacy of Cepharanthin for preventing leukopenia and thrombocytopenia induced by chemotherapy in breast cancer patient - Prospective randomized study
    • Suzuki S, Abe R, Nihei M, Kimijima I, Tsuchiya A, Nomizu T: Efficacy of Cepharanthin for preventing leukopenia and thrombocytopenia induced by chemotherapy in breast cancer patient - prospective randomized study. Gan To Kagaku Ryoho, 1990, 17, 1195-1200. (Pubitemid 20378247)
    • (1990) Japanese Journal of Cancer and Chemotherapy , vol.17 , Issue.6 , pp. 1195-1200
    • Suzuki, S.1    Abe, R.2    Nihei, M.3    Kimijima, I.4    Tsuchiya, A.5    Nomizu, T.6
  • 69
    • 0026659999 scopus 로고
    • Effects of cepharanthin on leukopenia and thrombocytopenia induced by chemotherapy in lung cancer patients
    • Suzuki R, Hara M, Shindoh J, Matsumoto S, Noda Y, Gonda H: Effects of cepharanthin on leukopenia and thrombocytopenia induced by chemotherapy in lung cancer patients. Gan To Kagaku Ryoho, 1992, 19, 647-652.
    • (1992) Gan To Kagaku Ryoho , vol.19 , pp. 647-652
    • Suzuki, R.1    Hara, M.2    Shindoh, J.3    Matsumoto, S.4    Noda, Y.5    Gonda, H.6
  • 70
    • 79955938814 scopus 로고    scopus 로고
    • Enhanced apoptosis induced by radiation and cepharanthine in human oral squamous cell carinoma cells
    • Tamatani T, Azuma M, Motegi K, Yoshida H: Enhanced apoptosis induced by radiation and cepharanthine in human oral squamous cell carinoma cells. Jap J Cancer Res, 2006, 65, 498.
    • (2006) Jap J Cancer Res , vol.65 , pp. 498
    • Tamatani, T.1    Azuma, M.2    Motegi, K.3    Yoshida, H.4
  • 71
    • 14844293192 scopus 로고    scopus 로고
    • Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum
    • DOI 10.1016/j.jep.2005.01.015
    • Tamez PA, Lantvit D, Lim E, Pezzuto JM: Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum. J Ethnopharmacol, 2005, 98, 137-142. (Pubitemid 40349178)
    • (2005) Journal of Ethnopharmacology , vol.98 , Issue.1-2 , pp. 137-142
    • Tamez, P.A.1    Lantvit, D.2    Lim, E.3    Pezzuto, J.M.4
  • 72
    • 33846520629 scopus 로고    scopus 로고
    • Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma
    • DOI 10.1007/s11060-006-9223-0
    • Terasaki M, Abe T, Miyagi N, Ogo E, Shigemori M: Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma. J Neurooncol, 2007, 81, 265-269. (Pubitemid 46165330)
    • (2007) Journal of Neuro-Oncology , vol.81 , Issue.3 , pp. 265-269
    • Terasaki, M.1    Abe, T.2    Miyagi, N.3    Ogo, E.4    Shigemori, M.5
  • 73
    • 0032928083 scopus 로고    scopus 로고
    • Nitric oxide in septic shock
    • Titheradge MA: Nitric oxide in septic shock. Biochim Biophys Acta, 1999, 1411, 437-455.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 437-455
    • Titheradge, M.A.1
  • 75
    • 44649122766 scopus 로고    scopus 로고
    • Experience using intra-arterial chemotherapy in combination with MDR-reversing agent for bone and soft-tissue metastases from renal cell carcinoma (Japanese)
    • Tsunemori H, Kitamura Y, Taniguchi S, Okazoe H, Taoka R, Inui M, Sugimoto M, Kakehi Y: Experience using intra-arterial chemotherapy in combination with MDR-reversing agent for bone and soft-tissue metastases from renal cell carcinoma (Japanese). Nish J Urol, 2008, 70, 245-249.
    • (2008) Nish J Urol , vol.70 , pp. 245-249
    • Tsunemori, H.1    Kitamura, Y.2    Taniguchi, S.3    Okazoe, H.4    Taoka, R.5    Inui, M.6    Sugimoto, M.7    Kakehi, Y.8
  • 76
    • 0024075174 scopus 로고
    • Effects of cepharanthin on leucopenia and thrombocytopenia caused by CDDP-ACR-CPA therapy against the ovarian cancer
    • Ushiki N, Jobo T, Shimoda T, Kuramoto H, Arai M: Effects of cepharanthin on leukopenia and thrombocytopenia caused by CDDP-ACR-CPA therapy of ovarian cancer. Gan To Kagaku Ryoho, 1988, 15, 2701-2706. (Pubitemid 18259883)
    • (1988) Japanese Journal of Cancer and Chemotherapy , vol.15 , Issue.9 , pp. 2701-2706
    • Ushiki, N.1    Jobo, T.2    Shimoda, T.3    Kuramoto, H.4    Arai, M.5
  • 78
    • 79955939683 scopus 로고    scopus 로고
    • Pediatric recurrent ITP case: Treatment and its application at the time of rethrombocytopenia
    • Yamazaki T, Shibuya S, Akatsuka J: Pediatric recurrent ITP case: treatment and its application at the time of rethrombocytopenia. Jpn J Pediatr Oncol, 2007, 44, 325.
    • (2007) Jpn J Pediatr Oncol , vol.44 , pp. 325
    • Yamazaki, T.1    Shibuya, S.2    Akatsuka, J.3
  • 79
    • 0025789059 scopus 로고
    • Cepharanthine inhibits two-stage tumor promotion by 12-O- tetradecanoylphorbol 13-acetate and mezerein on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene
    • Yasukawa K, Takido M, Takeuchi M, Akasu M, Nakagawa S: Cepharanthine inhibits two-stage tumor promotion by 12-O-tetradecanoylphorbol 13-acetate and mezerein on skin tumor formation in mice initiated with 7,12-dimethylbenz[a] anthracene. J Cancer Res Clin Oncol, 1991, 117, 421-424.
    • (1991) J Cancer Res Clin Oncol , vol.117 , pp. 421-424
    • Yasukawa, K.1    Takido, M.2    Takeuchi, M.3    Akasu, M.4    Nakagawa, S.5


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